FR18C0004I2 - Benzothiophenes a substituant piperazine pour le traitement de troubles mentaux - Google Patents

Benzothiophenes a substituant piperazine pour le traitement de troubles mentaux

Info

Publication number
FR18C0004I2
FR18C0004I2 FR18C0004C FR18C0004C FR18C0004I2 FR 18C0004 I2 FR18C0004 I2 FR 18C0004I2 FR 18C0004 C FR18C0004 C FR 18C0004C FR 18C0004 C FR18C0004 C FR 18C0004C FR 18C0004 I2 FR18C0004 I2 FR 18C0004I2
Authority
FR
France
Prior art keywords
benzothiophene
treatment
mental disorders
substitute piperazine
piperazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
FR18C0004C
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36645750&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR18C0004(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of FR18C0004I1 publication Critical patent/FR18C0004I1/fr
Application granted granted Critical
Publication of FR18C0004I2 publication Critical patent/FR18C0004I2/fr
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR18C0004C 2005-04-14 2018-09-18 Benzothiophenes a substituant piperazine pour le traitement de troubles mentaux Active FR18C0004I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005116698 2005-04-14
PCT/JP2006/308162 WO2006112464A1 (fr) 2005-04-14 2006-04-12 Benzothiophenes a substituant piperazine pour le traitement de troubles mentaux

Publications (2)

Publication Number Publication Date
FR18C0004I1 FR18C0004I1 (fr) 2018-11-02
FR18C0004I2 true FR18C0004I2 (fr) 2021-01-22

Family

ID=36645750

Family Applications (1)

Application Number Title Priority Date Filing Date
FR18C0004C Active FR18C0004I2 (fr) 2005-04-14 2018-09-18 Benzothiophenes a substituant piperazine pour le traitement de troubles mentaux

Country Status (28)

