OA12161A - PyridoÄ2,3-dÜpyrimidine-2,7-diamine kinase inhibitors. - Google Patents

PyridoÄ2,3-dÜpyrimidine-2,7-diamine kinase inhibitors. Download PDF

Info

Publication number: OA12161A
Authority: OA; OAPI
Prior art keywords: pyrido; pyrimidin; urea; piperazin; phenylamino
Prior art date: 2000-01-25

Application number

OA1200200213A

Other languages

English (en)

Inventor

Richard John Booth

Ellen Myra Dobrusin

Vara Prasad Venkata Na Josyula

Dennis Joseph Mcnamara

Peter Laurence Toogood

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-25

Filing date

2001-01-23

Publication date

2006-05-08

2001-01-23 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2006-05-08 Publication of OA12161A publication Critical patent/OA12161A/en

Links

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235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
239000012312 sodium hydride Substances 0.000 description 1
229940083608 sodium hydroxide Drugs 0.000 description 1
CMZUMMUJMWNLFH-UHFFFAOYSA-N sodium metavanadate Chemical compound [Na+].[O-][V](=O)=O CMZUMMUJMWNLFH-UHFFFAOYSA-N 0.000 description 1
MFRIHAYPQRLWNB-UHFFFAOYSA-N sodium tert-butoxide Chemical compound [Na+].CC(C)(C)[O-] MFRIHAYPQRLWNB-UHFFFAOYSA-N 0.000 description 1
206010041823 squamous cell carcinoma Diseases 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
239000000126 substance Substances 0.000 description 1
125000005017 substituted alkenyl group Chemical group 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
QAHVHSLSRLSVGS-UHFFFAOYSA-N sulfamoyl chloride Chemical compound NS(Cl)(=O)=O QAHVHSLSRLSVGS-UHFFFAOYSA-N 0.000 description 1
YBBRCQOCSYXUOC-UHFFFAOYSA-N sulfuryl dichloride Chemical compound ClS(Cl)(=O)=O YBBRCQOCSYXUOC-UHFFFAOYSA-N 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
GSALRQQUCCLTEJ-BETUJISGSA-N tert-butyl (2s,6r)-4-(4-aminophenyl)-2,6-dimethylpiperazine-1-carboxylate Chemical compound C1[C@@H](C)N(C(=O)OC(C)(C)C)[C@@H](C)CN1C1=CC=C(N)C=C1 GSALRQQUCCLTEJ-BETUJISGSA-N 0.000 description 1
MGYCIJUTYLUYJM-UHFFFAOYSA-N tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCN1C1=CC=C([N+]([O-])=O)C=C1 MGYCIJUTYLUYJM-UHFFFAOYSA-N 0.000 description 1
OSBIEGRZGZRSBF-UHFFFAOYSA-N tert-butyl 4-[4-[(5-acetyl-4-aminopyrimidin-2-yl)amino]phenyl]piperazine-1-carboxylate Chemical compound N1=C(N)C(C(=O)C)=CN=C1NC1=CC=C(N2CCN(CC2)C(=O)OC(C)(C)C)C=C1 OSBIEGRZGZRSBF-UHFFFAOYSA-N 0.000 description 1
