FR3050461A1 - - Google Patents

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Publication number: FR3050461A1
Authority: FR; France
Prior art keywords: culture vessel; test; culture; microorganism; sample
Prior art date: 2016-04-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

FR1753439A

Other languages

English (en)

French (fr)

Inventor

Jonas Jarvius

Anders Lind

Henrik Soderstrom

Jan Grawe

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Q Linea AB

Original Assignee

Q Linea AB

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-04-21

Filing date

2017-04-20

Publication date

2017-10-27

2016-04-21 Priority claimed from PCT/EP2016/058952 external-priority patent/WO2016170086A1/en

2017-04-20 Application filed by Q Linea AB filed Critical Q Linea AB

2017-10-27 Publication of FR3050461A1 publication Critical patent/FR3050461A1/fr

Status Ceased legal-status Critical Current

Links

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Classifications

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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
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- A01N1/142—Apparatus
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
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- A01N1/146—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving
- A01N1/148—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving with provisions specially adapted for transporting
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- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]

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Chemical & Material Sciences (AREA)
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Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Analytical Chemistry (AREA)
General Health & Medical Sciences (AREA)
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Physics & Mathematics (AREA)
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Biophysics (AREA)
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Chemical Kinetics & Catalysis (AREA)
Dentistry (AREA)
Environmental Sciences (AREA)
Thermal Sciences (AREA)
Mechanical Engineering (AREA)
Biomedical Technology (AREA)
Sustainable Development (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)

FR1753439A 2016-04-21 2017-04-20 Ceased FR3050461A1 (2)

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PCT/EP2016/058952 WO2016170086A1 (en)	2015-04-24	2016-04-21	Medical sample transportation container
GB201606991		2016-04-21
GB1617353.6A GB2554767A (en)	2016-04-21	2016-10-13	Detecting and characterising a microorganism

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US (2)	US11845978B2 (2)
EP (1)	EP3294057B1 (2)
FR (1)	FR3050461A1 (2)
GB (1)	GB2554767A (2)
WO (1)	WO2017182645A1 (2)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20210172000A1 (en) *	2017-04-19	2021-06-10	CAP Diagnostics, LLC, dba Pathnostics	Methods and systems for preparing therapeutic solutions for polymicrobial infections
US11053532B2 (en)	2017-04-19	2021-07-06	CAP Diagnostics, LLC	Methods for treating polymicrobial infections
EP3717657A1 (en) *	2017-11-30	2020-10-07	Ascilion AB	A system for assessing microbial susceptibility to antibiotic agents
EP3731959B1 (en)	2017-12-29	2025-10-08	Clear Labs, Inc.	Automated priming and library loading device
US20230089107A1 (en) *	2020-02-25	2023-03-23	Institute For Environmental Health, Inc.	Incubator for enrichment during transport
CA3175879A1 (en) *	2021-02-17	2022-08-25	CAP Diagnostics, LLC, dba Pathnostics	Methods and systems for determining suitability of compositions for inhibiting growth of polymicrobial samples
WO2024059305A1 (en) *	2022-09-15	2024-03-21	General Electric Company	Method and apparatus for using lyophilized reagent beads for antimicrobial susceptibility testing
CN116218893B (zh) *	2023-03-24	2025-07-29	哈尔滨医科大学	一种通过体外扩增重组质粒在其编码基因上生成短片段串联重复序列的方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1997012029A1 (en) *	1995-09-29	1997-04-03	Idexx Laboratories, Inc.	Self-contained incubator for growth of microorganism
US20050037408A1 (en) *	2003-07-24	2005-02-17	Christensen Jeffrey E.	Rapid identification of bacteria from positive blood cultures
US20100124763A1 (en) *	2008-10-31	2010-05-20	Biomerieux, Inc.	Method for detection, characterization and/or identification of microorganisms in a sealed container
US20140278136A1 (en) *	2013-03-15	2014-09-18	Accelerate Diagnostics, Inc.	Rapid determination of microbial growth and antimicrobial susceptibility
WO2015189390A1 (en) *	2014-06-13	2015-12-17	Q-Linea Ab	Method for detecting and characterising a microorganism
US20160053219A1 (en) *	2014-08-25	2016-02-25	Opgen, Inc.	Systems, methods, and devices for temperature control

