FI104173B1 - Menetelmä 3-asetoksi-2,3-dihydro-5-[2-(dimetyyliamino)etyyli]-2-(p-metoksifenyyli)-1,5-bentsotiatsepin-4(5H)-onin hydrokloridin valmistamiseksi - Google Patents

Menetelmä 3-asetoksi-2,3-dihydro-5-[2-(dimetyyliamino)etyyli]-2-(p-metoksifenyyli)-1,5-bentsotiatsepin-4(5H)-onin hydrokloridin valmistamiseksi

Info

Publication number: FI104173B1
Authority: FI; Finland
Prior art keywords: benzothiazepin; methoxyphenyl; dihydro; dimethylamino; ethyl
Prior art date: 1990-11-29

Application number

FI915625A

Other languages

English (en)

Swedish (sv)

Other versions

FI104173B (fi

FI915625L (fi

FI915625A0 (fi

Inventor

Masanori Yoshioka

Mitsuyoshi Wagatsuma

Akiyoshi Yoda

Yoshihisa Yamada

Gunji Yoshimura

Original Assignee

Tanabe Seiyaku Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-29

Filing date

1991-11-28

Publication date

1999-11-30

1991-11-28 Application filed by Tanabe Seiyaku Co filed Critical Tanabe Seiyaku Co

1991-11-28 Publication of FI915625A0 publication Critical patent/FI915625A0/fi

1992-05-30 Publication of FI915625L publication Critical patent/FI915625L/fi

1999-11-30 Application granted granted Critical

1999-11-30 Publication of FI104173B publication Critical patent/FI104173B/fi

1999-11-30 Publication of FI104173B1 publication Critical patent/FI104173B1/fi

Links

238000000034 method Methods 0.000 title abstract 2
HDRXZJPWHTXQRI-UHFFFAOYSA-N 2-[3-acetyloxy-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-5-yl]ethyl-dimethylazanium;chloride Chemical compound Cl.C1=CC(OC)=CC=C1C1C(OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HDRXZJPWHTXQRI-UHFFFAOYSA-N 0.000 title 1
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 5
WFDIJRYMOXRFFG-UHFFFAOYSA-N acetic acid anhydride Natural products CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 4
HSUGRBWQSSZJOP-UHFFFAOYSA-N 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate Chemical compound C1=CC(OC)=CC=C1C1C(OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-UHFFFAOYSA-N 0.000 abstract 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
NZHUXMZTSSZXSB-UHFFFAOYSA-N 5-[2-(dimethylamino)ethyl]-3-hydroxy-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-4-one Chemical compound C1=CC(OC)=CC=C1C1C(O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 NZHUXMZTSSZXSB-UHFFFAOYSA-N 0.000 abstract 1
WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 abstract 1
239000012346 acetyl chloride Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000012046 mixed solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Cardiology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Diaphragms For Electromechanical Transducers (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Other In-Based Heterocyclic Compounds (AREA)

FI915625A 1990-11-29 1991-11-28 Menetelmä 3-asetoksi-2,3-dihydro-5-[2-(dimetyyliamino)etyyli]-2-(p-metoksifenyyli)-1,5-bentsotiatsepin-4(5H)-onin hydrokloridin valmistamiseksi FI104173B1 (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP33601090		1990-11-29
JP33601090		1990-11-29

Publications (4)

Publication Number	Publication Date
FI915625A0 FI915625A0 (fi)	1991-11-28
FI915625L FI915625L (fi)	1992-05-30
FI104173B FI104173B (fi)	1999-11-30
FI104173B1 true FI104173B1 (fi)	1999-11-30

Family

ID=18294763

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI915625A FI104173B1 (fi)	1990-11-29	1991-11-28	Menetelmä 3-asetoksi-2,3-dihydro-5-[2-(dimetyyliamino)etyyli]-2-(p-metoksifenyyli)-1,5-bentsotiatsepin-4(5H)-onin hydrokloridin valmistamiseksi

Country Status (15)

