GR3017148T3 - Anti-sense regulation of plant gene expression. - Google Patents
Anti-sense regulation of plant gene expression.Info
- Publication number
- GR3017148T3 GR3017148T3 GR950402077T GR950402077T GR3017148T3 GR 3017148 T3 GR3017148 T3 GR 3017148T3 GR 950402077 T GR950402077 T GR 950402077T GR 950402077 T GR950402077 T GR 950402077T GR 3017148 T3 GR3017148 T3 GR 3017148T3
- Authority
- GR
- Greece
- Prior art keywords
- gene expression
- plant gene
- sense regulation
- regulation
- sense
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8249—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving ethylene biosynthesis, senescence or fruit development, e.g. modified tomato ripening, cut flower shelf-life
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/01—Carboxylic ester hydrolases (3.1.1)
- C12Y301/01011—Pectinesterase (3.1.1.11)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01015—Polygalacturonase (3.2.1.15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Nutrition Science (AREA)
- Cell Biology (AREA)
- Virology (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Fruits And Vegetables (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB868626879A GB8626879D0 (en) | 1986-11-11 | 1986-11-11 | Dna |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3017148T3 true GR3017148T3 (en) | 1995-11-30 |
Family
ID=10607120
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR950402077T GR3017148T3 (en) | 1986-11-11 | 1995-08-17 | Anti-sense regulation of plant gene expression. |
| GR20000402291T GR3034607T3 (en) | 1986-11-11 | 2000-10-12 | Anti-sense regulation of plant gene expression. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR20000402291T GR3034607T3 (en) | 1986-11-11 | 2000-10-12 | Anti-sense regulation of plant gene expression. |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US5073676A (el) |
| EP (2) | EP0532060B1 (el) |
| JP (1) | JP3098238B2 (el) |
| AT (2) | ATE194655T1 (el) |
| AU (4) | AU643184B2 (el) |
| DE (2) | DE3751466T2 (el) |
| ES (2) | ES2149162T3 (el) |
| GB (1) | GB8626879D0 (el) |
| GR (2) | GR3017148T3 (el) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5107065A (en) * | 1986-03-28 | 1992-04-21 | Calgene, Inc. | Anti-sense regulation of gene expression in plant cells |
| NZ219472A (en) * | 1986-03-28 | 1990-08-28 | Calgene Inc | Regulation of phenotype in plant cells using dsdna constructs |
| US5453566A (en) * | 1986-03-28 | 1995-09-26 | Calgene, Inc. | Antisense regulation of gene expression in plant/cells |
| US5296376A (en) * | 1986-11-04 | 1994-03-22 | Imperial Chemical Industries Plc | DNA, constructs, cells and plants derived therefrom |
| GB8927048D0 (en) * | 1989-11-30 | 1990-01-31 | Ici Plc | Dna,constructs,cells and plants derived therefrom |
| GB8626879D0 (en) * | 1986-11-11 | 1986-12-10 | Ici Plc | Dna |
| US6271033B1 (en) | 1986-11-11 | 2001-08-07 | Zeneca Limited | Method for modifying production of fruit ripening enzyme |
| NZ224787A (en) * | 1987-05-26 | 1990-08-28 | Calgene Inc | A dna construct for specifically modifying the phenotype of fruit as distinct from other plant tissue |
| GB8811115D0 (en) * | 1988-05-11 | 1988-06-15 | Ici Plc | Tomatoes |
| US6054566A (en) | 1988-02-26 | 2000-04-25 | Biosource Technologies, Inc. | Recombinant animal viral nucleic acids |
| US5316931A (en) * | 1988-02-26 | 1994-05-31 | Biosource Genetics Corp. | Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes |
