GR3023680T3 - Use of rapamycin for the manufacture of a medicament for the treatment of immunoinflammatory diseases - Google Patents

Use of rapamycin for the manufacture of a medicament for the treatment of immunoinflammatory diseases

Info

Publication number: GR3023680T3
Authority: GR; Greece
Prior art keywords: medicament; rapamycin; manufacture; treatment; immunoinflammatory diseases
Prior art date: 1991-09-17

Application number

GR970401324T

Other languages

English (en)

Inventor

Craig Eugene Caufield

John Henry Musser

Surendra Nath Sehgal

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-09-17

Filing date

1997-06-04

Publication date

1997-09-30

1997-06-04 Application filed by American Home Prod filed Critical American Home Prod

1997-09-30 Publication of GR3023680T3 publication Critical patent/GR3023680T3/el

Links

239000003814 drug Substances 0.000 title abstract 4
201000010099 disease Diseases 0.000 title abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
230000000495 immunoinflammatory effect Effects 0.000 title abstract 2
ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title abstract 2
229960002930 sirolimus Drugs 0.000 title abstract 2
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
229930105110 Cyclosporin A Natural products 0.000 abstract 1
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 1
108010036949 Cyclosporine Proteins 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
229960001265 ciclosporin Drugs 0.000 abstract 1
239000002552 dosage form Substances 0.000 abstract 1
230000000699 topical effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Dermatology (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

GR970401324T 1991-09-17 1997-06-04 Use of rapamycin for the manufacture of a medicament for the treatment of immunoinflammatory diseases GR3023680T3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US76112091A	1991-09-17	1991-09-17

Publications (1)

Publication Number	Publication Date
GR3023680T3 true GR3023680T3 (en)	1997-09-30

Family

ID=25061205

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR970401324T GR3023680T3 (en)	1991-09-17	1997-06-04	Use of rapamycin for the manufacture of a medicament for the treatment of immunoinflammatory diseases

Country Status (23)

Country	Link
US (1)	US5286730A (el)
EP (1)	EP0533433B1 (el)
JP (1)	JP2810599B2 (el)
KR (1)	KR100299394B1 (el)
AT (1)	ATE151289T1 (el)
AU (1)	AU659868B2 (el)
CA (1)	CA2078379C (el)
CZ (1)	CZ281900B6 (el)
DE (1)	DE69218864T2 (el)
DK (1)	DK0533433T3 (el)
ES (1)	ES2100297T3 (el)
GR (1)	GR3023680T3 (el)
HK (1)	HK108697A (el)
HU (1)	HU211112B (el)
IL (3)	IL103189A (el)
MX (1)	MX9205202A (el)
NZ (2)	NZ328124A (el)
PH (1)	PH30270A (el)
SG (1)	SG43126A1 (el)
SK (1)	SK279521B6 (el)
TW (1)	TW212759B (el)
UA (1)	UA27742C2 (el)
ZA (1)	ZA927010B (el)