Family Cites Families (134)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3159384A (en)	1962-07-02	1964-12-01	Bio Science Labor	Agitator for laboratory tubes and flasks
US3764780A (en)	1971-06-16	1973-10-09	C Ellis	Blood culture apparatus
US3975001A (en)	1973-10-19	1976-08-17	American Hospital Supply Corporation	Apparatus for mixing fluids held in tubes
GB1507026A (en) *	1974-04-11	1978-04-12	Nat Res Dev	Endoprosthetic devices
US4004883A (en)	1975-07-11	1977-01-25	G. D. Searle & Co.	Sensing, leveling and mixing apparatus
DE7922217U1 (de)	1979-08-03	1979-11-22	Binz Gmbh & Co, 7073 Lorch	Warmhaltebehaelter zum transport von infusionen o.dgl.
US4629686A (en)	1982-02-19	1986-12-16	Endotronics, Inc.	Apparatus for delivering a controlled dosage of a chemical substance
ATE202801T1 (de)	1983-01-10	2001-07-15	Gen Probe Inc	Verfahren zum nachweis, identifizieren und quantifizieren von organismen und viren
DE3483914D1 (de)	1983-04-15	1991-02-21	Terumo Corp	Verfahren zur abtrennung von bakterien aus blut.
US4666850A (en)	1983-10-28	1987-05-19	Becton, Dickinson And Company	Microbial pathogen detecting system and process
US4652517A (en)	1984-06-11	1987-03-24	Diagnostic Research Limited Partnership	Methods for the in vitro detection and identification of unknown pathogens or genetic entities
AU1363688A (en)	1987-02-12	1988-09-14	Sdi Diagnostics, Inc.	Test system, test device and method for detecting pathogenic organisms and antibiotic resistance genes in body fluids
US5217876A (en)	1988-03-15	1993-06-08	Akzo N.V.	Method for detecting microorganisms
CA2016699C (en)	1989-05-15	2003-11-18	Paul N. Marshall	Lytic agents and uses thereof
US6406844B1 (en)	1989-06-07	2002-06-18	Affymetrix, Inc.	Very large scale immobilized polymer synthesis
US5143854A (en)	1989-06-07	1992-09-01	Affymax Technologies N.V.	Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6346413B1 (en)	1989-06-07	2002-02-12	Affymetrix, Inc.	Polymer arrays
US5744101A (en)	1989-06-07	1998-04-28	Affymax Technologies N.V.	Photolabile nucleoside protecting groups
US5183994A (en)	1990-10-26	1993-02-02	Bowles Sr Dale D	Heated drug box
US5052812A (en)	1990-11-19	1991-10-01	New Brunswick Scientific Co., Inc.	Bath shaker
US5316146A (en)	1991-03-06	1994-05-31	Ulster Scientific, Inc.	Vial transporter
JP2565844B2 (ja)	1992-02-07	1996-12-18	アボツト・ラボラトリーズ	細胞溶解処理条件下で異種細胞集団を正確に計数し，感受性に関する格付けを行う方法
US5882918A (en)	1995-08-08	1999-03-16	Genespan Corporation	Cell culture incubator
SE9400522D0 (sv)	1994-02-16	1994-02-16	Ulf Landegren	Method and reagent for detecting specific nucleotide sequences
DE69527585T2 (de)	1994-06-08	2003-04-03	Affymetrix, Inc.	Verfahren und Vorrichtung zum Verpacken von Chips
US20020055101A1 (en)	1995-09-11	2002-05-09	Michel G. Bergeron	Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
AU4586096A (en)	1995-03-10	1996-09-19	Becton Dickinson & Company	Sample processing method for whole blood
JPH08285839A (ja)	1995-04-13	1996-11-01	Daiichi Kigyo:Kk	病理検体等運搬用容器
US5577837A (en)	1995-05-19	1996-11-26	Forma Scientific, Inc.	Temperature controlled HEPA-filtered console shaker
US6096532A (en)	1995-06-07	2000-08-01	Aastrom Biosciences, Inc.	Processor apparatus for use in a system for maintaining and growing biological cells
SE506908C2 (sv)	1995-09-08	1998-03-02	Ulf Landegren Inst F Medicinsk	Medicinsk användning av padlockprober
US5994066A (en)	1995-09-11	1999-11-30	Infectio Diagnostic, Inc.	Species-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
US5854033A (en)	1995-11-21	1998-12-29	Yale University	Rolling circle replication reporter systems
DK0862656T3 (da)	1995-11-21	2001-04-09	Univ Yale	Unimolekylær segmentamplifikation og -detektering
DE59604811D1 (de)	1995-12-08	2000-04-27	Martin Raithel	Verfahren und vorrichtung zur in-vitro diagnose allergischer erkrankungen