Country Link
US (14) US7888362B2 (fr)
EP (1) EP1869025B3 (fr)
KR (1) KR100937623B1 (fr)
CN (1) CN101155804B (fr)
AR (1) AR053577A1 (fr)
AT (1) ATE496911T3 (fr)
AU (1) AU2006237905C1 (fr)
BE (1) BE2018C037I2 (fr)
BR (1) BRPI0609785B8 (fr)
CA (1) CA2602247C (fr)
CY (2) CY1111206T1 (fr)
DE (1) DE602006019838D1 (fr)
DK (1) DK1869025T6 (fr)
ES (1) ES2358631T7 (fr)
FR (1) FR18C0004I2 (fr)
HU (2) HUE011611T6 (fr)
IL (1) IL185909A (fr)
IN (1) IN2012DN00855A (fr)
LT (1) LTC1869025I2 (fr)
LU (1) LUC00086I2 (fr)
MY (1) MY142746A (fr)
NL (1) NL300946I2 (fr)
PL (1) PL1869025T6 (fr)
PT (1) PT1869025E (fr)
SI (1) SI1869025T1 (fr)
TW (1) TWI320783B (fr)
WO (1) WO2006112464A1 (fr)
ZA (1) ZA200708686B (fr)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1558582E (pt) 2003-07-22 2006-05-31 Arena Pharm Inc Derivados de diaril- e aril-heteroaril-ureia como moduladores do receptor de serotonina 5-ht2a uteis para a profilaxia e tratamento de desordens relacionadas com o mesmo
SA05260357B1 (ar) 2004-11-19 2008-09-08 ارينا فارماسيتو تيكالز ، أنك مشتقات 3_فينيل_بيرازول كمعدلات لمستقبل سيروتينين 5_ht2a مفيدة في علاج الاضطرابات المتعلقه به
TWI320783B (en) * 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
JP5286254B2 (ja) 2006-05-18 2013-09-11 アリーナ ファーマシューティカルズ， インコーポレイテッド ５−ｈｔ２ａセロトニンレセプター活性のモジュレーターとして有用なフェニルピラゾールの結晶形態および調製方法
ES2536762T3 (es) 2006-05-18 2015-05-28 Arena Pharmaceuticals, Inc. Aminas primarias y sus derivados como moduladores del receptor de la serotonina 5-HT2A útiles para el tratamiento de trastornos relacionados con este
CA2646076C (fr) 2006-05-18 2015-06-30 Arena Pharmaceuticals, Inc. Ethers, amines secondaires et leurs derives utilises en tant que modulateurs des recepteurs 5-ht2a de la serotonine et utiles pour traiter les troubles lies a ces recepteurs
TWI415845B (zh) 2006-10-03 2013-11-21 Arena Pharm Inc 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物
AR063302A1 (es) * 2006-10-13 2009-01-21 Otsuka Pharma Co Ltd Derivados de 4-benzo[b]tiofen-4-il-piperazin-1-il con accion antagonista del receptor 5-ht2a de serotonina y receptor de adrenalina alfa1 y agonista parcial del receptor d2, una composicion farmaceutica que lo comprende y un proceso para producirla.
US20080186971A1 (en) * 2007-02-02 2008-08-07 Tarari, Inc. Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic
WO2009023253A2 (fr) 2007-08-15 2009-02-19 Arena Pharmaceuticals Inc. Dérivés d'imidazo[l,2-α]pyridine utilisés comme modulateurs du récepteur sérotoninergique 5-ht2a dans le traitement des troubles qui lui sont associés
BRPI0908807A2 (pt) * 2008-02-15 2015-07-28 Hoffmann La Roche Derivados de 3-alquil-piperazina e usos dos mesmos
RU2501799C2 (ru) 2008-02-22 2013-12-20 Актелион Фармасьютикалз Лтд Поизводные оксазолидинона
WO2009123714A2 (fr) 2008-04-02 2009-10-08 Arena Pharmaceuticals, Inc. Procédés de préparation de dérivés de pyrazole utiles comme modulateurs du récepteur de la sérotonine 5-ht<sb>2a</sb>
