PT98519A - Processo para a preparacao de 4-amino-delta 4,6-esteroides com accao inibidora da 5-alfa-redutase - Google Patents

Processo para a preparacao de 4-amino-delta 4,6-esteroides com accao inibidora da 5-alfa-redutase

Info

Publication number: PT98519A
Authority: PT; Portugal
Prior art keywords: steroids; delta; alpha; amino; redutase
Prior art date: 1990-08-01

Application number

PT98519A

Other languages

English (en)

Other versions

PT98519B (pt

Inventor

Philip Marvin Weintraub

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-08-01

Filing date

1991-07-31

Publication date

1992-06-30

1991-03-19 Priority claimed from US07/671,555 external-priority patent/US5143909A/en

1991-07-02 Priority claimed from US07/720,899 external-priority patent/US5130424A/en

1991-07-31 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1992-06-30 Publication of PT98519A publication Critical patent/PT98519A/pt

1999-01-29 Publication of PT98519B publication Critical patent/PT98519B/pt

Links

239000003112 inhibitor Substances 0.000 title abstract 2
PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 abstract 2
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 2
108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 abstract 1
239000004593 Epoxy Substances 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000012442 inert solvent Substances 0.000 abstract 1
150000003431 steroids Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0011—Unsubstituted amino radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

PT98519A 1990-08-01 1991-07-31 Processo para a preparacao de 4-amino-delta 4,6-esteroides com accao inibidora da 5-alfa-redutase PT98519B (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US56141090A	1990-08-01	1990-08-01
US07/671,555 US5143909A (en)	1991-03-19	1991-03-19	Aminosteroids in a method for inhibiting c17-20 lyase
US07/720,899 US5130424A (en)	1990-08-01	1991-07-02	4-amino-delta-4,6-steroids and their use as 5 alpha-reductase inhibitors

Publications (2)

Publication Number	Publication Date
PT98519A true PT98519A (pt)	1992-06-30
PT98519B PT98519B (pt)	1999-01-29

Family

ID=27415853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT98519A PT98519B (pt)	1990-08-01	1991-07-31	Processo para a preparacao de 4-amino-delta 4,6-esteroides com accao inibidora da 5-alfa-redutase

Country Status (17)

Country	Link
EP (1)	EP0469547B1 (pt)
JP (1)	JP3021818B2 (pt)
CN (1)	CN1031574C (pt)
AT (1)	ATE138073T1 (pt)
AU (1)	AU642757B2 (pt)
CA (1)	CA2048243C (pt)
DE (1)	DE69119502T2 (pt)
DK (1)	DK0469547T3 (pt)
ES (1)	ES2089063T3 (pt)
FI (1)	FI102378B (pt)
GR (1)	GR3020268T3 (pt)
HU (1)	HU210042B (pt)
IE (1)	IE75199B1 (pt)
IL (1)	IL98998A (pt)
NO (1)	NO180197C (pt)
NZ (1)	NZ239141A (pt)
PT (1)	PT98519B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0641356B1 (en) *	1991-12-20	1998-04-22	Glaxo Wellcome Inc.	Inhibitors of 5-alpha-testosterone reductase
US5302589A (en) *	1992-08-07	1994-04-12	Glaxo, Inc.	Heterocyclic inhibitors of 5-α-testosterone reductase
US5486511A (en) *	1993-05-25	1996-01-23	Merrell Dow Pharmaceuticals Inc.	4-amino-17β-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17β-(cyclopropylamino)androst-4-en-3-one and related compounds as C17-20 lyase and 5α-reductase
TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
US5356935A (en) *	1993-12-13	1994-10-18	Eli Lilly And Company	Reduced phenanthrenes
DK0758340T3 (da) *	1994-05-02	1999-08-30	Merrell Pharma Inc	Fremgangsmåde til fremstilling af 4-amino-delta 4-3-ketosteroider via 4-nitro-delta 4-3-ketosteroider
US5541322A (en) *	1994-10-14	1996-07-30	Glaxo Wellcome Inc.	Synthesis of 6-azaandrostenones
WO2001005364A1 (en) *	1999-07-15	2001-01-25	The Procter & Gamble Company	Nitrogen-containing steroid compounds and their use to regulate hair growth
JP6353939B1 (ja) *	2017-02-15	2018-07-04	横関油脂工業株式会社	油状組成物、その製法、油性基剤および皮膚外用剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1154008A (en) *	1979-05-02	1983-09-20	Thomas R. Blohm	STEROID 5.alpha.-REDUCTASE INHIBITORS
GB8503940D0 (en) *	1985-02-15	1985-03-20	Erba Farmitalia	4-substituted androstendione derivatives

1991
- 1991-07-26 AU AU81356/91A patent/AU642757B2/en not_active Ceased
- 1991-07-26 NZ NZ239141A patent/NZ239141A/en unknown
- 1991-07-29 IL IL9899891A patent/IL98998A/en active IP Right Grant
- 1991-07-30 DE DE69119502T patent/DE69119502T2/de not_active Expired - Fee Related
- 1991-07-30 EP EP91112795A patent/EP0469547B1/en not_active Expired - Lifetime
- 1991-07-30 DK DK91112795.9T patent/DK0469547T3/da active
- 1991-07-30 ES ES91112795T patent/ES2089063T3/es not_active Expired - Lifetime
- 1991-07-30 AT AT91112795T patent/ATE138073T1/de not_active IP Right Cessation
- 1991-07-31 IE IE270691A patent/IE75199B1/en not_active IP Right Cessation
- 1991-07-31 HU HU912559A patent/HU210042B/hu not_active IP Right Cessation
- 1991-07-31 NO NO912982A patent/NO180197C/no not_active IP Right Cessation
- 1991-07-31 CA CA002048243A patent/CA2048243C/en not_active Expired - Fee Related
- 1991-07-31 FI FI913658A patent/FI102378B/fi active
- 1991-07-31 PT PT98519A patent/PT98519B/pt not_active IP Right Cessation
- 1991-08-01 CN CN91105278A patent/CN1031574C/zh not_active Expired - Fee Related
- 1991-08-01 JP JP3214162A patent/JP3021818B2/ja not_active Expired - Lifetime
1996
- 1996-06-19 GR GR960401647T patent/GR3020268T3/el unknown

