GT200100016A - Pirido[2,3,-d]pirimidin-2,7-diaminas inhibidoras de cinasas. - Google Patents

Pirido[2,3,-d]pirimidin-2,7-diaminas inhibidoras de cinasas.

Info

Publication number: GT200100016A
Authority: GT; Guatemala
Prior art keywords: pirido; diamines; pyrimidin; kinases; inhibiting
Prior art date: 2000-01-25

Application number

GT200100016A

Other languages

English (en)

Spanish (es)

Inventor

Richard John Booth

Ellen Myra Dobrusin

Vara Prasad Venkata Nagendra Josyula

Dennis Joseph Mcnamara

Peter Laurence Toogood

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-25

Filing date

2001-01-23

Publication date

2001-10-19

2001-01-23 Application filed filed Critical

2001-10-19 Publication of GT200100016A publication Critical patent/GT200100016A/es

Links

150000004985 diamines Chemical class 0.000 title abstract 2
108091000080 Phosphotransferase Proteins 0.000 title 1
102000020233 phosphotransferase Human genes 0.000 title 1
102000004190 Enzymes Human genes 0.000 abstract 2
108090000790 Enzymes Proteins 0.000 abstract 2
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
230000001413 cellular effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003102 growth factor Substances 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
JTJMJGYZQZDUJJ-UHFFFAOYSA-N phencyclidine Chemical compound C1CCCCN1C1(C=2C=CC=CC=2)CCCCC1 JTJMJGYZQZDUJJ-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Enzymes And Modification Thereof (AREA)

GT200100016A 2000-01-25 2001-01-23 Pirido[2,3,-d]pirimidin-2,7-diaminas inhibidoras de cinasas. GT200100016A (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US17826100P	2000-01-25	2000-01-25

Publications (1)

Publication Number	Publication Date
GT200100016A true GT200100016A (es)	2001-10-19

Family

ID=22651853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GT200100016A GT200100016A (es)	2000-01-25	2001-01-23	Pirido[2,3,-d]pirimidin-2,7-diaminas inhibidoras de cinasas.

Country Status (34)