WO2010062321A1 (fr) 2008-10-28 2010-06-03 Arena Pharmaceuticals, Inc. Procédés utiles pour la préparation de 1-[3-(4-bromo-2-méthyl-2h-pyrazol-3-yl)-4-méthoxy-phényl]-3-(2,4-difluoro‑phényl)-urée, et formes cristallines associées
CN104739829B (zh) 2008-10-28 2018-11-06 艾尼纳制药公司 用于治疗5-ht2a5-羟色胺受体相关障碍的5-ht2a5-羟色胺受体调节剂组合物
LT2445502T (lt) 2009-06-25 2017-09-25 Alkermes Pharma Ireland Limited Heterocikliniai junginiai, skirti neurologinių ir fiziologinių susirgimų gydymui
WO2011075596A1 (fr) 2009-12-18 2011-06-23 Arena Pharmaceuticals, Inc. Formes cristallines de certains dérivés de 3-phényl-pyrazole, modulatrices du récepteur 5-ht2a de la sérotonine, utiles pour le traitement de troubles y étant associés
CA2797708C (fr) 2010-05-04 2016-08-16 Alkermes Pharma Ireland Limited Procede de synthese de lactames oxydes
AU2011270701B2 (en) 2010-06-24 2015-05-14 Alkermes Pharma Ireland Limited Prodrugs of NH-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
JOP20120083B1 (ar) 2011-04-05 2021-08-17 Otsuka Pharma Co Ltd توليفات تشتمل على بريكس ببرازول أو ملح منه وعقار ثاني للاستخدام في علاج اضطراب cns
US9206169B2 (en) 2011-07-28 2015-12-08 Otsuka Pharmaceutical Co., Ltd. Method for producing benzo[b]thiophene compound
JO3227B1 (ar) 2011-09-08 2018-03-08 Otsuka Pharma Co Ltd مشتقات بنزو ثيوفين بها استبدال ببرازين كعوامل مضادة للذهان
JO3753B1 (ar) * 2011-10-14 2021-01-31 Otsuka Pharma Co Ltd قرص يتألف من 7-[4-(4-بينزو[بي]ثيوفين-4-ايل-ببرازين-1-1ايل)بوتكسيل]-1اتش-كوينولين-2-وان أو ملح منه
TWI632921B (zh) 2011-10-19 2018-08-21 大塚製藥股份有限公司 口服溶液
TW201332572A (zh) * 2011-12-28 2013-08-16 Otsuka Pharma Co Ltd 具有經取代的β－環糊精之藥物製劑
TWI562991B (en) * 2012-04-23 2016-12-21 Otsuka Pharma Co Ltd Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same
JOP20200109A1 (ar) 2012-04-23 2017-06-16 Otsuka Pharma Co Ltd مستحضر قابل للحقن
AR090775A1 (es) * 2012-04-23 2014-12-03 Otsuka Pharma Co Ltd Preparado inyectable
JP6345651B2 (ja) * 2012-05-09 2018-06-20 サノビオン ファーマシューティカルズ インクＳｕｎｏｖｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃ． ヘテロアリール化合物及びその使用方法
EP2911670A1 (fr) 2012-10-25 2015-09-02 Otsuka Pharmaceutical Co., Ltd. Agent prophylactique et/ou thérapeutique pour des symptômes comportementaux et psychologiques associés à une maladie neurodégénérative ou des symptômes impulsifs associés à une maladie mentale contenant du brexpiprazole ou son sel
EP2792359A1 (fr) * 2013-04-19 2014-10-22 Merz Pharma GmbH & Co. KGaA Traitement de la dyskinésie induite par L-DOPA avec OPC-14523 ou OPC-34712
KR101472916B1 (ko) * 2013-06-27 2014-12-16 한국과학기술연구원 모르폴린 또는 피페라진 화합물, 및 도네페질을 포함하는 인지 장애 관련 질병의 예방 또는 치료용 약학적 조성물
CN104557896A (zh) 2013-10-18 2015-04-29 沈敬山 布瑞哌唑、其关键中间体及其盐的制备方法
CN104892589A (zh) * 2014-03-07 2015-09-09 中国科学院上海药物研究所 一类杂环化合物、其制备方法和用途
MX2016013889A (es) 2014-04-22 2017-03-09 Otsuka Pharma Co Ltd Medicamento.
CN104447723A (zh) * 2014-11-28 2015-03-25 瑞阳制药有限公司 7-(4-(4-(苯并[b]噻吩基)-1-哌嗪基)丁氧基)-2(1H)-喹啉酮的制备方法
CN105461703B (zh) * 2014-12-29 2019-05-17 深圳市泛谷药业股份有限公司 一种brexpiprazole的制备方法
CN105985314A (zh) * 2015-02-05 2016-10-05 苏州旺山旺水生物医药有限公司 布瑞哌唑类似物的制备方法
