PT96162A - Processo de preparacao de derivados da isatina e de composicoes farmaceuticas que os contem - Google Patents

Processo de preparacao de derivados da isatina e de composicoes farmaceuticas que os contem

Info

Publication number: PT96162A
Authority: PT; Portugal
Prior art keywords: alkyl; hydrogen; branched; compounds; independently
Prior art date: 1989-12-11

Application number

PT96162A

Other languages

English (en)

Other versions

PT96162B (pt

Inventor

Frank Watjen

Jorgen Drejer

Leif Helth Jensen

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-12-11

Filing date

1990-12-11

Publication date

1991-09-30

1989-12-11 Priority claimed from DK624889A external-priority patent/DK624889D0/da

1989-12-19 Priority claimed from DK647089A external-priority patent/DK647089D0/da

1990-01-12 Priority claimed from DK8590A external-priority patent/DK8590D0/da

1990-01-12 Priority claimed from DK8690A external-priority patent/DK8690D0/da

1990-02-12 Priority claimed from DK36390A external-priority patent/DK36390D0/da

1990-08-31 Priority claimed from DK209390A external-priority patent/DK209390D0/da

1990-12-11 Application filed by Neurosearch As filed Critical Neurosearch As

1991-09-30 Publication of PT96162A publication Critical patent/PT96162A/pt

1998-04-30 Publication of PT96162B publication Critical patent/PT96162B/pt

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 3
JXDYKVIHCLTXOP-UHFFFAOYSA-N isatin Chemical class C1=CC=C2C(=O)C(=O)NC2=C1 JXDYKVIHCLTXOP-UHFFFAOYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
229910052739 hydrogen Inorganic materials 0.000 abstract 7
239000001257 hydrogen Substances 0.000 abstract 7
150000001875 compounds Chemical class 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
208000015114 central nervous system disease Diseases 0.000 abstract 1
239000003257 excitatory amino acid Substances 0.000 abstract 1
230000002461 excitatory amino acid Effects 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Adhesives Or Adhesive Processes (AREA)
Lubricants (AREA)
Holo Graphy (AREA)

PT96162A 1989-12-11 1990-12-11 Processo de preparacao de derivados da isatina e de composicoes farmaceuticas que os contem PT96162B (pt)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
DK624889A DK624889D0 (da)	1989-12-11	1989-12-11	Forbindelser og anvendelse
DK647089A DK647089D0 (da)	1989-12-19	1989-12-19	Forbindelser og anvendelse
DK8590A DK8590D0 (da)	1990-01-12	1990-01-12	Forbindelser og anvendelse
DK8690A DK8690D0 (da)	1990-01-12	1990-01-12	Forbindelser og anvendelse
DK36390A DK36390D0 (da)	1990-02-12	1990-02-12	Forbindelser og anvendelse
DK209390A DK209390D0 (da)	1990-08-31	1990-08-31	Kondenserede lactamforbindelser, deres fremstilling og anvendelse

Publications (2)

Publication Number	Publication Date
PT96162A true PT96162A (pt)	1991-09-30
PT96162B PT96162B (pt)	1998-04-30

Family

ID=27545140

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT96162A PT96162B (pt)	1989-12-11	1990-12-11	Processo de preparacao de derivados da isatina e de composicoes farmaceuticas que os contem

Country Status (14)

