FR1519964A - Bis-benzimidazoles porteurs de substituants basiques et leur préparation - Google Patents

Bis-benzimidazoles porteurs de substituants basiques et leur préparation

Info

Publication number
FR1519964A
FR1519964A FR101212A FR101212A FR1519964A FR 1519964 A FR1519964 A FR 1519964A FR 101212 A FR101212 A FR 101212A FR 101212 A FR101212 A FR 101212A FR 1519964 A FR1519964 A FR 1519964A
Authority
FR
France
Prior art keywords
bis
preparation
basic substituents
carrying basic
benzimidazoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR101212A
Other languages
English (en)
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Farbwerke Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG, Farbwerke Hoechst AG filed Critical Hoechst AG
Priority to FR112465A priority Critical patent/FR6681M/fr
Application granted granted Critical
Publication of FR1519964A publication Critical patent/FR1519964A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR101212A 1966-04-01 1967-04-03 Bis-benzimidazoles porteurs de substituants basiques et leur préparation Expired FR1519964A (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR112465A FR6681M (2) 1966-04-01 1967-06-29

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEF0048833 1966-04-01

Publications (1)

Publication Number Publication Date
FR1519964A true FR1519964A (fr) 1968-04-05

Family

ID=7102516

Family Applications (2)

Application Number Title Priority Date Filing Date
FR101212A Expired FR1519964A (fr) 1966-04-01 1967-04-03 Bis-benzimidazoles porteurs de substituants basiques et leur préparation
FR112465A Expired FR6681M (2) 1966-04-01 1967-06-29

Family Applications After (1)

Application Number Title Priority Date Filing Date
FR112465A Expired FR6681M (2) 1966-04-01 1967-06-29

Country Status (9)

Country Link
US (1) US3538097A (2)
BE (1) BE696499A (2)
CH (2) CH533124A (2)
DE (1) DE1670684A1 (2)
FR (2) FR1519964A (2)
GB (1) GB1186723A (2)
MY (1) MY7100120A (2)
NL (1) NL6704539A (2)
OA (1) OA02583A (2)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0240026A1 (de) * 1986-04-04 1987-10-07 Roche Diagnostics GmbH Heterocyclisch substituierte Benzimidazole, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten
WO1996006831A1 (en) * 1994-08-26 1996-03-07 Auckland Division Cancer Society Of New Zealand Inc. Novel dna-targeted alkylating agents
WO1997004776A1 (en) * 1995-07-28 1997-02-13 The Inner And Eastern Health Care Network Radioprotectors
AU695936B2 (en) * 1994-08-26 1998-08-27 Auckland Division Cancer Society Of New Zealand Inc Novel dna-targeted alkylating agents
US10118920B2 (en) 2015-04-20 2018-11-06 Cellcentric Ltd Isoxazolyl substituted benzimidazoles
US10428065B2 (en) 2015-04-20 2019-10-01 Cellcentric Ltd Isoxazolyl substituted imidazopyridines

