GR3020268T3 - 4-Amino-delta4,6-steroids and their use as 5alpha-reductase inhibitors - Google Patents

4-Amino-delta4,6-steroids and their use as 5alpha-reductase inhibitors

Info

Publication number: GR3020268T3
Authority: GR; Greece
Prior art keywords: steroids; amino; delta4; 5alpha; reductase inhibitors
Prior art date: 1990-08-01

Application number

GR960401647T

Other languages

English (en)

Inventor

Philip M Weintraub

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-01

Filing date

1996-06-19

Publication date

1996-09-30

1991-03-19 Priority claimed from US07/671,555 external-priority patent/US5143909A/en

1991-07-02 Priority claimed from US07/720,899 external-priority patent/US5130424A/en

1996-06-19 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

1996-09-30 Publication of GR3020268T3 publication Critical patent/GR3020268T3/el

Links

239000002677 5-alpha reductase inhibitor Substances 0.000 title 1
PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 abstract 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 2
108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 abstract 1
239000004593 Epoxy Substances 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000012442 inert solvent Substances 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
150000003431 steroids Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0011—Unsubstituted amino radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

GR960401647T 1990-08-01 1996-06-19 4-Amino-delta4,6-steroids and their use as 5alpha-reductase inhibitors GR3020268T3 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US56141090A	1990-08-01	1990-08-01
US07/671,555 US5143909A (en)	1991-03-19	1991-03-19	Aminosteroids in a method for inhibiting c17-20 lyase
US07/720,899 US5130424A (en)	1990-08-01	1991-07-02	4-amino-delta-4,6-steroids and their use as 5 alpha-reductase inhibitors

Publications (1)

Publication Number	Publication Date
GR3020268T3 true GR3020268T3 (en)	1996-09-30

Family

ID=27415853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR960401647T GR3020268T3 (en)	1990-08-01	1996-06-19	4-Amino-delta4,6-steroids and their use as 5alpha-reductase inhibitors

Country Status (17)

Country	Link
EP (1)	EP0469547B1 (el)
JP (1)	JP3021818B2 (el)
CN (1)	CN1031574C (el)
AT (1)	ATE138073T1 (el)
AU (1)	AU642757B2 (el)
CA (1)	CA2048243C (el)
DE (1)	DE69119502T2 (el)
DK (1)	DK0469547T3 (el)
ES (1)	ES2089063T3 (el)
FI (1)	FI102378B (el)
GR (1)	GR3020268T3 (el)
HU (1)	HU210042B (el)
IE (1)	IE75199B1 (el)
IL (1)	IL98998A (el)
NO (1)	NO180197C (el)
NZ (1)	NZ239141A (el)
PT (1)	PT98519B (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0641356B1 (en) *	1991-12-20	1998-04-22	Glaxo Wellcome Inc.	Inhibitors of 5-alpha-testosterone reductase
US5302589A (en) *	1992-08-07	1994-04-12	Glaxo, Inc.	Heterocyclic inhibitors of 5-α-testosterone reductase
US5486511A (en) *	1993-05-25	1996-01-23	Merrell Dow Pharmaceuticals Inc.	4-amino-17β-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17β-(cyclopropylamino)androst-4-en-3-one and related compounds as C17-20 lyase and 5α-reductase
TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
US5356935A (en) *	1993-12-13	1994-10-18	Eli Lilly And Company	Reduced phenanthrenes
DK0758340T3 (da) *	1994-05-02	1999-08-30	Merrell Pharma Inc	Fremgangsmåde til fremstilling af 4-amino-delta 4-3-ketosteroider via 4-nitro-delta 4-3-ketosteroider
US5541322A (en) *	1994-10-14	1996-07-30	Glaxo Wellcome Inc.	Synthesis of 6-azaandrostenones
WO2001005364A1 (en) *	1999-07-15	2001-01-25	The Procter & Gamble Company	Nitrogen-containing steroid compounds and their use to regulate hair growth
JP6353939B1 (ja) *	2017-02-15	2018-07-04	横関油脂工業株式会社	油状組成物、その製法、油性基剤および皮膚外用剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1154008A (en) *	1979-05-02	1983-09-20	Thomas R. Blohm	STEROID 5.alpha.-REDUCTASE INHIBITORS
GB8503940D0 (en) *	1985-02-15	1985-03-20	Erba Farmitalia	4-substituted androstendione derivatives

