HK37392A - New morpholino derivatives of daunorubicin and doxorubicin - Google Patents

New morpholino derivatives of daunorubicin and doxorubicin

Info

Publication number
HK37392A
HK37392A HK373/92A HK37392A HK37392A HK 37392 A HK37392 A HK 37392A HK 373/92 A HK373/92 A HK 373/92A HK 37392 A HK37392 A HK 37392A HK 37392 A HK37392 A HK 37392A
Authority
HK
Hong Kong
Prior art keywords
daunorubicin
doxorubicin
new
morpholino derivatives
hydrogen
Prior art date
Application number
HK373/92A
Other languages
English (en)
Inventor
Bargiotti Alberto
Zini Pierangelo
Penco Sergio
Giuliani Fernando
Original Assignee
Farmitalia Carlo Erba S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba S.R.L. filed Critical Farmitalia Carlo Erba S.R.L.
Publication of HK37392A publication Critical patent/HK37392A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
HK373/92A 1985-03-22 1992-05-28 New morpholino derivatives of daunorubicin and doxorubicin HK37392A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB08507577A GB2172594B (en) 1985-03-22 1985-03-22 New morpholino derivatives of daunorubicin and doxorubicin

Publications (1)

Publication Number Publication Date
HK37392A true HK37392A (en) 1992-06-04

Family

ID=10576503

Family Applications (1)

Application Number Title Priority Date Filing Date
HK373/92A HK37392A (en) 1985-03-22 1992-05-28 New morpholino derivatives of daunorubicin and doxorubicin

Country Status (10)