| US6284492B1 (en) | 1988-02-26 | 2001-09-04 | Large Scale Biology Corporation | Recombinant animal viral nucleic acids |
| NL8800756A (nl) * | 1988-03-25 | 1989-10-16 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | Genetisch gemanipuleerde plantecellen en planten, alsmede daarvoor bruikbaar recombinant dna. |
| DE3908813A1 (de) * | 1989-03-17 | 1990-09-20 | Roehm Gmbh | Verfahren zur expression eines aus aspergillus niger stammenden gens in einem aspergillus |
| GB8916213D0 (en) * | 1989-07-14 | 1989-08-31 | Ici Plc | Dna constructs,cells and plants derived therefrom |
| EP0421919A3 (en) * | 1989-09-02 | 1992-04-15 | Ciba-Geigy Ag | Polygalacturonase encoding fungal expression system |
| DE3929741A1 (de) * | 1989-09-07 | 1991-03-28 | Hoechst Ag | Rna mit endoribonucleaseaktivitaet gegen mrna von reifungsgenen, ihre herstellung und ihre verwendung in pflanzen |
| GB8923716D0 (en) * | 1989-10-20 | 1989-12-06 | Ici Plc | Dna,constructs,cells and plants derived therefrom |
| US5744364A (en) * | 1989-10-20 | 1998-04-28 | Zeneca Limited | PTOM36 constructs and tomato cells transformed therewith |
| GB8928179D0 (en) * | 1989-12-13 | 1990-02-14 | Ici Plc | Dna,constructs,cells and plants derived therefrom |
| JPH04506155A (ja) * | 1990-03-16 | 1992-10-29 | カルジーン,インコーポレイティド | 初期種子形成において優先的に発現される新規配列およびそれに関連する方法 |
| US5168064A (en) * | 1990-04-20 | 1992-12-01 | The Regents Of The University Of California | Endo-1,4-β-glucanase gene and its use in plants |
| US5585545A (en) * | 1990-04-20 | 1996-12-17 | The Regents Of The University Of California | Endo-1,4-β-glucanase genes and their use in plants |
| GB9009307D0 (en) * | 1990-04-25 | 1990-06-20 | Ici Plc | Dna,constructs,cells and plant derived therefrom |
| GB9021923D0 (en) * | 1990-10-09 | 1990-11-21 | Ici Plc | Dna,dna constructs,cells and plants derived therefrom |
| GB9024323D0 (en) * | 1990-11-08 | 1990-12-19 | Ici Plc | Regulation of gene expression |
| US5260205A (en) * | 1990-11-14 | 1993-11-09 | Philip Morris Incorporated | Method of purifying putrescine N-methyltransferase from tobacco plant extract with a polyamine |
| JPH06505864A (ja) * | 1990-12-21 | 1994-07-07 | コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガナイゼイション | トマト酵素エンドポリガラクツロナーゼPG1β−サブ単位の少なくとも1部をコードするDNA配列 |
| BR9107191A (pt) * | 1990-12-26 | 1994-06-14 | Monsanto Co | Controle de amadurecimento de frutos e senescência em plantas |
| GB9105420D0 (en) * | 1991-03-14 | 1991-05-01 | Ici Plc | Expression of genes in transgenic plants |
| GB9127098D0 (en) * | 1991-12-20 | 1992-02-19 | Ici Plc | Dna,dna constructs,cells and plants derived therefrom |
| ZA933177B (en) * | 1992-05-08 | 1996-02-09 | Univ Arizona | Transgenic tomato plants with altered polygalacturonase isoforms |
| GB9210273D0 (en) * | 1992-05-13 | 1992-07-01 | Ici Plc | Dna |
| US5367065A (en) * | 1992-08-10 | 1994-11-22 | The Trustees Of The University Of Pennsylvania | Constitutive triple response gene and mutations |
| US5955652A (en) * | 1992-06-16 | 1999-09-21 | The Trustees Of The University Of Pennsylvania | Plant genes for sensitivity to ethylene and pathogens |
| RU94046396A (ru) * | 1992-06-29 | 1996-11-10 | Джин Ширс Пти.Лтд. (AU) | Нуклеиновая кислота, днк, вектор, способ получения растения или животного, способ получения клеток, способ создания животного, животное, трансгенное животное, трансгенное растение, плоды, черенки и семена, растительные клетки, способ вмешательства в репликацию вируса |