PWUUIKXPHXIFIT-UHFFFAOYSA-N tert-butyl 4-[4-[(7-amino-5-methylpyrido[2,3-d]pyrimidin-2-yl)amino]phenyl]piperazine-1-carboxylate Chemical group N=1C=C2C(C)=CC(N)=NC2=NC=1NC(C=C1)=CC=C1N1CCN(C(=O)OC(C)(C)C)CC1 PWUUIKXPHXIFIT-UHFFFAOYSA-N 0.000 description 1
FSVJKTYULHABKQ-UHFFFAOYSA-N tert-butyl 4-[4-[(7-amino-6-fluoropyrido[2,3-d]pyrimidin-2-yl)amino]phenyl]-2,2-dimethylpiperazine-1-carboxylate Chemical compound C1C(C)(C)N(C(=O)OC(C)(C)C)CCN1C(C=C1)=CC=C1NC1=NC=C(C=C(F)C(N)=N2)C2=N1 FSVJKTYULHABKQ-UHFFFAOYSA-N 0.000 description 1
UBSVDMOMDQNVDD-QFIPXVFZSA-N tert-butyl 4-[4-[[7-[[(2r)-1-hydroxy-3-methylbutan-2-yl]carbamoylamino]pyrido[2,3-d]pyrimidin-2-yl]amino]phenyl]piperazine-1-carboxylate Chemical compound N=1C2=NC(NC(=O)N[C@@H](CO)C(C)C)=CC=C2C=NC=1NC(C=C1)=CC=C1N1CCN(C(=O)OC(C)(C)C)CC1 UBSVDMOMDQNVDD-QFIPXVFZSA-N 0.000 description 1
210000001550 testis Anatomy 0.000 description 1
CBXCPBUEXACCNR-UHFFFAOYSA-N tetraethylammonium Chemical compound CC[N+](CC)(CC)CC CBXCPBUEXACCNR-UHFFFAOYSA-N 0.000 description 1
RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Substances C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 1
125000005958 tetrahydrothienyl group Chemical group 0.000 description 1
125000003831 tetrazolyl group Chemical group 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
210000001685 thyroid gland Anatomy 0.000 description 1
208000030901 thyroid gland follicular carcinoma Diseases 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
125000003944 tolyl group Chemical group 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
125000004665 trialkylsilyl group Chemical group 0.000 description 1
125000006000 trichloroethyl group Chemical group 0.000 description 1
IIHPVYJPDKJYOU-UHFFFAOYSA-N triphenylcarbethoxymethylenephosphorane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)(=CC(=O)OCC)C1=CC=CC=C1 IIHPVYJPDKJYOU-UHFFFAOYSA-N 0.000 description 1
231100000588 tumorigenic Toxicity 0.000 description 1
230000000381 tumorigenic effect Effects 0.000 description 1
208000010576 undifferentiated carcinoma Diseases 0.000 description 1
150000003672 ureas Chemical class 0.000 description 1
208000010570 urinary bladder carcinoma Diseases 0.000 description 1
229940070710 valerate Drugs 0.000 description 1
NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
230000002792 vascular Effects 0.000 description 1
239000011345 viscous material Substances 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000003871 white petrolatum Substances 0.000 description 1
229910000166 zirconium phosphate Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Enzymes And Modification Thereof (AREA)

