GT200100016A - Pirido[2,3,-d]pirimidin-2,7-diaminas inhibidoras de cinasas. - Google Patents

Pirido[2,3,-d]pirimidin-2,7-diaminas inhibidoras de cinasas.

Info

Publication number: GT200100016A
Authority: GT; Guatemala
Prior art keywords: pirido; diamines; pyrimidin; kinases; inhibiting
Prior art date: 2000-01-25

Application number

GT200100016A

Other languages

English (en)

Spanish (es)

Inventor

Richard John Booth

Ellen Myra Dobrusin

Vara Prasad Venkata Nagendra Josyula

Dennis Joseph Mcnamara

Peter Laurence Toogood

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-25

Filing date

2001-01-23

Publication date

2001-10-19

2001-01-23 Application filed filed Critical

2001-10-19 Publication of GT200100016A publication Critical patent/GT200100016A/es

Links

150000004985 diamines Chemical class 0.000 title abstract 2
108091000080 Phosphotransferase Proteins 0.000 title 1
102000020233 phosphotransferase Human genes 0.000 title 1
102000004190 Enzymes Human genes 0.000 abstract 2
108090000790 Enzymes Proteins 0.000 abstract 2
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
230000001413 cellular effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003102 growth factor Substances 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
JTJMJGYZQZDUJJ-UHFFFAOYSA-N phencyclidine Chemical compound C1CCCCN1C1(C=2C=CC=CC=2)CCCCC1 JTJMJGYZQZDUJJ-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Enzymes And Modification Thereof (AREA)

GT200100016A 2000-01-25 2001-01-23 Pirido[2,3,-d]pirimidin-2,7-diaminas inhibidoras de cinasas. GT200100016A (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US17826100P	2000-01-25	2000-01-25

Publications (1)

Publication Number	Publication Date
GT200100016A true GT200100016A (es)	2001-10-19

Family

ID=22651853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GT200100016A GT200100016A (es)	2000-01-25	2001-01-23	Pirido[2,3,-d]pirimidin-2,7-diaminas inhibidoras de cinasas.

Country Status (34)