CN104844586A (zh) * 2015-04-16 2015-08-19 重庆医药工业研究院有限责任公司 一种依匹哌唑无定型物及其制备方法
CN104829588B (zh) * 2015-04-30 2017-03-29 苏州苏旺森生物医药科技有限公司 一种苯并[b]噻吩的制备方法及其中间体
CN104829603A (zh) * 2015-05-19 2015-08-12 杭州新博思生物医药有限公司 A晶型依匹唑派盐酸盐及其制备方法
WO2016201373A1 (fr) 2015-06-12 2016-12-15 Axovant Sciences Ltd. Dérivés de diaryl et arylhétéroaryl urée utiles pour la prophylaxie et le traitement du trouble du comportement en sommeil rem
WO2017011767A2 (fr) 2015-07-15 2017-01-19 Axovant Sciences Ltd. Dérivés d'arylhérétoaryl urée en tant que modulateurs du récepteur sérotoninergique 5-ht2a utiles pour la prophylaxie et le traitement d'hallucinations associées à une maladie neurodégénérative
CN105061414B (zh) * 2015-07-21 2019-01-01 杭州新博思生物医药有限公司 一锅法制备Brexpiprazole
WO2017025987A1 (fr) 2015-08-11 2017-02-16 Mylan Laboratories Limited Procédé de préparation de brexpiprazole
EP3150591A1 (fr) 2015-10-02 2017-04-05 Crystal Pharma S.A.U Procédé et produits intermediaires pour la preparation des derivées de benzo[b]thiophene
CN106749219A (zh) 2015-11-20 2017-05-31 江苏恩华药业股份有限公司 一种内酰胺类衍生物及其应用
CN105440026A (zh) * 2015-12-04 2016-03-30 上海勋和医药科技有限公司 依匹哌唑的制备方法
CN105461704A (zh) * 2015-12-15 2016-04-06 南京艾德凯腾生物医药有限责任公司 一种依匹哌唑的制备方法
WO2017106641A1 (fr) 2015-12-17 2017-06-22 Assia Chemical Industries Ltd. Formes à l'état solide de brexpiprazole
CN106916148B (zh) * 2015-12-25 2021-07-06 上海科胜药物研发有限公司 一种合成依匹哌唑的方法
WO2017115287A1 (fr) * 2015-12-28 2017-07-06 Honour (R&D) Procédé de préparation de dérivés de quinoline-2(1h)-one
CN106938982A (zh) * 2016-01-05 2017-07-11 连云港皓海医药科技有限公司 布瑞哌唑的制备方法及用于制备布瑞哌唑的化合物
CN105399736B (zh) * 2016-01-07 2018-10-19 安徽省逸欣铭医药科技有限公司 一种依匹哌唑新的制备方法
WO2017134038A1 (fr) 2016-02-01 2017-08-10 Hexal Ag Dihydrate de brexpiprazole sous forme cristalline, micronisé, polymorphiquement pur, sans anhydrate, à utiliser dans des préparations à libération prolongée injectables par voie intramusculaire
CN105541819B (zh) * 2016-02-04 2018-09-14 浙江永宁药业股份有限公司 一种依匹唑派的制备方法及其中间体和中间体的制备方法
US20170320862A1 (en) 2016-05-03 2017-11-09 Cadila Healthcare Limited Process for the preparation of brexpiprazole and intermediates thereof
CN107365305A (zh) 2016-05-12 2017-11-21 上海奥博生物医药技术有限公司 一种依匹哌唑新晶型及其制备方法
WO2017208251A1 (fr) * 2016-05-31 2017-12-07 Cipla Limited Nouvelle forme polymorphe stable de brexpiprazole et son procédé de préparation
WO2017216661A1 (fr) 2016-06-17 2017-12-21 Jubilant Generics Limited Procédé pour la préparation de brexpiprazole à partir de 7-(4-chlorobutoxy)quinolin-2(1h)-one et du 1-(benzo[b]thiophen-4-yl)piperazine
US10034861B2 (en) 2016-07-04 2018-07-31 H. Lundbeck A/S 1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors
PL233778B1 (pl) 2016-07-19 2019-11-29 Adamed Spolka Z Ograniczona Odpowiedzialnoscia Sposob wytwarzania brekspiprazolu oraz zastosowanie zwiazkow posrednich w sposobie wytwarzania brekspiprazolu
WO2018033484A1 (fr) 2016-08-16 2018-02-22 Hexal Aktiengesellschaft Compositions pharmaceutiques d'un composé benzothiophène
