FI891700A0 - Menetelmä beta-laktaamijohdannaisten valmistamiseksi - Google Patents

Menetelmä beta-laktaamijohdannaisten valmistamiseksi

Info

Publication number: FI891700A0
Authority: FI; Finland
Prior art keywords: preparation; beta; lactam derivatives; carboxy; alkyl
Prior art date: 1988-04-13

Application number

FI891700A

Other languages

English (en)

Swedish (sv)

Other versions

FI93731C (fi

FI93731B (fi

FI891700L (fi

Inventor

Pierluigi Bissolino

Marco Alpegiani

Ettore Perrone

Piergiuseppe Orezzi

Giuseppe Cassinelli

Giovanni Franceschi

Original Assignee

Erba Carlo Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-04-13

Filing date

1989-04-11

Publication date

1989-04-11

1989-04-11 Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa

1989-04-11 Publication of FI891700A0 publication Critical patent/FI891700A0/fi

1989-10-14 Publication of FI891700L publication Critical patent/FI891700L/fi

1995-02-15 Application granted granted Critical

1995-02-15 Publication of FI93731B publication Critical patent/FI93731B/fi

1995-05-26 Publication of FI93731C publication Critical patent/FI93731C/fi

Links

150000003952 β-lactams Chemical class 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000002849 elastaseinhibitory effect Effects 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
125000000962 organic group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Pyrrole Compounds (AREA)

FI891700A 1988-04-13 1989-04-11 Menetelmä beta-laktaamijohdannaisten valmistamiseksi FI93731C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB8808701		1988-04-13
GB888808701A GB8808701D0 (en)	1988-04-13	1988-04-13	Beta-lactam derivatives

Publications (4)

Publication Number	Publication Date
FI891700A0 true FI891700A0 (fi)	1989-04-11
FI891700L FI891700L (fi)	1989-10-14
FI93731B FI93731B (fi)	1995-02-15
FI93731C FI93731C (fi)	1995-05-26

Family

ID=10635113

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI891700A FI93731C (fi)	1988-04-13	1989-04-11	Menetelmä beta-laktaamijohdannaisten valmistamiseksi

Country Status (23)