Country	Link
EP (1)	EP1254137A1 (fr)
JP (1)	JP4047010B2 (fr)
KR (1)	KR20020065939A (fr)
CN (1)	CN1395578A (fr)
AP (1)	AP2002002586A0 (fr)
AR (1)	AR030044A1 (fr)
AU (1)	AU2542501A (fr)
BG (1)	BG106850A (fr)
BR (1)	BR0107751A (fr)
CA (1)	CA2397961C (fr)
CO (1)	CO5261549A1 (fr)
CR (1)	CR6706A (fr)
CZ (1)	CZ20022475A3 (fr)
DZ (1)	DZ3266A1 (fr)
EA (1)	EA200200643A1 (fr)
EE (1)	EE200200405A (fr)
GT (1)	GT200100016A (fr)
HN (1)	HN2001000013A (fr)
HU (1)	HUP0204141A3 (fr)
IL (1)	IL150545A0 (fr)
IS (1)	IS6443A (fr)
MA (1)	MA26868A1 (fr)
MX (1)	MXPA02007221A (fr)
NO (1)	NO20023527L (fr)
OA (1)	OA12161A (fr)
PA (1)	PA8510701A1 (fr)
PE (1)	PE20011066A1 (fr)
PL (1)	PL356802A1 (fr)
SK (1)	SK10632002A3 (fr)
SV (1)	SV2002000294A (fr)
TN (1)	TNSN01014A1 (fr)
WO (1)	WO2001055147A1 (fr)
YU (1)	YU50402A (fr)
ZA (1)	ZA200205879B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7235551B2 (en)	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
ATE521353T1 (de)	2000-10-23	2011-09-15	Glaxosmithkline Llc	Neues trisubstitutiertes 8h-pyridoä2,3- düpyrimidin-7-onderivat zur behandlung von durch csbp/p38kinase vermittelten krankheiten
PE20030008A1 (es) *	2001-06-19	2003-01-22	Bristol Myers Squibb Co	Inhibidores duales de pde 7 y pde 4
KR20040103972A (ko)	2002-04-19	2004-12-09	스미스클라인 비참 코포레이션	신규 화합물
BR0316680A (pt) *	2002-11-28	2005-10-18	Schering Ag	Pirimidinas inibidoras de chk, pdk e akt, sua produção e uso como agentes farmacêuticos
US7157455B2 (en) *	2003-02-10	2007-01-02	Hoffmann-La Roche Inc.	4-Aminopyrimidine-5-one derivatives
TW200502236A (en)	2003-03-28	2005-01-16	Hoffmann La Roche	Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
FR2873118B1 (fr)	2004-07-15	2007-11-23	Sanofi Synthelabo	Derives de pyrido-pyrimidine, leur application en therapeutique
CN101014600A (zh) *	2004-09-21	2007-08-08	霍夫曼-拉罗奇有限公司	用作蛋白激酶抑制剂的6－(2－烷基－苯基)－吡啶并[2,3－d]嘧啶类
UY29439A1 (es)	2005-03-25	2006-10-02	Glaxo Group Ltd	Nuevos compuestos
UY29440A1 (es)	2005-03-25	2006-10-02	Glaxo Group Ltd	Nuevos compuestos
EP1865959A2 (fr)	2005-03-25	2007-12-19	Glaxo Group Limited	Procede de preparation de derives pyridoý2,3-d¨pyrimidin-7-one et 3,4-dihydropyrimidoý4,5-d¨pyrimidin-2(1h)-one
WO2006110298A2 (fr)	2005-03-25	2006-10-19	Glaxo Group Limited	Nouveaux composes
FR2887882B1 (fr)	2005-07-01	2007-09-07	Sanofi Aventis Sa	Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
WO2007009911A1 (fr) *	2005-07-21	2007-01-25	F. Hoffmann-La Roche Ag	Composes pyrido [2, 3-d] pyrimidine-2, 4-diamine utilises comme inhibiteurs de ptp1b
ATE482958T1 (de) *	2005-08-09	2010-10-15	Irm Llc	Verbindungen und zusammensetzungen als proteinkinaseinhibitoren
FR2896246B1 (fr)	2006-01-13	2008-08-15	Sanofi Aventis Sa	Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
EP1914234A1 (fr)	2006-10-16	2008-04-23	GPC Biotech Inc.	Pyrido[2,3-d]pyrimidines et leur utilisation comme inhibiteurs de kinases
JO2985B1 (ar)	2006-12-20	2016-09-05	Takeda Pharmaceuticals Co	مثبطات كينازmapk/erk
FR2910813B1 (fr)	2006-12-28	2009-02-06	Sanofi Aventis Sa	Nouvelle utilisation therapeutique pour le traitement des leucemies
EP2112150B1 (fr)	2008-04-22	2013-10-16	Forma Therapeutics, Inc.	Inhibiteurs Raf améliorés
WO2010063352A1 (fr) *	2008-12-01	2010-06-10	Merck Patent Gmbh	Pyrido[4,3-d]pyrimidines 2,5-diamino-substituées en tant qu'inhibiteurs d'autotaxine contre le cancer
GB201104267D0 (en)	2011-03-14	2011-04-27	Cancer Rec Tech Ltd	Pyrrolopyridineamino derivatives
GB201216017D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Inhibitor compounds
GB201216018D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Pharmacologically active compounds
WO2014151682A1 (fr)	2013-03-14	2014-09-25	Icahn School Of Medicine At Mount Sinai	Composés pyrimidines en tant qu'inhibiteurs de kinase
GB201403536D0 (en)	2014-02-28	2014-04-16	Cancer Rec Tech Ltd	Inhibitor compounds
KR101671404B1 (ko) *	2014-09-02	2016-11-02	한국원자력의학원	항암 효과, 방사선 병용치료 효과 및 당뇨병 치료 효과를 갖는 피리미딘 유도체 및 이의 의학적 용도
CN107286180B (zh) *	2016-04-11	2019-07-02	上海勋和医药科技有限公司	杂代吡啶并嘧啶酮衍生物作为cdk抑制剂及其应用
GB201709840D0 (en)	2017-06-20	2017-08-02	Inst Of Cancer Research: Royal Cancer Hospital	Methods and medical uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL115256A0 (en) *	1994-11-14	1995-12-31	Warner Lambert Co	6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
HUT76853A (en) *	1994-11-14	1997-12-29	Warner Lambert Co	6-aryl pyrido[2,3-d]pyrimidines and naphthyridines for inhibiting protein tyrosine kinase mediated cellular proliferation and pharmaceutical compositions containing the same
US5620981A (en) *	1995-05-03	1997-04-15	Warner-Lambert Company	Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
AU763839B2 (en) *	1998-05-26	2003-07-31	Warner-Lambert Company	Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation

