FR2404005A1 - Analogues de la prostaglandine i2 et compositions pharmaceutiques les contenant - Google Patents

Analogues de la prostaglandine i2 et compositions pharmaceutiques les contenant

Info

Publication number
FR2404005A1
FR2404005A1 FR7826948A FR7826948A FR2404005A1 FR 2404005 A1 FR2404005 A1 FR 2404005A1 FR 7826948 A FR7826948 A FR 7826948A FR 7826948 A FR7826948 A FR 7826948A FR 2404005 A1 FR2404005 A1 FR 2404005A1
Authority
FR
France
Prior art keywords
prostaglandin
analogues
pharmaceutical compositions
compositions containing
alkyloxycarbonylalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7826948A
Other languages
English (en)
Other versions
FR2404005B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ono Pharmaceutical Co Ltd
Original Assignee
Ono Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd
Publication of FR2404005A1 publication Critical patent/FR2404005A1/fr
Application granted granted Critical
Publication of FR2404005B1 publication Critical patent/FR2404005B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)

Abstract

L'invention concerne de nouveaux analogues de la prostaglandine I2 . Ces composés ont la formule ci-dessous, dans laquelle Y = éthylène ou vinylène trans, R** 1 = groupe alcoyloxycarbonylalcoyle, hydroxyalcoyle, alcoxyalcoyle ou aminoalcoyle, R**2 = H, méthyle ou éthyle, R**3 = liaison simple ou alcoylène, R**4 = H, alcoyle, cycloalcoyle, ou phényle ou phénoxy substitués ou non. Applications pharmacologiques dans les domaines habituels pour les prostaglandines.
FR7826948A 1977-09-22 1978-09-20 Analogues de la prostaglandine i2 et compositions pharmaceutiques les contenant Granted FR2404005A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP11329177A JPS5446773A (en) 1977-09-22 1977-09-22 Prostaglandin i2 analog and its preparation

Publications (2)

Publication Number Publication Date
FR2404005A1 true FR2404005A1 (fr) 1979-04-20
FR2404005B1 FR2404005B1 (fr) 1981-12-18

Family

ID=14608453

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7826948A Granted FR2404005A1 (fr) 1977-09-22 1978-09-20 Analogues de la prostaglandine i2 et compositions pharmaceutiques les contenant

Country Status (6)

Country Link
US (1) US4207332A (fr)
JP (1) JPS5446773A (fr)
DE (1) DE2839850A1 (fr)
FR (1) FR2404005A1 (fr)
GB (1) GB2006754B (fr)
IT (1) IT1099122B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2401139A2 (fr) * 1977-03-07 1979-03-23 Upjohn Co Nouveaux derives d5 de prostaglandines, leur procede de preparation et medicaments les contenant

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4178367A (en) * 1977-02-21 1979-12-11 Ono Pharmaceutical Co. Ltd. Prostaglandin I2 analogues
JPS5585578A (en) * 1978-12-22 1980-06-27 Toray Ind Inc Prostaglandin i2 derivative
JPS6013779A (ja) * 1983-07-05 1985-01-24 Green Cross Corp:The プロスタグランジンｉ↓２誘導体
JPH07126161A (ja) * 1993-10-29 1995-05-16 Toray Ind Inc 心不全治療剤
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
US20090238763A1 (en) * 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
CA2665081C (fr) * 2006-10-02 2015-12-01 Techfields Biochem Co. Ltd Promedicaments hydrosolubles de prostaglandines et composes analogues, positivement charges, a taux de penetration cutanee tres eleve
JP2010529101A (ja) * 2007-06-04 2010-08-26 テックフィールズ インコーポレイテッド 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用
CN108191846B (zh) 2008-12-04 2021-08-20 于崇曦 高穿透性组合物及其应用
JP5925158B2 (ja) * 2013-06-04 2016-05-25 テックフィールズ バイオケム カンパニー リミテッド 非常に高い皮膚浸透率を有するプロスタグランジン及び関連化合物の正荷電水溶性プロドラッグ
JP6030168B2 (ja) * 2015-03-09 2016-11-24 テックフィールズ バイオケム カンパニー リミテッド 非常に高い皮膚浸透率を有するプロスタグランジン及び関連化合物の正荷電水溶性プロドラッグ

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/76 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2401139A2 (fr) * 1977-03-07 1979-03-23 Upjohn Co Nouveaux derives d5 de prostaglandines, leur procede de preparation et medicaments les contenant
FR2401141A1 (fr) * 1977-03-07 1979-03-23 Upjohn Co Nouveaux derives halogenes de prostaglandines et medicaments les contenant

Also Published As

Publication number Publication date
FR2404005B1 (fr) 1981-12-18
US4207332A (en) 1980-06-10
IT7827956A0 (it) 1978-09-21
GB2006754A (en) 1979-05-10
JPS5446773A (en) 1979-04-12
GB2006754B (en) 1982-03-17
DE2839850A1 (de) 1979-04-05
IT1099122B (it) 1985-09-18

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Legal Events

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