GR3017487T3 - Isatine derivatives, their preparation and use. - Google Patents

Isatine derivatives, their preparation and use.

Info

Publication number: GR3017487T3
Authority: GR; Greece
Prior art keywords: alkyl; hydrogen; branched; compounds; independently
Prior art date: 1989-12-11

Application number

GR950402604T

Other languages

English (en)

Inventor

Frank Waetjen

Jorgen Drejer

Leif Helth Jensen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-11

Filing date

1995-09-21

Publication date

1995-12-31

1989-12-11 Priority claimed from DK624889A external-priority patent/DK624889D0/da

1989-12-19 Priority claimed from DK647089A external-priority patent/DK647089D0/da

1990-01-12 Priority claimed from DK8590A external-priority patent/DK8590D0/da

1990-01-12 Priority claimed from DK8690A external-priority patent/DK8690D0/da

1990-02-12 Priority claimed from DK36390A external-priority patent/DK36390D0/da

1990-08-31 Priority claimed from DK209390A external-priority patent/DK209390D0/da

1995-09-21 Application filed by Neurosearch As filed Critical Neurosearch As

1995-12-31 Publication of GR3017487T3 publication Critical patent/GR3017487T3/el

Links

JXDYKVIHCLTXOP-UHFFFAOYSA-N isatin Chemical class C1=CC=C2C(=O)C(=O)NC2=C1 JXDYKVIHCLTXOP-UHFFFAOYSA-N 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
229910052739 hydrogen Inorganic materials 0.000 abstract 7
239000001257 hydrogen Substances 0.000 abstract 7
150000001875 compounds Chemical class 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
239000003257 excitatory amino acid Substances 0.000 abstract 1
230000002461 excitatory amino acid Effects 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Lubricants (AREA)
Holo Graphy (AREA)
Adhesives Or Adhesive Processes (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

GR950402604T 1989-12-11 1995-09-21 Isatine derivatives, their preparation and use. GR3017487T3 (en)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
DK624889A DK624889D0 (da)	1989-12-11	1989-12-11	Forbindelser og anvendelse
DK647089A DK647089D0 (da)	1989-12-19	1989-12-19	Forbindelser og anvendelse
DK8590A DK8590D0 (da)	1990-01-12	1990-01-12	Forbindelser og anvendelse
DK8690A DK8690D0 (da)	1990-01-12	1990-01-12	Forbindelser og anvendelse
DK36390A DK36390D0 (da)	1990-02-12	1990-02-12	Forbindelser og anvendelse
DK209390A DK209390D0 (da)	1990-08-31	1990-08-31	Kondenserede lactamforbindelser, deres fremstilling og anvendelse

Publications (1)

Publication Number	Publication Date
GR3017487T3 true GR3017487T3 (en)	1995-12-31

Family

ID=27545140

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR950402604T GR3017487T3 (en)	1989-12-11	1995-09-21	Isatine derivatives, their preparation and use.

Country Status (14)

Country	Link
EP (1)	EP0432648B1 (el)
JP (1)	JP3057095B2 (el)
AT (1)	ATE125795T1 (el)
AU (1)	AU629075B2 (el)
CA (1)	CA2031756C (el)
DE (1)	DE69021347T2 (el)
DK (1)	DK0432648T3 (el)
ES (1)	ES2077623T3 (el)
FI (1)	FI100880B (el)
GR (1)	GR3017487T3 (el)
IE (1)	IE69677B1 (el)
NO (1)	NO174464C (el)
NZ (1)	NZ236200A (el)
PT (1)	PT96162B (el)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5164404A (en) *	1991-03-15	1992-11-17	Neurosearch A/S	Hydrazone derivatives and their use
AU655643B2 (en) *	1991-07-09	1995-01-05	Neurosearch A/S	Novel isatineoxime derivatives, their preparation and use
US5223527A (en) *	1991-07-09	1993-06-29	Neurosearch A/S	Isatineoxime derivatives and their use
CA2076948C (en) *	1991-08-28	2002-04-16	Frank Watjen	Isatineoxime derivatives, their preparation and use
DK69693D0 (da) *	1993-06-14	1993-06-14	Neurosearch As	Farven lilla
US5565580A (en) *	1994-01-27	1996-10-15	Neurosearch A/S	Glutamate Antagonists
AU687255B2 (en) *	1994-09-14	1998-02-19	Neurosearch A/S	Indole-2,3-dione-3-oxime derivatives, their preparation and use
UA54403C2 (uk) *	1996-10-01	2003-03-17	Н'Юросерч А/С	Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
KR19980050063A (ko) *	1996-12-20	1998-09-15	이덕림	신규한 하이드라존 유도체
KR20010041625A (ko)	1998-03-06	2001-05-25	아스트라제네카 악티에볼라그	신규 용도
EP1135123B1 (en)	1998-12-04	2004-12-29	Neurosearch A/S	Use of isatin derivatives as ion channel activating agents
WO2000071102A2 (en) *	1999-05-19	2000-11-30	Neurosearch A/S	Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
EP1736468A3 (en) *	2000-01-24	2007-01-03	NeuroSearch A/S	Isatin derivatives with neurotrophic activity useful in the treatment of diseases mediated by the nerve growth factor (NGF) activation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GR65270B (en) *	1978-10-10	1980-07-31	Fujisawa Pharmaceutical Co	Isatin derivatives and processes for the preparation thereof