SE9601676D0 (sv)	1996-04-30	1996-04-30	Ulf Landegren	Improved probing of specific mucleic acids
US5770394A (en)	1996-05-22	1998-06-23	Becton Dickinson And Company	Method and apparatus for detecting bacteria using a blood culture froth
EP0822261B1 (en)	1996-07-29	2002-07-03	Academia Sinica	Methods for rapid antimicrobial susceptibility testing
US5817508A (en)	1996-09-27	1998-10-06	Becton Dickinson And Company	Blood culture apparatus having an auto-unloading and sorting device
CA2276462C (en)	1996-12-31	2007-06-12	High Throughput Genomics, Inc.	Multiplexed molecular analysis system apparatus and method
US6255467B1 (en)	1997-11-06	2001-07-03	Pathobiotek Diagnostics Inc.	Human blood bacterium
US6028293A (en)	1998-04-20	2000-02-22	Tcp Reliable Inc.	Temperature-controlled container with heating means
US6059446A (en)	1998-05-08	2000-05-09	Dschida; William J. A.	Apparatus for mixing the contents of microcentrifuge tubes
JP2002532103A (ja)	1998-12-11	2002-10-02	ビジブルジェネティクスインコーポレイテッド	マイコバクテリウムツバキュロシスにおける抗生物質耐性変異の特徴付けのための方法及びキット
WO2000067037A2 (en)	1999-04-29	2000-11-09	Dade Microscan Inc.	A combined rapid anti-microbial susceptibility assay and microorganism identification system
AU4857700A (en)	1999-05-25	2000-12-12	Millipore Corporation	Method for rapidly detecting and enumerating microorganisms in mammalian cell preparations using atp bioluminescence
DE60029582T3 (de)	1999-05-28	2012-03-08	Cepheid	Patrone zum durchführen einer chemischen reaktion
JP2001103981A (ja)	1999-08-03	2001-04-17	Nisshinbo Ind Inc	結核菌診断キット
US6465448B1 (en)	1999-08-13	2002-10-15	Case Western Reserve University	Methoxyamine potentiation of temozolomide anti-cancer activity
JP2001169778A (ja)	1999-12-17	2001-06-26	Joji Oshima	迅速細菌遺伝子検査法及びキット
CN2436459Y (zh)	2000-08-14	2001-06-27	青岛市家用电器研究所	一种血液运输用储藏箱
WO2004060278A2 (en)	2002-12-06	2004-07-22	Isis Pharmaceuticals, Inc.	Methods for rapid identification of pathogens in humans and animals
US20040121309A1 (en)	2002-12-06	2004-06-24	Ecker David J.	Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues
JP4148778B2 (ja)	2001-03-09	2008-09-10	バイオミクロシステムズインコーポレイティッド	アレイとのミクロ流体的インターフェース機器
US7008788B2 (en)	2001-07-30	2006-03-07	Agilent Technologies, Inc.	Containers for supports comprising biopolymers
US6803208B2 (en)	2001-07-30	2004-10-12	The United States Of America As Represented By The Secretary Of The Navy	Automated epifluorescence microscopy for detection of bacterial contamination in platelets
GB2378245A (en)	2001-08-03	2003-02-05	Mats Nilsson	Nucleic acid amplification method
DK2184346T3 (en)	2001-09-06	2017-06-26	Rapid Micro Biosystems Inc	Rapid detection of replicating cells
US20030098271A1 (en)	2001-11-26	2003-05-29	Ralph Somack	Capsule and tray systems for combined sample collection, archiving, purification, and PCR
DE10201463B4 (de)	2002-01-16	2005-07-21	Clondiag Chip Technologies Gmbh	Reaktionsgefäß zur Durchführung von Array-Verfahren
RU2228735C2 (ru)	2002-04-10	2004-05-20	Абанин Вячеслав Владимирович	Устройство для хранения концентрата тромбоцитов
EP1527172B1 (en)	2002-05-17	2008-11-26	Molzym GmbH & Co. KG	Method for nucleic acid extraction and nucleic acid purification
DE10222133A1 (de)	2002-05-17	2003-12-04	Gl Biotech Gmbh	Verfahren zur Nukleinsäure-Extraktion und Nukleinsäure-Reinigung
US20060094034A1 (en)	2003-04-30	2006-05-04	Roland Brousseau	Virulence and antibiotic resistance array and uses thereof
CA2875478A1 (en)	2003-05-13	2005-02-24	Gen-Probe Incorporated	Method and kit for identifying antibiotic-resistant microorganisms
US20120077206A1 (en)	2003-07-12	2012-03-29	Accelr8 Technology Corporation	Rapid Microbial Detection and Antimicrobial Susceptibility Testing
US7341841B2 (en)	2003-07-12	2008-03-11	Accelr8 Technology Corporation	Rapid microbial detection and antimicrobial susceptibility testing
