CR5278A - Formulacion oral de 2-metil-tieno-benzodiacepina - Google Patents

Formulacion oral de 2-metil-tieno-benzodiacepina

Info

Publication number
CR5278A
CR5278A CR5278A CR5278A CR5278A CR 5278 A CR5278 A CR 5278A CR 5278 A CR5278 A CR 5278A CR 5278 A CR5278 A CR 5278A CR 5278 A CR5278 A CR 5278A
Authority
CR
Costa Rica
Prior art keywords
oral formulation
benzodiacepine
theno
methyl
solid oral
Prior art date
Application number
CR5278A
Other languages
English (en)
Inventor
Randall Cochran George
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23624847&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR5278(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CR5278A publication Critical patent/CR5278A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Una formulacion oral solida que comprende olanzapina como ingrediente activo,mezclada intimamente con un agente de cargaaglutinante,disgregante,un aglutinante seco para proporcionar friabilidad adecuada,y un lubricante,en la que dicha formulacion oral solida esta recubierta con un polimero seleccionado dentro del grupo formado por hidroxipropil hipromelosa, hidroxietil celulosa,hidroxidopropil celulosa entre otros.
CR5278A 1995-03-24 1996-03-12 Formulacion oral de 2-metil-tieno-benzodiacepina CR5278A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41046595A 1995-03-24 1995-03-24

Publications (1)

Publication Number Publication Date
CR5278A true CR5278A (es) 1996-07-04

Family

ID=23624847

Family Applications (1)

Application Number Title Priority Date Filing Date
CR5278A CR5278A (es) 1995-03-24 1996-03-12 Formulacion oral de 2-metil-tieno-benzodiacepina

Country Status (46)

Country Link
US (4) US5919485A (es)
EP (2) EP1093815B1 (es)
JP (1) JPH11502848A (es)
KR (1) KR100408172B1 (es)
CN (1) CN1178662C (es)
AP (1) AP679A (es)
AR (2) AR002720A1 (es)
AT (3) ATE284695T1 (es)
AU (1) AU696601B2 (es)
BG (1) BG62594B1 (es)
BR (1) BR9607791A (es)
CA (1) CA2216372C (es)
CH (1) CH691217A5 (es)
CO (1) CO4700474A1 (es)
CR (1) CR5278A (es)
CZ (1) CZ296007B6 (es)
DE (3) DE69634053T2 (es)
DK (3) DK0733367T3 (es)
EA (1) EA000938B1 (es)
EE (1) EE03551B1 (es)
EG (1) EG24077A (es)
ES (2) ES2164837T3 (es)
FI (1) FI973749A7 (es)
GB (1) GB2313783B (es)
HU (1) HU225269B1 (es)
IL (1) IL117611A (es)
IS (1) IS1903B (es)
LT (1) LT4350B (es)
LU (1) LU90115B1 (es)
LV (1) LV11983B (es)
MY (1) MY113440A (es)
NO (1) NO320388B1 (es)
NZ (1) NZ306111A (es)
OA (1) OA10511A (es)
PE (1) PE44997A1 (es)
PL (1) PL188316B1 (es)
PT (2) PT1093815E (es)
RO (1) RO118370B1 (es)
SE (1) SE9703206L (es)
SI (3) SI0733367T1 (es)
SK (1) SK283745B6 (es)
TR (1) TR199701018T1 (es)
TW (1) TW426526B (es)
UA (1) UA44766C2 (es)
WO (1) WO1996029995A1 (es)
ZA (1) ZA962338B (es)

