FR2585703B1 - 7-oxabicycloheptane amides-thioamides, analogues de prostaglandines, a action cardio-vasculaire - Google Patents

7-oxabicycloheptane amides-thioamides, analogues de prostaglandines, a action cardio-vasculaire

Info

Publication number
FR2585703B1
FR2585703B1 FR8611126A FR8611126A FR2585703B1 FR 2585703 B1 FR2585703 B1 FR 2585703B1 FR 8611126 A FR8611126 A FR 8611126A FR 8611126 A FR8611126 A FR 8611126A FR 2585703 B1 FR2585703 B1 FR 2585703B1
Authority
FR
France
Prior art keywords
oxabicycloheptane
thioamides
amides
prostaglandin analogs
cardiovascular action
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8611126A
Other languages
English (en)
Other versions
FR2585703A1 (fr
Inventor
Masami Nakane
Joyce A Reid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2585703A1 publication Critical patent/FR2585703A1/fr
Application granted granted Critical
Publication of FR2585703B1 publication Critical patent/FR2585703B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
FR8611126A 1985-08-01 1986-07-31 7-oxabicycloheptane amides-thioamides, analogues de prostaglandines, a action cardio-vasculaire Expired FR2585703B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/761,261 US4654355A (en) 1985-08-01 1985-08-01 7-oxabicycloheptane substituted amide-thioamide prostaglandin analogs

Publications (2)

Publication Number Publication Date
FR2585703A1 FR2585703A1 (fr) 1987-02-06
FR2585703B1 true FR2585703B1 (fr) 1988-08-19

Family

ID=25061678

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8611126A Expired FR2585703B1 (fr) 1985-08-01 1986-07-31 7-oxabicycloheptane amides-thioamides, analogues de prostaglandines, a action cardio-vasculaire

Country Status (7)

Country Link
US (1) US4654355A (fr)
JP (1) JPS6233181A (fr)
CA (1) CA1285569C (fr)
DE (1) DE3625870A1 (fr)
FR (1) FR2585703B1 (fr)
GB (1) GB2178430B (fr)
IT (1) IT1197033B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH038636A (ja) * 1989-06-07 1991-01-16 Delphi Co Ltd 分離送り装置
US5290799A (en) * 1990-09-19 1994-03-01 E. R. Squibb & Sons, Inc. 7-oxabicycloheptyl substituted heterocyclic thioamide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
JP4202250B2 (ja) 2001-07-25 2008-12-24 バイオマリン ファーマシューティカル インコーポレイテッド 血液脳関門輸送を調節するための組成物および方法
EP2671507A3 (fr) 2005-04-28 2014-02-19 Proteus Digital Health, Inc. Système pharma-informatique
US20090018142A9 (en) * 2006-05-02 2009-01-15 Zhengping Zhuang Use of phosphatases to treat tumors overexpressing N-CoR
MX2009002893A (es) 2006-09-18 2009-07-10 Raptor Pharmaceutical Inc Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap).
BRPI0806365B8 (pt) 2007-02-06 2021-05-25 Lixte Biotechnology Holdings Inc composto, uso do composto, composição farmacêutica e uso da composição farmacêutica
US20090035292A1 (en) * 2007-08-03 2009-02-05 Kovach John S Use of phosphatases to treat neuroblastomas and medulloblastomas
JP5730575B2 (ja) * 2007-10-01 2015-06-10 リクスト・バイオテクノロジー，インコーポレイテッド Ｈｄａｃ阻害剤
WO2010014141A1 (fr) * 2008-08-01 2010-02-04 Lixte Biotechnology, Inc. Procédés de régulation de la mitose cellulaire par inhibition de la phosphatase de sérine/thréonine
US8227473B2 (en) * 2008-08-01 2012-07-24 Lixte Biotechnology, Inc. Oxabicycloheptanes and oxabicycloheptenes, their preparation and use
WO2010147612A1 (fr) 2009-06-18 2010-12-23 Lixte Biotechnology, Inc. Procédés de modulation de la régulation cellulaire par inhibition de p53
WO2010014220A1 (fr) * 2008-08-01 2010-02-04 Lixte Biotechnology, Inc. Agents neuroprotecteurs pour la prévention et le traitement de maladies neurodégénératives
CA2752373C (fr) 2009-02-20 2017-10-10 To-Bbb Holding B.V. Systeme d'administration de medicament a base de glutathionne
IL255113B (en) 2009-05-06 2022-09-01 Laboratory Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
KR20160004299A (ko) 2013-04-09 2016-01-12 릭스트 바이오테크놀로지, 인코포레이티드 옥사바이시클로헵탄류 및 옥사바이시클로헵텐류의 제형
EP4324477A3 (fr) 2016-12-08 2024-05-22 Lixte Biotechnology, Inc. Oxabicycloheptanes pour la modulation de la réponse immunitaire

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4220594A (en) * 1977-11-04 1980-09-02 E. R. Squibb & Sons, Inc. Hexa- and octahydro-4,7-epoxyisobenzofuran-1-ol and hexa- and octahydro-5,8-epoxy-1H-2-benzopyran-3-ol
US4254044A (en) * 1977-11-04 1981-03-03 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane- and 7-oxabicycloheptene compounds
US4187236A (en) * 1977-11-04 1980-02-05 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane compounds
US4143054A (en) * 1977-11-04 1979-03-06 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane- and 7-oxabicycloheptene compounds
US4368332A (en) * 1979-01-05 1983-01-11 National Research Development Corporation Prostaglandins
US4228180A (en) * 1979-11-01 1980-10-14 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane and 7-oxabicycloheptene prostaglandin analogs
ZA829068B (en) * 1980-07-01 1983-02-23 Nat Res Dev Prostaglandins
US4416896A (en) * 1982-05-17 1983-11-22 E. R. Squibb & Sons, Inc. 7-Oxabicyclopheptane substituted amino prostaglandin analogs useful in the treatment of thrombolytic disease
US4456615A (en) * 1982-10-25 1984-06-26 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
US4456617A (en) * 1983-01-12 1984-06-26 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
US4525479A (en) * 1983-08-29 1985-06-25 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted thiocarbamate prostaglandin analogs useful as cardiovascular agents
US4526901A (en) * 1984-01-26 1985-07-02 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted oxamide prostaglandin analogs and their use in treating thrombolytic disease

Also Published As

Publication number Publication date
GB2178430B (en) 1989-04-26
GB8618698D0 (en) 1986-09-10
IT8621342A1 (it) 1988-01-31
CA1285569C (fr) 1991-07-02
FR2585703A1 (fr) 1987-02-06
DE3625870A1 (de) 1987-02-05
JPS6233181A (ja) 1987-02-13
IT8621342A0 (it) 1986-07-31
IT1197033B (it) 1988-11-25
US4654355A (en) 1987-03-31
GB2178430A (en) 1987-02-11

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Legal Events

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