FR2404006A1 - Complexes d'inclusion de prostacycline et de derives de prostacycline avec des cyclodextrines, leur preparation et leur application comme medicaments - Google Patents

Complexes d'inclusion de prostacycline et de derives de prostacycline avec des cyclodextrines, leur preparation et leur application comme medicaments

Info

Publication number
FR2404006A1
FR2404006A1 FR7827079A FR7827079A FR2404006A1 FR 2404006 A1 FR2404006 A1 FR 2404006A1 FR 7827079 A FR7827079 A FR 7827079A FR 7827079 A FR7827079 A FR 7827079A FR 2404006 A1 FR2404006 A1 FR 2404006A1
Authority
FR
France
Prior art keywords
prostacyclin
cyclodextrins
application
preparation
prostacycline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7827079A
Other languages
English (en)
Other versions
FR2404006B1 (fr
Inventor
Jozsef Szejtly
Magdolna Szejtly
Gyorgy Cseh
Istvan Stadler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinoin Private Co Ltd
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Publication of FR2404006A1 publication Critical patent/FR2404006A1/fr
Application granted granted Critical
Publication of FR2404006B1 publication Critical patent/FR2404006B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Complexes d'inclusion de prostacycline et de dérivés de prostacycline avec des cyclodextrines, leur préparation et leur application comme médicaments. On obtient les complexes d'inclusion selon l'invention en ajoutant dans une solution aqueuse d' alpha -, beta - ou gamma -cyclodextrines ou un mélange éventuel de ces corps, contenant éventuellement en outre des sels organiques ou inorganiques, une solution organique de prostacycline ou d'un dérivé de ce corps, en éliminant le solvant organique du mélange obtenu et en isolant le complexe prostacycline ou dérivé de prostacycline - cyclodextrine du reste de la solution aqueuse. Application comme anti-agrégant plaquettaire.
FR7827079A 1977-09-23 1978-09-21 Complexes d'inclusion de prostacycline et de derives de prostacycline avec des cyclodextrines, leur preparation et leur application comme medicaments Granted FR2404006A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU77CI1770A HU179141B (fr) 1977-09-23 1977-09-23

Publications (2)

Publication Number Publication Date
FR2404006A1 true FR2404006A1 (fr) 1979-04-20
FR2404006B1 FR2404006B1 (fr) 1981-07-31

Family

ID=10994670

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7827079A Granted FR2404006A1 (fr) 1977-09-23 1978-09-21 Complexes d'inclusion de prostacycline et de derives de prostacycline avec des cyclodextrines, leur preparation et leur application comme medicaments

Country Status (20)

Country Link
JP (1) JPS5456685A (fr)
AT (1) AT369362B (fr)
BE (1) BE870646A (fr)
CH (1) CH637388A5 (fr)
CS (1) CS200242B2 (fr)
DD (1) DD138600A5 (fr)
DE (1) DE2840142A1 (fr)
DK (1) DK420778A (fr)
FI (1) FI65912C (fr)
FR (1) FR2404006A1 (fr)
GB (1) GB2006193B (fr)
GR (1) GR65001B (fr)
HU (1) HU179141B (fr)
IL (1) IL55569A (fr)
IT (1) IT1160661B (fr)
NL (1) NL7809643A (fr)
PL (1) PL121664B1 (fr)
SE (1) SE447574B (fr)
SU (1) SU847914A3 (fr)
YU (1) YU220678A (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2398498A1 (fr) * 1977-05-06 1979-02-23 Ono Pharmaceutical Co Compositions stabilisees a usage pharmacologique contenant un analogue de la prostaglandine i2
EP0018773A1 (fr) * 1979-04-26 1980-11-12 Sumitomo Chemical Company, Limited Composition pharmaceutique contenant du fumarate de bencyclane, un procédé pour sa préparation et un composé d'inclusion contenant le fumarate de bencyclane

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5920230A (ja) * 1982-07-19 1984-02-01 チバ−ガイギ−・アクチエンゲゼルシヤフト ピルプロフエン含有薬剤
JPS61289034A (ja) * 1985-06-17 1986-12-19 Teijin Ltd イソカルバサイクリン類脂肪乳剤
DE3608088C2 (de) * 1986-03-07 1995-11-16 Schering Ag Pharmazeutische Präparate, enthaltend Cyclodextrinclathrate von Carbacyclinderivaten
DE3740838A1 (de) * 1987-11-27 1989-06-08 Schering Ag Cyclodextrinclathrate von 5-cyano-prostacyclinderivaten und ihre verwendung als arzneimittel
US7655442B2 (en) 2004-01-29 2010-02-02 Eisai R&D Management Co., Ltd. Method for stabilizing macrolide compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2128674A1 (de) * 1970-06-10 1971-12-16 Ono Pharmaceutical Co. Ltd., Osaka (Japan) Clathratverbindungen
FR2378777A1 (fr) * 1977-01-31 1978-08-25 Ono Pharmaceutical Co Nouveaux analogues de prostaglandines
FR2381043A1 (fr) * 1977-02-21 1978-09-15 Ono Pharmaceutical Co Nouveaux analogues de prostaglandines, leur preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3953435A (en) * 1974-01-10 1976-04-27 Ono Pharmaceutical Company Aldehyde derivatives of prostaglandins
JPS53136513A (en) * 1977-05-06 1978-11-29 Ono Pharmaceut Co Ltd Stabilization of prostaglandin-x-related compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2128674A1 (de) * 1970-06-10 1971-12-16 Ono Pharmaceutical Co. Ltd., Osaka (Japan) Clathratverbindungen
FR2378777A1 (fr) * 1977-01-31 1978-08-25 Ono Pharmaceutical Co Nouveaux analogues de prostaglandines
FR2381043A1 (fr) * 1977-02-21 1978-09-15 Ono Pharmaceutical Co Nouveaux analogues de prostaglandines, leur preparation et les compositions pharmaceutiques qui les contiennent

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2398498A1 (fr) * 1977-05-06 1979-02-23 Ono Pharmaceutical Co Compositions stabilisees a usage pharmacologique contenant un analogue de la prostaglandine i2
EP0018773A1 (fr) * 1979-04-26 1980-11-12 Sumitomo Chemical Company, Limited Composition pharmaceutique contenant du fumarate de bencyclane, un procédé pour sa préparation et un composé d'inclusion contenant le fumarate de bencyclane

Also Published As

Publication number Publication date
FI65912C (fi) 1984-08-10
SE7809946L (sv) 1979-03-24
DK420778A (da) 1979-03-24
SU847914A3 (ru) 1981-07-15
IT7869160A0 (it) 1978-09-19
HU179141B (fr) 1982-08-28
FI65912B (fi) 1984-04-30
CH637388A5 (de) 1983-07-29
YU220678A (en) 1983-10-31
CS200242B2 (en) 1980-08-29
ATA677478A (de) 1982-05-15
GR65001B (en) 1980-06-12
DE2840142A1 (de) 1979-04-05
FR2404006B1 (fr) 1981-07-31
GB2006193A (en) 1979-05-02
DD138600A5 (de) 1979-11-14
IT1160661B (it) 1987-03-11
IL55569A (en) 1981-12-31
NL7809643A (nl) 1979-03-27
PL121664B1 (en) 1982-05-31
PL209773A1 (pl) 1979-06-04
BE870646A (fr) 1979-01-15
JPS5456685A (en) 1979-05-07
SE447574B (sv) 1986-11-24
IL55569A0 (en) 1978-12-17
AT369362B (de) 1982-12-27
GB2006193B (en) 1982-05-26
FI782878A7 (fi) 1979-03-24

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ST Notification of lapse