Country	Link
US (1)	US5077286A (fi)
EP (1)	EP0337704B1 (fi)
JP (1)	JP2840286B2 (fi)
KR (1)	KR0138771B1 (fi)
CN (1)	CN1037151A (fi)
AT (1)	ATE123778T1 (fi)
AU (1)	AU615048B2 (fi)
CA (1)	CA1325077C (fi)
DE (1)	DE68923033T2 (fi)
DK (1)	DK175689A (fi)
ES (1)	ES2075850T3 (fi)
FI (1)	FI93731C (fi)
GB (1)	GB8808701D0 (fi)
GR (1)	GR3017081T3 (fi)
HU (1)	HU206118B (fi)
IE (1)	IE67549B1 (fi)
IL (1)	IL89929A0 (fi)
MY (1)	MY104428A (fi)
NO (1)	NO173016C (fi)
NZ (1)	NZ228681A (fi)
SU (2)	SU1750430A3 (fi)
YU (1)	YU47481B (fi)
ZA (1)	ZA892629B (fi)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5132301A (en) *	1983-05-02	1992-07-21	Merck & Co., Inc.	Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
GB8811388D0 (en) *	1988-05-13	1988-06-15	Erba Carlo Spa	1,1-dioxo-cephem-4-carbothiolic acid derivatives
EP0494914B1 (en) *	1989-10-06	1998-12-23	Synphar Laboratories Inc.	2-spirocyclopropyl cephalosporin derivatives and processes for the preparation thereof
US5264429A (en) *	1989-10-06	1993-11-23	Synphar Laboratories, Inc.	2-spirocyclopropyl cephalosporin sulfone derivatives
GB8928373D0 (en) *	1989-12-15	1990-02-21	Erba Carlo Spa	Beta-lactam derivatives
GB9011463D0 (en) *	1990-05-22	1990-07-11	Erba Carlo Spa	Process for the preparation of 7 alpha-alkoxycephem derivatives
US5162348A (en) *	1990-05-24	1992-11-10	Imperial Chemical Industries Plc	Treatment of cystic fibrosis
IE911698A1 (en) *	1990-05-24	1991-12-04	Ici Plc	Therapeutic compound
EP0458536B1 (en) *	1990-05-24	1998-03-18	Zeneca Limited	Therapeutic agent for treatment and prevention of adult respiratory distress syndrome
US5258377A (en) *	1991-04-08	1993-11-02	Taiho Pharmaceutical Co., Ltd.	2-spirocyclopropyl 4-acylcephems
US5446037A (en) *	1991-12-05	1995-08-29	Synphar Laboratories, Inc.	2-[(substituted) methylene]cephalosporin sulfones as antiinflammatory, antidegenerative and antithrombin agents
WO1993016043A1 (en) *	1992-02-18	1993-08-19	Otsuka Kagaku Kabushiki Kaisha	β-LACTAM COMPOUND AND CEPHEM COMPOUND, AND PRODUCTION THEREOF
GB9207715D0 (en) *	1992-04-08	1992-05-27	Erba Carlo Spa	2,2-disubstituted cephem sulphones
WO1993024493A1 (en) *	1992-05-27	1993-12-09	Teijin Limited	Cephalosporin derivative
GB2273097B (en) *	1992-12-04	1996-09-18	Erba Carlo Spa	4-Alkyl and 4-alkenyl delta-3-cephem sulphone human leukocyte elastase inhibitors
WO1994017822A1 (en) *	1993-02-12	1994-08-18	T Cell Sciences, Inc.	PULMONARY ADMINISTRATION OF sCR1 AND OTHER COMPLEMENT INHIBITORY PROTEINS
GB9304440D0 (en) *	1993-03-04	1993-04-21	Erba Carlo Spa	2-acyloxycephem derivatives
US5439904A (en) *	1993-12-07	1995-08-08	Synphar Laboratories, Inc.	2-spiro(2'-spirocycloalkyl)cyclopropyl cephalosporin sulfones as antiinflammatory and antigenerative agents
US5629306A (en)	1994-12-09	1997-05-13	Research Corporation Technologies, Inc.	7-alkylidene cephalosporanic acid derivatives and methods of using the same
US5597817A (en) *	1994-12-09	1997-01-28	Southern Methodist University	7-vinylidene cephalosporins and methods of using the same
GB9513818D0 (en) *	1995-07-06	1995-09-06	Pharmacia Spa	7,7-Disubstituted cephem-4-ketones
US5760027A (en) *	1996-12-06	1998-06-02	Research Corporation Technologies, Inc.	Use of 7-alkylidene cephalosporins to inhibit elastase activity
US6407091B1 (en)	1999-04-15	2002-06-18	Research Corporation Technologies, Inc.	β-lactamase inhibiting compounds
MXPA06002125A (es) *	2003-08-25	2006-05-31	Revaax Pharmaceuticals Llc	Composiciones orales de cefazolin neuroterapeutico.

