GR3019512T3 - Immunoassay reagents and method for determining cyclosporine - Google Patents

Immunoassay reagents and method for determining cyclosporine

Info

Publication number: GR3019512T3
Authority: GR; Greece
Prior art keywords: cyclosporine; amino acid; immunoassay; disclosed; immunoassay reagents
Prior art date: 1990-08-15

Application number

GR960400900T

Other languages

Greek (el)

English (en)

Inventor

Marjorie A Morrison

Victoria P Meucci

Steven E Lunetta

Mariola B Zajac

Elizabeth A Simpson

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-15

Filing date

1996-04-02

Publication date

1996-07-31

1996-04-02 Application filed by Abbott Lab filed Critical Abbott Lab

1996-07-31 Publication of GR3019512T3 publication Critical patent/GR3019512T3/el

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 12
108010036949 Cyclosporine Proteins 0.000 title abstract 9
229960001265 ciclosporin Drugs 0.000 title abstract 9
229930182912 cyclosporin Natural products 0.000 title abstract 9
238000003018 immunoassay Methods 0.000 title abstract 5
239000003153 chemical reaction reagent Substances 0.000 title 1
238000000034 method Methods 0.000 title 1
150000001413 amino acids Chemical class 0.000 abstract 2
230000010287 polarization Effects 0.000 abstract 2
XJODGRWDFZVTKW-LURJTMIESA-N (2s)-4-methyl-2-(methylamino)pentanoic acid Chemical compound CN[C@H](C(O)=O)CC(C)C XJODGRWDFZVTKW-LURJTMIESA-N 0.000 abstract 1
AHQFCPOIMVMDEZ-UNISNWAASA-N (e,2s,3r,4r)-3-hydroxy-4-methyl-2-(methylamino)oct-6-enoic acid Chemical compound CN[C@H](C(O)=O)[C@H](O)[C@H](C)C\C=C\C AHQFCPOIMVMDEZ-UNISNWAASA-N 0.000 abstract 1
QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000700 radioactive tracer Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Investigating Or Analysing Biological Materials (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

GR960400900T 1990-08-15 1996-04-02 Immunoassay reagents and method for determining cyclosporine GR3019512T3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US56784290A	1990-08-15	1990-08-15

Publications (1)

Publication Number	Publication Date
GR3019512T3 true GR3019512T3 (en)	1996-07-31

Family

ID=24268868

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR960400900T GR3019512T3 (en)	1990-08-15	1996-04-02	Immunoassay reagents and method for determining cyclosporine

Country Status (10)

