FI962492L - Alpha-2-adrenoseptoriagonisteina käyttökelpoisia 7-(2-imidatsolinyyliamino)kinoliiniyhdisteitä - Google Patents

Alpha-2-adrenoseptoriagonisteina käyttökelpoisia 7-(2-imidatsolinyyliamino)kinoliiniyhdisteitä Download PDF

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Publication number
FI962492L
FI962492L FI962492A FI962492A FI962492L FI 962492 L FI962492 L FI 962492L FI 962492 A FI962492 A FI 962492A FI 962492 A FI962492 A FI 962492A FI 962492 L FI962492 L FI 962492L
Authority
FI
Finland
Prior art keywords
imidazolinylamino
alpha
compounds useful
adrenoceptor agonists
quinoline compounds
Prior art date
Application number
FI962492A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI962492A0 (fi
FI962492A7 (fi
Inventor
Thomas Lee Cupps
Sophie Eva Bogdan
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of FI962492A0 publication Critical patent/FI962492A0/fi
Publication of FI962492L publication Critical patent/FI962492L/fi
Publication of FI962492A7 publication Critical patent/FI962492A7/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI962492A 1993-12-17 1994-12-15 Alpha-2-adrenoseptoriagonisteina käyttökelpoisia 7-(2-imidatsolinyylia mino)kinoliiniyhdisteitä FI962492A7 (fi)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16934293A 1993-12-17 1993-12-17
US08/292,672 US5576437A (en) 1993-12-17 1994-08-18 7-(2-imidazolnylamino) quinoline compounds useful as alpha-2 adrenoceptor agonists
PCT/US1994/014290 WO1995020386A1 (en) 1993-12-17 1994-12-15 7-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists

Publications (3)

Publication Number Publication Date
FI962492A0 FI962492A0 (fi) 1996-06-14
FI962492L true FI962492L (fi) 1996-07-25
FI962492A7 FI962492A7 (fi) 1996-07-25

Family

ID=26864973

Family Applications (1)

Application Number Title Priority Date Filing Date
FI962492A FI962492A7 (fi) 1993-12-17 1994-12-15 Alpha-2-adrenoseptoriagonisteina käyttökelpoisia 7-(2-imidatsolinyylia mino)kinoliiniyhdisteitä

Country Status (23)

Country Link
US (2) US5576437A (de)
EP (1) EP0734261B1 (de)
JP (1) JPH09507219A (de)
CN (1) CN1085945C (de)
AT (1) ATE202475T1 (de)
AU (1) AU704857B2 (de)
BR (1) BR9408344A (de)
CA (1) CA2179011C (de)
CZ (1) CZ285990B6 (de)
DE (1) DE69427591T2 (de)
DK (1) DK0734261T3 (de)
ES (1) ES2158076T3 (de)
FI (1) FI962492A7 (de)
GR (1) GR3036199T3 (de)
HU (1) HU219494B (de)
NO (1) NO311749B1 (de)
NZ (1) NZ333369A (de)
PE (1) PE38095A1 (de)
PL (1) PL178054B1 (de)
SG (1) SG49111A1 (de)
SK (1) SK77296A3 (de)
TW (1) TW406077B (de)
WO (1) WO1995020386A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0944601T3 (da) * 1996-11-25 2003-06-10 Procter & Gamble Heterocykliske quanidinylaminoforbindelser som alfa-2-adrenoceptoragonister
US6306877B1 (en) 1999-08-09 2001-10-23 The Procter & Gamble Co. Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
US6172095B1 (en) 1996-11-25 2001-01-09 The Procter & Gamble Company Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
SG72827A1 (en) * 1997-06-23 2000-05-23 Hoffmann La Roche Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives
TW527355B (en) * 1997-07-02 2003-04-11 Bristol Myers Squibb Co Inhibitors of farnesyl protein transferase
WO2000066107A2 (en) * 1999-04-30 2000-11-09 Apt Pharmaceuticals, L.L.C. Antimalarian agents for the treatment of asthma
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
JP2007529555A (ja) * 2004-03-18 2007-10-25 ザ ブライハム アンド ウイメンズ ホスピタル， インコーポレイテッド シヌクレイノパチーを治療する方法
US20070293539A1 (en) * 2004-03-18 2007-12-20 Lansbury Peter T Methods for the treatment of synucleinopathies
EP1744751A4 (de) * 2004-03-18 2010-03-10 Brigham & Womens Hospital Verfahren zur behandlung von synucleinopathien
WO2005089515A2 (en) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
US20060106060A1 (en) * 2004-03-18 2006-05-18 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies (Lansbury)
DE102004049008A1 (de) * 2004-10-05 2006-04-06 Merck Patent Gmbh Neue Verwendung für α-Sympathomimetika mit 2-Imidazolinstruktur
ZA200804550B (en) 2005-11-09 2009-08-26 Combinatorx Inc Methods, compositions, and kits for the treatment of medical conditions
US8232402B2 (en) * 2008-03-12 2012-07-31 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
US20110060005A1 (en) * 2008-11-13 2011-03-10 Link Medicine Corporation Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
MX2011005096A (es) * 2008-11-13 2011-11-18 Link Medicine Corp Derivados de azaquinolinona y usos de los mismos.
US20100331363A1 (en) * 2008-11-13 2010-12-30 Link Medicine Corporation Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
HK1198762A1 (en) * 2011-07-25 2015-06-05 Allergan, Inc. N-(imidazolidin-2-ylidene)quinoline derivatives as modulators of alpha 2 adrenergic receptors