Country	Link
US (1)	US5169946A (fi)
EP (1)	EP0488210B1 (fi)
JP (1)	JPH0822856B2 (fi)
KR (1)	KR0133056B1 (fi)
CN (1)	CN1031342C (fi)
AT (1)	ATE107638T1 (fi)
AU (1)	AU634108B2 (fi)
DE (1)	DE69102614T2 (fi)
DK (1)	DK0488210T3 (fi)
ES (1)	ES2059020T3 (fi)
FI (1)	FI104173B1 (fi)
HK (1)	HK174295A (fi)
HU (1)	HU209830B (fi)
IE (1)	IE914135A1 (fi)
IL (1)	IL100157A (fi)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5705638A (en) *	1995-12-05	1998-01-06	Tanabe Seiyaku Co., Ltd.	Process for preparing optically active 3-hydroxy-1,5-benzothiazepine derivative and intermediate therefor
DE69601210T2 (de) *	1995-12-05	1999-05-20	Tanabe Seiyaku Co., Ltd., Osaka	Optisch aktive Benzothiazepinderivate und Verfahren zu ihrer Herstellung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3562257A (en) *	1967-10-28	1971-02-09	Tanabe Seiyaku Co	Benzothiazepine derivatives
FR2360124A1 (fr) *	1976-07-30	1978-02-24	Amiens Const Electro Mecan	Procede de controle de commutation de la puissance de chauffage dans un appareil electrodomestique a programmateur et dispositif pour la mise en oeuvre dudit procede
US4590188A (en) *	1984-02-18	1986-05-20	Tanabe Seiyaku Co., Ltd.	1,5-benzothiazepine derivatives and their pharmaceutical use
JPS62132876A (ja) *	1985-12-04	1987-06-16	Kohjin Co Ltd	１，５−ベンゾチアゼピン誘導体の製法
JPH085869B2 (ja) *	1990-03-08	1996-01-24	田辺製薬株式会社	１，５−ベンゾチアゼピン誘導体の製法

1991
- 1991-11-26 IL IL10015791A patent/IL100157A/en not_active IP Right Cessation
- 1991-11-27 IE IE413591A patent/IE914135A1/en not_active IP Right Cessation
- 1991-11-27 DK DK91120269.5T patent/DK0488210T3/da active
- 1991-11-27 EP EP91120269A patent/EP0488210B1/en not_active Expired - Lifetime
- 1991-11-27 AT AT91120269T patent/ATE107638T1/de not_active IP Right Cessation
- 1991-11-27 KR KR1019910021366A patent/KR0133056B1/ko not_active Expired - Lifetime
- 1991-11-27 JP JP3356115A patent/JPH0822856B2/ja not_active Expired - Lifetime
- 1991-11-27 US US07/805,561 patent/US5169946A/en not_active Expired - Lifetime
- 1991-11-27 ES ES91120269T patent/ES2059020T3/es not_active Expired - Lifetime
- 1991-11-27 DE DE69102614T patent/DE69102614T2/de not_active Expired - Lifetime
- 1991-11-28 FI FI915625A patent/FI104173B1/fi not_active IP Right Cessation
- 1991-11-28 HU HU913713A patent/HU209830B/hu unknown
- 1991-11-28 AU AU88253/91A patent/AU634108B2/en not_active Expired
- 1991-11-29 CN CN91111039A patent/CN1031342C/zh not_active Expired - Lifetime
1995
- 1995-11-16 HK HK174295A patent/HK174295A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
HUT61988A (en)	1993-03-29
IL100157A0 (en)	1992-08-18
DE69102614T2 (de)	1994-11-24
HU913713D0 (en)	1992-02-28
CN1031342C (zh)	1996-03-20
JPH0543564A (ja)	1993-02-23
FI104173B (fi)	1999-11-30
ATE107638T1 (de)	1994-07-15
US5169946A (en)	1992-12-08
KR920009808A (ko)	1992-06-25
DK0488210T3 (da)	1994-08-01
ES2059020T3 (es)	1994-11-01
KR0133056B1 (ko)	1998-04-17
DE69102614D1 (de)	1994-07-28
FI915625L (fi)	1992-05-30
AU634108B2 (en)	1993-02-11
HU209830B (en)	1994-11-28
AU8825391A (en)	1992-06-04
IE914135A1 (en)	1992-06-03
CN1062141A (zh)	1992-06-24
IL100157A (en)	1995-12-08
FI915625A0 (fi)	1991-11-28
JPH0822856B2 (ja)	1996-03-06
EP0488210A1 (en)	1992-06-03
HK174295A (en)	1995-11-24
EP0488210B1 (en)	1994-06-22

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Legal Events

Date	Code	Title	Description
2011-12-22	MA	Patent expired