2001
- 2001-01-23 CZ CZ20022475A patent/CZ20022475A3/cs unknown
- 2001-01-23 HU HU0204141A patent/HUP0204141A3/hu unknown
- 2001-01-23 PL PL01356802A patent/PL356802A1/xx not_active Application Discontinuation
- 2001-01-23 EA EA200200643A patent/EA200200643A1/ru unknown
- 2001-01-23 PA PA20018510701A patent/PA8510701A1/es unknown
- 2001-01-23 GT GT200100016A patent/GT200100016A/es unknown
- 2001-01-23 PE PE2001000072A patent/PE20011066A1/es not_active Application Discontinuation
- 2001-01-23 DZ DZ013266A patent/DZ3266A1/fr active
- 2001-01-23 YU YU50402A patent/YU50402A/sh unknown
- 2001-01-23 MX MXPA02007221A patent/MXPA02007221A/es not_active Application Discontinuation
- 2001-01-23 AU AU25425/01A patent/AU2542501A/en not_active Abandoned
- 2001-01-23 EE EEP200200405A patent/EE200200405A/xx unknown
- 2001-01-23 OA OA1200200213A patent/OA12161A/en unknown
- 2001-01-23 BR BR0107751-1A patent/BR0107751A/pt not_active IP Right Cessation
- 2001-01-23 SK SK1063-2002A patent/SK10632002A3/sk not_active Application Discontinuation
- 2001-01-23 JP JP2001561006A patent/JP4047010B2/ja not_active Expired - Fee Related
- 2001-01-23 CN CN01804048A patent/CN1395578A/zh active Pending
- 2001-01-23 CA CA002397961A patent/CA2397961C/fr not_active Expired - Fee Related
- 2001-01-23 WO PCT/IB2001/000069 patent/WO2001055147A1/fr not_active Ceased
- 2001-01-23 IL IL15054501A patent/IL150545A0/xx unknown
- 2001-01-23 AR ARP010100285A patent/AR030044A1/es not_active Application Discontinuation
- 2001-01-23 EP EP01900591A patent/EP1254137A1/fr not_active Withdrawn
- 2001-01-23 KR KR1020027009516A patent/KR20020065939A/ko not_active Ceased
- 2001-01-23 AP APAP/P/2002/002586A patent/AP2002002586A0/en unknown
- 2001-01-24 TN TNTNSN01014A patent/TNSN01014A1/fr unknown
- 2001-01-24 CO CO01005268A patent/CO5261549A1/es not_active Application Discontinuation
- 2001-01-24 HN HN2001000013A patent/HN2001000013A/es unknown
- 2001-01-24 SV SV2001000294A patent/SV2002000294A/es not_active Application Discontinuation
2002
- 2002-06-20 BG BG106850A patent/BG106850A/bg unknown
- 2002-06-25 IS IS6443A patent/IS6443A/is unknown
- 2002-07-17 CR CR6706A patent/CR6706A/es not_active Application Discontinuation
- 2002-07-22 MA MA26736A patent/MA26868A1/fr unknown
- 2002-07-23 ZA ZA200205879A patent/ZA200205879B/en unknown
- 2002-07-24 NO NO20023527A patent/NO20023527L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA2397961C (fr)	2008-08-26
CZ20022475A3 (cs)	2003-03-12
JP4047010B2 (ja)	2008-02-13
NO20023527D0 (no)	2002-07-24
IS6443A (is)	2002-06-25
BG106850A (bg)	2003-02-28
CO5261549A1 (es)	2003-03-31
MXPA02007221A (es)	2002-11-29
SV2002000294A (es)	2002-07-16
ZA200205879B (en)	2003-09-29
MA26868A1 (fr)	2004-12-20
CR6706A (es)	2005-04-04
NO20023527L (no)	2002-09-10
TNSN01014A1 (fr)	2005-11-10
BR0107751A (pt)	2002-11-12
PA8510701A1 (es)	2002-12-11
HUP0204141A3 (en)	2005-03-29
OA12161A (en)	2006-05-08
HN2001000013A (es)	2001-06-18
EA200200643A1 (ru)	2002-12-26
PE20011066A1 (es)	2001-10-22
AU2542501A (en)	2001-08-07
SK10632002A3 (sk)	2003-06-03
CA2397961A1 (fr)	2001-08-02
HUP0204141A2 (hu)	2003-04-28
KR20020065939A (ko)	2002-08-14
EE200200405A (et)	2003-12-15
AR030044A1 (es)	2003-08-13
IL150545A0 (en)	2003-02-12
CN1395578A (zh)	2003-02-05
EP1254137A1 (fr)	2002-11-06
PL356802A1 (en)	2004-07-12
JP2003523357A (ja)	2003-08-05
WO2001055147A1 (fr)	2001-08-02
DZ3266A1 (fr)	2001-08-02
AP2002002586A0 (en)	2002-09-30
YU50402A (sh)	2005-11-28