ES2661168T3 (es)	2003-07-12	2018-03-27	Accelerate Diagnostics, Inc.	Biodetección sensible y rápida
US20050042144A1 (en)	2003-08-18	2005-02-24	A. Robert Hubbard	Portable insulated container for biological specimens
JP4677600B2 (ja)	2003-09-12	2011-04-27	独立行政法人産業技術総合研究所	基板及びその製造方法
DE602004019564D1 (de)	2003-12-09	2009-04-02	Bio Merieux Inc	Verfahren zum nachweis bakterieller krankheitserreger
US7429464B2 (en)	2003-12-09	2008-09-30	Biomerieux, Inc.	Methods for detecting bacterial pathogens
EP1574583A1 (en)	2004-03-10	2005-09-14	Roche Diagnostics GmbH	Methods for isolation of bacteria from biological samples
CA2559943A1 (en)	2004-03-15	2005-10-06	Purdue Research Foundation	Cell concentration and pathogen recovery
US7580920B2 (en)	2004-07-22	2009-08-25	Microsoft Corporation	System and method for graceful degradation of a database query
US7662562B2 (en)	2004-08-10	2010-02-16	Becton, Dickinson And Company	Method for rapid identification of microorganisms
DE102005009479A1 (de)	2005-03-02	2006-09-07	Molzym Gmbh & Co. Kg	Verwendung von Nukleasen zum Abbau von Nukleinsäure in Gegenwart von chaotropen Agenzien und/oder Tensiden
US20060223098A1 (en)	2005-03-31	2006-10-05	Lane David J	Circularizable nucleic acid probes and amplification methods
US8074465B2 (en)	2005-09-12	2011-12-13	Genzyme Corporation	Thermally insulated transport container for cell-based products and related methods
US20080286757A1 (en)	2005-09-15	2008-11-20	Microphage Incorporated	Method and Apparatus for Identification of Microorganisms Using Bacteriophage
WO2007058898A2 (en)	2005-11-10	2007-05-24	Panomics, Inc.	Detection of nucleic acids through amplification of surrogate nucleic acids
US20090209031A1 (en)	2006-01-26	2009-08-20	Tyco Healthcare Group Lp	Medical device package
US7334516B2 (en)	2006-03-08	2008-02-26	Taiwan Supercritical Technology Co., Ltd.	Aging device for liquor or wine
DE602007012045D1 (de)	2006-06-06	2011-03-03	Gen Probe Inc	Markierte oligonukleotide und ihre verwendung in nukleinsäureverstärkungsverfahren
US7819934B2 (en)	2006-07-14	2010-10-26	Xcellerex, Inc.	Environmental containment systems
JP4872511B2 (ja)	2006-08-02	2012-02-08	株式会社日立製作所	温度調整部材
ATE517192T1 (de)	2006-08-10	2011-08-15	Merck Patent Gmbh	Verfahren zur isolierung von zellen
US8652782B2 (en)	2006-09-12	2014-02-18	Longhorn Vaccines & Diagnostics, Llc	Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids
US20080145919A1 (en) *	2006-12-18	2008-06-19	Franklin Thomas D	Portable organ and tissue preservation apparatus, kit and methods
EP2147125A4 (en)	2007-04-18	2010-12-15	Univ Cornell	Microorganism detection method and apparatus
CN101130808B (zh)	2007-07-27	2011-08-17	南京市胸科医院	分枝杆菌快速培养药敏及鉴定微量检测法及装置
WO2009015484A1 (en)	2007-08-02	2009-02-05	Universite Laval	Concentration and enrichment of microbial cells and microbial nucleic acids from bodily fluids
DE102007041864B4 (de)	2007-09-04	2012-05-03	Sirs-Lab Gmbh	Verfahren zum Nachweis von Bakterien und Pilzen
EP2056114A1 (en)	2007-10-29	2009-05-06	Koninklijke Philips Electronics N.V.	Automatic detection of infectious diseases
EP2087934A1 (de)	2008-02-07	2009-08-12	Qiagen GmbH	Verfahren und Vorrichtung zur automatisierten Prozessierung einer Probe
DE102008029356A1 (de)	2008-06-20	2009-12-24	Siemens Healthcare Diagnostics Gmbh	Verfahren zur Aufreinigung von Nukleinsäuren, insbesondere aus fixiertem Gewebe
US8512975B2 (en)	2008-07-24	2013-08-20	Biomerieux, Inc.	Method for detection and characterization of a microorganism in a sample using time dependent spectroscopic measurements
WO2010048511A1 (en)	2008-10-24	2010-04-29	Becton, Dickinson And Company	Antibiotic susceptibility profiling methods
BRPI0919895B1 (pt)	2008-10-31	2019-08-13	Bio Merieux Inc	método para identificação de um microorganismo desconhecido a partir de uma amostra de teste
