HUP0204141A3 - Pyrido[2,3d]pyrimidine-2,7-diamine inhibitors, pharmaceutical compositions containing them and their use - Google Patents

Pyrido[2,3d]pyrimidine-2,7-diamine inhibitors, pharmaceutical compositions containing them and their use

Info

Publication number: HUP0204141A3
Authority: HU; Hungary
Prior art keywords: pyrido; pyrimidine; pharmaceutical compositions; compositions containing; diamine
Prior art date: 2000-01-25

Application number

HU0204141A

Other languages

English (en)

Hungarian (hu)

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-25

Filing date

2001-01-23

Publication date

2005-03-29

2001-01-23 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2003-04-28 Publication of HUP0204141A2 publication Critical patent/HUP0204141A2/hu

2005-03-29 Publication of HUP0204141A3 publication Critical patent/HUP0204141A3/hu

Links

239000003112 inhibitor Substances 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
QRRCMVPZJCHBLQ-UHFFFAOYSA-N pyrido[2,3-d]pyrimidine-2,7-diamine Chemical compound C1=NC(N)=NC2=NC(N)=CC=C21 QRRCMVPZJCHBLQ-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Enzymes And Modification Thereof (AREA)

HU0204141A 2000-01-25 2001-01-23 Pyrido[2,3d]pyrimidine-2,7-diamine inhibitors, pharmaceutical compositions containing them and their use HUP0204141A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17826100P	2000-01-25	2000-01-25
PCT/IB2001/000069 WO2001055147A1 (fr)	2000-01-25	2001-01-23	Inhibiteurs de pyrido[2,3-d]pyrimidine-2,7-diamine kinase

Publications (2)

Publication Number	Publication Date
HUP0204141A2 HUP0204141A2 (hu)	2003-04-28
HUP0204141A3 true HUP0204141A3 (en)	2005-03-29

Family

ID=22651853

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0204141A HUP0204141A3 (en)	2000-01-25	2001-01-23	Pyrido[2,3d]pyrimidine-2,7-diamine inhibitors, pharmaceutical compositions containing them and their use

Country Status (34)