| WO1994005795A1 (en) * | 1992-08-27 | 1994-03-17 | Commonwealth Scientific And Industrial Research Organisation | Dna sequences encoding peach polygalacturonase |
| AU690530B2 (en) * | 1992-12-15 | 1998-04-30 | Commonwealth Scientific And Industrial Research Organisation | DNA molecules encoding inducible plant promoters and tomato ADH2 enzyme |
| US5534660A (en) * | 1993-04-16 | 1996-07-09 | Dna Plant Technology Corporation | Ph genes and their uses |
| GB9506684D0 (en) * | 1995-03-31 | 1995-05-24 | Nickerson Biocem Ltd | Control of pod dehiscence |
| JPH11513256A (ja) | 1995-10-06 | 1999-11-16 | プラント ジエネテイツク システムズ エヌ.ブイ | 種子粉砕 |
| GB9521848D0 (en) * | 1995-10-25 | 1996-01-03 | Zeneca Ltd | Modification of lignin synthesis in plants |
| US6452067B1 (en) | 1997-09-19 | 2002-09-17 | Dna Plant Technology Corporation | Methods to assay for post-transcriptional suppression of gene expression |
| WO1999041371A1 (en) | 1998-02-13 | 1999-08-19 | Genetrace Systems, Inc. | Use of ribozymes for functionating genes |
| GB9810159D0 (en) * | 1998-05-12 | 1998-07-08 | Danisco | Short amino acid sequence |
| US7897843B2 (en) | 1999-03-23 | 2011-03-01 | Mendel Biotechnology, Inc. | Transcriptional regulation of plant biomass and abiotic stress tolerance |
| US20050086718A1 (en) | 1999-03-23 | 2005-04-21 | Mendel Biotechnology, Inc. | Plant transcriptional regulators of abiotic stress |
| US6441272B1 (en) | 1998-12-02 | 2002-08-27 | The University Of Georgia Research Foundation, Inc. | Modification of lignin content and composition in plants |
| GB9914209D0 (en) | 1999-06-17 | 1999-08-18 | Danisco | Process |
| CA2364983A1 (en) * | 2000-12-13 | 2002-06-13 | John R. Coleman | Nucleic acid molecules and polypeptides for catabolism of abscisic acid |
| EP1390514A2 (en) * | 2001-05-04 | 2004-02-25 | Ato B.V. | Regulatory protein involved in pectin modification |
| US7230168B2 (en) | 2001-12-20 | 2007-06-12 | The Curators Of The University Of Missouri | Reversible male sterility in transgenic plants by expression of cytokinin oxidase |
| KR20030073033A (ko) * | 2002-03-08 | 2003-09-19 | 이채붕 | 치과기공용 서멀툴 어셈블리 |
| US20040052161A1 (en) * | 2002-09-17 | 2004-03-18 | Steven Liao | Mechanical clock having wireless manipulation and adjustment function |
| EP3249046B1 (en) | 2002-09-18 | 2020-07-08 | Mendel Biotechnology, Inc. | Polynucleotides and polypeptides in plants |
| US20040250322A1 (en) * | 2002-10-22 | 2004-12-09 | Anawah, Inc. | Tomatoes having reduced polygalacturonase activity caused by non-transgenic mutations in the polygalacturonase gene |
| US7365186B2 (en) | 2002-11-22 | 2008-04-29 | Arborgen, Llc | Vascular-preferred promoter sequences and uses thereof |
| WO2005001051A2 (en) | 2003-06-06 | 2005-01-06 | Arborgen Llc. | Compositions and methods for regulating polysaccharides of a plant cell |
| AR047574A1 (es) | 2003-12-30 | 2006-01-25 | Arborgen Llc 2 Genesis Res 1 | Genes del ciclo celular y metodos de uso relacionados |
| US7402428B2 (en) | 2004-09-22 | 2008-07-22 | Arborgen, Llc | Modification of plant lignin content |
| US7456338B2 (en) | 2004-09-22 | 2008-11-25 | Arborgen Llc | Modification of plant lignin content |
| US7453025B2 (en) | 2004-09-22 | 2008-11-18 | Arborgen, Llc | Reproductive ablation constructs |
| US7799906B1 (en) | 2004-09-22 | 2010-09-21 | Arborgen, Llc | Compositions and methods for modulating lignin of a plant |
| US20110088126A1 (en) | 2005-06-17 | 2011-04-14 | Arborgen, Llc | Cell signaling genes and related methods |