Country	Link
US (2)	US5489668A (fr)
EP (1)	EP0473961B1 (fr)
JP (1)	JP3171460B2 (fr)
AT (1)	ATE132504T1 (fr)
AU (1)	AU642035B2 (fr)
CA (1)	CA2049089C (fr)
DE (1)	DE69116034T2 (fr)
DK (1)	DK0473961T3 (fr)
ES (1)	ES2084069T3 (fr)
GR (1)	GR3019512T3 (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69121844T2 (de) *	1990-11-20	1997-01-23	Behringwerke Ag	Immunotest für Cyclosporin
ES2148225T3 (es) *	1992-03-30	2000-10-16	Abbott Lab	Reactivos y procedimientos que permiten la deteccion y la cuantificacion de la tiroxina en muestras de fluido.
US5352803A (en) *	1992-03-30	1994-10-04	Abbott Laboratories	5(6)-methyl substituted fluorescein derivatives
GB9307491D0 (en) *	1993-04-08	1993-06-02	Sandoz Ltd	Organic compounds
USRE40596E1 (en) *	1993-04-08	2008-12-02	Novartis Ag	Rapamycin assay
US7279561B1 (en)	1993-04-23	2007-10-09	Wyeth	Anti-rapamycin monoclonal antibodies
US5504091A (en) *	1993-04-23	1996-04-02	American Home Products Corporation	Biotin esters of rapamycin
DE69435044T2 (de)	1993-04-23	2008-09-18	Wyeth	Rapamycin - Konjugate und Antikörper
US5393891A (en) *	1993-06-08	1995-02-28	The Du Pont Merck Pharmaceutical Company	Immunoassay reagents and methods for detecting brequinar and analogs
US5650288A (en) *	1995-07-14	1997-07-22	Macfarlane; Gordon D.	Immunophilin-bound immunosuppressant assay
EP0991660B8 (fr)	1997-10-08	2006-04-05	Isotechnika,Inc.	ANALOGUES DE CYCLOSPORINE DEUTERES et non-deuteres ET LEUR UTILISATION COMME IMMUNOMODULATEURS
US20030220234A1 (en) *	1998-11-02	2003-11-27	Selvaraj Naicker	Deuterated cyclosporine analogs and their use as immunodulating agents
US5990274A (en)	1997-11-25	1999-11-23	Dade Behring Inc.	Cyclosporine derivatives and uses thereof
US8569516B2 (en)	2001-09-07	2013-10-29	Elitech Holding B.V.	Compounds and methods for fluorescent labeling
US6972339B2 (en)	2001-09-07	2005-12-06	Epoch Biosciences, Inc.	Compounds and methods for fluorescent labeling
US7141648B2 (en)	2001-10-19	2006-11-28	Isotechnika Inc.	Synthesis of cyclosporin analogs
KR100444698B1 (ko) *	2001-11-08	2004-08-21	한국과학기술연구원	면역복합체 단일검출시약, 그의 제조방법 및 그를 이용한농약의 검출방법
EP1603512A2 (fr)	2003-03-17	2005-12-14	Albany Molecular Research, Inc.	Nouvelles cyclosporines
US7378391B2 (en)	2004-09-29	2008-05-27	Amr Technology, Inc.	Cyclosporin alkyne analogues and their pharmaceutical uses
WO2006039164A2 (fr)	2004-09-29	2006-04-13	Amr Technology, Inc.	Nouveaux analogues de la cyclosporine et leurs utilisations pharmaceutiques
WO2006041631A2 (fr)	2004-10-06	2006-04-20	Amr Technology, Inc.	Alcynes de cyclosporine, et leur utilite comme agents pharmaceutiques
US8022188B2 (en) *	2006-04-24	2011-09-20	Abbott Laboratories	Immunosuppressant binding antibodies and methods of obtaining and using same
US7883855B2 (en) *	2006-07-21	2011-02-08	Abbott Laboratories	Immunosuppressant drug extraction reagent for immunoassays
WO2008069917A2 (fr)	2006-11-20	2008-06-12	Scynexis, Inc.	Nouveaux peptides cycliques
US7914999B2 (en) *	2006-12-29	2011-03-29	Abbott Laboratories	Non-denaturing lysis reagent
WO2008082979A2 (fr) *	2006-12-29	2008-07-10	Abbott Laboratories	Essai diagnostique pour la détection d'une molécule ou d'un médicament dans du sang entier
CA2673314C (fr) *	2006-12-29	2014-03-11	Abbott Laboratories	Reactif de lyse non denaturante destine a etre utilise en immunoessai de capture en solution
CA2673296C (fr) *	2006-12-29	2012-10-16	Abbott Laboratories	Dosage ameliore de medicaments immunosuppresseurs
US8288111B2 (en)	2007-05-24	2012-10-16	Abbott Laboratories	Immunoassays exhibiting reduced cross-reactivity with hydrophobic drug analyte metabolites
BRPI0722361B8 (pt) *	2007-12-19	2021-07-27	Abbott Lab	métodos para avaliar a concentração de um fármaco imunossupressor em uma amostra de sangue humano, composição de reagente de extração e kit de teste
US20090170218A1 (en) *	2008-01-02	2009-07-02	Dade Behring Inc.	Methods for detection of cyclosporin a
CN110320364B (zh) *	2018-03-30	2023-03-31	洛阳普泰生物技术有限公司	一种双抗夹心胶体金检测试剂盒、及其制备方法与应用
US12345641B2 (en)	2020-04-17	2025-07-01	IDEZZ Laboratories, Inc.	Fluorescence quenching immunoassay
JP7755932B2 (ja) *	2021-01-08	2025-10-17	ＴｉａｎｍａＪａｐａｎ株式会社	蛍光偏光免疫分析用支持体、蛍光偏光免疫分析用キットおよび蛍光偏光免疫分析法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1023287A (fr) *	1972-12-08	1977-12-27	Boehringer Mannheim G.M.B.H.	Procede de fixation d'une proteine sur un substrat
US4117118A (en) *	1976-04-09	1978-09-26	Sandoz Ltd.	Organic compounds
DE2819094A1 (de) *	1977-05-10	1978-11-23	Sandoz Ag	Cyclosporin-derivate, ihre verwendung und herstellung
ATE92501T1 (de) *	1984-10-04	1993-08-15	Sandoz Ag	Monoklonale antikoerper gegen zyklosporine.
US5169773A (en) *	1984-10-04	1992-12-08	Sandoz Ltd.	Monoclonal antibodies to cyclosporins
US4727035A (en) *	1984-11-14	1988-02-23	Mahoney Walter C	Immunoassay for cyclosporin
US5124457A (en) *	1986-05-21	1992-06-23	Abbott Laboratories	Phencyclidine and phencyclidine metabolites assay, tracers, immunogens and antibodies
US4939264A (en) *	1986-07-14	1990-07-03	Abbott Laboratories	Immunoassay for opiate alkaloids and their metabolites; tracers, immunogens and antibodies
US5427960A (en) *	1987-03-27	1995-06-27	Abbott Laboratories	Fluorescence polarization assay for cyclosporin A and metabolites and related immunogens and antibodies
US5239057A (en) *	1987-03-27	1993-08-24	Abbott Laboratories	Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies
EP0283801A3 (fr) *	1987-03-27	1990-05-30	Abbott Laboratories	Essais de polarisation par fluorescence pour cyclosporine A et les métabolites et immunogènes et anticorps apparentés
EP0329184A3 (fr) *	1988-02-19	1990-05-23	Neorx Corporation	Antimères et conjugaison antimère

