FI104175B1 - Förfarande för framställning av terapeutiskt användbara imidazo[2,1-b][3]bensazepinderivat och mellanprodukten - Google Patents

Förfarande för framställning av terapeutiskt användbara imidazo[2,1-b][3]bensazepinderivat och mellanprodukten

Info

Publication number
FI104175B1
FI104175B1 FI935556A FI935556A FI104175B1 FI 104175 B1 FI104175 B1 FI 104175B1 FI 935556 A FI935556 A FI 935556A FI 935556 A FI935556 A FI 935556A FI 104175 B1 FI104175 B1 FI 104175B1
Authority
FI
Finland
Prior art keywords
4alkyl
represents hydrogen
4alkyloxy
halo
substituted
Prior art date
Application number
FI935556A
Other languages
English (en)
Finnish (fi)
Other versions
FI935556A0 (fi
FI935556A7 (fi
FI104175B (sv
Inventor
Frans Eduard Janssens
Gaston Stanislas Marcell Diels
Joseph Elisabeth Leenaerts
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of FI935556A0 publication Critical patent/FI935556A0/fi
Publication of FI935556A7 publication Critical patent/FI935556A7/fi
Application granted granted Critical
Publication of FI104175B1 publication Critical patent/FI104175B1/sv
Publication of FI104175B publication Critical patent/FI104175B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Detergent Compositions (AREA)
  • Paper (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI935556A 1991-06-13 1993-12-10 Förfarande för framställning av terapeutiskt användbara imidazo£2,1-b|£3|bensazepinderivat och mellanprodukten FI104175B (sv)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US71448691A 1991-06-13 1991-06-13
US71448691 1991-06-13
US85363192A 1992-03-18 1992-03-18
US85363192 1992-03-18
EP9201330 1992-06-09
PCT/EP1992/001330 WO1992022551A1 (en) 1991-06-13 1992-06-09 IMIDAZO[2,1-b][3]BENZAZEPINE DERIVATIVES, COMPOSITIONS AND METHOD OF USE

Publications (4)

Publication Number Publication Date
FI935556A0 FI935556A0 (fi) 1993-12-10
FI935556A7 FI935556A7 (fi) 1993-12-10
FI104175B1 true FI104175B1 (sv) 1999-11-30
FI104175B FI104175B (sv) 1999-11-30

Family

ID=27109168

Family Applications (1)

Application Number Title Priority Date Filing Date
FI935556A FI104175B (sv) 1991-06-13 1993-12-10 Förfarande för framställning av terapeutiskt användbara imidazo£2,1-b|£3|bensazepinderivat och mellanprodukten

Country Status (28)