Country	Link
EP (1)	EP0432648B1 (pt)
JP (1)	JP3057095B2 (pt)
AT (1)	ATE125795T1 (pt)
AU (1)	AU629075B2 (pt)
CA (1)	CA2031756C (pt)
DE (1)	DE69021347T2 (pt)
DK (1)	DK0432648T3 (pt)
ES (1)	ES2077623T3 (pt)
FI (1)	FI100880B (pt)
GR (1)	GR3017487T3 (pt)
IE (1)	IE69677B1 (pt)
NO (1)	NO174464C (pt)
NZ (1)	NZ236200A (pt)
PT (1)	PT96162B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5164404A (en) *	1991-03-15	1992-11-17	Neurosearch A/S	Hydrazone derivatives and their use
AU655643B2 (en) *	1991-07-09	1995-01-05	Neurosearch A/S	Novel isatineoxime derivatives, their preparation and use
US5223527A (en) *	1991-07-09	1993-06-29	Neurosearch A/S	Isatineoxime derivatives and their use
CA2076948C (en) *	1991-08-28	2002-04-16	Frank Watjen	Isatineoxime derivatives, their preparation and use
DK69693D0 (da) *	1993-06-14	1993-06-14	Neurosearch As	Farven lilla
US5565580A (en) *	1994-01-27	1996-10-15	Neurosearch A/S	Glutamate Antagonists
AU687255B2 (en) *	1994-09-14	1998-02-19	Neurosearch A/S	Indole-2,3-dione-3-oxime derivatives, their preparation and use
UA54403C2 (uk) *	1996-10-01	2003-03-17	Н'Юросерч А/С	Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму
KR19980050063A (ko) *	1996-12-20	1998-09-15	이덕림	신규한 하이드라존 유도체
ATE249828T1 (de)	1998-03-06	2003-10-15	Astrazeneca Ab	Verwendung von isatin- und oxindolderivaten zur herstellung von arzeneimittel für die behandlung von mykobakteriellen erkrankungen
ATE285769T1 (de)	1998-12-04	2005-01-15	Neurosearch As	Verwendung von isatinderivaten als ionenkanalaktivierende mittel
WO2000071102A2 (en) *	1999-05-19	2000-11-30	Neurosearch A/S	Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
EP1736468A3 (en) *	2000-01-24	2007-01-03	NeuroSearch A/S	Isatin derivatives with neurotrophic activity useful in the treatment of diseases mediated by the nerve growth factor (NGF) activation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GR65270B (en) *	1978-10-10	1980-07-31	Fujisawa Pharmaceutical Co	Isatin derivatives and processes for the preparation thereof

1990
- 1990-11-20 IE IE417590A patent/IE69677B1/en not_active IP Right Cessation
- 1990-11-23 NZ NZ236200A patent/NZ236200A/en unknown
- 1990-11-30 JP JP2330898A patent/JP3057095B2/ja not_active Expired - Fee Related
- 1990-12-03 FI FI905943A patent/FI100880B/fi not_active IP Right Cessation
- 1990-12-06 AT AT90123474T patent/ATE125795T1/de not_active IP Right Cessation
- 1990-12-06 DE DE69021347T patent/DE69021347T2/de not_active Expired - Fee Related
- 1990-12-06 EP EP90123474A patent/EP0432648B1/en not_active Expired - Lifetime
- 1990-12-06 DK DK90123474.0T patent/DK0432648T3/da active
- 1990-12-06 ES ES90123474T patent/ES2077623T3/es not_active Expired - Lifetime
- 1990-12-07 CA CA002031756A patent/CA2031756C/en not_active Expired - Fee Related
- 1990-12-10 NO NO905320A patent/NO174464C/no unknown
- 1990-12-10 AU AU67920/90A patent/AU629075B2/en not_active Ceased
- 1990-12-11 PT PT96162A patent/PT96162B/pt not_active IP Right Cessation
1995
- 1995-09-21 GR GR950402604T patent/GR3017487T3/el unknown

Also Published As

Publication number	Publication date
NO174464C (no)	1994-05-11
IE69677B1 (en)	1996-10-02
FI905943L (fi)	1991-06-12
AU629075B2 (en)	1992-09-24
NO174464B (no)	1994-01-31
JP3057095B2 (ja)	2000-06-26
IE904175A1 (en)	1991-06-19
NO905320D0 (no)	1990-12-10
NZ236200A (en)	1994-12-22
AU6792090A (en)	1991-06-13
FI905943A0 (fi)	1990-12-03
ATE125795T1 (de)	1995-08-15
ES2077623T3 (es)	1995-12-01
EP0432648A2 (en)	1991-06-19
PT96162B (pt)	1998-04-30
FI100880B (fi)	1998-03-13
DE69021347D1 (de)	1995-09-07
GR3017487T3 (en)	1995-12-31
CA2031756C (en)	2002-06-11
EP0432648B1 (en)	1995-08-02
DE69021347T2 (de)	1996-01-04
JPH03204856A (ja)	1991-09-06
EP0432648A3 (en)	1991-09-25
CA2031756A1 (en)	1991-06-12
DK0432648T3 (da)	1995-11-06
NO905320L (no)	1991-06-12

