GR3034196T3 - Nitrogen mustard prodrugs with novel lipophilic protecting groups, and processes for their production - Google Patents
Nitrogen mustard prodrugs with novel lipophilic protecting groups, and processes for their productionInfo
- Publication number
- GR3034196T3 GR3034196T3 GR20000401890T GR20000401890T GR3034196T3 GR 3034196 T3 GR3034196 T3 GR 3034196T3 GR 20000401890 T GR20000401890 T GR 20000401890T GR 20000401890 T GR20000401890 T GR 20000401890T GR 3034196 T3 GR3034196 T3 GR 3034196T3
- Authority
- GR
- Greece
- Prior art keywords
- pct
- independently
- nitrogen mustard
- date jul
- processes
- Prior art date
Links
- HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical class ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 title abstract 2
- 229960004961 mechlorethamine Drugs 0.000 title abstract 2
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 125000006239 protecting group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 102000005367 Carboxypeptidases Human genes 0.000 abstract 1
- 108010006303 Carboxypeptidases Proteins 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000004459 Nitroreductase Human genes 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- -1 carboxyethyl Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 108020001162 nitroreductase Proteins 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
- C07C271/42—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/54—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9501052.6A GB9501052D0 (en) | 1995-01-19 | 1995-01-19 | Improvements relating to prodrugs |
| PCT/GB1996/000112 WO1996022277A1 (en) | 1995-01-19 | 1996-01-19 | Nitrogen mustard prodrugs with novel lipophilic protecting groups, and processes for their production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3034196T3 true GR3034196T3 (en) | 2000-11-30 |
Family
ID=10768261
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR20000401890T GR3034196T3 (en) | 1995-01-19 | 2000-08-14 | Nitrogen mustard prodrugs with novel lipophilic protecting groups, and processes for their production |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6005002A (el) |
| EP (1) | EP0804413B1 (el) |
| JP (1) | JPH10512565A (el) |
| AT (1) | ATE193012T1 (el) |
| AU (1) | AU709251B2 (el) |
| CA (1) | CA2210347A1 (el) |
| DE (1) | DE69608412T2 (el) |
| DK (1) | DK0804413T3 (el) |
| ES (1) | ES2149445T3 (el) |
| GB (1) | GB9501052D0 (el) |
| GR (1) | GR3034196T3 (el) |
| NZ (1) | NZ298847A (el) |
| PT (1) | PT804413E (el) |
| WO (1) | WO1996022277A1 (el) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4465109B2 (ja) | 1997-12-17 | 2010-05-19 | エンゾン ファーマシューティカルズ，インコーポレーテッド | アミノ及びヒドロキシル含有生物活性剤のポリマープロドラッグ |
| WO1999039741A2 (en) | 1998-02-03 | 1999-08-12 | Inex Pharmaceuticals Corporation | Systemic delivery of serum stable plasmid lipid particles for cancer therapy |
| US6410328B1 (en) | 1998-02-03 | 2002-06-25 | Protiva Biotherapeutics Inc. | Sensitizing cells to compounds using lipid-mediated gene and compound delivery |
| US5969133A (en) * | 1998-05-22 | 1999-10-19 | Shiongi Bioresearch Corp. | Bioreductive cytotoxic agents |
| AU750381B2 (en) * | 1998-05-22 | 2002-07-18 | Shionogi Bioresearch Corp. | Bioreductive cytotoxic agents |
| US6433199B1 (en) | 1998-05-22 | 2002-08-13 | Shionogi Bioresearch Corporation | Quinone derivatives |
| GB9907414D0 (en) | 1999-03-31 | 1999-05-26 | Cancer Res Campaign Tech | Improvements relating to prodrugs |
| US6656718B2 (en) | 2000-07-07 | 2003-12-02 | Cancer Research Technology Limited | Modified carboxypeptidase enzymes and their use |
| EP1343494A4 (en) * | 2000-12-01 | 2005-08-03 | Enzon Inc | PROMOTERS TETRAPARTATES |
| MXPA03007392A (es) * | 2001-02-20 | 2003-12-04 | Enzon Inc | Enlazantes polimericos ramificados terminalmente y conjugados polimericos que contienen los mismos. |