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3799922A (en) *	1971-11-17	1974-03-26	Smithkline Corp	4-substituted 3-cephem compounds
IN149747B (fi) *	1977-06-07	1982-04-03	Pfizer
NZ190797A (en) *	1978-06-06	1982-08-17	Pfizer	Combination of penicillanic 1,1-dioxide and 7-(d-2-(4-ethylpiperazin-2 3-dione-1-carboxamido)-2-(4-hydroxphenyl)acetamido)-3-(1-methyl-5-tetrazolyl)-thiomethyl-3-desacetoxymethylcephalosporanic acid
NZ193020A (en) *	1979-03-05	1982-11-23	Pfizer	Preparation of penicillanic acid 1,1-dioxide and intermediates therefor
US4244951A (en) *	1979-05-16	1981-01-13	Pfizer Inc.	Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
IN159362B (fi) *	1981-03-23	1987-05-09	Pfizer
US4381263A (en) *	1981-03-23	1983-04-26	Pfizer Inc.	Process for the preparation of penicillanic acid esters
US4547371A (en) *	1983-04-18	1985-10-15	Merck & Co., Inc.	Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
EP0124081A3 (en) *	1983-05-02	1986-11-26	Merck & Co. Inc.	New substituted cephalosporin sulfones as antiinflammatory and antidegenerative agents, pharmaceutical compositions containing the same and processes for making them
US4637999A (en) *	1983-05-02	1987-01-20	Merck & Co., Inc.	Substituted cephalosporins as anti-inflammatory and antidegenerative agents
US4468351A (en) *	1983-06-06	1984-08-28	Pfizer Inc.	Process for debromination of dibromopenicillanic acid and derivatives
JPS62284386A (ja) *	1986-06-03	1987-12-10	日立電子エンジニアリング株式会社	プロ−ビング方式
ATE133954T1 (de) *	1986-11-12	1996-02-15	Merck & Co Inc	Substituierte cephalosporinsulfone als anti- entzündliche und anti-degenerative mittel

1988
- 1988-04-13 GB GB888808701A patent/GB8808701D0/en active Pending
1989
- 1989-04-10 EP EP89303520A patent/EP0337704B1/en not_active Expired - Lifetime
- 1989-04-10 US US07/335,824 patent/US5077286A/en not_active Expired - Fee Related
- 1989-04-10 IE IE113289A patent/IE67549B1/en not_active IP Right Cessation
- 1989-04-10 ES ES89303520T patent/ES2075850T3/es not_active Expired - Lifetime
- 1989-04-10 DE DE68923033T patent/DE68923033T2/de not_active Expired - Fee Related
- 1989-04-10 AT AT89303520T patent/ATE123778T1/de active
- 1989-04-10 NZ NZ228681A patent/NZ228681A/en unknown
- 1989-04-11 FI FI891700A patent/FI93731C/fi not_active IP Right Cessation
- 1989-04-11 ZA ZA892629A patent/ZA892629B/xx unknown
- 1989-04-12 MY MYPI89000464A patent/MY104428A/en unknown
- 1989-04-12 HU HU891752A patent/HU206118B/hu not_active IP Right Cessation
- 1989-04-12 SU SU894613926A patent/SU1750430A3/ru active
- 1989-04-12 NO NO891516A patent/NO173016C/no unknown
- 1989-04-12 YU YU74489A patent/YU47481B/sh unknown
- 1989-04-12 IL IL89929A patent/IL89929A0/xx not_active IP Right Cessation
- 1989-04-12 JP JP1092768A patent/JP2840286B2/ja not_active Expired - Fee Related
- 1989-04-12 AU AU32762/89A patent/AU615048B2/en not_active Ceased
- 1989-04-12 KR KR1019890004794A patent/KR0138771B1/ko not_active Expired - Fee Related
- 1989-04-12 CA CA000596480A patent/CA1325077C/en not_active Expired - Fee Related
- 1989-04-12 CN CN89102218A patent/CN1037151A/zh active Pending
- 1989-04-12 DK DK175689A patent/DK175689A/da not_active Application Discontinuation
1990
- 1990-03-26 SU SU904743427A patent/SU1766261A3/ru active
1995
- 1995-08-09 GR GR950402210T patent/GR3017081T3/el unknown