WO2018033481A1 (fr) 2016-08-16 2018-02-22 H E X A L Aktiengesellschaft Comprimé à libération immédiate d'un composé benzothiophène
WO2018060916A1 (fr) * 2016-09-28 2018-04-05 Alembic Pharmaceuticals Limited Procédé de préparation de brexpiprazole et d'intermédiaires de celui-ci
CN107936005A (zh) * 2016-10-13 2018-04-20 上海科胜药物研发有限公司 一种依匹哌唑新晶型ii及其制备方法
WO2018087775A1 (fr) * 2016-11-09 2018-05-17 Msn Laboratories Private Limited, R&D Center Procédés de préparation de 7-{4-[4-(1-benzothiophén-4-yl)pipérazin-1-yl]butoxy}quinolin-2(1h)-one
CN106699745A (zh) * 2016-12-14 2017-05-24 上海博志研新药物技术有限公司 一种依匹哌唑甲醇合物、晶型a、及其制备方法和应用
US11072605B2 (en) 2017-02-02 2021-07-27 Hexal Ag Crystalline brexpiprazole
WO2018172463A1 (fr) 2017-03-22 2018-09-27 Amneal Pharmaceuticals Company Gmbh Procédé de préparation de brexpiprazole
WO2019073481A1 (fr) * 2017-10-12 2019-04-18 Indoco Remedies Limited Procédé de préparation de brexpiprazole et de ses intermédiaires
MX2020006174A (es) 2017-12-14 2022-09-27 H Lundbeck As Tratamientos de combinación que comprenden la administración de 1h-pirazol[4,3-b]piridinas.
AR113926A1 (es) 2017-12-14 2020-07-01 H Lundbeck As Derivados de 1h-pirazolo[4,3-b]piridinas
EP3501506B1 (fr) 2017-12-19 2019-10-09 Alfred E. Tiefenbacher (GmbH & Co. KG) Composition de comprimé pharmaceutique comprenant du brexpiprazole
WO2019121840A1 (fr) 2017-12-20 2019-06-27 H. Lundbeck A/S Pyrazolo[3,4-b]pyridines et imidazo[1,5-b]pyridazines utilisées en tant qu'inhibiteurs de pde1
CN109988162A (zh) * 2017-12-29 2019-07-09 武汉兴华智慧医药科技有限公司 一种依匹哌唑衍生物及其制备方法
EP3545950A1 (fr) 2018-03-26 2019-10-02 Adamed sp. z o.o. Composition pharmaceutique comprenant du brexpiprazole
WO2019242717A1 (fr) * 2018-06-21 2019-12-26 中国科学院上海药物研究所 Sel de maléate d'un composé de benzothiophène, forme cristalline correspondante et utilisation associée
CN108947990A (zh) * 2018-07-20 2018-12-07 成都苑东生物制药股份有限公司 一种苯并噻吩类化合物的制备方法
US20210393621A1 (en) 2018-10-26 2021-12-23 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
CN111320619A (zh) * 2018-12-17 2020-06-23 江苏恩华药业股份有限公司 一种类酰胺类衍生物的杂质及用途
CN111320582A (zh) * 2018-12-17 2020-06-23 江苏恩华药业股份有限公司 一种类酰胺类衍生物及其中间体的制备方法
CN109970705B (zh) * 2019-05-14 2021-02-09 浙江工业大学 一种应用廉价金属铜制备依匹哌唑中间体及依匹哌唑的方法
WO2021029020A1 (fr) * 2019-08-13 2021-02-18 大塚製薬株式会社 Composition pharmaceutique orale
MX2022012678A (es) * 2020-04-08 2023-01-11 Remix Therapeutics Inc Compuestos y metodos para modular el corte y empalme.
CA3182412A1 (fr) * 2020-07-06 2022-01-13 Mathew BAGGOTT Compositions de benzothiophene avantageuses pour troubles mentaux ou amelioration mentale
US11229644B1 (en) * 2020-12-31 2022-01-25 Lake O'hara Llc Methods of treating psychiatric disorders in obese patients with brexpiprazole
CN117769545A (zh) * 2021-08-05 2024-03-26 上海枢境生物科技有限公司 含三并环类衍生物调节剂、其制备方法和应用
CN115772175A (zh) * 2021-09-07 2023-03-10 中国科学院分子细胞科学卓越创新中心 噻吩并环化合物及其制备方法和应用
CN114181202A (zh) * 2021-12-17 2022-03-15 湖南省湘中制药有限公司 一种依匹哌唑的制备方法
CN118580229B (zh) * 2024-08-07 2024-12-27 湖南一格制药有限公司 布瑞哌唑的制备方法