OA1200200213A 2000-01-25 2001-01-23 PyridoÄ2,3-dÜpyrimidine-2,7-diamine kinase inhibitors. OA12161A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US17826100P	2000-01-25	2000-01-25

Publications (1)

Publication Number	Publication Date
OA12161A true OA12161A (en)	2006-05-08

Family

ID=22651853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA1200200213A OA12161A (en)	2000-01-25	2001-01-23	PyridoÄ2,3-dÜpyrimidine-2,7-diamine kinase inhibitors.

Country Status (34)

Country	Link
EP (1)	EP1254137A1 (fr)
JP (1)	JP4047010B2 (fr)
KR (1)	KR20020065939A (fr)
CN (1)	CN1395578A (fr)
AP (1)	AP2002002586A0 (fr)
AR (1)	AR030044A1 (fr)
AU (1)	AU2542501A (fr)
BG (1)	BG106850A (fr)
BR (1)	BR0107751A (fr)
CA (1)	CA2397961C (fr)
CO (1)	CO5261549A1 (fr)
CR (1)	CR6706A (fr)
CZ (1)	CZ20022475A3 (fr)
DZ (1)	DZ3266A1 (fr)
EA (1)	EA200200643A1 (fr)
EE (1)	EE200200405A (fr)
GT (1)	GT200100016A (fr)
HN (1)	HN2001000013A (fr)
HU (1)	HUP0204141A3 (fr)
IL (1)	IL150545A0 (fr)
IS (1)	IS6443A (fr)
MA (1)	MA26868A1 (fr)
MX (1)	MXPA02007221A (fr)
NO (1)	NO20023527L (fr)
OA (1)	OA12161A (fr)
PA (1)	PA8510701A1 (fr)
PE (1)	PE20011066A1 (fr)
PL (1)	PL356802A1 (fr)
SK (1)	SK10632002A3 (fr)
SV (1)	SV2002000294A (fr)
TN (1)	TNSN01014A1 (fr)
WO (1)	WO2001055147A1 (fr)
YU (1)	YU50402A (fr)
ZA (1)	ZA200205879B (fr)

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US7235551B2 (en)	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
CN100525768C (zh)	2000-10-23	2009-08-12	史密丝克莱恩比彻姆公司	新化合物
PE20030008A1 (es) *	2001-06-19	2003-01-22	Bristol Myers Squibb Co	Inhibidores duales de pde 7 y pde 4
KR20040103972A (ko)	2002-04-19	2004-12-09	스미스클라인 비참 코포레이션	신규 화합물
JP2006508997A (ja) *	2002-11-28	2006-03-16	シエーリングアクチエンゲゼルシャフト	Ｃｈｋ−、Ｐｄｋ−およびＡｋｔ−阻害性ピリミジン、それらの製造および薬剤としての使用
US7157455B2 (en) *	2003-02-10	2007-01-02	Hoffmann-La Roche Inc.	4-Aminopyrimidine-5-one derivatives
TW200502236A (en)	2003-03-28	2005-01-16	Hoffmann La Roche	Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
FR2873118B1 (fr)	2004-07-15	2007-11-23	Sanofi Synthelabo	Derives de pyrido-pyrimidine, leur application en therapeutique
CA2579406A1 (fr) *	2004-09-21	2006-03-30	F.Hoffmann-La Roche Ag	6-(2-alkyl-phenyl)-pyrido[2,3-d]pyrimidines utiles comme inhibiteurs de la proteine kinase