Country	Link
EP (1)	EP1254137A1 (fr)
JP (1)	JP4047010B2 (fr)
KR (1)	KR20020065939A (fr)
CN (1)	CN1395578A (fr)
AP (1)	AP2002002586A0 (fr)
AR (1)	AR030044A1 (fr)
AU (1)	AU2542501A (fr)
BG (1)	BG106850A (fr)
BR (1)	BR0107751A (fr)
CA (1)	CA2397961C (fr)
CO (1)	CO5261549A1 (fr)
CR (1)	CR6706A (fr)
CZ (1)	CZ20022475A3 (fr)
DZ (1)	DZ3266A1 (fr)
EA (1)	EA200200643A1 (fr)
EE (1)	EE200200405A (fr)
GT (1)	GT200100016A (fr)
HN (1)	HN2001000013A (fr)
HU (1)	HUP0204141A3 (fr)
IL (1)	IL150545A0 (fr)
IS (1)	IS6443A (fr)
MA (1)	MA26868A1 (fr)
MX (1)	MXPA02007221A (fr)
NO (1)	NO20023527L (fr)
OA (1)	OA12161A (fr)
PA (1)	PA8510701A1 (fr)
PE (1)	PE20011066A1 (fr)
PL (1)	PL356802A1 (fr)
SK (1)	SK10632002A3 (fr)
SV (1)	SV2002000294A (fr)
TN (1)	TNSN01014A1 (fr)
WO (1)	WO2001055147A1 (fr)
YU (1)	YU50402A (fr)
ZA (1)	ZA200205879B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7235551B2 (en)	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
CN100525768C (zh)	2000-10-23	2009-08-12	史密丝克莱恩比彻姆公司	新化合物
PE20030008A1 (es) *	2001-06-19	2003-01-22	Bristol Myers Squibb Co	Inhibidores duales de pde 7 y pde 4
KR20040103972A (ko)	2002-04-19	2004-12-09	스미스클라인 비참 코포레이션	신규 화합물
JP2006508997A (ja) *	2002-11-28	2006-03-16	シエーリングアクチエンゲゼルシャフト	Ｃｈｋ−、Ｐｄｋ−およびＡｋｔ−阻害性ピリミジン、それらの製造および薬剤としての使用
US7157455B2 (en) *	2003-02-10	2007-01-02	Hoffmann-La Roche Inc.	4-Aminopyrimidine-5-one derivatives
TW200502236A (en)	2003-03-28	2005-01-16	Hoffmann La Roche	Novel pyrido[2,3-d]pyrimidin-7-carboxylic acid derivatives, their manufacture and use as pharmaceutical agents
FR2873118B1 (fr)	2004-07-15	2007-11-23	Sanofi Synthelabo	Derives de pyrido-pyrimidine, leur application en therapeutique
CA2579406A1 (fr) *	2004-09-21	2006-03-30	F.Hoffmann-La Roche Ag	6-(2-alkyl-phenyl)-pyrido[2,3-d]pyrimidines utiles comme inhibiteurs de la proteine kinase
US20080096905A1 (en)	2005-03-25	2008-04-24	Glaxo Group Limited	Process For Preparing Pyrido[2,3-D]Pyrimidin-7-One And 3,4-Dihydropyrimido{4,5-D}Pyrimidin-2(1H)-One Derivatives
PE20061193A1 (es)	2005-03-25	2006-12-02	Glaxo Group Ltd	DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2-[1H]-0NA COMO INHIBIDORES DE QUINASA p38
US7423042B2 (en)	2005-03-25	2008-09-09	Glaxo Group Limited	Compounds
MY145343A (en)	2005-03-25	2012-01-31	Glaxo Group Ltd	Novel compounds
FR2887882B1 (fr) *	2005-07-01	2007-09-07	Sanofi Aventis Sa	Derives de pyrido[2,3-d] pyrimidine, leur preparation, leur application en therapeutique
ES2336603T3 (es) *	2005-07-21	2010-04-14	F. Hoffmann-La Roche Ag	Compuestos de pirido(2,3-d)pirimidina-2,4-diamina como inhibidores de ptp1b.
WO2007021795A2 (fr) *	2005-08-09	2007-02-22	Irm Llc	Composes et compositions utiles comme inhibiteurs de proteines kinases
FR2896246B1 (fr)	2006-01-13	2008-08-15	Sanofi Aventis Sa	Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique.
EP1914234A1 (fr)	2006-10-16	2008-04-23	GPC Biotech Inc.	Pyrido[2,3-d]pyrimidines et leur utilisation comme inhibiteurs de kinases
JO2985B1 (ar)	2006-12-20	2016-09-05	Takeda Pharmaceuticals Co	مثبطات كينازmapk/erk
FR2910813B1 (fr)	2006-12-28	2009-02-06	Sanofi Aventis Sa	Nouvelle utilisation therapeutique pour le traitement des leucemies
EP2112150B1 (fr)	2008-04-22	2013-10-16	Forma Therapeutics, Inc.	Inhibiteurs Raf améliorés
CN102216299B (zh) *	2008-12-01	2015-02-11	默克专利有限公司	作为自体毒素抑制剂的2,5-二氨基取代的吡啶并[4,3-d]嘧啶化合物
GB201104267D0 (en)	2011-03-14	2011-04-27	Cancer Rec Tech Ltd	Pyrrolopyridineamino derivatives
GB201216018D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Pharmacologically active compounds
GB201216017D0 (en)	2012-09-07	2012-10-24	Cancer Rec Tech Ltd	Inhibitor compounds
US9815847B2 (en)	2013-03-14	2017-11-14	Icahn School Of Medicine At Mount Sinai	Pyrimidine compounds as kinase inhibitors
GB201403536D0 (en)	2014-02-28	2014-04-16	Cancer Rec Tech Ltd	Inhibitor compounds
KR101671404B1 (ko) *	2014-09-02	2016-11-02	한국원자력의학원	항암 효과, 방사선 병용치료 효과 및 당뇨병 치료 효과를 갖는 피리미딘 유도체 및 이의 의학적 용도
CN107286180B (zh) *	2016-04-11	2019-07-02	上海勋和医药科技有限公司	杂代吡啶并嘧啶酮衍生物作为cdk抑制剂及其应用
GB201709840D0 (en)	2017-06-20	2017-08-02	Inst Of Cancer Research: Royal Cancer Hospital	Methods and medical uses

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL115256A0 (en) *	1994-11-14	1995-12-31	Warner Lambert Co	6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use
PL181893B1 (pl) *	1994-11-14	2001-10-31	Warner Lambert Co	Zwiazki bedace pochodnymi pirymidyny i naftyrydyny oraz preparat farmaceutyczny zawierajacy je PL PL PL
US5620981A (en) *	1995-05-03	1997-04-15	Warner-Lambert Company	Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation
TR200003429T2 (tr) *	1998-05-26	2001-07-23	Warner-Lambert Company	Hücresel çoğalma inhibitörleri olarak bisiklik pirimidinler ve bisiklik 3,4-dihidropirimidinler.