CN102272601B (zh)	2008-10-31	2014-09-17	生物梅里埃公司	采用鉴定剂分离和表征微生物的方法
DK200801722A (en)	2008-12-05	2010-06-06	Unisensor As	Optical sectioning of a sample and detection of particles in a sample
WO2010132749A2 (en)	2009-05-15	2010-11-18	Biomerieux, Inc.	Automated transfer mechanism for microbial. detection apparatus
CN102803959B (zh)	2009-05-15	2015-07-08	生物梅里埃有限公司	用于样品中的微生物剂的快速的识别和/或表征的系统和方法
CA2777322A1 (en)	2009-08-12	2011-02-17	President And Fellows Of Harvard College	Biodetection methods and compositions
EP2325312A1 (de)	2009-11-19	2011-05-25	Qiagen GmbH	Verfahren zur selektiven Anreicherung und Isolierung mikrobieller und optional zusätzlich viraler Nukleinsäuren
EP2333105A1 (en)	2009-12-08	2011-06-15	Koninklijke Philips Electronics N.V.	Selective lysis of cells
MX345230B (es)	2010-02-24	2017-01-20	The Broad Inst Inc *	Metodos para diagnosticar patogenos de enfermedad infecciosa y su sensibilidad a farmacos.
DE102010012790B4 (de)	2010-03-25	2015-08-06	Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.	Inkubatoreinrichtung und Verfahren zu deren Betrieb
CN101845390B (zh)	2010-04-30	2013-09-11	武汉迪艾斯科技有限公司	自动化细菌培养仪
EP2388312A1 (en)	2010-05-17	2011-11-23	Curetis AG	Universally applicable lysis buffer and processing methods for the lysis of bodily samples
US20130261196A1 (en)	2010-06-11	2013-10-03	Lisa Diamond	Nucleic Acids For Multiplex Organism Detection and Methods Of Use And Making The Same
US9739788B2 (en)	2010-07-20	2017-08-22	Biomerieux, Inc.	Detector arrangement for blood culture bottles with colorimetric sensors
CN104306005A (zh) *	2010-11-04	2015-01-28	日立化成株式会社	用于体外刺激全血的便携设备
CA2839794A1 (en)	2011-05-20	2012-11-29	Advandx, Inc.	Selective ultrasonic lysis of blood and other biological fluids and tissues
KR20140023326A (ko)	2011-06-06	2014-02-26	비오까르띠 에스아	이온성 계면활성제에 의한 세포의 선택적 용해
CN103813845B (zh)	2011-07-22	2016-08-17	生物梅里埃有限公司	从培养物离析微生物的方法和试剂盒
US8603769B2 (en)	2011-10-07	2013-12-10	Becton, Dickinson And Company	Method for direct and rapid identification of microorganisms and antimicrobial susceptibility testing from positive blood cultures
WO2013101741A1 (en)	2011-12-30	2013-07-04	Abbott Molecular, Inc.	Channels with cross-sectional thermal gradients
US10475527B2 (en) *	2012-03-22	2019-11-12	Biomerieux, Inc.	Method and system for detection of microbial growth in a specimen container
WO2013163210A1 (en)	2012-04-23	2013-10-31	Philip Alexander Rolfe	Method and system for detection of an organism
JP6018808B2 (ja)	2012-06-12	2016-11-02	株式会社日立ハイテクノロジーズ	微生物検査方法および検査システム
EP2684947A1 (en)	2012-07-09	2014-01-15	Biocartis SA	A method for filtering a biological sample
CA2923795A1 (en)	2012-09-10	2014-03-13	Accelerate Diagnostics, Inc.	Same-day blood culture with digital microscopy
EP2920324B1 (en)	2012-11-14	2017-12-27	Olink Bioscience AB	Localised rca-based amplification method
US20140287408A1 (en)	2013-03-13	2014-09-25	Abbott Molecular Inc.	Target sequence enrichment
GB201321123D0 (en)	2013-11-29	2014-01-15	Linea Ab Q	Amplification of circular molecules
GB2520765A (en)	2013-12-02	2015-06-03	Vanadis Diagnostics Ab	Multiplex detection of nucleic acids
EP2942394A1 (en)	2014-05-09	2015-11-11	Molzym GmbH & Co. KG	New method for isolating microbial DNA
CN204255722U (zh)	2014-12-15	2015-04-08	王东生	血液孵育器
JP6853177B2 (ja)	2015-01-26	2021-03-31	ベンタナメディカルシステムズ，インコーポレイテッド	組織試料を移送するためのトランスポータシステム、組立体、および関連する方法
CN113801911B (zh) *	2015-04-17	2024-05-28	威克斯免疫有限责任公司	用于病原体快速诊断的便携式一次性、可再使用培养装置
GB201507026D0 (en) *	2015-04-24	2015-06-10	Linea Ab Q	Medical sample transportation container
GB201511129D0 (en) *	2015-06-24	2015-08-05	Linea Ab Q	Method of determining antimicrobial susceptibility of a microorganism
US10407659B2 (en) *	2015-11-09	2019-09-10	Sahar M. H Jaffal	Mini-incubator carrier box “Mini-incubator”