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3910955A (en) 1970-12-21 1975-10-07 Aspro Nicholas Ltd Benzothiophene-ethylamines
DK574274A (fr) 1973-12-06 1975-07-28 Ciba Geigy Ag
JPS54130587A (en) 1978-03-30 1979-10-09 Otsuka Pharmaceut Co Ltd Carbostyryl derivative
DE2960178D1 (en) 1978-06-06 1981-04-09 Hoechst Ag New substituted phenylpiperazine derivatives, pharmaceutical compositions containing them and process for their preparation
DE2827566A1 (de) 1978-06-23 1980-01-10 Boehringer Mannheim Gmbh 1,2-dihydro-chinolin-2-on-derivate und verfahren zu ihrer herstellung
JPS5646812A (en) 1979-09-27 1981-04-28 Otsuka Pharmaceut Co Ltd Central nervous system depressant
JPS5649361A (en) 1979-09-28 1981-05-02 Otsuka Pharmaceut Co Ltd Carbostyril derivative
PH17194A (en) 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
JPS56164186A (en) 1980-05-21 1981-12-17 Otsuka Pharmaceut Co Ltd Carbostyril derivative
IT1201087B (it) 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
DE3586794T2 (de) 1984-12-21 1993-05-27 Duphar Int Res Arzneimittel mit psychotroper wirkung.
US4704390A (en) 1986-02-13 1987-11-03 Warner-Lambert Company Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents
GB8704572D0 (en) 1987-02-26 1987-04-01 Lundbeck & Co As H Organic compounds
US4883795A (en) 1988-01-22 1989-11-28 Pfizer Inc. Piperazinyl-heterocyclic compounds
US4831031A (en) 1988-01-22 1989-05-16 Pfizer Inc. Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
US5006528A (en) 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives
WO1991000863A1 (fr) 1989-07-07 1991-01-24 Pfizer Inc. Agents antipsychotiques a base de piperazine d'heteroaryle
CA2067475C (fr) 1991-05-08 2000-10-10 Yasuo Oshiro Derives du carbostyrile et leurs utilisations
US5436246A (en) * 1992-09-17 1995-07-25 Merrell Dow Pharmaceuticals Inc. Serotonin receptor agents
DK148392D0 (da) 1992-12-09 1992-12-09 Lundbeck & Co As H Heterocykliske forbindelser
US5506248A (en) 1993-08-02 1996-04-09 Bristol-Myers Squibb Company Pharmaceutical compositions having good dissolution properties
CN1154105A (zh) * 1994-06-08 1997-07-09 H·隆德贝克有限公司 4-芳基-1-(二氢化茚甲基、二氢苯并呋喃甲基或二氢苯并噻吩甲基)哌啶、-四氢吡啶或哌嗪类化合物
CA2157348A1 (fr) 1994-09-01 1996-03-02 Aventis Pharmaceuticals Inc. Composes 3-¬4-(1-substituant-4-piperazinyl)butyl|-4-thiazolidinone et composes connexes
US5576321A (en) 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
ATE211137T1 (de) 1995-03-17 2002-01-15 Aventis Pharma Inc Substituierte benzylthienylpiperazine, ihre anwendung als arzneimittel und verfahren für ihre herstellung
CR5278A (es) 1995-03-24 1996-07-04 Lilly Co Eli Formulacion oral de 2-metil-tieno-benzodiacepina
FR2735127B1 (fr) 1995-06-09 1997-08-22 Pf Medicament Nouvelles piperazines heteroaromatiques utiles comme medicaments.
SI0850235T1 (en) 1995-09-15 2000-04-30 Sanofi-Synthelabo Quinolein-2(1h)-one derivatives as serotonin antagonists
WO1997011070A1 (fr) 1995-09-22 1997-03-27 Warner-Lambert Company Cyclohexylamines substituees, utilisees comme agents du systeme nerveux central
DE69736704T2 (de) 1996-03-29 2007-09-13 Duphar International Research B.V. Piperazin- und piperidin- derivate
US5846982A (en) 1996-06-14 1998-12-08 Eli Lilly And Company Inhibition of serotonin reuptake
WO1998007703A1 (fr) 1996-08-22 1998-02-26 Meiji Seika Kaisha, Ltd. Derives quinoleine et agent psychotrope
FR2761068B1 (fr) 1997-03-20 1999-04-23 Synthelabo Derives de piperazin-4-ylthieno[3,2-c]pyridin-4-yl-2- carboxamide, leur preparation et leur application en therapeutique
ES2128266B1 (es) 1997-07-08 2000-01-16 Vita Invest Sa Compuestos derivados de tiofeno y benzotiofeno y utilizacion y composicion correspondientes.
DE69819266T2 (de) 1997-09-02 2004-07-29 Duphar International Research B.V. Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten
EP0901787B1 (fr) 1997-09-10 2003-05-28 Takeda Chemical Industries, Ltd. Composition pharmaceutique stabilisée