Country Link
US (1) US5468743A (sv)
EP (2) EP0588858B1 (sv)
JP (1) JP2845407B2 (sv)
KR (1) KR0184017B1 (sv)
CN (2) CN1033586C (sv)
AT (1) ATE250061T1 (sv)
AU (1) AU652840B2 (sv)
CA (1) CA2103242C (sv)
DE (1) DE69233205T2 (sv)
DK (1) DK0588858T3 (sv)
DZ (1) DZ1582A1 (sv)
ES (1) ES2207632T3 (sv)
FI (1) FI104175B (sv)
HR (1) HRP920155A2 (sv)
HU (2) HU221016B1 (sv)
IE (1) IE921918A1 (sv)
IL (1) IL101850A (sv)
MA (1) MA22553A1 (sv)
MX (1) MX9202856A (sv)
NO (2) NO934492D0 (sv)
NZ (1) NZ242774A (sv)
PT (1) PT588858E (sv)
SG (1) SG47823A1 (sv)
SI (1) SI9200105B (sv)
TN (1) TNSN92048A1 (sv)
TW (1) TW218381B (sv)
WO (1) WO1992022551A1 (sv)
YU (1) YU61192A (sv)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
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IL101851A (en) * 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv 10-(4-piperidinyl- and piperidinylidene)-imidazo [1,2-a] (pyrrolo thieno or furano) [2,3] azepine derivatives their preparation and pharmaceutical compositions containing them and certain novel intermediates therefor
GR1001393B (el) * 1992-10-12 1993-10-29 Janssen Pharmaceutica Nv Παράγωγα ιμιδαζο[2,1-Β] 3] βενζαζεπίνης, συν?έσεις και μέ?οδος χρήσεως.
DE69332830T2 (de) * 1992-12-04 2004-01-29 Janssen Pharmaceutica Nv Antiallergische triazolobenzazepinderivate
EP0708776B1 (en) * 1993-07-13 2001-01-03 Janssen Pharmaceutica N.V. Antiallergic imidazoazepines
TW382017B (en) * 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives
TW527186B (en) 1996-03-19 2003-04-11 Janssen Pharmaceutica Nv Fused imidazole derivatives as multidrug resistance modulators
AU1146099A (en) 1997-09-18 1999-04-05 Janssen Pharmaceutica N.V. Fused imidazole derivatives for improving oral bioavailability of pharmaceuticalagents
HK1043128B (zh) * 1998-12-19 2007-01-19 詹森药业有限公司 抗组胺的螺环化合物
CN100491378C (zh) 2001-06-12 2009-05-27 詹森药业有限公司 新的取代四环咪唑衍生物,其制备方法,包含它们的药物组合物及它们作为药物的用途
CN1160557C (zh) * 2001-09-03 2004-08-04 北京埃索特核电子机械有限公司 钴60γ射线源-碘化铯或钨酸镉阵列探测器集装箱检测设备
DE602006016244D1 (de) 2005-03-08 2010-09-30 Janssen Pharmaceutica Nv Diazaspiro-ä4,4ü-nonanderivate als neurokinin-(nk1)-antagonisten
US20070077302A1 (en) * 2005-09-30 2007-04-05 Azaam Alli Methods for stabilizing ophthalmic compositions
US20070077303A1 (en) * 2005-09-30 2007-04-05 Azaam Alli Methods for providing oxidatively stable ophthalmic compositions
JP5292277B2 (ja) * 2006-03-31 2013-09-18 ビスタコン・フアーマシユーチカルズ・エルエルシー 眼アレルギーの処置
US20080139531A1 (en) * 2006-12-04 2008-06-12 Alcon Manufacturing Ltd. Use of connective tissue mast cell stabilizers to facilitate ocular surface re-epithelization and wound repair
RU2009141592A (ru) * 2007-04-11 2011-05-20 Алькон Рисерч, Лтд. (Us) ПРИМЕНЕНИЕ ИНГИБИТОРА TNFα В СОЧЕТАНИИ С АНТИГИСТАМИННЫМ СРЕДСТВОМ ДЛЯ ЛЕЧЕНИЯ АЛЛЕРГИЧЕСКОГО РИНИТА И АЛЛЕРГИЧЕСКОГО КОНЪЮНКТИВИТА
US20090182035A1 (en) * 2007-04-11 2009-07-16 Alcon Research, Ltd. Use of a combination of olopatadine and cilomilast to treat non-infectious rhinitis and allergic conjunctivitis
RU2012117141A (ru) * 2009-10-01 2013-11-10 Алькон Рисерч, Лтд. Композиции олопатадина и способы их применения
AR079170A1 (es) * 2009-12-10 2011-12-28 Lilly Co Eli Compuesto de ciclopropil-benzamida-imidazo-benzazepina inhibidor de diacil-glicerol aciltransferasa, sal del mismo, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para el tratamiento de obesidad o para mejorar la sensibilidad a insulina y compuesto intermedio par
JP2014518278A (ja) * 2011-06-29 2014-07-28 アラーガン インコーポレイテッド 蕁麻疹の治療に用いるアルカフタジン
WO2014080259A1 (en) * 2012-11-21 2014-05-30 Enaltec Labs Pvt. Ltd. Novel polymorphic forms of alcaftadine
WO2014083571A1 (en) 2012-11-29 2014-06-05 Neuland Laboratories Limited A process for the preparation of alcaftadine
WO2014087208A2 (en) * 2012-12-06 2014-06-12 Enaltec Labs Pvt. Ltd. A process of preparing alcaftadine
WO2014154620A1 (en) * 2013-03-25 2014-10-02 Crystal Pharma S.A.U. Methods for the preparation of alcaftadine
CN103408549B (zh) * 2013-06-14 2016-01-20 苏州汇和药业有限公司 一种阿卡他定中间体的制备方法
EP3186242B1 (en) 2014-08-29 2021-10-06 Tes Pharma S.r.l. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
CN104710427A (zh) * 2014-12-20 2015-06-17 威海法莫斯特医药技术开发有限公司 一种阿卡他定新晶型
CN104860920B (zh) * 2015-04-15 2017-08-25 武汉武药科技有限公司 一种阿卡他定中间体的制备方法
CN104987337B (zh) * 2015-07-28 2018-01-12 武汉武药科技有限公司 一种制备阿卡他定的氧化方法
CN105130993B (zh) * 2015-07-28 2018-01-12 武汉武药科技有限公司 一种合成阿卡他定的新氧化方法
AU2017310520A1 (en) 2016-08-12 2019-03-21 Silk Technologies, Ltd. Silk-derived protein for treating inflammation
CN108727384A (zh) * 2018-07-07 2018-11-02 张正光 一种阿卡他定中间体的制备方法
WO2021141672A2 (en) 2019-11-15 2021-07-15 Silk Technologies, Ltd. Stable formulations of silk-derived protein
JP7791119B2 (ja) * 2020-06-15 2025-12-23 アルケム・ラボラトリーズ・リミテッド アルカフタジンとコルチコステロイドの組み合わせ
US20240173331A1 (en) 2021-04-01 2024-05-30 Alkem Laboratories Limited Nasal compositions comprising alcaftadine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4148903A (en) * 1977-07-28 1979-04-10 Merck & Co., Inc. Antipsychotic, antiserotonin and antihistaminic pyrrolo[2,1-b][3]benzazepines
GB8900380D0 (en) * 1989-01-09 1989-03-08 Janssen Pharmaceutica Nv 2-aminopyrimidinone derivatives
US5393753A (en) * 1990-10-10 1995-02-28 Schering Corporation Substituted imidazobenzazepines
IL101851A (en) * 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv 10-(4-piperidinyl- and piperidinylidene)-imidazo [1,2-a] (pyrrolo thieno or furano) [2,3] azepine derivatives their preparation and pharmaceutical compositions containing them and certain novel intermediates therefor