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091101A (en) * 1977-06-15 1978-05-23 Merck & Co., Inc. 6-(1-Piperazinyl)quinoxaline
US5767142A (en) * 1996-03-20 1998-06-16 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
US5807874A (en) * 1995-05-17 1998-09-15 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
JP2001501197A (ja) * 1996-09-23 2001-01-30 ルトガーズ，ザ ステイト ユニバーシティ オブ ニュージャージー 抗―腫瘍剤としての置換された複素環式化合物類
US6140328A (en) * 1997-12-12 2000-10-31 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
JP2002509858A (ja) * 1997-12-31 2002-04-02 ルトガーズ，ザ ステイト ユニバーシティ オブ ニュージャージー 複素環式トポイソメラーゼ毒化合物
US6063801A (en) 1998-02-12 2000-05-16 Rutgers, The State University Of New Jersey Heterocyclic topoisomerase poisons
US6740650B2 (en) 1999-10-29 2004-05-25 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
MXPA04004607A (es) * 2001-11-14 2004-09-10 Univ Rutgers Agentes de venenos de topoisomerasa solubilizados.
DE60235287D1 (de) * 2001-11-14 2010-03-25 Univ Rutgers Löslich gemachte topoisomerase-gifte
AU2002364953A1 (en) * 2001-11-14 2003-06-17 Edmond J. Lavoie Topoisomerase poison agents
EP1453812B1 (en) * 2001-11-14 2008-08-20 Rutgers, The State University Cytotoxic agents
US20050119251A1 (en) * 2001-12-21 2005-06-02 Jian-Min Fu Nicotinamide derivatives and their use as therapeutic agents
AU2003268075A1 (en) * 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents
US6992088B2 (en) * 2002-08-09 2006-01-31 Rutgers, The State University Of New Jersey Nitro and amino substituted heterocycles as topoisomerase I targeting agents
US6989387B2 (en) 2002-08-09 2006-01-24 Rutgers, The State University Of New Jersey Nitro and amino substituted topoisomerase agents
CA2510337C (en) * 2002-11-12 2013-01-08 Rutgers, The State University Of New Jersey Topoisomerase-targeting agents
CA2580857A1 (en) * 2004-09-20 2006-09-28 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
AU2005286648A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
AU2006343359A1 (en) * 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
AU2007335185B2 (en) * 2006-12-21 2013-06-27 Peter Maccallum Cancer Institute Radioprotector compounds and related methods
GB0821913D0 (en) 2008-12-02 2009-01-07 Price & Co Antibacterial compounds
DK2403856T3 (da) 2009-03-06 2013-04-08 Univ Rutgers Methylendioxybenzo[i]phenanthridinderivater anvendt til behandling af cancer
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
JP5712524B2 (ja) * 2009-10-28 2015-05-07 Jsr株式会社 液晶配向剤および液晶表示素子
ES2568455T3 (es) * 2010-06-01 2016-04-29 Summit Therapeutics Plc Compuestos para el tratamiento de enfermedad asociada a Clostridium difficile
KR101913619B1 (ko) * 2011-06-09 2018-12-28 리젠 파마슈티컬스 소시에떼 아노님 Gpr-119의 조절제로서의 신규한 화합물
US11434227B2 (en) * 2016-01-23 2022-09-06 Vibha TANDON Broad spectrum antibacterial activity of novel bisbenzimidazoles targeting topoisomerase IA and the synergistic composition of bisbenzimidazole with efflux pump inhibitors against pathogenic bacteria
US11091498B2 (en) 2016-04-04 2021-08-17 Rutgers, The State University Of New Jersey Topoisomerase poisons

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3103403A (en) * 1963-09-10 Dyeing of polyester fibers with com-
US2980690A (en) * 1957-08-30 1961-04-18 Ciba Pharm Prod Inc New basically substituted benzylbenzimidazoles
US3072661A (en) * 1960-08-24 1963-01-08 Interchem Corp New process for improved bis-imidazole vat dyestuff pigments
US3133056A (en) * 1961-05-15 1964-05-12 May & Baker Ltd N-phenylpiperazine derivatives of tetrahydrobenzodiazepines
BE631368A (2) * 1962-04-21
NL135043C (2) * 1963-10-11
GB1122988A (en) * 1964-10-22 1968-08-07 Fisons Pest Control Ltd Benzimidazole derivatives
US3336191A (en) * 1966-03-11 1967-08-15 Smith Kline French Lab Anthelmintic 2-amidobenzimidazoles
US3362956A (en) * 1965-08-19 1968-01-09 Sterling Drug Inc 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0240026A1 (de) * 1986-04-04 1987-10-07 Roche Diagnostics GmbH Heterocyclisch substituierte Benzimidazole, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten
WO1996006831A1 (en) * 1994-08-26 1996-03-07 Auckland Division Cancer Society Of New Zealand Inc. Novel dna-targeted alkylating agents
AU695936B2 (en) * 1994-08-26 1998-08-27 Auckland Division Cancer Society Of New Zealand Inc Novel dna-targeted alkylating agents
WO1997004776A1 (en) * 1995-07-28 1997-02-13 The Inner And Eastern Health Care Network Radioprotectors
US6194414B1 (en) 1995-07-28 2001-02-27 The Inner And Eastern Health Care Network Radioprotectors
US6548505B1 (en) 1995-07-28 2003-04-15 Peter Maccallum Cancer Institute Radioprotectors
US10118920B2 (en) 2015-04-20 2018-11-06 Cellcentric Ltd Isoxazolyl substituted benzimidazoles
US10428065B2 (en) 2015-04-20 2019-10-01 Cellcentric Ltd Isoxazolyl substituted imidazopyridines

Also Published As

Publication number Publication date
US3538097A (en) 1970-11-03
CH533124A (de) 1973-01-31
DE1670684A1 (de) 1970-12-03
GB1186723A (en) 1970-04-02
FR6681M (2) 1969-02-03
MY7100120A (en) 1971-12-31
CH525902A (de) 1972-07-31
BE696499A (2) 1967-10-03
OA02583A (fr) 1970-05-05
NL6704539A (2) 1967-10-02

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