Also Published As

Publication number	Publication date
US5077286A (en)	1991-12-31
KR890016048A (ko)	1989-11-28
EP0337704A3 (en)	1991-09-25
ES2075850T3 (es)	1995-10-16
CN1037151A (zh)	1989-11-15
EP0337704B1 (en)	1995-06-14
HU206118B (en)	1992-08-28
KR0138771B1 (ko)	1998-05-15
DE68923033D1 (de)	1995-07-20
NO173016C (no)	1993-10-13
GR3017081T3 (en)	1995-11-30
MY104428A (en)	1994-03-31
FI93731C (fi)	1995-05-26
EP0337704A2 (en)	1989-10-18
HUT50348A (en)	1990-01-29
JPH0228183A (ja)	1990-01-30
ATE123778T1 (de)	1995-06-15
CA1325077C (en)	1993-12-07
IE67549B1 (en)	1996-04-17
YU47481B (sh)	1995-10-03
NO173016B (no)	1993-07-05
AU615048B2 (en)	1991-09-19
FI93731B (fi)	1995-02-15
FI891700L (fi)	1989-10-14
YU74489A (en)	1991-02-28
AU3276289A (en)	1989-10-19
JP2840286B2 (ja)	1998-12-24
NO891516D0 (no)	1989-04-12
IE891132L (en)	1989-10-13
DE68923033T2 (de)	1995-10-26
NZ228681A (en)	1991-07-26
SU1750430A3 (ru)	1992-07-23
NO891516L (no)	1989-10-16
IL89929A0 (en)	1989-12-15
ZA892629B (en)	1989-12-27
DK175689A (da)	1989-10-14
DK175689D0 (da)	1989-04-12
GB8808701D0 (en)	1988-05-18
SU1766261A3 (ru)	1992-09-30

Legal Events

Date	Code	Title	Description
1995-01-16	BB	Publication of examined application
1997-01-21	PC	Transfer of assignment of patent	Owner name: PHARMACIA & UPJOHN S.P.A.
1998-04-11	MM	Patent lapsed
2004-08-31	MM	Patent lapsed	Owner name: PHARMACIA & UPJOHN S., P.A.

Publication	Publication Date	Title
ATE123778T1 (de)	1995-06-15	Beta-lactam-derivate.
AU2454295A (en)	1995-12-18	Novel fused indan derivative and pharmaceutically acceptablesalt thereof
DE69431691D1 (de)	2002-12-19	Cephalosporin-Derivate
EP0275482A3 (en)	1988-12-28	Novel prolinal derivatives
AU6366386A (en)	1987-04-09	3-vinyl- and 3- ethinyl-beta-carboline derivatives their production and their use as drugs
ATE9474T1 (de)	1984-10-15	Cephalosporinverbindungen und ihre herstellung.
YU45423B (en)	1992-05-28	Process for obtaining heterocyclical benzene derivatives
DK0597423T3 (da)	2002-05-21	Azetidinonforbindelse og fremgangsmåde til fremstilling deraf
AU3029189A (en)	1989-09-07	Process for preparing 2 alpha-methyl-2 beta - (1,2,3- triazol-1-yl) methylpenam- 3 alpha - carboxylic acid derivatives
MY104566A (en)	1994-04-30	Beta-lactam derivatives.
AU531578B2 (en)	1983-09-01	Silyl protected 3-bromomethyl-3-cephem-4-carboxylate 1-oxides
AU9462298A (en)	1999-05-10	Process for producing 3-cephem compounds
ZA895670B (en)	1991-03-27	Use of imidazopyrazole derivatives as analgesics and antiinflammatory agents
AU610913B2 (en)	1991-05-30	2'-deoxy-5-fluorouridine derivatives
EP1043320A4 (en)	2000-12-06	INNOVATIVE METHOD FOR THE PRODUCTION OF AMINOPIPERAZINES
KR860007264A (ko)	1986-10-10	새로운 1-옥사-1-데티아 세팔로스포린 화합물의 제조방법
CA2359031A1 (en)	1996-09-06	Thiazolidinone or oxazolidinone derivatives for treatment of ulcerative disease
AU1317688A (en)	1988-09-22	Benzoxazine derivatives and processes for preparation thereof