FI104179B - Förfarande för framställning av en terapeutiskt användbar polypeptid - Google Patents
Förfarande för framställning av en terapeutiskt användbar polypeptid Download PDFInfo
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- FI104179B FI104179B FI961398A FI961398A FI104179B FI 104179 B FI104179 B FI 104179B FI 961398 A FI961398 A FI 961398A FI 961398 A FI961398 A FI 961398A FI 104179 B FI104179 B FI 104179B
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- 229960004919 procaine Drugs 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000013074 reference sample Substances 0.000 description 1
- 230000008844 regulatory mechanism Effects 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
- 229960001052 streptozocin Drugs 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000001179 synovial fluid Anatomy 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 125000001239 threonyl group Chemical group 0.000 description 1
- 229960002175 thyroglobulin Drugs 0.000 description 1
- 230000024664 tolerance induction Effects 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000563 toxic property Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000005945 translocation Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 208000007089 vaccinia Diseases 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Claims (3)
1 MAKTIAYDEE ARRGLERGLN ALADAVKVTL GPKGRHWLE KKWGAPTITN DGVSIAKEIE 61 LEDPYEKICA ELVKEVAKKT DDVAGDGTTT ATVLAQALVR EGLRNVAAGA NPLGLKRGIE 121 KAVEKVTETL LKGAKEVETK EQIAATAAIS AGDQSIGDLI AEAMDKVGNE GVITVEESNT 181 FGLQLELTEG MRFDKGYISG YFVTDPERQE AVLEDPYILL VSSKVSTVKD LLPLLEKVIG 241 AGKPLLIIAE DVEGEALSTL WNKIRGTFK SVAVKAPGFG DRRKAMLQDM AILTGGQVIS 15 301 EEVGLTLENA DLSLLGKARX WVTKDETTI VEGAGDTDAI AGRVAQIRQE IENSDSDYDR
361 EKLQERLAKL AGGVAVIKAG AATEVELKER KHRIEDAVRN AKAAVEEGIV AGGGVTLLQA 421 APTLDELKLE GDEATGANIV KVALEAPLKQ IAFNSGLEPG WAEKVRNLP AGHGLNAQTG 481 VYEDLLAAGV ADPVKVTRSA LQNAASIAGL FLTTEAWAD KPEKEKASVP GGGDHGGMDF och polypeptiden med aminosyrasekvenserna 234 - 540, 61 -20 540, 109 - 540, 171 -540, 272 - 540 och 280 - 540 samt humant mitokondrieprotein P1 är uteslutna, kanne -tecknat av att polypeptiden syntetiseras med inom peptidkemin konventionella metoder.
1. Förfarande för framställning av en polypeptid innehällande sekvensen Val-Leu-Gly-Gly-Gly-Cys-Ala-Leu-
5 Leu-Arg-Cys-Ile-Pro-Ala-Leu-Asp-Ser-Leu-Thr-Pro-Ala-Asn-Glu-Asp eller nägon modifikation av denna, vilken modifi-kation är immunologiskt korsreaktiv med denna, men inte är ett helt värmechockprotein, under förutsättning att poly-peptiden med aminosyrasekvensen 10
2. Förfarande enligt patentkrav 1, k ä n n e - ^ 25 tecknat av att man framställer en polypeptid inne- hällande sekvensen Val-Leu-Gly-Gly-Gly-Cys-Ala-Leu-Leu-Arg-Cys-Ile-Pro-Ala-Leu-Asp-Ser-Leu-Thr-Pro-Ala-Asn-Glu-Asp eller nägon modifikation av denna, vars sekvens tili ätminstone 40 % är homolog med denna. 30
3. Förfarande enligt patentkrav 1, k ä n n e - ’I tecknat av att man framställer en polypeptid med 24 aminosyror.
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32286489A | 1989-03-14 | 1989-03-14 | |
| US32286489 | 1989-03-14 | ||
| US37124989 | 1989-06-26 | ||
| US07/371,249 US5114844A (en) | 1989-03-14 | 1989-06-26 | Diagnosis and treatment of insulin dependent diabetes mellitus |
| PCT/US1990/001397 WO1990010449A1 (en) | 1989-03-14 | 1990-03-14 | Diagnosis and treatment of insulin dependent diabetes mellitus |
| US9001397 | 1990-03-14 | ||
| FI905614A FI103976B1 (sv) | 1989-03-14 | 1990-11-13 | Förfarande för in vitro diagnostisering av insulinberoende diabetes mellitus (IDDM) och däri användbar testförpackning och polypeptid |
| FI905614 | 1990-11-13 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI961398L FI961398L (sv) | 1996-03-27 |
| FI961398A0 FI961398A0 (sv) | 1996-03-27 |
| FI104179B1 FI104179B1 (sv) | 1999-11-30 |
| FI104179B true FI104179B (sv) | 1999-11-30 |
Family
ID=27241437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI961398A FI104179B (sv) | 1989-03-14 | 1996-03-27 | Förfarande för framställning av en terapeutiskt användbar polypeptid |
Country Status (1)
| Country | Link |
|---|---|
| FI (1) | FI104179B (sv) |
-
1996
- 1996-03-27 FI FI961398A patent/FI104179B/sv active
Also Published As
| Publication number | Publication date |
|---|---|
| FI961398L (sv) | 1996-03-27 |
| FI104179B1 (sv) | 1999-11-30 |
| FI961398A0 (sv) | 1996-03-27 |
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