Publication	Publication Date	Title
GT200100016A (es)	2001-10-19	Pirido[2,3,-d]pirimidin-2,7-diaminas inhibidoras de cinasas.
TW200510380A (en)	2005-03-16	Mitotic kinesin inhibitors
DE60231439D1 (de)	2009-04-16	Mitotische kinesinhemmer
DE60234278D1 (de)	2009-12-17	Mitotische kinesin-hemmer
WO2003050064A3 (fr)	2003-10-16	Inhibiteurs de kinesine mitotique
WO2003049527A3 (fr)	2004-03-04	Inhibiteurs miotitiques de la kinesine
WO2003050122A3 (fr)	2003-12-04	Inhibiteurs mitotiques de la kinesine
GEP20053660B (en)	2005-11-10	Novel Tyrosine Kinase Inhibitors
IL165624A0 (en)	2006-01-15	Mitotic kinesin inhibitors
AU2003225800A1 (en)	2003-09-29	Azolylaminoazine as inhibitors of protein kinases
AU2003218215A1 (en)	2003-09-29	Azolylaminoazines as inhibitors of protein kinases
AU2003220300A1 (en)	2003-09-29	Compositions useful as inhibitors of protein kinases
PT1664026E (pt)	2009-04-23	Inibidores de cinesina mitótica
WO2003039460A3 (fr)	2003-07-31	Inhibiteurs de la kinesine mitotique
WO2004037171A3 (fr)	2004-07-08	Inhibiteurs de kinesine mitotiques
ZA200704476B (en)	2008-09-25	Pyrazolo[1,5-a]pyrimidines useful as inhibitors of protein kinases
WO2005017190A3 (fr)	2005-12-15	Inhibiteurs de kinesine mitotique
DE60329990D1 (de)	2009-12-24	Mitotische kinesin-hemmer
AU2002319814A1 (en)	2003-03-03	Substituted 1h-dihydropyrazoles, their preparation and use
WO2004058700A3 (fr)	2004-10-14	Inhibiteurs de kinesine mitotique
WO2005018547A3 (fr)	2005-09-15	Inhibiteurs de kinesine mitotique
WO2004058148A3 (fr)	2004-09-16	Inhibiteurs de la kinesine mitotique
WO2005065183A3 (fr)	2005-09-29	Inhibiteurs mitotiques de la kinesine
AU5173501A (en)	2001-10-08	Polyamine analogues as cytotoxic agents
MXPA03008635A (es)	2004-02-23	Compuestos de dihidropirimidina ciano sustituidos y su uso para tratar enfermedades.