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CR5278A (es) * 1995-03-24 1996-07-04 Lilly Co Eli Formulacion oral de 2-metil-tieno-benzodiacepina
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US20020035071A1 (en) * 1997-07-08 2002-03-21 Josef Pitha Mimicking the metabolic effects of caloric restriction by administration of glucose antimetabolites
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US6617321B2 (en) 1997-09-30 2003-09-09 Eli Lilly And Company 2-methyl-thieno-benzodiazepine formulation
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US6348458B1 (en) 1999-12-28 2002-02-19 U & I Pharmaceuticals Ltd. Polymorphic forms of olanzapine
US7022698B2 (en) 1999-12-28 2006-04-04 U & I Pharmaceuticals, Ltd. Pharmaceutical compositions containing new polymorphic forms of olanzapine and uses thereof
US6740753B2 (en) 2001-01-04 2004-05-25 Geneva Pharmaceuticals, Inc. Olanzapine crystal modification
US20030070584A1 (en) 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing cellulose ethers
US20030072731A1 (en) * 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing starch or dextrin
US20030072729A1 (en) * 2001-05-15 2003-04-17 Christopher Szymczak Simethicone as weight gain enhancer
US8309118B2 (en) 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
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AU2002255196A1 (en) * 2002-04-18 2003-10-27 Dr. Reddy's Laboratories Ltd. Rapidly dispersing solid oral compositions
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SI21270A (sl) * 2002-07-15 2004-02-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Kristalne oblike olanzapina in postopki za njihovo pripravo
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US7029112B2 (en) 2002-08-05 2006-04-18 Mars, Incorporated Ink-jet printing on surface modified edibles and products made
US8168170B2 (en) * 2002-10-03 2012-05-01 The Procter And Gamble Company Compositions having an inner core and at least three surrounding layers
PL202856B1 (pl) * 2002-12-20 2009-07-31 Adamed Spo & Lstrok Ka Z Ogran Sposób otrzymywania farmaceutycznie czystej polimorficznej postaci I olanzapiny
WO2005009407A2 (en) * 2003-07-29 2005-02-03 Ranbaxy Laboratories Limited Oral pharmaceutical formulations of olanzapine
CA2540040C (en) * 2003-10-07 2012-09-11 Andrx Pharmaceuticals Llc Rapidly disintegrating formulation
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US20050152884A1 (en) * 2003-12-19 2005-07-14 The Procter & Gamble Company Canine probiotic Bifidobacteria globosum
US8894991B2 (en) * 2003-12-19 2014-11-25 The Iams Company Canine probiotic Lactobacilli
US7785635B1 (en) 2003-12-19 2010-08-31 The Procter & Gamble Company Methods of use of probiotic lactobacilli for companion animals
US20050158294A1 (en) * 2003-12-19 2005-07-21 The Procter & Gamble Company Canine probiotic Bifidobacteria pseudolongum
US8877178B2 (en) 2003-12-19 2014-11-04 The Iams Company Methods of use of probiotic bifidobacteria for companion animals
ES2253091B1 (es) * 2004-07-27 2007-02-01 Inke, S.A. Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
PL1838716T3 (pl) 2005-01-05 2011-09-30 Lilly Co Eli Dihydrat embonianu olanzapiny
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
WO2006115770A2 (en) * 2005-04-22 2006-11-02 Teva Pharmaceuticals Usa, Inc. Orally disintegrating pharmaceutical tablet formulations of olanzapine
ES2607988T3 (es) * 2005-05-31 2017-04-05 Iams Europe B.V. Bifidobacterias probióticas felinas
ATE512211T1 (de) * 2005-05-31 2011-06-15 Iams Company Feline probiotische lactobacilli
US20070014847A1 (en) * 2005-07-05 2007-01-18 Ahmed Salah U Coated capsules and methods of making and using the same
JP2009502807A (ja) * 2005-07-22 2009-01-29 ミリアド ジェネティクス， インコーポレイテッド 薬剤含有率の高い製剤および投与量形態
WO2007049304A2 (en) * 2005-10-27 2007-05-03 Jubilant Organosys Limited Stable coated pharmaceutical formulation of olanzapine and process for preparing the same
GB0522473D0 (en) * 2005-11-03 2005-12-14 Actavis Group A pharmaceutical formulation
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US7834176B2 (en) 2006-01-26 2010-11-16 Sandoz Ag Polymorph E of Olanzapine and preparation of anhydrous non-solvated crystalline polymorphic Form I of 2-methyl-4(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Olanzapine Form I) from the polymorphic Olanzapine Form E
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ATE465720T1 (de) * 2006-07-05 2010-05-15 Bilim Ilac Sanayii Ve Ticaret Stabile olanzapin-formulierung mit antioxidantien
US20080138409A1 (en) * 2006-09-29 2008-06-12 Osinga Niels J Olanzapine pharmaceutical composition
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JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
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CN103919782B (zh) * 2013-01-15 2016-12-28 天津药物研究院有限公司 一种含有奥氮平的药物组合物及其制备方法
JP2016531151A (ja) * 2013-09-13 2016-10-06 バイエル ファーマ アクチエンゲゼルシャフト レファメチニブを含有する医薬組成物
CN107007559B (zh) * 2017-04-21 2020-05-15 浙江京新药业股份有限公司 一种稳定的口服药物组合物及其制备方法
ES2982668T3 (es) * 2017-06-02 2024-10-17 Xeris Pharmaceuticals Inc Formulaciones de fármacos de moléculas pequeñas resistentes a la precipitación
CN113143878A (zh) * 2021-03-19 2021-07-23 杭州新诺华医药有限公司 奥氮平组合物及其制备方法