Also Published As

Publication number Publication date
FI935556A0 (fi) 1993-12-10
DK0588858T3 (da) 2004-01-26
CN1070368C (zh) 2001-09-05
HU221016B1 (hu) 2002-07-29
HUT70529A (en) 1995-10-30
CN1033586C (zh) 1996-12-18
AU1900192A (en) 1993-01-12
WO1992022551A1 (en) 1992-12-23
SI9200105B (en) 2001-10-31
CN1068118A (zh) 1993-01-20
US5468743A (en) 1995-11-21
TW218381B (sv) 1994-01-01
NO934492L (no) 1994-01-04
DZ1582A1 (fr) 2002-02-17
SG47823A1 (en) 1998-04-17
IE921918A1 (en) 1992-12-16
YU61192A (sh) 1994-09-09
HU9303553D0 (en) 1994-04-28
HRP920155A2 (en) 1994-08-31
NO300636B1 (no) 1997-06-30
EP0588858A1 (en) 1994-03-30
SI9200105A (en) 1992-12-31
CN1142360A (zh) 1997-02-12
NZ242774A (en) 1995-02-24
ATE250061T1 (de) 2003-10-15
IL101850A (en) 1996-01-31
AU652840B2 (en) 1994-09-08
DE69233205D1 (de) 2003-10-23
DE69233205T2 (de) 2004-06-24
CA2103242C (en) 2002-11-12
MX9202856A (es) 1992-12-01
NO934492D0 (no) 1993-12-09
EP0518435A1 (en) 1992-12-16
CA2103242A1 (en) 1992-12-14
TNSN92048A1 (fr) 1993-06-08
KR0184017B1 (ko) 1999-05-01
EP0588858B1 (en) 2003-09-17
IL101850A0 (en) 1992-12-30
FI935556A7 (fi) 1993-12-10
JPH06507889A (ja) 1994-09-08
HU211289A9 (en) 1995-11-28
PT588858E (pt) 2004-02-27
MA22553A1 (fr) 1992-12-31
ES2207632T3 (es) 2004-06-01
FI104175B (sv) 1999-11-30
JP2845407B2 (ja) 1999-01-13

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