2016
- 2016-10-13 GB GB1617353.6A patent/GB2554767A/en not_active Withdrawn
2017
- 2017-04-20 FR FR1753439A patent/FR3050461A1/fr not_active Ceased
- 2017-04-21 EP EP17719557.5A patent/EP3294057B1/en active Active
- 2017-04-21 US US16/094,699 patent/US11845978B2/en active Active
- 2017-04-21 WO PCT/EP2017/059542 patent/WO2017182645A1/en not_active Ceased
2023
- 2023-10-30 US US18/385,099 patent/US20240368670A1/en active Pending

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1997012029A1 (en) *	1995-09-29	1997-04-03	Idexx Laboratories, Inc.	Self-contained incubator for growth of microorganism
US20050037408A1 (en) *	2003-07-24	2005-02-17	Christensen Jeffrey E.	Rapid identification of bacteria from positive blood cultures
US20100124763A1 (en) *	2008-10-31	2010-05-20	Biomerieux, Inc.	Method for detection, characterization and/or identification of microorganisms in a sealed container
US20140278136A1 (en) *	2013-03-15	2014-09-18	Accelerate Diagnostics, Inc.	Rapid determination of microbial growth and antimicrobial susceptibility
WO2015189390A1 (en) *	2014-06-13	2015-12-17	Q-Linea Ab	Method for detecting and characterising a microorganism
US20160053219A1 (en) *	2014-08-25	2016-02-25	Opgen, Inc.	Systems, methods, and devices for temperature control
WO2016033077A1 (en) *	2014-08-25	2016-03-03	Opgen, Inc.	Systems, methods, and devices for temperature control