WO2000000198A1 (fr) 1998-06-30 2000-01-06 Eli Lilly And Company Derives de piperidine agissant sur les systemes lies a la serotonine
AR022303A1 (es) 1999-01-22 2002-09-04 Lundbeck & Co As H Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion
CN1164574C (zh) 1999-05-24 2004-09-01 三菱制药株式会社 苯氧基丙胺类化合物
CA2378879A1 (fr) 1999-07-29 2001-02-08 Yao-Chang Xu Benzothiophenes serotoninergiques
US6562375B1 (en) 1999-08-04 2003-05-13 Yamanouchi Pharmaceuticals, Co., Ltd. Stable pharmaceutical composition for oral use
ATE266660T1 (de) 1999-12-20 2004-05-15 Lilly Co Eli Piperidin-derivate und ihre verwendung als serotonin rezeptor antagonisten
AR027133A1 (es) 1999-12-30 2003-03-12 Lundbeck & Co As H Derivados de heteroarilo, su preparacion y uso.
US20020076437A1 (en) 2000-04-12 2002-06-20 Sanjeev Kothari Flashmelt oral dosage formulation
DE10043659A1 (de) 2000-09-05 2002-03-14 Merck Patent Gmbh Arylpiperazinderivate
ES2188344B1 (es) 2000-11-29 2004-09-16 Laboratorios Vita, S.A. Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos.
US7053092B2 (en) 2001-01-29 2006-05-30 Otsuka Pharmaceutical Co., Ltd. 5-HT1a receptor subtype agonist
IL157412A0 (en) 2001-02-16 2004-03-28 Aventis Pharmaceuticals Inc Av Novel heterocyclic amide derivatives and their use as dopamine d3 receptor ligands
JP4310605B2 (ja) 2001-05-25 2009-08-12 大塚製薬株式会社 医薬用組成物
AR033485A1 (es) 2001-09-25 2003-12-26 Otsuka Pharma Co Ltd Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma
DE10151569A1 (de) 2001-10-23 2003-04-30 Basf Ag Thermisch härtbare Bindemittel
WO2003055467A1 (fr) 2001-12-18 2003-07-10 Synthon B.V. Formes posologiques de simvastatine
HRP20050248A2 (en) 2002-09-17 2005-10-31 Warner-Lambert Company Llc Heterocyclic substituted piperazines for the treatment of schizophrenia
JP2005539344A (ja) 2002-09-20 2005-12-22 オスラム　オプト　セミコンダクターズ　ゲゼルシャフト　ミット　ベシュレンクテル　ハフツング 光学式の走査ヘッド及び該走査ヘッドの製造のための方法
WO2004029048A1 (fr) 2002-09-26 2004-04-08 Warner-Lambert Company Llc Piperazines substituees heterocycliques destinees au traitement de la schizophrenie
CN1989968B (zh) 2002-12-27 2011-05-11 大塚制药株式会社 用于治疗情绪障碍的喹诺酮衍生物和5-羟色胺再摄取抑制剂
SI1480953T2 (sl) 2003-01-09 2010-12-31 Otsuka Pharma Co Ltd Postopek za pripravo aripiprazola
EA008596B1 (ru) 2003-04-29 2007-06-29 Пфайзер Инк. 5,7-ДИАМИНОПИРАЗОЛО[4,3-d]ПИРИМИДИНЫ, ПОЛЕЗНЫЕ ПРИ ЛЕЧЕНИИ ГИПЕРТЕНЗИИ
CN102166359A (zh) 2003-05-23 2011-08-31 大塚制药株式会社 用于治疗情感障碍的喹诺酮衍生物和情绪稳定剂
US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
GB0504203D0 (en) 2005-03-01 2005-04-06 Novartis Ag Organic compounds
WO2006097344A1 (fr) 2005-03-17 2006-09-21 Synthon B.V. Comprimes pharmaceutiques de forme cristalline d'aripiprazole ii
TWI320783B (en) * 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
UA97349C2 (uk) 2005-09-08 2012-02-10 Х. Луннбэк А/С Стійкі тверді склади сертиндолу
PT1808164E (pt) 2006-01-05 2009-03-17 Teva Pharma Método de granulação húmida para a preparação de composições farmacêuticas de aripiprazole
RU2470635C2 (ru) 2007-05-11 2012-12-27 Сантен Фармасьютикал Ко., Лтд. Профилактическое или терапевтическое средство, применяемое при заболеваниях заднего отдела глаза
US7968431B2 (en) 2008-07-15 2011-06-28 Taiwan Semiconductor Manufacturing Company, Ltd. Diffusion region routing for narrow scribe-line devices
WO2010052727A1 (fr) 2008-11-04 2010-05-14 Ideal Cures Private Limited Compositions de revêtement fdlm à hautes performances
US9206169B2 (en) * 2011-07-28 2015-12-08 Otsuka Pharmaceutical Co., Ltd. Method for producing benzo[b]thiophene compound
JO3227B1 (ar) * 2011-09-08 2018-03-08 Otsuka Pharma Co Ltd مشتقات بنزو ثيوفين بها استبدال ببرازين كعوامل مضادة للذهان
JO3753B1 (ar) 2011-10-14 2021-01-31 Otsuka Pharma Co Ltd قرص يتألف من 7-[4-(4-بينزو[بي]ثيوفين-4-ايل-ببرازين-1-1ايل)بوتكسيل]-1اتش-كوينولين-2-وان أو ملح منه
TWI562991B (en) * 2012-04-23 2016-12-21 Otsuka Pharma Co Ltd Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same