US20080096905A1 (en)	2005-03-25	2008-04-24	Glaxo Group Limited	Process For Preparing Pyrido[2,3-D]Pyrimidin-7-One And 3,4-Dihydropyrimido{4,5-D}Pyrimidin-2(1H)-One Derivatives
PE20061193A1 (es)	2005-03-25	2006-12-02	Glaxo Group Ltd	DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2-[1H]-0NA COMO INHIBIDORES DE QUINASA p38
US7423042B2 (en)	2005-03-25	2008-09-09	Glaxo Group Limited	Compounds
MY145343A (en)	2005-03-25	2012-01-31	Glaxo Group Ltd	Novel compounds
FR2887882B1 (fr) *	2005-07-01	2007-09-07	Sanofi Aventis Sa	Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
ES2336603T3 (es) *	2005-07-21	2010-04-14	F. Hoffmann-La Roche Ag	Compuestos de pirido(2,3-d)pirimidina-2,4-diamina como inhibidores de ptp1b.
WO2007021795A2 (fr) *	2005-08-09	2007-02-22	Irm Llc	Composes et compositions utiles comme inhibiteurs de proteines kinases
FR2896246B1 (fr)	2006-01-13	2008-08-15	Sanofi Aventis Sa	Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
EP1914234A1 (fr)	2006-10-16	2008-04-23	GPC Biotech Inc.	Pyrido[2,3-d]pyrimidines et leur utilisation comme inhibiteurs de kinases
JO2985B1 (ar)	2006-12-20	2016-09-05	Takeda Pharmaceuticals Co	مثبطات كينازmapk/erk
FR2910813B1 (fr)	2006-12-28	2009-02-06	Sanofi Aventis Sa	Nouvelle utilisation therapeutique pour le traitement des leucemies
EP2112150B1 (fr)	2008-04-22	2013-10-16	Forma Therapeutics, Inc.	Inhibiteurs Raf améliorés
CN102216299B (zh) *	2008-12-01	2015-02-11	默克专利有限公司	作为自体毒素抑制剂的2,5-二氨基取代的吡啶并[4,3-d]嘧啶化合物
GB201104267D0 (en)	2011-03-14	2011-04-27	Cancer Rec Tech Ltd	Pyrrolopyridineamino derivatives
GB201216018D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Pharmacologically active compounds
GB201216017D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Inhibitor compounds
US9815847B2 (en)	2013-03-14	2017-11-14	Icahn School Of Medicine At Mount Sinai	Pyrimidine compounds as kinase inhibitors
GB201403536D0 (en)	2014-02-28	2014-04-16	Cancer Rec Tech Ltd	Inhibitor compounds
KR101671404B1 (ko) *	2014-09-02	2016-11-02	한국원자력의학원	항암 효과, 방사선 병용치료 효과 및 당뇨병 치료 효과를 갖는 피리미딘 유도체 및 이의 의학적 용도
CN107286180B (zh) *	2016-04-11	2019-07-02	上海勋和医药科技有限公司	杂代吡啶并嘧啶酮衍生物作为cdk抑制剂及其应用
GB201709840D0 (en)	2017-06-20	2017-08-02	Inst Of Cancer Research: Royal Cancer Hospital	Methods and medical uses