| CA2867139A1 (en) | 2011-04-11 | 2012-10-18 | Targeted Growth, Inc. | Identification and the use of krp mutants in plants |
| US9988641B2 (en) | 2016-04-05 | 2018-06-05 | Corn Products Development, Inc. | Compositions and methods for producing starch with novel functionality |
| IL272713B2 (en) | 2017-09-18 | 2024-10-01 | Futuragene Israel Ltd | Tissue-specific expression control of della polypeptides |
| CN110393809A (zh) * | 2019-07-29 | 2019-11-01 | 天津大学 | 一种纳米级磁共振成像造影剂及其制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ219472A (en) * | 1986-03-28 | 1990-08-28 | Calgene Inc | Regulation of phenotype in plant cells using dsdna constructs |
| US4801540A (en) * | 1986-10-17 | 1989-01-31 | Calgene, Inc. | PG gene and its use in plants |
| GB8626879D0 (en) * | 1986-11-11 | 1986-12-10 | Ici Plc | Dna |
| NZ224787A (en) * | 1987-05-26 | 1990-08-28 | Calgene Inc | A dna construct for specifically modifying the phenotype of fruit as distinct from other plant tissue |
-
1986
- 1986-11-11 GB GB868626879A patent/GB8626879D0/en active Pending
-
1987
- 1987-11-06 AT AT92117411T patent/ATE194655T1/de not_active IP Right Cessation
- 1987-11-06 ES ES92117411T patent/ES2149162T3/es not_active Expired - Lifetime
- 1987-11-06 ES ES87309853T patent/ES2075831T3/es not_active Expired - Lifetime
- 1987-11-06 DE DE3751466T patent/DE3751466T2/de not_active Expired - Fee Related
- 1987-11-06 EP EP92117411A patent/EP0532060B1/en not_active Expired - Lifetime
- 1987-11-06 EP EP87309853A patent/EP0271988B1/en not_active Expired - Lifetime
- 1987-11-06 DE DE3752317T patent/DE3752317T2/de not_active Expired - Fee Related
- 1987-11-06 AT AT87309853T patent/ATE126536T1/de not_active IP Right Cessation
- 1987-11-10 AU AU80956/87A patent/AU643184B2/en not_active Ceased
- 1987-11-11 JP JP62283201A patent/JP3098238B2/ja not_active Expired - Fee Related
-
1989
- 1989-09-29 US US07/419,779 patent/US5073676A/en not_active Expired - Fee Related
- 1989-09-29 US US07/414,915 patent/US5457281A/en not_active Expired - Fee Related
-
1991
- 1991-04-12 AU AU74350/91A patent/AU633202B2/en not_active Ceased
-
1993
- 1993-02-26 US US08/024,866 patent/US5447867A/en not_active Expired - Fee Related
- 1993-12-22 AU AU52632/93A patent/AU663811B2/en not_active Ceased
-
1995
- 1995-08-02 AU AU28312/95A patent/AU2831295A/en not_active Abandoned
- 1995-08-17 GR GR950402077T patent/GR3017148T3/el unknown
-
2000
- 2000-10-12 GR GR20000402291T patent/GR3034607T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU5263293A (en) | 1994-03-17 |
| US5457281A (en) | 1995-10-10 |
| DE3751466T2 (de) | 1996-01-18 |
| GB8626879D0 (en) | 1986-12-10 |
| AU7435091A (en) | 1991-07-11 |
| ATE194655T1 (de) | 2000-07-15 |
| AU643184B2 (en) | 1993-11-11 |
| AU663811B2 (en) | 1995-10-19 |
| AU8095687A (en) | 1988-05-12 |
| US5073676A (en) | 1991-12-17 |
| EP0271988B1 (en) | 1995-08-16 |
| US5447867A (en) | 1995-09-05 |
| DE3752317D1 (de) | 2000-08-17 |
| EP0271988A2 (en) | 1988-06-22 |
| AU2831295A (en) | 1996-01-04 |
| ES2075831T3 (es) | 1995-10-16 |
| JPS63164892A (ja) | 1988-07-08 |
| DE3751466D1 (de) | 1995-09-21 |
| AU633202B2 (en) | 1993-01-21 |
| GR3034607T3 (en) | 2001-01-31 |
| EP0532060A1 (en) | 1993-03-17 |
| DE3752317T2 (de) | 2000-11-30 |
| JP3098238B2 (ja) | 2000-10-16 |
| ES2149162T3 (es) | 2000-11-01 |
| EP0532060B1 (en) | 2000-07-12 |
| EP0271988A3 (en) | 1989-04-26 |
| ATE126536T1 (de) | 1995-09-15 |
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