NO311749B1 - 7-(2-imidazolinylamino) kinolin-forbindelser og anvendelser derav for fremstilling av medikamenter - Google Patents

7-(2-imidazolinylamino) kinolin-forbindelser og anvendelser derav for fremstilling av medikamenter Download PDF

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Publication number
NO311749B1
NO311749B1 NO19962537A NO962537A NO311749B1 NO 311749 B1 NO311749 B1 NO 311749B1 NO 19962537 A NO19962537 A NO 19962537A NO 962537 A NO962537 A NO 962537A NO 311749 B1 NO311749 B1 NO 311749B1
Authority
NO
Norway
Prior art keywords
compound
cyano
compounds
unsubstituted
alkanyl
Prior art date
Application number
NO19962537A
Other languages
English (en)
Norwegian (no)
Other versions
NO962537L (no
NO962537D0 (no
Inventor
Thomas Lee Cupps
Sophie Eva Bogdan
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of NO962537D0 publication Critical patent/NO962537D0/no
Publication of NO962537L publication Critical patent/NO962537L/no
Publication of NO311749B1 publication Critical patent/NO311749B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO19962537A 1993-12-17 1996-06-14 7-(2-imidazolinylamino) kinolin-forbindelser og anvendelser derav for fremstilling av medikamenter NO311749B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16934293A 1993-12-17 1993-12-17
US08/292,672 US5576437A (en) 1993-12-17 1994-08-18 7-(2-imidazolnylamino) quinoline compounds useful as alpha-2 adrenoceptor agonists
PCT/US1994/014290 WO1995020386A1 (en) 1993-12-17 1994-12-15 7-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists

Publications (3)

Publication Number Publication Date
NO962537D0 NO962537D0 (no) 1996-06-14
NO962537L NO962537L (no) 1996-08-14
NO311749B1 true NO311749B1 (no) 2002-01-21

Family

ID=26864973

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19962537A NO311749B1 (no) 1993-12-17 1996-06-14 7-(2-imidazolinylamino) kinolin-forbindelser og anvendelser derav for fremstilling av medikamenter

Country Status (23)

Country Link
US (2) US5576437A (de)
EP (1) EP0734261B1 (de)
JP (1) JPH09507219A (de)
CN (1) CN1085945C (de)
AT (1) ATE202475T1 (de)
AU (1) AU704857B2 (de)
BR (1) BR9408344A (de)
CA (1) CA2179011C (de)
CZ (1) CZ285990B6 (de)
DE (1) DE69427591T2 (de)
DK (1) DK0734261T3 (de)
ES (1) ES2158076T3 (de)
FI (1) FI962492A7 (de)
GR (1) GR3036199T3 (de)
HU (1) HU219494B (de)
NO (1) NO311749B1 (de)
NZ (1) NZ333369A (de)
PE (1) PE38095A1 (de)
PL (1) PL178054B1 (de)
SG (1) SG49111A1 (de)
SK (1) SK77296A3 (de)
TW (1) TW406077B (de)
WO (1) WO1995020386A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306877B1 (en) 1999-08-09 2001-10-23 The Procter & Gamble Co. Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
CZ183799A3 (cs) * 1996-11-25 1999-09-15 The Procter & Gamble Company Sloučenina, farmaceutický prostředek a způsob prevence nebo léčby
US6172095B1 (en) 1996-11-25 2001-01-09 The Procter & Gamble Company Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
SG72827A1 (en) * 1997-06-23 2000-05-23 Hoffmann La Roche Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives
TW527355B (en) * 1997-07-02 2003-04-11 Bristol Myers Squibb Co Inhibitors of farnesyl protein transferase
JP2002543122A (ja) * 1999-04-30 2002-12-17 エイピーティー ファーマスーティカルズ エルエルスィー 抗マラリア治療剤についての新規使用
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
US20070293539A1 (en) * 2004-03-18 2007-12-20 Lansbury Peter T Methods for the treatment of synucleinopathies
CA2559285A1 (en) * 2004-03-18 2005-09-29 Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
US20060106060A1 (en) * 2004-03-18 2006-05-18 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies (Lansbury)
CA2559282A1 (en) * 2004-03-18 2005-09-29 Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
US20050272722A1 (en) * 2004-03-18 2005-12-08 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
DE102004049008A1 (de) 2004-10-05 2006-04-06 Merck Patent Gmbh Neue Verwendung für α-Sympathomimetika mit 2-Imidazolinstruktur
WO2007056457A2 (en) 2005-11-09 2007-05-18 Combinatorx, Incorporated Methods, compositions, and kits for the treatment of medical conditions
WO2009151683A2 (en) * 2008-03-12 2009-12-17 Link Medicine Corporation Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
US20100331363A1 (en) * 2008-11-13 2010-12-30 Link Medicine Corporation Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
JP2012508768A (ja) * 2008-11-13 2012-04-12 リンク・メディスン・コーポレーション アザキノリノン誘導体及びその使用
US20110060005A1 (en) * 2008-11-13 2011-03-10 Link Medicine Corporation Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
AU2012287164A1 (en) 2011-07-25 2014-02-20 Allergan, Inc. N-(imidazolidin-2-ylidene)quinoline derivatives as modulators of alpha 2 adrenergic receptors