2001
- 2001-01-23 CA CA002397961A patent/CA2397961C/fr not_active Expired - Fee Related
- 2001-01-23 JP JP2001561006A patent/JP4047010B2/ja not_active Expired - Fee Related
- 2001-01-23 CN CN01804048A patent/CN1395578A/zh active Pending
- 2001-01-23 KR KR1020027009516A patent/KR20020065939A/ko not_active Ceased
- 2001-01-23 WO PCT/IB2001/000069 patent/WO2001055147A1/fr not_active Ceased
- 2001-01-23 CZ CZ20022475A patent/CZ20022475A3/cs unknown
- 2001-01-23 AR ARP010100285A patent/AR030044A1/es not_active Application Discontinuation
- 2001-01-23 HU HU0204141A patent/HUP0204141A3/hu unknown
- 2001-01-23 AP APAP/P/2002/002586A patent/AP2002002586A0/en unknown
- 2001-01-23 SK SK1063-2002A patent/SK10632002A3/sk not_active Application Discontinuation
- 2001-01-23 BR BR0107751-1A patent/BR0107751A/pt not_active IP Right Cessation
- 2001-01-23 AU AU25425/01A patent/AU2542501A/en not_active Abandoned
- 2001-01-23 EA EA200200643A patent/EA200200643A1/ru unknown
- 2001-01-23 EP EP01900591A patent/EP1254137A1/fr not_active Withdrawn
- 2001-01-23 PL PL01356802A patent/PL356802A1/xx not_active Application Discontinuation
- 2001-01-23 YU YU50402A patent/YU50402A/sh unknown
- 2001-01-23 PA PA20018510701A patent/PA8510701A1/es unknown
- 2001-01-23 IL IL15054501A patent/IL150545A0/xx unknown
- 2001-01-23 EE EEP200200405A patent/EE200200405A/xx unknown
- 2001-01-23 GT GT200100016A patent/GT200100016A/es unknown
- 2001-01-23 MX MXPA02007221A patent/MXPA02007221A/es not_active Application Discontinuation
- 2001-01-23 OA OA1200200213A patent/OA12161A/en unknown
- 2001-01-23 PE PE2001000072A patent/PE20011066A1/es not_active Application Discontinuation
- 2001-01-23 DZ DZ013266A patent/DZ3266A1/fr active
- 2001-01-24 CO CO01005268A patent/CO5261549A1/es not_active Application Discontinuation
- 2001-01-24 SV SV2001000294A patent/SV2002000294A/es not_active Application Discontinuation
- 2001-01-24 HN HN2001000013A patent/HN2001000013A/es unknown
- 2001-01-24 TN TNTNSN01014A patent/TNSN01014A1/fr unknown
2002
- 2002-06-20 BG BG106850A patent/BG106850A/bg unknown
- 2002-06-25 IS IS6443A patent/IS6443A/is unknown
- 2002-07-17 CR CR6706A patent/CR6706A/es not_active Application Discontinuation
- 2002-07-22 MA MA26736A patent/MA26868A1/fr unknown
- 2002-07-23 ZA ZA200205879A patent/ZA200205879B/en unknown
- 2002-07-24 NO NO20023527A patent/NO20023527L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
SK10632002A3 (sk)	2003-06-03
HUP0204141A2 (hu)	2003-04-28
SV2002000294A (es)	2002-07-16
GT200100016A (es)	2001-10-19
EA200200643A1 (ru)	2002-12-26
ZA200205879B (en)	2003-09-29
AP2002002586A0 (en)	2002-09-30
PL356802A1 (en)	2004-07-12
KR20020065939A (ko)	2002-08-14
IL150545A0 (en)	2003-02-12
EP1254137A1 (fr)	2002-11-06
OA12161A (en)	2006-05-08
NO20023527D0 (no)	2002-07-24
AU2542501A (en)	2001-08-07
BR0107751A (pt)	2002-11-12
DZ3266A1 (fr)	2001-08-02
CA2397961C (fr)	2008-08-26
CA2397961A1 (fr)	2001-08-02
CR6706A (es)	2005-04-04
HN2001000013A (es)	2001-06-18
WO2001055147A1 (fr)	2001-08-02
JP2003523357A (ja)	2003-08-05
NO20023527L (no)	2002-09-10
AR030044A1 (es)	2003-08-13
MA26868A1 (fr)	2004-12-20
YU50402A (sh)	2005-11-28
PE20011066A1 (es)	2001-10-22
CZ20022475A3 (cs)	2003-03-12
IS6443A (is)	2002-06-25
CN1395578A (zh)	2003-02-05
JP4047010B2 (ja)	2008-02-13
CO5261549A1 (es)	2003-03-31
TNSN01014A1 (fr)	2005-11-10
PA8510701A1 (es)	2002-12-11
EE200200405A (et)	2003-12-15
MXPA02007221A (es)	2002-11-29
BG106850A (bg)	2003-02-28