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MARK BROOKES ET AL: "Pathology TRANSPORT OF PATHOLOGY SAMPLES GP/MP6 Version 3.4 / August 2014 Page 1 of 11 CONTROLLED COPIES MUST BE SIGNED AND PHOTOCOPIES ARE NOT ALLOWED POLICY FOR THE TRANSPORT OF PATHOLOGY SAMPLES Reviewed by Approved by Summary of Changes <Signature> <Signature> Added ISO15189 requirements for tem", 22 August 2014 (2014-08-22), XP055555057, Retrieved from the Internet <URL:http://www.southend.nhs.uk/media/64058/gp-mp6.pdf> [retrieved on 20190212] *
WALTER C OLSON ET AL: "R Background", JOURNAL OF TRANSLATIONAL MEDICINE, 1 January 2011 (2011-01-01), pages 26, XP055554919, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063218/pdf/1479-5876-9-26.pdf> *

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US20240368670A1 (en)	2024-11-07
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US11845978B2 (en)	2023-12-19
US20190119724A1 (en)	2019-04-25
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Publication	Publication Date	Title
FR3050461A1 (2)	2017-10-27
US11505835B2 (en)	2022-11-22	Method for determining the identity and antimicrobial susceptibility of a microorganism
US10457934B2 (en)	2019-10-29	Methods for genome assembly, haplotype phasing, and target independent nucleic acid detection
IL287247B2 (en)	2023-07-01	High-resolution systems, kits, devices and methods for high-throughput microbiology applications
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EP2255197B1 (fr)	2011-11-02	Procede de detection et/ou de quantification et/ou d'identification in vitro de bacteries dans un materiau biologique
US20250305029A1 (en)	2025-10-02	Generation of phased read-sets for genome assembly and haplotype phasing
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