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US5480988A (en) *	1992-10-13	1996-01-02	American Home Products Corporation	Carbamates of rapamycin
US5489680A (en) *	1992-10-13	1996-02-06	American Home Products Corporation	Carbamates of rapamycin
US5434260A (en) *	1992-10-13	1995-07-18	American Home Products Corporation	Carbamates of rapamycin
CH686761A5 (de) *	1993-05-27	1996-06-28	Sandoz Ag	Galenische Formulierungen.
AT408520B (de) *	1993-05-27	2001-12-27	Novartis Erfind Verwalt Gmbh	Galenische formulierungen
DE4329503A1 (de) *	1993-09-01	1995-03-02	Galenik Labor Freiburg Gmbh	Pharmazeutische Präparate zur gezielten Behandlung von Morbus Crohn und Colitis Ulcerosa
US6204243B1 (en)	1993-09-01	2001-03-20	Novatis Ag	Pharmaceutical preparations for the targeted treatment of crohn's disease and ulcerative colitis
WO1995014023A1 (en) *	1993-11-19	1995-05-26	Abbott Laboratories	Semisynthetic analogs of rapamycin (macrolides) being immunomodulators
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FR2736550B1 (fr)	1995-07-14	1998-07-24	Sandoz Sa	Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
WO1997031020A1 (en) *	1996-02-22	1997-08-28	The General Hospital Corporation	METHODS AND COMPOSITIONS FOR ENHANCING CELLULAR RESPONSE TO TGF-β LIGANDS
WO1998004279A1 (en) *	1996-07-30	1998-02-05	Novartis Ag	Pharmaceutical compositions for the treatment of transplant rejection, autoimmune or inflammatory conditions comprising cyclosporin a and 40-0-(2-hydroxiethyl)-rapamycin
CA2270373A1 (en) *	1996-10-31	1998-05-07	American Home Products Corporation	Synergistic composition comprising rapamycin and calcitriol
DE19844397A1 (de) *	1998-09-28	2000-03-30	Hilti Ag	Abrasive Schneidkörper enthaltend Diamantpartikel und Verfahren zur Herstellung der Schneidkörper
US6670355B2 (en) *	2000-06-16	2003-12-30	Wyeth	Method of treating cardiovascular disease
CA2421485A1 (en)	2000-09-19	2002-03-28	Wyeth	Water soluble rapamycin esters
US6399625B1 (en)	2000-09-27	2002-06-04	Wyeth	1-oxorapamycins
US6440991B1 (en)	2000-10-02	2002-08-27	Wyeth	Ethers of 7-desmethlrapamycin
US6399626B1 (en)	2000-10-02	2002-06-04	Wyeth	Hydroxyesters of 7-desmethylrapamycin
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TWI286074B (en)	2000-11-15	2007-09-01	Wyeth Corp	Pharmaceutical composition containing CCI-779 as an antineoplastic agent
KR20020050135A (ko) *	2000-12-20	2002-06-26	조명재	피부 주름 예방 및 완화를 목적으로 하는 피부 외용 조성물
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TWI233359B (en) *	2001-04-06	2005-06-01	Wyeth Corp	Pharmaceutical composition for treating neoplasm
US20020198137A1 (en) *	2001-06-01	2002-12-26	Wyeth	Antineoplastic combinations
UA77200C2 (en)	2001-08-07	2006-11-15	Wyeth Corp	Antineoplastic combination of cci-779 and bkb-569
CA2455311A1 (en)	2001-08-22	2003-03-06	Wyeth	Rapamycin dialdehydes
EP1419154B1 (en)	2001-08-22	2005-10-05	Wyeth	Rapamycin 29-enols
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EP1389480A1 (en) *	2002-08-14	2004-02-18	Mondobiotech Interferon SA	Therapeutical use of guanylhydrazones for the inhibition of CD83 dependent processes and dendritic cell maturation
DE60324609D1 (de) *	2002-09-17	2008-12-18	Wyeth Corp	GRANULIERTE FORMULIERUNG DES RAPAMYCINESTERS CCl-779
AR042938A1 (es) *	2003-02-06	2005-07-06	Wyeth Corp	Uso del cci-779 en el tratamiento de la fibrosis hepatica
UA83484C2 (uk) *	2003-03-05	2008-07-25	Уайт	Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція
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1992
- 1992-08-17 US US07/931,242 patent/US5286730A/en not_active Expired - Lifetime
- 1992-09-09 SK SK2785-92A patent/SK279521B6/sk unknown
- 1992-09-09 CZ CS922785A patent/CZ281900B6/cs not_active IP Right Cessation
- 1992-09-11 MX MX9205202A patent/MX9205202A/es not_active IP Right Cessation
- 1992-09-14 ZA ZA927010A patent/ZA927010B/xx unknown
- 1992-09-14 JP JP4244549A patent/JP2810599B2/ja not_active Expired - Fee Related
- 1992-09-15 DE DE69218864T patent/DE69218864T2/de not_active Expired - Fee Related
- 1992-09-15 AT AT92308384T patent/ATE151289T1/de not_active IP Right Cessation
- 1992-09-15 EP EP92308384A patent/EP0533433B1/en not_active Expired - Lifetime
- 1992-09-15 ES ES92308384T patent/ES2100297T3/es not_active Expired - Lifetime
- 1992-09-15 NZ NZ328124A patent/NZ328124A/xx unknown
- 1992-09-15 NZ NZ244340A patent/NZ244340A/xx unknown
- 1992-09-15 SG SG1996004061A patent/SG43126A1/en unknown
- 1992-09-15 DK DK92308384.4T patent/DK0533433T3/da active
- 1992-09-16 IL IL10318992A patent/IL103189A/en not_active IP Right Cessation
- 1992-09-16 AU AU24507/92A patent/AU659868B2/en not_active Ceased
- 1992-09-16 IL IL11764092A patent/IL117640A/xx not_active IP Right Cessation
- 1992-09-16 PH PH44946A patent/PH30270A/en unknown
- 1992-09-16 KR KR1019920016795A patent/KR100299394B1/ko not_active Expired - Fee Related
- 1992-09-16 CA CA002078379A patent/CA2078379C/en not_active Expired - Fee Related
- 1992-09-16 HU HU9202955A patent/HU211112B/hu not_active IP Right Cessation
- 1992-10-02 TW TW081107842A patent/TW212759B/zh active
1993
- 1993-06-15 UA UA93002912A patent/UA27742C2/uk unknown
1996
- 1996-03-25 IL IL11764096A patent/IL117640A0/xx unknown
1997
- 1997-06-04 GR GR970401324T patent/GR3023680T3/el unknown
- 1997-06-26 HK HK108697A patent/HK108697A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK0533433T3 (da)	1997-05-12
SG43126A1 (en)	1997-10-17
IL117640A (en)	1999-08-17
ZA927010B (en)	1994-03-14
HU9202955D0 (en)	1992-12-28
IL117640A0 (en)	1996-07-23
SK278592A3 (en)	1995-03-08
PH30270A (en)	1997-02-20
UA27742C2 (uk)	2000-10-16
JPH05194529A (ja)	1993-08-03
KR100299394B1 (ko)	2001-10-22
TW212759B (el)	1993-09-11
CA2078379C (en)	2003-07-29
CA2078379A1 (en)	1993-03-18
JP2810599B2 (ja)	1998-10-15
NZ328124A (en)	2000-01-28
AU2450792A (en)	1993-03-18
EP0533433B1 (en)	1997-04-09
SK279521B6 (sk)	1998-12-02
AU659868B2 (en)	1995-06-01
MX9205202A (es)	1993-03-01
HK108697A (en)	1997-08-22
DE69218864D1 (de)	1997-05-15
IL103189A (en)	1996-08-04
ATE151289T1 (de)	1997-04-15
CZ278592A3 (en)	1993-04-14
EP0533433A1 (en)	1993-03-24
HU211112B (en)	1995-10-30
HUT64846A (en)	1994-03-28
ES2100297T3 (es)	1997-06-16
US5286730A (en)	1994-02-15
CZ281900B6 (cs)	1997-03-12
DE69218864T2 (de)	1997-07-17
NZ244340A (en)	1999-06-29
IL103189A0 (en)	1993-02-21

