HK18796A - New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same - Google Patents

New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same

Info

Publication number
HK18796A
HK18796A HK18796A HK18796A HK18796A HK 18796 A HK18796 A HK 18796A HK 18796 A HK18796 A HK 18796A HK 18796 A HK18796 A HK 18796A HK 18796 A HK18796 A HK 18796A
Authority
HK
Hong Kong
Prior art keywords
methyl
methanol
chloroform
hydroxy
amino
Prior art date
Application number
HK18796A
Other languages
English (en)
French (fr)
Inventor
Hemmi Keiji
Neya Masahiro
Marusawa Hiroshi
Imai Keisuke
Kayakiri Natsuko
Hashimoto Masashi
Original Assignee
Fujisawa Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878714597A external-priority patent/GB8714597D0/en
Priority claimed from GB878725511A external-priority patent/GB8725511D0/en
Priority claimed from GB888805389A external-priority patent/GB8805389D0/en
Application filed by Fujisawa Pharmaceutical Co., Ltd. filed Critical Fujisawa Pharmaceutical Co., Ltd.
Publication of HK18796A publication Critical patent/HK18796A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cardiology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (16)

1. Verfahren zur Herstellung einer Verbindung der Formel: worin R1 (C1-C7)Alkyl, wahlweise substituiert mit einem Substituenten, ausgewählt aus der Gruppe, bestehend aus Acyl, Hydroxy, (C1-C7) Alkoxy, Aryl, (C1-C7)Alkylthio und einer Gruppe der Formel:in der R5 Wasserstoff oder Acyl ist, und R6 Wasserstoff oder (C1-C7)Alkyl ist; Aryl; oder Amino, wahlweise substituiert mit Substituent(en), ausgewählt aus der Gruppe, bestehend aus (C1-C7)Alkyl und Acyl ist; und R2 Wasserstoff oder (C1-C7)Alkyl ist; oder R1 und R2 mit dem an sie gebundenen Stickstoffatom zusammengenommen werden, um eine heterocyclische Gruppe zu bilden, die wahlweise substituiert mit Substituent(en) ist, ausgewählt aus der Gruppe, bestehend aus (C1-C7)Alkyl, Hydroxy-(C1-C7)alkyl, (C1-C7)Alkoxy(C1-C7)alkyl, Acyl(C1-C7)Alkyl, Oxo und Acyl; R3 Wasserstoff oder (Ci-C7)-Alkyl ist; und R4 (C1-C7)Alkyl ist, oder ihres Salzes, das umfaßt
a) Reagieren einer Verbindung der Formel: worin R8 Wasserstoff oder eine N-Schutzgruppe ist, und R3 und R4 jeweils wie oben definiert sind, oder ihres reaktiven Derivates an der Aminogruppe oder eines Salzes davon mit einer Verbindung der Formel: worin R1 und R2 jeweils wie oben definiert sind, oder ihrem reaktiven Derivat an der Carboxygruppe oder einem Salz davon, und, falls notwendig, Elininierung der N-Schutzgruppe, um eine Verbindung der Formel: worin R1, R2, R3 und R4 jeweils wie oben definiert sind, oder ihr Salz zu ergeben oder
b) Unterwerfen einer Verbindung der Formel: worin R7 eine N-Schutzgruppe ist, A (C1-C7)Alkylen ist, und R2, R3, R4 und R6 jeweils wie oben definiert sind, oder ihres Salzes der Eliminierungsreaktion der N-Schutzgruppe, um eine Verbindung der Formel: worin R2, R3, R4, R6 und A jeweils wie oben definiert sind, oder ihr Salz zu ergeben.
2. Modifizierung des Verfahrens nach Anspruch 1, dadurch charakterisiert, daß eine Verbindung der Formel [I] oder ein nichttoxisches Salz davon, hergestellt durch das Verfahren nach Anspruch 1, durch Beimischen oder Präsentation der genannten Verbindung mit einem pharmazeutisch verträglichen Verdünnungsmittel oder Träger in eine pharmazeutisch verträgliche Form gebracht wird.
HK18796A 1987-06-22 1996-02-01 New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same HK18796A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB878714597A GB8714597D0 (en) 1987-06-22 1987-06-22 Peptide compounds
GB878725511A GB8725511D0 (en) 1987-10-30 1987-10-30 Peptide compounds
GB888805389A GB8805389D0 (en) 1988-03-07 1988-03-07 New peptide compounds process for preparation thereof & pharmaceutical composition comprising same

Publications (1)

Publication Number Publication Date
HK18796A true HK18796A (en) 1996-02-09

Family

ID=27263470

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18796A HK18796A (en) 1987-06-22 1996-02-01 New amino acid derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same

Country Status (20)

Country Link
US (2) US4921855A (de)
EP (1) EP0300189B1 (de)
JP (1) JPH0625147B2 (de)
KR (1) KR950003926B1 (de)
CN (1) CN1026892C (de)
AR (1) AR247733A1 (de)
AT (1) ATE113585T1 (de)
AU (1) AU617674B2 (de)
DE (1) DE3851986T2 (de)
DK (1) DK340088A (de)
ES (1) ES2067456T3 (de)
FI (1) FI96202C (de)
HK (1) HK18796A (de)
HU (2) HU202212B (de)
IE (1) IE65807B1 (de)
IL (1) IL86782A (de)
NO (1) NO175371C (de)
PH (1) PH27181A (de)
PT (1) PT87754B (de)
RU (1) RU1801107C (de)

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Also Published As

Publication number Publication date
FI882875A7 (fi) 1988-12-23
CN1026892C (zh) 1994-12-07
FI96202C (fi) 1996-05-27
NO175371C (no) 1994-10-05
DE3851986T2 (de) 1995-03-09
DE3851986D1 (de) 1994-12-08
FI96202B (fi) 1996-02-15
HU202212B (en) 1991-02-28
RU1801107C (ru) 1993-03-07
IL86782A (en) 1993-04-04
KR890000434A (ko) 1989-03-14
EP0300189A3 (en) 1990-08-22
PH27181A (en) 1993-04-16
IE65807B1 (en) 1995-11-15
ES2067456T3 (es) 1995-04-01
NO882732D0 (no) 1988-06-21
NO882732L (no) 1988-12-23
US4921855A (en) 1990-05-01
CN1030411A (zh) 1989-01-18
US5142048A (en) 1992-08-25
NO175371B (no) 1994-06-27
PT87754A (pt) 1988-07-01
HUT47917A (en) 1989-04-28
DK340088A (da) 1988-12-23
EP0300189A2 (de) 1989-01-25
DK340088D0 (da) 1988-06-21
IE881778L (en) 1988-12-22
KR950003926B1 (ko) 1995-04-20
JPS6419071A (en) 1989-01-23
AR247733A1 (es) 1995-03-31
HU211977A9 (en) 1996-01-29
IL86782A0 (en) 1988-11-30
JPH0625147B2 (ja) 1994-04-06
FI882875A0 (fi) 1988-06-16
ATE113585T1 (de) 1994-11-15
AU1819088A (en) 1988-12-22
AU617674B2 (en) 1991-12-05
PT87754B (pt) 1992-10-30
EP0300189B1 (de) 1994-11-02

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