1991
- 1991-07-26 AU AU81356/91A patent/AU642757B2/en not_active Ceased
- 1991-07-26 NZ NZ239141A patent/NZ239141A/en unknown
- 1991-07-29 IL IL9899891A patent/IL98998A/en active IP Right Grant
- 1991-07-30 DE DE69119502T patent/DE69119502T2/de not_active Expired - Fee Related
- 1991-07-30 EP EP91112795A patent/EP0469547B1/en not_active Expired - Lifetime
- 1991-07-30 DK DK91112795.9T patent/DK0469547T3/da active
- 1991-07-30 ES ES91112795T patent/ES2089063T3/es not_active Expired - Lifetime
- 1991-07-30 AT AT91112795T patent/ATE138073T1/de not_active IP Right Cessation
- 1991-07-31 IE IE270691A patent/IE75199B1/en not_active IP Right Cessation
- 1991-07-31 HU HU912559A patent/HU210042B/hu not_active IP Right Cessation
- 1991-07-31 NO NO912982A patent/NO180197C/no not_active IP Right Cessation
- 1991-07-31 CA CA002048243A patent/CA2048243C/en not_active Expired - Fee Related
- 1991-07-31 FI FI913658A patent/FI102378B/fi active
- 1991-07-31 PT PT98519A patent/PT98519B/pt not_active IP Right Cessation
- 1991-08-01 CN CN91105278A patent/CN1031574C/zh not_active Expired - Fee Related
- 1991-08-01 JP JP3214162A patent/JP3021818B2/ja not_active Expired - Lifetime
1996
- 1996-06-19 GR GR960401647T patent/GR3020268T3/el unknown

Also Published As

Publication number	Publication date
FI102378B1 (fi)	1998-11-30
JP3021818B2 (ja)	2000-03-15
EP0469547A2 (en)	1992-02-05
CN1031574C (zh)	1996-04-17
IL98998A (en)	1996-01-19
NO912982L (no)	1992-02-03
PT98519A (pt)	1992-06-30
FI913658A0 (fi)	1991-07-31
ES2089063T3 (es)	1996-10-01
IE75199B1 (en)	1997-08-27
NO912982D0 (no)	1991-07-31
DE69119502T2 (de)	1996-09-26
CN1059150A (zh)	1992-03-04
ATE138073T1 (de)	1996-06-15
AU8135691A (en)	1992-02-06
IL98998A0 (en)	1992-07-15
PT98519B (pt)	1999-01-29
NO180197B (no)	1996-11-25
FI913658L (fi)	1992-02-02
NZ239141A (en)	1994-04-27
HU912559D0 (en)	1992-01-28
CA2048243A1 (en)	1992-02-02
AU642757B2 (en)	1993-10-28
HU210042B (en)	1995-01-30
HUT59157A (en)	1992-04-28
DE69119502D1 (de)	1996-06-20
DK0469547T3 (da)	1996-06-10
EP0469547B1 (en)	1996-05-15
FI102378B (fi)	1998-11-30
JPH05320189A (ja)	1993-12-03
IE912706A1 (en)	1992-02-12
NO180197C (no)	1997-03-05
CA2048243C (en)	2003-04-08
EP0469547A3 (en)	1992-06-03

Publication	Publication Date	Title
IE791565L (en)	1980-02-29	Crop cutting apparatus
TW358110B (en)	1999-05-11	Mixture of polyalkylpiperidin-4-yl dicarboxylic acid esters as stabilizers for organic materials
IL98998A0 (en)	1992-07-15	4-amino-delta 4,6-steroids and their use as 5alpha-reductase inhibitors
CA2196900A1 (en)	1996-02-15	Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells
ATE19058T1 (de)	1986-04-15	Substituierte hydroxymalonsaeurediamide, verfahren zu ihrer herstellung sowie ihre verwendung als schaedlingsbekaempfungsmittel.
NO912981D0 (no)	1991-07-31	Fremgangsmaate for fremstilling av 4-amino-delta4-steroider
AU563990B2 (en)	1987-07-30	Hexahydropyrrolo (2,1-a) isoquinoline derivatives
JPS5585551A (en)	1980-06-27	New tricycloundecane amino acid amide
AU681727B2 (en)	1997-09-04	Method for the preparation of 2-perfluoroalkyl-3-oxazolin- 5-one
KR850003889A (ko)	1985-06-29	복소환식 화합물
IE41394B1 (en)	1979-12-19	Substituted benimidazoles
IT1151532B (it)	1986-12-24	Procedimento per la preparazione di p. clorofenossiacetil-piperonilpiperazina
Boyer et al.	1982	Oxidation at nitrogen in benzo-benzodi-and benzotrifuroxans
JPS6479158A (en)	1989-03-24	2-nitroimidazole derivative
JPS6440463A (en)	1989-02-10	Novel nitrobenzene derivative
KR940005542A (ko)	1994-03-21	친전자성 반응에 의한 방향족 화합물의 제조방법 및 방향족 화합물 유도체
JPS5697291A (en)	1981-08-05	Preparation of rifamycin derivative
JPS56147769A (en)	1981-11-16	Preparation of n-substituted piperidinol derivative
JPS57156447A (en)	1982-09-27	Ether compound and its synthesis
JPS5646882A (en)	1981-04-28	3-aminorifamycin derivative and its novel preparation
KR970061895A (ko)	1997-09-12	3-할로메틸-3-세펨의 신규 제조 방법