Also Published As

Publication number Publication date
AR053577A1 (es) 2007-05-09
AU2006237905A1 (en) 2006-10-26
IN2012DN00855A (fr) 2015-07-10
US20130158044A1 (en) 2013-06-20
US8618109B2 (en) 2013-12-31
ZA200708686B (en) 2009-01-28
US20140163039A1 (en) 2014-06-12
CA2602247A1 (fr) 2006-10-26
CN101155804B (zh) 2013-03-27
US20210113556A1 (en) 2021-04-22
US20190321359A1 (en) 2019-10-24
MY142746A (en) 2010-12-31
US20100179322A1 (en) 2010-07-15
CY1111206T1 (el) 2015-06-11
PT1869025E (pt) 2011-02-04
AU2006237905C1 (en) 2015-11-19
HUS1800041I1 (hu) 2018-11-28
US20110152286A1 (en) 2011-06-23
KR100937623B1 (ko) 2010-01-20
KR20080002817A (ko) 2008-01-04
US20190117648A1 (en) 2019-04-25
TW200716619A (en) 2007-05-01
IL185909A (en) 2014-08-31
FR18C0004I1 (fr) 2018-11-02
US9839637B1 (en) 2017-12-12
DK1869025T6 (da) 2017-01-02
SI1869025T1 (sl) 2011-04-29
IL185909A0 (en) 2008-01-06
ES2358631T7 (es) 2016-11-17
US8349840B2 (en) 2013-01-08
LUC00086I2 (fr) 2018-11-26
DE602006019838D1 (de) 2011-03-10
US20170000786A1 (en) 2017-01-05
EP1869025B3 (fr) 2016-08-31
US20200237755A1 (en) 2020-07-30
WO2006112464A1 (fr) 2006-10-26
TWI320783B (en) 2010-02-21
US9206167B2 (en) 2015-12-08
DK1869025T3 (da) 2011-04-04
EP1869025A1 (fr) 2007-12-26
ES2358631T3 (es) 2011-05-12
US20170368060A1 (en) 2017-12-28
HK1112236A1 (en) 2008-08-29
US9480686B2 (en) 2016-11-01
AU2006237905B2 (en) 2009-09-03
USRE48059E1 (en) 2020-06-23
CN101155804A (zh) 2008-04-02
PL1869025T6 (pl) 2017-10-31
BRPI0609785B8 (pt) 2021-05-25
CY2018028I1 (el) 2019-07-10
US20180214444A1 (en) 2018-08-02
US7888362B2 (en) 2011-02-15
US20160051548A1 (en) 2016-02-25
HUE011611T6 (en) 2017-04-28
PL1869025T3 (pl) 2011-06-30
EP1869025B1 (fr) 2011-01-26
BRPI0609785A2 (pt) 2010-04-27
CA2602247C (fr) 2013-04-02
BE2018C037I2 (fr) 2025-12-10
BRPI0609785B1 (pt) 2020-10-20
LTPA2018509I1 (lt) 2018-09-10
LTC1869025I2 (lt) 2019-05-10
CY2018028I2 (el) 2019-07-10
ATE496911T3 (de) 2011-02-15
NL300946I2 (nl) 2018-09-26
US20170231983A1 (en) 2017-08-17

Similar Documents

Publication Publication Date Title
FR18C0004I2 (fr) Benzothiophenes a substituant piperazine pour le traitement de troubles mentaux
MA28791B1 (fr) Derives de piperazine convenant pour le traitement de troubles gastro-intestinaux
FR13C0029I2 (fr) Compositions pour le traitement de troubles gastro-intestinaux
EP1601251A4 (fr) Compos s pour le traitement de troubles m taboliques
MA28481B1 (fr) Dérivés d&#39;imidazole pour le traitement de troubles neurodégénératifs
EP1993589A4 (fr) Traitements pour troubles neurologiques
EP2063889A4 (fr) Inhibiteurs de la spiropipéridine bêta-sécrétase pour le traitement de la maladie d&#39;alzheimer
MA28555B1 (fr) Derives de morpholine substitues pour le traitement de troubles du systeme nerveux central
MA28871B1 (fr) Derives tricycliques accoles pour le traitement de troubles psychotiques
EP2470553A4 (fr) Acides biliaires polyhydroxylés pour le traitement des troubles biliaires
ZA200903772B (en) Treatment of pervasive developmental disorders
EP2120930A4 (fr) Utilisation d&#39;histidinate de chrome pour le traitement de troubles cardiometaboliques
EP2307011A4 (fr) Utilisation d&#39;isoindoles pour le traitement de troubles neurocomportementaux
ZA200806455B (en) Use of 2-imidazoles for the treatment of CNS disorders
EP2311472A4 (fr) Agent pour l&#39; amélioration des troubles cognitifs
EP2077838A4 (fr) Procedes pour le traitement de troubles en rapport avec a , et compositions pour ceux-ci
EP1940428A4 (fr) Préparations biliaires pour troubles gastro-intestinaux
IL192877A0 (en) Use of 2-imidazoles for the treatment of cns disorders
MA28493B1 (fr) Sulfonamides destinés au traitement de troubles neurodégénératifs
EP2474544A4 (fr) Agent thérapeutique pour des troubles de l&#39;anxiété
EP1896042A4 (fr) Procedes et reactifs pour le traitement de troubles inflammatoires
EP2219447A4 (fr) Dérivés de s-alkylisothiouronium utilisés dans le traitement des troubles liés à l&#39;hypercontractilité utérine
EP1732549A4 (fr) Procedes pour le traitement de synucleinopathies
ZA200902453B (en) PAI-1 binding modulators for the treatment of ocular disorders
EP2026659A4 (fr) Composés destinés au traitement de troubles métaboliques