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Also Published As

Publication number Publication date
PT1093815E (pt) 2005-03-31
SI0733367T1 (en) 2002-06-30
FI973749A0 (fi) 1997-09-22
EP1093815B1 (en) 2004-12-15
WO1996029995A1 (en) 1996-10-03
IL117611A (en) 2002-05-23
LT97149A (lt) 1998-01-26
RO118370B1 (ro) 2003-05-30
PT733367E (pt) 2002-03-28
DE69615887T2 (de) 2002-04-11
AR002720A1 (es) 1998-04-29
EP0733367A1 (en) 1996-09-25
CZ296007B6 (cs) 2005-12-14
HUP9800410A2 (hu) 1998-07-28
US7229643B2 (en) 2007-06-12
BR9607791A (pt) 1998-07-07
TR199701018T1 (xx) 1998-01-21
NZ306111A (en) 1999-02-25
MY113440A (en) 2002-02-28
AP9701064A0 (en) 1997-10-31
ATA902296A (de) 1999-02-15
SI9620041A (sl) 1998-06-30
EP0733367B1 (en) 2001-10-17
DK109097A (da) 1997-11-12
FI973749L (fi) 1997-09-22
US20010018071A1 (en) 2001-08-30
DK1093815T3 (da) 2005-04-25
DE69634053D1 (de) 2005-01-20
LU90115B1 (fr) 1997-09-10
US6190698B1 (en) 2001-02-20
ZA962338B (en) 1997-09-22
NO320388B1 (no) 2005-11-28
DK0733367T3 (da) 2001-11-26
KR100408172B1 (ko) 2004-02-18
SK283745B6 (sk) 2003-12-02
DE69634053T2 (de) 2005-12-22
UA44766C2 (uk) 2002-03-15
IL117611A0 (en) 1996-07-23
ES2164837T3 (es) 2002-03-01
ATE284695T1 (de) 2005-01-15
PL322579A1 (en) 1998-02-02
SK128297A3 (en) 1998-03-04
MX9707186A (es) 1997-11-29
DE19681287T1 (de) 1998-03-19
SE9703206D0 (sv) 1997-09-05
KR19980703189A (ko) 1998-10-15
BG101901A (bg) 1998-10-30
DK173323B1 (da) 2000-07-24
PL188316B1 (pl) 2005-01-31
NO974363L (no) 1997-11-17
ES2232379T3 (es) 2005-06-01
LV11983A (lv) 1998-03-20
ATE206924T1 (de) 2001-11-15
GB2313783A (en) 1997-12-10
HU225269B1 (en) 2006-08-28
HUP9800410A3 (en) 2000-01-28
PE44997A1 (es) 1997-10-23
JPH11502848A (ja) 1999-03-09
CH691217A5 (de) 2001-05-31
EE03551B1 (et) 2001-12-17
US5919485A (en) 1999-07-06
CN1179102A (zh) 1998-04-15
FI973749A7 (fi) 1997-09-22
BG62594B1 (bg) 2000-03-31
EE9700328A (et) 1998-06-15
AU5428096A (en) 1996-10-16
NO974363D0 (no) 1997-09-22
AR001405A1 (es) 1997-10-22
AT405606B (de) 1999-10-25
AP679A (en) 1998-09-28
CA2216372C (en) 2007-11-20
AU696601B2 (en) 1998-09-17
CZ300197A3 (en) 1997-12-17
LT4350B (lt) 1998-05-25
IS4565A (is) 1997-09-22
IS1903B (is) 2003-11-20
EG24077A (en) 2008-05-11
US20050085462A1 (en) 2005-04-21
CA2216372A1 (en) 1996-10-03
TW426526B (en) 2001-03-21
SI1093815T1 (en) 2005-06-30
GB2313783B (en) 1998-11-18
SE9703206L (sv) 1997-09-05
CO4700474A1 (es) 1998-12-29
EA000938B1 (ru) 2000-06-26
GB9719817D0 (en) 1997-11-19
EP1093815A1 (en) 2001-04-25
OA10511A (en) 2002-04-24
CN1178662C (zh) 2004-12-08
US6780433B2 (en) 2004-08-24
DE69615887D1 (de) 2001-11-22
EA199700260A1 (ru) 1998-02-26
LV11983B (en) 1998-07-20

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