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IL115256A0 (en) *	1994-11-14	1995-12-31	Warner Lambert Co	6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
PL181893B1 (pl) *	1994-11-14	2001-10-31	Warner Lambert Co	Zwiazki bedace pochodnymi pirymidyny i naftyrydyny oraz preparat farmaceutyczny zawierajacy je PL PL PL
US5620981A (en) *	1995-05-03	1997-04-15	Warner-Lambert Company	Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
TR200003429T2 (tr) *	1998-05-26	2001-07-23	Warner-Lambert Company	Hücresel çoğalma inhibitörleri olarak bisiklik pirimidinler ve bisiklik 3,4-dihidropirimidinler.

2001
- 2001-01-23 CA CA002397961A patent/CA2397961C/fr not_active Expired - Fee Related
- 2001-01-23 JP JP2001561006A patent/JP4047010B2/ja not_active Expired - Fee Related
- 2001-01-23 CN CN01804048A patent/CN1395578A/zh active Pending
- 2001-01-23 KR KR1020027009516A patent/KR20020065939A/ko not_active Ceased
- 2001-01-23 WO PCT/IB2001/000069 patent/WO2001055147A1/fr not_active Ceased
- 2001-01-23 CZ CZ20022475A patent/CZ20022475A3/cs unknown
- 2001-01-23 AR ARP010100285A patent/AR030044A1/es not_active Application Discontinuation
- 2001-01-23 HU HU0204141A patent/HUP0204141A3/hu unknown
- 2001-01-23 AP APAP/P/2002/002586A patent/AP2002002586A0/en unknown
- 2001-01-23 SK SK1063-2002A patent/SK10632002A3/sk not_active Application Discontinuation
- 2001-01-23 BR BR0107751-1A patent/BR0107751A/pt not_active IP Right Cessation
- 2001-01-23 AU AU25425/01A patent/AU2542501A/en not_active Abandoned
- 2001-01-23 EA EA200200643A patent/EA200200643A1/ru unknown
- 2001-01-23 EP EP01900591A patent/EP1254137A1/fr not_active Withdrawn
- 2001-01-23 PL PL01356802A patent/PL356802A1/xx not_active Application Discontinuation
- 2001-01-23 YU YU50402A patent/YU50402A/sh unknown
- 2001-01-23 PA PA20018510701A patent/PA8510701A1/es unknown
- 2001-01-23 IL IL15054501A patent/IL150545A0/xx unknown
- 2001-01-23 EE EEP200200405A patent/EE200200405A/xx unknown
- 2001-01-23 GT GT200100016A patent/GT200100016A/es unknown
- 2001-01-23 MX MXPA02007221A patent/MXPA02007221A/es not_active Application Discontinuation
- 2001-01-23 OA OA1200200213A patent/OA12161A/en unknown
- 2001-01-23 PE PE2001000072A patent/PE20011066A1/es not_active Application Discontinuation
- 2001-01-23 DZ DZ013266A patent/DZ3266A1/fr active
- 2001-01-24 CO CO01005268A patent/CO5261549A1/es not_active Application Discontinuation
- 2001-01-24 SV SV2001000294A patent/SV2002000294A/es not_active Application Discontinuation
- 2001-01-24 HN HN2001000013A patent/HN2001000013A/es unknown
- 2001-01-24 TN TNTNSN01014A patent/TNSN01014A1/fr unknown
2002
- 2002-06-20 BG BG106850A patent/BG106850A/bg unknown
- 2002-06-25 IS IS6443A patent/IS6443A/is unknown
- 2002-07-17 CR CR6706A patent/CR6706A/es not_active Application Discontinuation
- 2002-07-22 MA MA26736A patent/MA26868A1/fr unknown
- 2002-07-23 ZA ZA200205879A patent/ZA200205879B/en unknown
- 2002-07-24 NO NO20023527A patent/NO20023527L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
SK10632002A3 (sk)	2003-06-03
HUP0204141A2 (hu)	2003-04-28
SV2002000294A (es)	2002-07-16
GT200100016A (es)	2001-10-19
EA200200643A1 (ru)	2002-12-26
ZA200205879B (en)	2003-09-29
AP2002002586A0 (en)	2002-09-30
PL356802A1 (en)	2004-07-12
KR20020065939A (ko)	2002-08-14
IL150545A0 (en)	2003-02-12
EP1254137A1 (fr)	2002-11-06
NO20023527D0 (no)	2002-07-24
AU2542501A (en)	2001-08-07
BR0107751A (pt)	2002-11-12
DZ3266A1 (fr)	2001-08-02
CA2397961C (fr)	2008-08-26
CA2397961A1 (fr)	2001-08-02
CR6706A (es)	2005-04-04
HN2001000013A (es)	2001-06-18
HUP0204141A3 (en)	2005-03-29
WO2001055147A1 (fr)	2001-08-02
JP2003523357A (ja)	2003-08-05
NO20023527L (no)	2002-09-10
AR030044A1 (es)	2003-08-13
MA26868A1 (fr)	2004-12-20
YU50402A (sh)	2005-11-28
PE20011066A1 (es)	2001-10-22
CZ20022475A3 (cs)	2003-03-12
IS6443A (is)	2002-06-25
CN1395578A (zh)	2003-02-05
JP4047010B2 (ja)	2008-02-13
CO5261549A1 (es)	2003-03-31
TNSN01014A1 (fr)	2005-11-10
PA8510701A1 (es)	2002-12-11
EE200200405A (et)	2003-12-15
MXPA02007221A (es)	2002-11-29
BG106850A (bg)	2003-02-28

Publication	Publication Date	Title
OA12161A (en)	2006-05-08	PyridoÄ2,3-dÜpyrimidine-2,7-diamine kinase inhibitors.
US7053070B2 (en)	2006-05-30	Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors
US7244729B2 (en)	2007-07-17	4-amino-6-phenyl-pyrrolo[2,3-d]pyrimidine derivatives
AU777468B2 (en)	2004-10-21	Pteridinones as kinase inhibitors
ES2274526T3 (es)	2007-05-16	Pirido(2,3-d)pirimidinas para inhibir la proliferacion celular mediada por tirosinaquinasa.
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