Also Published As

Publication number	Publication date
FI102378B1 (fi)	1998-11-30
JP3021818B2 (ja)	2000-03-15
EP0469547A2 (en)	1992-02-05
GR3020268T3 (en)	1996-09-30
CN1031574C (zh)	1996-04-17
IL98998A (en)	1996-01-19
NO912982L (no)	1992-02-03
FI913658A0 (fi)	1991-07-31
ES2089063T3 (es)	1996-10-01
IE75199B1 (en)	1997-08-27
NO912982D0 (no)	1991-07-31
DE69119502T2 (de)	1996-09-26
CN1059150A (zh)	1992-03-04
ATE138073T1 (de)	1996-06-15
AU8135691A (en)	1992-02-06
IL98998A0 (en)	1992-07-15
PT98519B (pt)	1999-01-29
NO180197B (no)	1996-11-25
FI913658L (fi)	1992-02-02
NZ239141A (en)	1994-04-27
HU912559D0 (en)	1992-01-28
CA2048243A1 (en)	1992-02-02
AU642757B2 (en)	1993-10-28
HU210042B (en)	1995-01-30
HUT59157A (en)	1992-04-28
DE69119502D1 (de)	1996-06-20
DK0469547T3 (da)	1996-06-10
EP0469547B1 (en)	1996-05-15
FI102378B (fi)	1998-11-30
JPH05320189A (ja)	1993-12-03
IE912706A1 (en)	1992-02-12
NO180197C (no)	1997-03-05
CA2048243C (en)	2003-04-08
EP0469547A3 (en)	1992-06-03

Legal Events

Date

Code

Title

Description

1992-06-30

BB1A

Laying open of patent application

Effective date: 19920204

1999-01-29

FG3A

Patent granted, date of granting

Effective date: 19981009

2004-07-30

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20040430

Publication	Publication Date	Title
BR9812895A (pt)	2000-08-08	Processo para a preparação de derivados de triazolintiona
FI913658A0 (fi)	1991-07-31	4-amino-d4,6-steroider och deras anvaendning som 5a-reduktas-inhibitorer.
PT98518A (pt)	1992-06-30	Processo para a preparacao de 4-amino-delta-4-esteroides com accao inibidora da5alfa-redutase
KR830009015A (ko)	1983-12-17	메르캅토 아실 카르니틴 에스테르류의 제조방법
DE69809888D1 (de)	2003-01-16	Verfahren zur Herstellung von alpha-Aminoketonen
DE3781383D1 (de)	1992-10-01	2,2-dimethylcyclopropancarbonsaeurederivate, die eine gesaettigte halogenierte kette an c-3 tragen, verfahren und zwischenprodukte zu ihrer herstellung, ihre verwendung als pestizide und sie enthaltende zusammensetzungen.
GB977071A (en)	1964-12-02	Hydroxylamine derivatives and process for making them
AU563990B2 (en)	1987-07-30	Hexahydropyrrolo (2,1-a) isoquinoline derivatives
KR870011102A (ko)	1987-12-21	치환된 안트라〔1,9-cd〕피라졸-6(2H)-온 제조의 개선된 방법
ES2194361T3 (es)	2003-11-16	Procedimiento y compuestos intermedios para la preparacion de un herbicida de triazol.
KR960007577A (ko)	1996-03-22	2-시아노이미노티아졸리딘 제조방법
ATE19065T1 (de)	1986-04-15	Verfahren zur herstellung von 1-(4-chlorbenzoyl)5-methoxy-2-methyl-3-indolacetoxyessigs\|ure.
KR970061866A (ko)	1997-09-12	아세토니트릴을 용매로 사용하는 3-니트로-9-에틸카바졸의 제조방법
ATE244228T1 (de)	2003-07-15	Verfahren zur herstellung von chloroacetylaminothiazoleaceticsäure derivate
JPS6440463A (en)	1989-02-10	Novel nitrobenzene derivative
DE69702171D1 (de)	2000-07-06	Verfahren zur Herstellung von Aminoalkynen
KR970061898A (ko)	1997-09-12	세팔로스포린 중간체의 제조방법
JPH01283261A (ja)	1989-11-14	アルキル化方法
KR970061895A (ko)	1997-09-12	3-할로메틸-3-세펨의 신규 제조 방법
KR940018364A (ko)	1994-08-16	신규한 엔(n)-아릴설포닐-2-이미다졸리디논 유도체 및 그의 제조방법
KR970006299A (ko)	1997-02-19	란소프라졸의 제조방법
KR880000445A (ko)	1988-03-25	7-아미노-3-알콕시메틸-3-세펨-4-카복실산 유도체의 제조방법
KR930012788A (ko)	1993-07-21	7-adca 유도체의 제조방법
FI851073L (fi)	1985-09-20	Inhibitor foer dopamin- -hydroxylas.
ES8204430A1 (es)	1982-05-01	Un procedimiento para la preparacion de derivados de acidos fenil-alcanoicos.