Publication	Publication Date	Title
HUP0204141A3 (en)	2005-03-29	Pyrido[2,3d]pyrimidine-2,7-diamine inhibitors, pharmaceutical compositions containing them and their use
HUP0301722A3 (en)	2004-03-29	Pyrimidine derivatives, pharmaceutical compositions containing them and their use
HUP0400692A3 (en)	2007-09-28	Substituted 7h-pyrrolo[2,3-d]pyrimidine derivatives, their use and pharmaceutical compositions containing them
HUP0400837A3 (en)	2007-11-28	2-phenyl-thiazole derivatives, their use and pharmaceutical compositions containing them
HUP0204474A3 (en)	2004-07-28	1h-imidazopyridine derivatives, pharmaceutical compositions containing them and their use
HUP0200355A2 (en)	2002-06-29	4-aminopyrrolopyrimidines as kinase inhibitors, pharmaceutical compositions containing them and their use
HUP0204514A3 (en)	2004-07-28	Pyridinylimidazoles, pharmaceutical compositions containing them and their use
IL150734A0 (en)	2003-02-12	Azaindole derivatives and pharmaceutical compositions containing the same
HUP0400384A3 (en)	2008-08-28	Benzamidine derivative and pharmaceutical compositions containing them and their use
HUP0301573A3 (en)	2004-03-29	Substituted arylpyrazines, pharmaceutical compositions containing them and their use
HUP0204410A3 (en)	2003-07-28	Pyrimidine-4-one derivatives, process for their preparation, pharmaceutical compositions containing them and their use
GC0000307A (en)	2006-11-01	Pyrimidone compounds and pharmaceutical composition containing them
HUP0203895A3 (en)	2004-09-28	Substituted azaindoles and pharmaceutical compositions containing them and their use
IL156354A0 (en)	2004-01-04	Pyridoindole derivatives and pharmaceutical compositions containing the same
HUP0303016A3 (en)	2007-03-28	Xanthine phosphodiesterase v inhibitors, process for their preparation and pharmaceutical compositions containing them and their use
HUP0300207A3 (en)	2005-07-28	1,2,3,4-tetrahydroisquinoline derivatives, pharmaceutical compositions containing them and their preparation processes
IL151952A0 (en)	2003-04-10	Aminopyridine derivatives and pharmaceutical compositions containing the same
IL151209A0 (en)	2003-04-10	Pharmaceutical compositions containing 3-aminoazetidine derivatives, novel derivatives and their preparation
HUP0302969A3 (en)	2005-05-30	Npyy5 antagonists, pharmaceutical compositions containing them and their use
HUP0300798A3 (en)	2006-02-28	Substituted-triazolopyrimidines and their use as anticancer agents and pharmaceutical compositions containing them
HUP0402018A3 (en)	2008-06-30	5-amino-7h-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives, their use and pharmaceutical compositions containing them
HUP0302455A3 (en)	2005-05-30	Combination pharmaceutical compositions containing amplodipine and benazepril and their use
HUP0400967A3 (en)	2004-10-28	Substituted 2-anilino-benzimidazoles, their use and pharmaceutical compositions containing them
HUP0300578A3 (en)	2009-01-28	Alkylated imidazopyridine derivatives, pharmaceutical compositions containing them and their use
HUP0201730A3 (en)	2004-12-28	Thienopyrimidines as phosphodiesterase inhibitors, their use, pharmaceutical compositions containing them and process for the preparation thereof