HK183795A - One-step enzymatic conversion of cephalosporin c and derivatives to 7-aminocephalosporanic acid and derivatives - Google Patents

One-step enzymatic conversion of cephalosporin c and derivatives to 7-aminocephalosporanic acid and derivatives

Info

Publication number
HK183795A
HK183795A HK183795A HK183795A HK183795A HK 183795 A HK183795 A HK 183795A HK 183795 A HK183795 A HK 183795A HK 183795 A HK183795 A HK 183795A HK 183795 A HK183795 A HK 183795A
Authority
HK
Hong Kong
Prior art keywords
cephalosporin
amidase
derivatives
producing
formula
Prior art date
Application number
HK183795A
Other languages
English (en)
French (fr)
Inventor
Lein Joseph
Original Assignee
Merck & Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.
Publication of HK183795A publication Critical patent/HK183795A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/06—Arthrobacter
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/83—Arthrobacter

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)

Claims (5)

  1. Verfahren zur einstufigen Umwandlung von Cephalosporin C und Derivaten davon in die entsprechende 7-Aminocephalosporansäure und Derivate, umfassend die Behandlung des Cephalosporins C und der Derivate mit einer Cephalosporin-C-Amidase, abgeleitet von Arthrobacter viscosus ATCC 53594 oder von beliebigen, Cephalosporin-C-Amidase bildenden oder potentiell bildenden Abkömmlingen davon.
  2. Verfahren zur einstufigen Umwandlung von Cephalosporin C und Derivaten davon der Formel in der
    R¹   
    R²   -H;
    R³   -H oder oder CH₂R⁴ ist, wobei
    R⁴   -H, -OH oder ist, und
    M   ⊖, H, Alkalimetall oder ein anderes pharmazeutisch annehmbares Salz, ein pharmazeutisch annehmbarer Ester oder eine leicht entfernbare eine Carboxylgruppe schützende (covering) Gruppe ist, in eine 7-Amino-cephalosporansäure der Formel
    umfassend die Behandlung einer Verbindung der Formel I mit einem Enzym, Cephalosporin-C-Amidase, das in der Lage ist, eine Verbindung der Formel I in einer Stufe in eine Verbindung der Formel II umzuwandeln, wobei das Enzym dadurch gekennzeichnet ist, daß es abgeleitet ist von Arthrobacter viscosus ATCC 53594 oder von beliebigen, Cephalosporin-C-Amidase bildenden oder potentiell bildenden Abkömmlingen davon.
  3. Verfahren nach Anspruch 2, wobei die Verbindung der Formel I Cephalosporin C und die Verbindung der Formel II 7-Aminocephalosporansäure ist.
  4. Mikroorganismus Arthrobacter viscosus ATCC 53594 oder beliebige Cephalosporin-C-Amidase bildende oder potentiell bildende Abkömmlinge davon.
  5. Arthrobacter viscosus ATCC 53594.
HK183795A 1987-03-18 1995-11-30 One-step enzymatic conversion of cephalosporin c and derivatives to 7-aminocephalosporanic acid and derivatives HK183795A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2757887A 1987-03-18 1987-03-18
US07/136,227 US4981789A (en) 1987-03-18 1987-12-21 One-step enzymatic conversion of cephalosporin C and derivatives to 7-aminocephalosporanic acid and derivatives

Publications (1)

Publication Number Publication Date
HK183795A true HK183795A (en) 1995-12-08

Family

ID=26702659

Family Applications (1)

Application Number Title Priority Date Filing Date
HK183795A HK183795A (en) 1987-03-18 1995-11-30 One-step enzymatic conversion of cephalosporin c and derivatives to 7-aminocephalosporanic acid and derivatives

Country Status (6)