Legal Events

Date	Code	Title	Description
1991-09-30	BB1A	Laying open of patent application	Effective date: 19910509
1998-04-30	FG3A	Patent granted, date of granting	Effective date: 19980113
1999-10-29	TE3A	Change of address (patent)	Owner name: NEUROSEARCH A/S Effective date: 19990730
2004-12-31	NF3A	Restitutio in integrum	Free format text: RESTITUTIO IN INTEGRUM Effective date: 19901211
2006-09-29	MM3A	Annulment or lapse	Effective date: 20060713

Publication	Publication Date	Title
NO921000D0 (no)	1992-03-13	Hydrazonderivater, fremgangsmaate for fremstilling derav samt anvendelse derav
FI890508A0 (fi)	1989-02-02	Menetelmä farmaseuttisesti aktiivisten 3-indolipalorypälehappojohdannaisten valmistamiseksi
NO905253L (no)	1991-06-07	Fremgangsmaate for fremstilling av substituerte cykloheksanoler.
PT85055A (pt)	1988-07-01	Processo para a preparacao de composicoes farmaceuticas contendo ester metilico da levodopa
NO905320D0 (no)	1990-12-10	Fremgangsmaate for fremstilling av isatinderivater.
EA200000592A1 (ru)	2000-12-25	Азаполициклические соединения, конденсированные с арилом
PT93947A (pt)	1991-01-08	Processo para a preparacao de novos derivados de maleinimidas e de composicoes farmaceuticas que os contem
FR2737725B1 (fr)	1997-10-31	Nouveaux derives acyles de la melatonine et d'analogues melatoninergiques, leur procede de preparation et leur utilisation en tant que medicament
PT99445A (pt)	1992-09-30	Processo para preparacao de derivados do 1,4,7,10-tetraazaciclododecano mono-n--substituidos e de composicoes farmaceuticas que os contem
PT92714A (pt)	1990-06-29	Processo de preparacao de compostos de quinoxalina e de composicoes farmaceuticas que os contem
PT82032B (pt)	1988-07-01	Processo para a preparacao de derivados de aminoacidos com accao anticonvulsiva e de composicoes farmaceuticas que os contem
ES2157565T3 (es)	2001-08-16	N-azacicloalquilalquildibenzotiofenocarboxamidas: ligandos especificos de un subtipo de receptor de la dopamina.
PT90865A (pt)	1989-12-29	Processo para a preparacao de compostos de imidazoquinoxalina e de composicoes farmaceuticas que os contem
NO905254D0 (no)	1990-12-05	Fremgangsmaate for fremstilling av substituerte cykloheksener.
PT92952A (pt)	1990-07-31	Processo para a preparacao de acidos 3-fenil-5,6-di-hidrobenz { c }acridina-7- carboxilicos, de compostos relacionados e de composicoes farmaceuticas que os contem
PT82550B (pt)	1988-08-17	Processo de preparacao de derivados de 1,3-oxatiano e de composicoes farmaceuticas que os contem
DE69827706D1 (de)	2004-12-30	5-(Heteroaryl)alkyl)-3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid (PBI) Derivate zur Behandlung von Störungen des zentralen Nervensystems
PT92155A (pt)	1990-05-31	Processo para a preparacao de derivados de acidos 2-amino-carboxilicos e de composicoes farmaceuticas que os contem
PT89350A (pt)	1989-12-29	Processo para a preparacao de uma combinacao sinergistica de inibidores de descarboxilase e de l-dopa e de composicoes farmaceuticas que a contem
DK0865422T3 (da)	2001-10-22	Anvendelse af aminoalkoholderivater som lægemidler, hidtil ukendte derivater og fremgangsmåde til fremstilling deraf
ES2094850T3 (es)	1997-02-01	Nuevos derivados de isatinoxima, su preparacion y su utilizacion.