Country	Link
EP (1)	EP1254137A1 (fr)
JP (1)	JP4047010B2 (fr)
KR (1)	KR20020065939A (fr)
CN (1)	CN1395578A (fr)
AP (1)	AP2002002586A0 (fr)
AR (1)	AR030044A1 (fr)
AU (1)	AU2542501A (fr)
BG (1)	BG106850A (fr)
BR (1)	BR0107751A (fr)
CA (1)	CA2397961C (fr)
CO (1)	CO5261549A1 (fr)
CR (1)	CR6706A (fr)
CZ (1)	CZ20022475A3 (fr)
DZ (1)	DZ3266A1 (fr)
EA (1)	EA200200643A1 (fr)
EE (1)	EE200200405A (fr)
GT (1)	GT200100016A (fr)
HN (1)	HN2001000013A (fr)
HU (1)	HUP0204141A3 (fr)
IL (1)	IL150545A0 (fr)
IS (1)	IS6443A (fr)
MA (1)	MA26868A1 (fr)
MX (1)	MXPA02007221A (fr)
NO (1)	NO20023527L (fr)
OA (1)	OA12161A (fr)
PA (1)	PA8510701A1 (fr)
PE (1)	PE20011066A1 (fr)
PL (1)	PL356802A1 (fr)
SK (1)	SK10632002A3 (fr)
SV (1)	SV2002000294A (fr)
TN (1)	TNSN01014A1 (fr)
WO (1)	WO2001055147A1 (fr)
YU (1)	YU50402A (fr)
ZA (1)	ZA200205879B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7235551B2 (en)	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
EP2404603A1 (fr)	2000-10-23	2012-01-11	Glaxosmithkline LLC	Nouveaux composés 8H-pyrido[2,3-d]pyrimidin-7-one trisubstituté pour le traitement des maladies faisant intervenir les kinases CSBP/p38.
PE20030008A1 (es) *	2001-06-19	2003-01-22	Bristol Myers Squibb Co	Inhibidores duales de pde 7 y pde 4
MXPA04010267A (es)	2002-04-19	2005-02-03	Smithkline Beecham Corp	Compuestos novedosos.
KR20050084027A (ko) *	2002-11-28	2005-08-26	쉐링 악티엔게젤샤프트	Ｃｈｋ-, ｐｄｋ- 및 ａｋｔ-억제성 피리미딘, 그의제조방법 및 약제로서의 그의 용도
US7157455B2 (en) *	2003-02-10	2007-01-02	Hoffmann-La Roche Inc.	4-Aminopyrimidine-5-one derivatives
TW200502236A (en) *	2003-03-28	2005-01-16	Hoffmann La Roche	Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
FR2873118B1 (fr)	2004-07-15	2007-11-23	Sanofi Synthelabo	Derives de pyrido-pyrimidine, leur application en therapeutique
US7550589B2 (en) *	2004-09-21	2009-06-23	Hoffman-La Roche Inc.	6-(2-alkyl-phenyl)-pyrido[2,3-D]pyrimidines useful as protein kinase inhibitors
PE20061351A1 (es)	2005-03-25	2007-01-14	Glaxo Group Ltd	COMPUESTOS 8H-PIRIDO[2,3-d]PIRIMIDIN-7-ONA 2,4,8-TRISUSTITUIDOS COMO INHIBIDORES DE LA QUINASA CSBP/RK/p38
US20090137550A1 (en)	2005-03-25	2009-05-28	Glaxo Group Limited	Novel Compounds
TW200724142A (en)	2005-03-25	2007-07-01	Glaxo Group Ltd	Novel compounds
EP1865959A2 (fr)	2005-03-25	2007-12-19	Glaxo Group Limited	Procede de preparation de derives pyridoý2,3-d¨pyrimidin-7-one et 3,4-dihydropyrimidoý4,5-d¨pyrimidin-2(1h)-one
FR2887882B1 (fr) *	2005-07-01	2007-09-07	Sanofi Aventis Sa	Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
WO2007009911A1 (fr) *	2005-07-21	2007-01-25	F. Hoffmann-La Roche Ag	Composes pyrido [2, 3-d] pyrimidine-2, 4-diamine utilises comme inhibiteurs de ptp1b
AU2006279992A1 (en)	2005-08-09	2007-02-22	Irm Llc	Compounds and compositions as protein kinase inhibitors
FR2896246B1 (fr)	2006-01-13	2008-08-15	Sanofi Aventis Sa	Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
EP1914234A1 (fr)	2006-10-16	2008-04-23	GPC Biotech Inc.	Pyrido[2,3-d]pyrimidines et leur utilisation comme inhibiteurs de kinases
JO2985B1 (ar)	2006-12-20	2016-09-05	Takeda Pharmaceuticals Co	مثبطات كينازmapk/erk
FR2910813B1 (fr) *	2006-12-28	2009-02-06	Sanofi Aventis Sa	Nouvelle utilisation therapeutique pour le traitement des leucemies
EP2112150B1 (fr)	2008-04-22	2013-10-16	Forma Therapeutics, Inc.	Inhibiteurs Raf améliorés
EA201100879A1 (ru) *	2008-12-01	2012-01-30	Мерк Патент Гмбх	Производные пиридопиримидина в качестве ингибиторов аутотаксина
GB201104267D0 (en)	2011-03-14	2011-04-27	Cancer Rec Tech Ltd	Pyrrolopyridineamino derivatives
GB201216017D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Inhibitor compounds
GB201216018D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Pharmacologically active compounds
EP3733184B1 (fr) *	2013-03-14	2023-08-30	Icahn School of Medicine at Mount Sinai	Composés de pyrimidine pour l'utililisation dans la traitment de cancer
GB201403536D0 (en)	2014-02-28	2014-04-16	Cancer Rec Tech Ltd	Inhibitor compounds
KR101671404B1 (ko) *	2014-09-02	2016-11-02	한국원자력의학원	항암 효과, 방사선 병용치료 효과 및 당뇨병 치료 효과를 갖는 피리미딘 유도체 및 이의 의학적 용도
CN107286180B (zh) *	2016-04-11	2019-07-02	上海勋和医药科技有限公司	杂代吡啶并嘧啶酮衍生物作为cdk抑制剂及其应用
GB201709840D0 (en)	2017-06-20	2017-08-02	Inst Of Cancer Research: Royal Cancer Hospital	Methods and medical uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL115256A0 (en) *	1994-11-14	1995-12-31	Warner Lambert Co	6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
MX9702245A (es) *	1994-11-14	1997-06-28	Warner Lambert Co	Seis-aril-pirido(2,3-d)pirimidinas y naftiridinas para inhibir la proliferacion celular mediada por la proteina cinasa tirosina.
US5620981A (en) *	1995-05-03	1997-04-15	Warner-Lambert Company	Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
EE200000706A (et) *	1998-05-26	2002-06-17	Warner-Lambert Company	Bitsüklilised pürimidiinid ja bitsüklilised 3,4-dihüdropürimidiinid kui rakkude proliferatsiooni inhibiitorid