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029792A (en) * 1972-02-29 1977-06-14 Pfizer Inc. (2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents
BE795970A (fr) * 1972-02-29 1973-08-27 Pfizer Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant
US4036976A (en) * 1973-04-05 1977-07-19 Sandoz, Inc. Substituted imidazolinylamino-indazoles
US4217356A (en) * 1975-08-22 1980-08-12 Sandoz Ltd. 2-Imidazolinylamino-2,1,3-benzothiadiazoles
US4398028A (en) * 1977-01-14 1983-08-09 Sandoz Ltd. Bicyclic heterocyclic amino derivatives
EP0025269B1 (de) * 1979-08-23 1985-11-13 Beecham Group Plc Veterinärzusammensetzung gegen Diarrhöe
US4436913A (en) * 1980-09-05 1984-03-13 Siegfried Aktiengesellschaft 1H- and 2H- indazole derivatives
FR2638356A1 (fr) * 1988-10-28 1990-05-04 Anben Nouveaux derives de la 2-arylimino-imidazolidine pour diminuer la pression intra-oculaire et traiter le glaucome
US5180721A (en) * 1989-05-22 1993-01-19 Allergan, Inc. Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
US5281591A (en) * 1989-05-22 1994-01-25 Allergan, Inc. Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
US5231096A (en) * 1989-10-12 1993-07-27 Allergan, Inc. Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
US5021416A (en) * 1989-10-31 1991-06-04 Allergan, Inc. Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure
US5091528A (en) * 1990-09-12 1992-02-25 Allergan, Inc. 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents

Also Published As

Publication number Publication date
NO962537D0 (no) 1996-06-14
PL178054B1 (pl) 2000-02-29
AU704857B2 (en) 1999-05-06
HUT76278A (en) 1997-07-28
NO311749B1 (no) 2002-01-21
DK0734261T3 (da) 2001-09-03
JPH09507219A (ja) 1997-07-22
HU9601661D0 (en) 1996-08-28
GR3036199T3 (en) 2001-10-31
US5716966A (en) 1998-02-10
HU219494B (hu) 2001-04-28
FI962492A0 (fi) 1996-06-14
CN1137754A (zh) 1996-12-11
EP0734261B1 (de) 2001-06-27
NZ333369A (en) 2001-04-27
NO962537L (no) 1996-08-14
CN1085945C (zh) 2002-06-05
WO1995020386A1 (en) 1995-08-03
AU1339495A (en) 1995-08-15
DE69427591T2 (de) 2002-04-25
ATE202475T1 (de) 2001-07-15
SG49111A1 (en) 1998-05-18
TW406077B (en) 2000-09-21
BR9408344A (pt) 1997-08-19
EP0734261A1 (de) 1996-10-02
SK77296A3 (en) 1997-04-09
US5576437A (en) 1996-11-19
PL315058A1 (en) 1996-09-30
CZ175296A3 (en) 1996-11-13
ES2158076T3 (es) 2001-09-01
PE38095A1 (es) 1995-11-28
DE69427591D1 (de) 2001-08-02
CA2179011A1 (en) 1995-08-03
FI962492A7 (fi) 1996-07-25
CZ285990B6 (cs) 1999-12-15
CA2179011C (en) 1999-11-30

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