FR16C1027I2 - Composes de quinoxaline macrocycliques en tant qu'inhibiteurs de protease ns3 du virus de l'hepatite c (hcv) - Google Patents

Composes de quinoxaline macrocycliques en tant qu'inhibiteurs de protease ns3 du virus de l'hepatite c (hcv)

Info

Publication number
FR16C1027I2
FR16C1027I2 FR16C1027C FR16C1027C FR16C1027I2 FR 16C1027 I2 FR16C1027 I2 FR 16C1027I2 FR 16C1027 C FR16C1027 C FR 16C1027C FR 16C1027 C FR16C1027 C FR 16C1027C FR 16C1027 I2 FR16C1027 I2 FR 16C1027I2
Authority
FR
France
Prior art keywords
hcv
hepatitis
virus
protease inhibitors
quinoxaline compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR16C1027C
Other languages
English (en)
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Pharma UK Ltd
MSD Italia SRL
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme Ltd
MSD Italia SRL
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41130248&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR16C1027(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp and Dohme Ltd, MSD Italia SRL, Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme Ltd
Publication of FR16C1027I1 publication Critical patent/FR16C1027I1/fr
Application granted granted Critical
Publication of FR16C1027I2 publication Critical patent/FR16C1027I2/fr
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FR16C1027C 2008-07-22 2016-12-26 Composes de quinoxaline macrocycliques en tant qu'inhibiteurs de protease ns3 du virus de l'hepatite c (hcv) Active FR16C1027I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13555908P 2008-07-22 2008-07-22
PCT/US2009/050915 WO2010011566A1 (en) 2008-07-22 2009-07-17 Macrocyclic quinoxaline compounds as hcv ns3 protease inhibitors

Publications (2)

Publication Number Publication Date
FR16C1027I1 FR16C1027I1 (fr) 2017-02-03
FR16C1027I2 true FR16C1027I2 (fr) 2017-12-08

Family

ID=41130248

Family Applications (1)

Application Number Title Priority Date Filing Date
FR16C1027C Active FR16C1027I2 (fr) 2008-07-22 2016-12-26 Composes de quinoxaline macrocycliques en tant qu'inhibiteurs de protease ns3 du virus de l'hepatite c (hcv)

Country Status (43)

Country Link
US (2) US7973040B2 (no)
EP (3) EP2310095B1 (no)
JP (1) JP4920797B2 (no)
KR (1) KR101313675B1 (no)
CN (1) CN102159285B (no)
AR (1) AR072588A1 (no)
AU (1) AU2009274190B2 (no)
BR (1) BRPI0916235B8 (no)
CA (1) CA2731177C (no)
CL (1) CL2011000145A1 (no)
CO (1) CO6351757A2 (no)
CR (1) CR20110089A (no)
CY (3) CY1113752T1 (no)
DK (2) DK2540350T3 (no)
DO (1) DOP2011000023A (no)
EA (1) EA019327B1 (no)
EC (1) ECSP11010777A (no)
ES (2) ES2491090T3 (no)
FR (1) FR16C1027I2 (no)
HN (1) HN2011000209A (no)
HR (2) HRP20120866T1 (no)
HU (1) HUS1700001I1 (no)
IL (1) IL210580A (no)
LT (1) LTC2310095I2 (no)
LU (1) LUC00002I2 (no)
MA (1) MA32502B1 (no)
ME (2) ME02024B (no)
MX (1) MX2011000826A (no)
MY (1) MY152070A (no)
NI (1) NI201100023A (no)
NL (1) NL300857I2 (no)
NO (1) NO2017004I1 (no)
NZ (1) NZ590638A (no)
PE (1) PE20110212A1 (no)
PL (2) PL2540350T3 (no)
PT (2) PT2540350E (no)
RS (2) RS53420B (no)
SI (2) SI2310095T1 (no)
SV (1) SV2011003813A (no)
TN (1) TN2011000014A1 (no)
TW (1) TWI441638B (no)
UA (1) UA100436C2 (no)
WO (1) WO2010011566A1 (no)

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