2001
- 2001-01-23 WO PCT/IB2001/000069 patent/WO2001055147A1/fr not_active Ceased
- 2001-01-23 EE EEP200200405A patent/EE200200405A/xx unknown
- 2001-01-23 YU YU50402A patent/YU50402A/sh unknown
- 2001-01-23 PA PA20018510701A patent/PA8510701A1/es unknown
- 2001-01-23 HU HU0204141A patent/HUP0204141A3/hu unknown
- 2001-01-23 DZ DZ013266A patent/DZ3266A1/fr active
- 2001-01-23 EA EA200200643A patent/EA200200643A1/ru unknown
- 2001-01-23 EP EP01900591A patent/EP1254137A1/fr not_active Withdrawn
- 2001-01-23 AR ARP010100285A patent/AR030044A1/es not_active Application Discontinuation
- 2001-01-23 CZ CZ20022475A patent/CZ20022475A3/cs unknown
- 2001-01-23 SK SK1063-2002A patent/SK10632002A3/sk not_active Application Discontinuation
- 2001-01-23 CA CA002397961A patent/CA2397961C/fr not_active Expired - Fee Related
- 2001-01-23 PE PE2001000072A patent/PE20011066A1/es not_active Application Discontinuation
- 2001-01-23 OA OA1200200213A patent/OA12161A/en unknown
- 2001-01-23 BR BR0107751-1A patent/BR0107751A/pt not_active IP Right Cessation
- 2001-01-23 JP JP2001561006A patent/JP4047010B2/ja not_active Expired - Fee Related
- 2001-01-23 GT GT200100016A patent/GT200100016A/es unknown
- 2001-01-23 MX MXPA02007221A patent/MXPA02007221A/es not_active Application Discontinuation
- 2001-01-23 AU AU25425/01A patent/AU2542501A/en not_active Abandoned
- 2001-01-23 PL PL01356802A patent/PL356802A1/xx not_active Application Discontinuation
- 2001-01-23 KR KR1020027009516A patent/KR20020065939A/ko not_active Ceased
- 2001-01-23 CN CN01804048A patent/CN1395578A/zh active Pending
- 2001-01-23 AP APAP/P/2002/002586A patent/AP2002002586A0/en unknown
- 2001-01-23 IL IL15054501A patent/IL150545A0/xx unknown
- 2001-01-24 CO CO01005268A patent/CO5261549A1/es not_active Application Discontinuation
- 2001-01-24 SV SV2001000294A patent/SV2002000294A/es not_active Application Discontinuation
- 2001-01-24 TN TNTNSN01014A patent/TNSN01014A1/fr unknown
- 2001-01-24 HN HN2001000013A patent/HN2001000013A/es unknown
2002
- 2002-06-20 BG BG106850A patent/BG106850A/bg unknown
- 2002-06-25 IS IS6443A patent/IS6443A/is unknown
- 2002-07-17 CR CR6706A patent/CR6706A/es not_active Application Discontinuation
- 2002-07-22 MA MA26736A patent/MA26868A1/fr unknown
- 2002-07-23 ZA ZA200205879A patent/ZA200205879B/en unknown
- 2002-07-24 NO NO20023527A patent/NO20023527L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
TNSN01014A1 (fr)	2005-11-10
NO20023527L (no)	2002-09-10
PL356802A1 (en)	2004-07-12
CZ20022475A3 (cs)	2003-03-12
AP2002002586A0 (en)	2002-09-30
JP2003523357A (ja)	2003-08-05
WO2001055147A1 (fr)	2001-08-02
EA200200643A1 (ru)	2002-12-26
CN1395578A (zh)	2003-02-05
EP1254137A1 (fr)	2002-11-06
CA2397961C (fr)	2008-08-26
YU50402A (sh)	2005-11-28
MA26868A1 (fr)	2004-12-20
CA2397961A1 (fr)	2001-08-02
NO20023527D0 (no)	2002-07-24
OA12161A (en)	2006-05-08
KR20020065939A (ko)	2002-08-14
BG106850A (bg)	2003-02-28
CO5261549A1 (es)	2003-03-31
DZ3266A1 (fr)	2001-08-02
HUP0204141A2 (hu)	2003-04-28
AU2542501A (en)	2001-08-07
IL150545A0 (en)	2003-02-12
BR0107751A (pt)	2002-11-12
IS6443A (is)	2002-06-25
HUP0204141A3 (en)	2005-03-29
SV2002000294A (es)	2002-07-16
SK10632002A3 (sk)	2003-06-03
HN2001000013A (es)	2001-06-18
AR030044A1 (es)	2003-08-13
ZA200205879B (en)	2003-09-29
PA8510701A1 (es)	2002-12-11
CR6706A (es)	2005-04-04
MXPA02007221A (es)	2002-11-29
EE200200405A (et)	2003-12-15
PE20011066A1 (es)	2001-10-22
JP4047010B2 (ja)	2008-02-13