1990
- 1990-11-20 IE IE417590A patent/IE69677B1/en not_active IP Right Cessation
- 1990-11-23 NZ NZ236200A patent/NZ236200A/en unknown
- 1990-11-30 JP JP2330898A patent/JP3057095B2/ja not_active Expired - Fee Related
- 1990-12-03 FI FI905943A patent/FI100880B/fi not_active IP Right Cessation
- 1990-12-06 DE DE69021347T patent/DE69021347T2/de not_active Expired - Fee Related
- 1990-12-06 AT AT90123474T patent/ATE125795T1/de not_active IP Right Cessation
- 1990-12-06 EP EP90123474A patent/EP0432648B1/en not_active Expired - Lifetime
- 1990-12-06 ES ES90123474T patent/ES2077623T3/es not_active Expired - Lifetime
- 1990-12-06 DK DK90123474.0T patent/DK0432648T3/da active
- 1990-12-07 CA CA002031756A patent/CA2031756C/en not_active Expired - Fee Related
- 1990-12-10 NO NO905320A patent/NO174464C/no unknown
- 1990-12-10 AU AU67920/90A patent/AU629075B2/en not_active Ceased
- 1990-12-11 PT PT96162A patent/PT96162B/pt not_active IP Right Cessation
1995
- 1995-09-21 GR GR950402604T patent/GR3017487T3/el unknown

Also Published As

Publication number	Publication date
NO905320L (no)	1991-06-12
NO174464C (no)	1994-05-11
NZ236200A (en)	1994-12-22
DK0432648T3 (da)	1995-11-06
ATE125795T1 (de)	1995-08-15
PT96162B (pt)	1998-04-30
EP0432648B1 (en)	1995-08-02
FI905943A0 (fi)	1990-12-03
AU6792090A (en)	1991-06-13
FI100880B (fi)	1998-03-13
NO905320D0 (no)	1990-12-10
JPH03204856A (ja)	1991-09-06
EP0432648A2 (en)	1991-06-19
CA2031756C (en)	2002-06-11
ES2077623T3 (es)	1995-12-01
FI905943L (fi)	1991-06-12
JP3057095B2 (ja)	2000-06-26
DE69021347D1 (de)	1995-09-07
IE69677B1 (en)	1996-10-02
DE69021347T2 (de)	1996-01-04
EP0432648A3 (en)	1991-09-25
NO174464B (no)	1994-01-31
AU629075B2 (en)	1992-09-24
CA2031756A1 (en)	1991-06-12
PT96162A (pt)	1991-09-30
IE904175A1 (en)	1991-06-19

Publication	Publication Date	Title
ZA921328B (en)	1992-11-25	Hydrazone derivatives,their preparation and use
EP0432648A3 (en)	1991-09-25	Isatine derivatives, their preparation and use
AU1943388A (en)	1989-01-04	3-indolepyruvic acid derivatives and pharmaceutical use thereof
UA66825C2 (uk)	2004-06-15	Азаполіциклічні сполуки, конденсовані з арилом, фармацевтична композиція, спосіб лікування та спосіб зниження нікотинової залежності
EP0431580A3 (en)	1991-12-11	Substituted cyclohexanols as central nervous system agents
AU1326088A (en)	1988-09-22	Heterocyclic dihydroquinoxaline compounds and their preparation and use
FI980471A0 (fi)	1998-03-02	1,3-substituoidut sykloalkeenit ja sykloalkaanit keskushermostoon vaikuttavina aineina
ATE62222T1 (de)	1991-04-15	Aminosaeure-derivate und ihre anwendung zur herstellung eines antikrampfmittels.
NO905254D0 (no)	1990-12-05	Fremgangsmaate for fremstilling av substituerte cykloheksener.
PT85869A (en)	1987-11-01	Process for preparing amino acid derivative anti-convulsant
EP0272596A3 (en)	1990-03-28	Theophyllinemethyldithiolan and theophyllinemethyldithianyl derivates, a method for their preparation and pharmaceutical compositions in which they are included
PT1025101E (pt)	2003-04-30	Derivados de nafto-imidazo¬1,2-a\|piridina sua preparacao e uso no tratamento de perturbacoes do sistema nervoso central
DE69827706D1 (de)	2004-12-30	5-(Heteroaryl)alkyl)-3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid (PBI) Derivate zur Behandlung von Störungen des zentralen Nervensystems
FR2781482B1 (fr)	2001-08-31	Nouveaux derives de 8h-thieno-[2,3-b]pyrrolizine-8-one, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE69010606D1 (de)	1994-08-18	3-Isoxazolonderivate, ihre Herstellung und ihre Anwendung in der Therapeutik.