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4029792A (en) * 1972-02-29 1977-06-14 Pfizer Inc. (2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents
BE795970A (fr) * 1972-02-29 1973-08-27 Pfizer Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant
US4036976A (en) * 1973-04-05 1977-07-19 Sandoz, Inc. Substituted imidazolinylamino-indazoles
US4217356A (en) * 1975-08-22 1980-08-12 Sandoz Ltd. 2-Imidazolinylamino-2,1,3-benzothiadiazoles
US4398028A (en) * 1977-01-14 1983-08-09 Sandoz Ltd. Bicyclic heterocyclic amino derivatives
EP0086428B1 (de) * 1979-08-23 1987-07-29 Beecham Group Plc Veterinärmittel gegen Diarrhöe, seine Herstellung und dieses enthaltende orale Dosierungsvorrichtung
JPS57501378A (de) * 1980-09-05 1982-08-05
FR2638356A1 (fr) * 1988-10-28 1990-05-04 Anben Nouveaux derives de la 2-arylimino-imidazolidine pour diminuer la pression intra-oculaire et traiter le glaucome
US5180721A (en) * 1989-05-22 1993-01-19 Allergan, Inc. Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
US5281591A (en) * 1989-05-22 1994-01-25 Allergan, Inc. Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
US5231096A (en) * 1989-10-12 1993-07-27 Allergan, Inc. Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
US5021416A (en) * 1989-10-31 1991-06-04 Allergan, Inc. Method for using (2-imidazolin-2-ylamino) quinoxalines to reduce or maintain intraocular pressure
US5091528A (en) * 1990-09-12 1992-02-25 Allergan, Inc. 6- or 7- (2-imino-2-imidazolidine)-1,4-benzoxazines as α adrenergic agents

Also Published As

Publication number Publication date
CA2179011A1 (en) 1995-08-03
NZ333369A (en) 2001-04-27
HU219494B (hu) 2001-04-28
JPH09507219A (ja) 1997-07-22
HU9601661D0 (en) 1996-08-28
SG49111A1 (en) 1998-05-18
HUT76278A (en) 1997-07-28
PE38095A1 (es) 1995-11-28
DE69427591D1 (de) 2001-08-02
DE69427591T2 (de) 2002-04-25
AU704857B2 (en) 1999-05-06
NO962537L (no) 1996-08-14
SK77296A3 (en) 1997-04-09
CA2179011C (en) 1999-11-30
FI962492L (fi) 1996-07-25
EP0734261A1 (de) 1996-10-02
NO962537D0 (no) 1996-06-14
ES2158076T3 (es) 2001-09-01
CN1085945C (zh) 2002-06-05
FI962492A7 (fi) 1996-07-25
CZ285990B6 (cs) 1999-12-15
WO1995020386A1 (en) 1995-08-03
FI962492A0 (fi) 1996-06-14
EP0734261B1 (de) 2001-06-27
CZ175296A3 (en) 1996-11-13
ATE202475T1 (de) 2001-07-15
US5576437A (en) 1996-11-19
CN1137754A (zh) 1996-12-11
DK0734261T3 (da) 2001-09-03
US5716966A (en) 1998-02-10
BR9408344A (pt) 1997-08-19
PL315058A1 (en) 1996-09-30
PL178054B1 (pl) 2000-02-29
GR3036199T3 (en) 2001-10-31
AU1339495A (en) 1995-08-15
TW406077B (en) 2000-09-21

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