1991
- 1991-08-08 EP EP91113328A patent/EP0473961B1/fr not_active Expired - Lifetime
- 1991-08-08 ES ES91113328T patent/ES2084069T3/es not_active Expired - Lifetime
- 1991-08-08 DK DK91113328.8T patent/DK0473961T3/da active
- 1991-08-08 DE DE69116034T patent/DE69116034T2/de not_active Expired - Fee Related
- 1991-08-08 AT AT91113328T patent/ATE132504T1/de not_active IP Right Cessation
- 1991-08-13 CA CA002049089A patent/CA2049089C/fr not_active Expired - Fee Related
- 1991-08-14 AU AU82471/91A patent/AU642035B2/en not_active Ceased
- 1991-08-15 JP JP20523391A patent/JP3171460B2/ja not_active Expired - Fee Related
1993
- 1993-11-04 US US08/148,164 patent/US5489668A/en not_active Expired - Lifetime
1995
- 1995-05-04 US US08/433,104 patent/US5750413A/en not_active Expired - Lifetime
1996
- 1996-04-02 GR GR960400900T patent/GR3019512T3/el unknown

Also Published As

Publication number	Publication date
AU8247191A (en)	1992-02-20
EP0473961B1 (fr)	1996-01-03
EP0473961A2 (fr)	1992-03-11
ATE132504T1 (de)	1996-01-15
AU642035B2 (en)	1993-10-07
DE69116034D1 (de)	1996-02-15
DE69116034T2 (de)	1996-06-20
DK0473961T3 (da)	1996-07-01
EP0473961A3 (en)	1993-04-14
CA2049089C (fr)	2002-09-03
CA2049089A1 (fr)	1992-02-16
JPH04253999A (ja)	1992-09-09
US5750413A (en)	1998-05-12
JP3171460B2 (ja)	2001-05-28
ES2084069T3 (es)	1996-05-01
US5489668A (en)	1996-02-06

Publication	Publication Date	Title
GR3019512T3 (en)	1996-07-31	Immunoassay reagents and method for determining cyclosporine
DK261386A (da)	1986-06-03	Monoklonale antistoffer
ES2181734T3 (es)	2003-03-01	Ensayo inmunologico de ciclosporina.
CA2191950A1 (fr)	1995-12-14	Peptides marques au technetium-99m pour l'imagerie
CA2140794A1 (fr)	1995-08-08	Methode de detection des proteines d'un echantillon biologique
EP0363110A3 (fr)	1991-07-17	Composition d'extraction ayant un pH élevé et son utilisation pour déterminer des antigènes de chlamydia, de gonocoque ou d'herpes
EP0869177A3 (fr)	1999-10-20	Récepteurs humains du facteur de croissance dérivé des plaquettes du type A et B
CA2001206A1 (fr)	1990-05-18	Support pour phosphatase alcaline et methode d'analyse a l'aide de ce support
CA2106563A1 (fr)	1993-06-17	Derives de cocaine, conjugues de derives de cocaine avec des proteines et des polypeptides et composes marqueurs
CA2100586A1 (fr)	1992-08-09	Antigenes peptidiques de htlv-i et de htlv-ii et methodes d'utilisation
CS34889A2 (en)	1990-08-14	Method of affinitive-enzymatic compounds preparation for cholesterol's visul indication
FI912054A0 (fi)	1991-04-29	Entsymaattinen menetelmä -laktaamiantibioottien määrittämiseksi
CA2247009A1 (fr)	1997-09-25	Peptides cryptiques et leur procede d'identification
CA2223090A1 (fr)	1996-12-19	Conjugues haptene/peptide ameliores utilises pour detecter des anticorps anti-vih1 ou anti-vih2
WO1997024621A3 (fr)	1997-08-14	Reactifs permettant de mesurer des teneurs en plomb au moyen de la quantification du porphobilinogene
EP0642023A4 (fr)	1997-05-14	Reactif et procede pour depister l'hepatite c.
NO924226L (no)	1992-12-08	Proteinnukleinsyreprober og immunoanalyser som anvender disse
EP0379347A3 (fr)	1992-04-08	Composition de récepteur margue par une enzyme, trousse diagnostique et son utilisation pour déterminer un ligand