Publication	Publication Date	Title
NZ244340A (en)	1999-06-29	Use of rapamycin in treating immunoinflammatory skin or bowel diseases
HU9301978D0 (en)	1993-09-28	Application of complementary inhibitors in medical preparatives used for treatment of inflammatory diseases of intestines and skin
RO115700B1 (ro)	2000-05-30	Metodă de tratament cu interferon
ES2173111T3 (es)	2002-10-16	Uso de fenserina para la preparacion de medicamentos para el tratamiento de desordenes cognoscitivos.
GR3036691T3 (en)	2001-12-31	Dna sequences related to isolated fragile x syndrome
DE69424777D1 (de)	2000-07-06	3,4-diarylchromane zur behandlung von dermatitis
LT97135A (en)	1997-12-29	Use of melatonin in the manufacture of a medicament for treating patients suffering from drug addiction
LV11728A (lv)	1997-04-20	Farmaceitiska kompozicija
JPS6483020A (en)	1989-03-28	Medicinal composition for preventing or treating aids
MD1716C2 (ro)	2002-02-28	Utilizare a melatoninei pentru tratamentul pacienţilor dependenţi de benzodiazepine
NO990450L (no)	1999-01-29	Behandling av sinnslidelser
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CZ223199A3 (cs)	1999-11-17	Použití inhibitorů COMT nebo jejich farmaceuticky vhodných solí nebo esterů pro výrobu léčiva k prevenci diabetických vaskulárních dysfunkcí
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