Publication	Publication Date	Title
TW200510380A (en)	2005-03-16	Mitotic kinesin inhibitors
DE60231439D1 (de)	2009-04-16	Mitotische kinesinhemmer
DE60234278D1 (de)	2009-12-17	Mitotische kinesin-hemmer
WO2003050064A3 (fr)	2003-10-16	Inhibiteurs de kinesine mitotique
WO2003049527A3 (fr)	2004-03-04	Inhibiteurs miotitiques de la kinesine
WO2003050122A3 (fr)	2003-12-04	Inhibiteurs mitotiques de la kinesine
GEP20053660B (en)	2005-11-10	Novel Tyrosine Kinase Inhibitors
IL165624A0 (en)	2006-01-15	Mitotic kinesin inhibitors
AU2003225800A1 (en)	2003-09-29	Azolylaminoazine as inhibitors of protein kinases
AU2003218215A1 (en)	2003-09-29	Azolylaminoazines as inhibitors of protein kinases
AU2003220300A1 (en)	2003-09-29	Compositions useful as inhibitors of protein kinases
PL1664026T3 (pl)	2009-06-30	Inhibitory kinezyny mitotycznej
MX337817B (es)	2011-11-04	Pirazolo [1,5-a] pirimidinas de utilidad como inhibidores de proteina quinasas.
WO2003039460A3 (fr)	2003-07-31	Inhibiteurs de la kinesine mitotique
WO2004037171A3 (fr)	2004-07-08	Inhibiteurs de kinesine mitotiques
WO2005017190A3 (fr)	2005-12-15	Inhibiteurs de kinesine mitotique
DE60329990D1 (de)	2009-12-24	Mitotische kinesin-hemmer
WO2004058700A3 (fr)	2004-10-14	Inhibiteurs de kinesine mitotique
WO2005018547A3 (fr)	2005-09-15	Inhibiteurs de kinesine mitotique
WO2004058148A3 (fr)	2004-09-16	Inhibiteurs de la kinesine mitotique
WO2005065183A3 (fr)	2005-09-29	Inhibiteurs mitotiques de la kinesine
AU5173501A (en)	2001-10-08	Polyamine analogues as cytotoxic agents
YU75603A (sh)	2006-05-25	Dihidropirimidinska jedinjenja koja su supstituisana na cijano grupi i njihova upotreba u lečenju oboljenja
BG108180A (en)	2004-09-30	Novel cyano-substituted dihydropyrimidine compounds and their use to treat diseases
WO2002096420A3 (fr)	2003-02-06	Procede de traitement d'accidents nerveux entraines par une operation