| GB0220319D0 (en) | 2002-09-02 | 2002-10-09 | Cancer Res Campaign Tech | Enzyme activated self-immolative nitrogen mustard drugs |
| JP4723380B2 (ja) * | 2003-09-25 | 2011-07-13 | テルモ株式会社 | ポリエチレングリコール誘導体及びこれを膜構成成分とする薬物担体 |
| PT103030A (pt) * | 2003-10-17 | 2005-04-29 | Bruno Manuel Nunes Ra Carvalho | Vestuario autonomo, alimentado por paineis solares e com controlo activo da temperatura |
| US20110039943A1 (en) * | 2005-03-14 | 2011-02-17 | Robert Alonso | Methods for treating skin disorders with topical nitrogen mustard compositions |
| US8501818B2 (en) * | 2005-03-14 | 2013-08-06 | Ceptaris Therapeutics, Inc. | Stabilized compositions of alkylating agents and methods of using same |
| US7872050B2 (en) * | 2005-03-14 | 2011-01-18 | Yaupon Therapeutics Inc. | Stabilized compositions of volatile alkylating agents and methods of using thereof |
| US20070119950A1 (en) * | 2005-11-30 | 2007-05-31 | Auslander Judith D | Document edge encoding using multi-spectral encoding tags |
| US7926730B2 (en) * | 2005-11-30 | 2011-04-19 | Pitney Bowes Inc. | Combined multi-spectral document markings |
| EP2792670A1 (en) | 2006-10-03 | 2014-10-22 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of mustards and related compounds with very high skin penetration rates |
| JP5167699B2 (ja) * | 2007-06-12 | 2013-03-21 | 宇部興産株式会社 | Ｎ−グルコノ−グルタミン酸エステル及びその製造方法、並びにその中間体 |
| LT2273876T (lt) * | 2008-03-27 | 2019-05-27 | Helsinn Healthcare Sa | Stabilizuotos alkilinimo medžiagų kompozicijos ir jų panaudojimo būdai |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB915454A (en) * | 1960-06-28 | 1963-01-16 | Nat Res Dev | Nitrogen mustards |
| GB8705477D0 (en) * | 1987-03-09 | 1987-04-15 | Carlton Med Prod | Drug delivery systems |
| US5633158A (en) * | 1991-10-23 | 1997-05-27 | Cancer Research Campaign Technology Limited | Bacterial nitroreductase for the reduction of CB 1954 and analogues thereof to a cytotoxic form |
| GB9314960D0 (en) * | 1992-07-23 | 1993-09-01 | Zeneca Ltd | Chemical compounds |
| WO1995002420A2 (en) * | 1993-07-15 | 1995-01-26 | Cancer Research Campaign Technology Ltd. | Prodrugs of protein tyrosine kinase inhibitors |
| GB9315494D0 (en) * | 1993-07-27 | 1993-09-08 | Springer Caroline | Improvements relating to prodrugs |
-
1995
- 1995-01-19 GB GBGB9501052.6A patent/GB9501052D0/en active Pending
-
1996
- 1996-01-19 CA CA002210347A patent/CA2210347A1/en not_active Abandoned
- 1996-01-19 NZ NZ298847A patent/NZ298847A/xx unknown
- 1996-01-19 PT PT96900627T patent/PT804413E/pt unknown
- 1996-01-19 DK DK96900627T patent/DK0804413T3/da active
- 1996-01-19 EP EP96900627A patent/EP0804413B1/en not_active Expired - Lifetime
- 1996-01-19 US US08/875,099 patent/US6005002A/en not_active Expired - Fee Related
- 1996-01-19 JP JP8522127A patent/JPH10512565A/ja not_active Ceased
- 1996-01-19 WO PCT/GB1996/000112 patent/WO1996022277A1/en not_active Ceased
- 1996-01-19 DE DE69608412T patent/DE69608412T2/de not_active Expired - Fee Related
- 1996-01-19 ES ES96900627T patent/ES2149445T3/es not_active Expired - Lifetime
- 1996-01-19 AU AU44535/96A patent/AU709251B2/en not_active Ceased
- 1996-01-19 AT AT96900627T patent/ATE193012T1/de not_active IP Right Cessation
-
2000
- 2000-08-14 GR GR20000401890T patent/GR3034196T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69608412T2 (de) | 2000-10-26 |
| DE69608412D1 (de) | 2000-06-21 |
| DK0804413T3 (da) | 2000-09-25 |
| NZ298847A (en) | 1999-06-29 |
| ES2149445T3 (es) | 2000-11-01 |
| PT804413E (pt) | 2001-03-30 |
| AU4453596A (en) | 1996-08-07 |
| CA2210347A1 (en) | 1996-07-25 |
| US6005002A (en) | 1999-12-21 |
| GB9501052D0 (en) | 1995-03-08 |
| EP0804413B1 (en) | 2000-05-17 |
| EP0804413A1 (en) | 1997-11-05 |
| WO1996022277A1 (en) | 1996-07-25 |
| ATE193012T1 (de) | 2000-06-15 |
| AU709251B2 (en) | 1999-08-26 |
| JPH10512565A (ja) | 1998-12-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ML | Lapse due to non-payment of fees |