Country Link
US (1) US4981789A (de)
EP (1) EP0283218B1 (de)
JP (1) JPS63276498A (de)
CY (1) CY1892A (de)
DE (1) DE3882255T2 (de)
HK (1) HK183795A (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1224252B (it) * 1988-04-08 1990-09-26 Sclavo Spa Metodo di protezione del gruppo carbossilico nella chimica dei composti beta lattamici
EP0465600B1 (de) * 1989-04-04 1995-06-07 Biopure Corporation Enzymatisches verfahren zur herstellung von 7-aminocephalosporansäure
US5229274A (en) * 1989-06-27 1993-07-20 Merck & Co., Inc. Gene encoding one step cephalosporin C amidase and expression thereof in recombinant bacillus
ES2119756T3 (es) * 1990-04-18 1998-10-16 Gist Brocades Nv Genes de beta lactama acilasa mutados.
DE4030040A1 (de) * 1990-09-22 1992-03-26 Bayer Ag Enzymatische de-acylierung von acyl-aminosorbosen und dessen verwendung bei der herstellung von 1-desoxynojirimicin
SK280569B6 (sk) * 1991-10-15 2000-03-13 Gist-Brocades B.V. Biologický spôsob výroby kyseliny7-aminodeacetylce
ES2144139T3 (es) * 1994-08-12 2000-06-01 Dsm Nv Genes de la penicilina g-acilasa mutados.
DE4437420A1 (de) * 1994-10-19 1996-04-25 Hoechst Ag Verbessertes, induktionsfreies Verfahren zur gentechnischen Herstellung von Glutarylamidase
ATE402997T1 (de) 1996-11-05 2008-08-15 Bristol Myers Squibb Co Mutierte penicillin g acylasen
DK1322751T3 (da) * 2000-09-22 2006-02-20 Bristol Myers Squibb Co Glutarylcephalosporinamidase fra Pseudomonas diminuta BS-203
WO2002085914A2 (en) 2001-04-19 2002-10-31 Bioferma Murcia, S.A. ENZYMATIC PROCESS FOR PREPARING CEPHALOSPORANIC ACID DERIVATIVES USING α-KETOACID DERIVATIVES

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3144395A (en) * 1962-08-01 1964-08-11 Olin Mathieson Process for preparing 6-aminopenicillanic acid by bacillus megaterium
FR1357977A (fr) * 1963-05-20 1964-04-10 Merck & Co Inc Procédé de production d'acide 7-aminocéphalosphalosporanique par voie enzymatique
US3239394A (en) * 1964-06-15 1966-03-08 Merck & Co Inc Process for producing 7-amino-cephalosporanic acid
US3565763A (en) * 1967-12-19 1971-02-23 Us Agriculture Nitrogen source for improved productions of microbial polysaccharides
US3522250A (en) * 1968-10-15 1970-07-28 American Home Prod Derivatives of 7-aminocephalosporanic acid
JPS4948760B1 (de) * 1970-12-25 1974-12-23
GB1385685A (en) * 1971-04-21 1975-02-26 Glaxo Lab Ltd Cephalosporin derivatives
PL82333B1 (de) * 1971-05-31 1975-10-31
JPS5341232B2 (de) * 1972-06-17 1978-11-01
JPS5417030B2 (de) * 1972-12-06 1979-06-27
GB1473100A (de) * 1973-05-10 1977-05-11
FR2241557A1 (en) * 1973-08-22 1975-03-21 Aries Robert 7-Amino-desacetoxy cephalosporanic acid prepn - from cephalosporin C, using an amido hydrolase enzyme
DE2355078A1 (de) * 1973-11-03 1975-05-07 Bayer Ag Verfahren zur herstellung von 7-amino-delta hoch 3-cephem-derivaten
CH590292A5 (de) * 1973-12-20 1977-07-29 Ciba Geigy Ag
JPS5417032B2 (de) * 1974-01-23 1979-06-27
JPS5619999B2 (de) * 1974-02-07 1981-05-11
JPS5282791A (en) * 1975-12-27 1977-07-11 Toyo Jozo Co Ltd Preparation of 7-amino compounds
JPS5920360B2 (ja) * 1976-04-19 1984-05-12 萬有製薬株式会社 ７−アミノセフアロスポラン酸および其の誘導体の製造法
JPS52143289A (en) * 1976-05-24 1977-11-29 Meiji Seika Kaisha Ltd Production of 7-amino-cephem derivatives by filamentous fungi
JPS60995B2 (ja) * 1977-01-27 1985-01-11 明治製菓株式会社 ７−アミノ−セフアロスポラン酸およびその誘導体の新規製造法
US4171395A (en) * 1977-03-30 1979-10-16 Tillotson John G Method and apparatus for forming a layer of foam urethane on a carpet backing and product
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DE3447023A1 (de) * 1984-12-22 1986-06-26 Hoechst Ag, 6230 Frankfurt Neue d-aminosaeure-transaminase und ihre verwendung
JPS61152286A (ja) * 1984-12-27 1986-07-10 Asahi Chem Ind Co Ltd セフアロスポリンｃアシラ−ゼ産生遺伝情報を担うｄｎａ断片
JPH0829114B2 (ja) * 1986-09-18 1996-03-27 旭化成工業株式会社 ７−アミノセフアロスポラン酸およびその誘導体の製造法

Also Published As

Publication number Publication date
EP0283218B1 (de) 1993-07-14
US4981789A (en) 1991-01-01
CY1892A (en) 1996-08-30
DE3882255T2 (de) 1993-12-09
DE3882255D1 (de) 1993-08-19
EP0283218A3 (en) 1990-07-11
JPS63276498A (ja) 1988-11-14
EP0283218A2 (de) 1988-09-21

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