Country Link
US (1) US4672057A (fr)
JP (1) JPS61221194A (fr)
BE (1) BE904431A (fr)
BG (1) BG60535B2 (fr)
BR (1) BR1100255A (fr)
CZ (1) CZ419591A3 (fr)
DE (1) DE3609052C2 (fr)
GB (1) GB2172594B (fr)
HK (1) HK37392A (fr)
MX (1) MX9203114A (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3823224A1 (de) * 1988-07-08 1990-01-11 Behringwerke Ag Morpholino-derivate der rhodomycine, verfahren zu ihrer herstellung und ihre verwendung
GB8905668D0 (en) * 1989-03-13 1989-04-26 Erba Carlo Spa New 3'-(4-morpholinyl)-and 3'-(2-methoxy-4-morpholinyl)-anthracycline derivatives
US5304687A (en) * 1989-12-19 1994-04-19 Farmitalia Carlo Erba S.R.L. Morpholinyl derivatives of doxorubicin and process for their preparation
DK0434960T3 (da) * 1989-12-19 1996-10-14 Pharmacia Spa Chirale 1,5-diiod-2-methoxy- eller benzyloxymellemprodukter
GB9019933D0 (en) * 1990-09-12 1990-10-24 Erba Carlo Spa 13-dihydro-3'-(2-alkoxy-4-morphlinyl)anthracyclines
GB9019934D0 (en) * 1990-09-12 1990-10-24 Erba Carlo Spa 2-hydroxy-and 2-acyloxy-4-morpholinyl anthracyclines
US5776458A (en) * 1990-12-05 1998-07-07 Pharmacia & Upjohn S.P.A. Anthracycline-conjugates
GB9026491D0 (en) * 1990-12-05 1991-01-23 Erba Carlo Spa Anthracycline-conjugates
GB9028105D0 (en) * 1990-12-27 1991-02-13 Erba Carlo Spa Process for the preparation of substituted benzofuran derivatives
GB9216962D0 (en) * 1992-08-11 1992-09-23 Erba Carlo Spa Therapeutically active naphthalenesulfonic-pyrrolecarboxamido derivatives
GB9909925D0 (en) 1999-04-29 1999-06-30 Pharmacia & Upjohn Spa Combined preparations comprising anthracycline derivatives
ATE344801T1 (de) 1999-12-29 2006-11-15 Immunogen Inc Doxorubicin- und daunorubicin-enthaltende, zytotoxische mittel und deren therapeutische anwendung
US20040038904A1 (en) * 2002-05-21 2004-02-26 Angela Ogden Method of treating multiple sclerosis
BRPI0408494A (pt) * 2003-03-18 2006-04-04 Pharmacia Italia Spa terapia combinada contra tumores compreendendo nemorubicina com terapia de radiação
US20060198882A1 (en) * 2003-03-21 2006-09-07 Yechezkel Barenholz Stable liposomes or micelles comprising a sphinolipid and a peg-lipopolymer
EP1817004A2 (fr) * 2004-11-15 2007-08-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Therapie de combinaison associant preferablement un ceramide avec une substance active cytotoxique
JP4513765B2 (ja) * 2005-04-15 2010-07-28 日本ビクター株式会社 電気音響変換器
AU2007271749A1 (en) * 2006-07-12 2008-01-17 Nerviano Medical Sciences S.R.L. Crystalline nemorubicin hydrochloride
JP2010516741A (ja) * 2007-01-29 2010-05-20 ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ モルホリニルアントラサイクリンおよび抗体を含む抗腫瘍の組み合わせ
WO2008138758A1 (fr) 2007-05-11 2008-11-20 Nerviano Medical Sciences S.R.L. Composition pharmaceutique d'une anthracycline
US20100190736A1 (en) * 2007-08-02 2010-07-29 Nerviano Medical Sciences S.R.L. Morpholinyl anthracycline derivative combined with protein kinase inhibitors
US8742076B2 (en) * 2008-02-01 2014-06-03 Genentech, Inc. Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
EP2257310A2 (fr) * 2008-02-26 2010-12-08 Nerviano Medical Sciences S.r.l. Combinaison antitumorale comprenant un dérivé de morpholinyle anthracycline et des agents de déméthylation
CN102159248B (zh) * 2008-07-15 2013-09-11 健泰科生物技术公司 蒽环类衍生物缀合物、它们的制备方法以及它们作为抗肿瘤化合物的用途
RU2013103763A (ru) 2010-07-02 2014-08-10 Ангиохем Инк. Короткие и содержащие d-аминокислоты полипептиды для терапевтических конъюгатов и их применения
TWI603738B (zh) 2010-11-08 2017-11-01 建南德克公司 皮下投予抗－ｉｌ－６受體抗體
ES2533710T3 (es) 2010-12-02 2015-04-14 Nerviano Medical Sciences S.R.L. Proceso para la preparación de derivados de morfolinil antraciclina
US8962577B2 (en) 2012-03-16 2015-02-24 The Johns Hopkins University Controlled release formulations for the delivery of HIF-1 inhibitors
KR101640912B1 (ko) * 2014-07-03 2016-07-20 현대자동차주식회사 고온 저마찰성 코팅층 및 이의 제조방법
WO2016040825A1 (fr) 2014-09-12 2016-03-17 Genentech, Inc. Intermédiaires disulfure d'anthracycline, conjugué anticorps-médicaments et procédés
EP4180061A1 (fr) 2021-11-10 2023-05-17 Nerviano Medical Sciences S.r.l. Réactifs de liaison dérivés d'anthracycline, conjugués anticorps-médicament et procédés
WO2025168481A1 (fr) 2024-02-05 2025-08-14 Nerviano Medical Sciences S.R.L. Dérivés d'imino-anthracycline et procédés

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1003383A (fr) *
US4464529A (en) * 1982-07-20 1984-08-07 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin

Also Published As

Publication number Publication date
GB2172594A (en) 1986-09-24
BG60535B2 (bg) 1995-07-28
JPS61221194A (ja) 1986-10-01
JPH0482160B2 (fr) 1992-12-25
BE904431A (fr) 1986-07-16
MX9203114A (es) 1992-07-01
US4672057A (en) 1987-06-09
BR1100255A (pt) 2002-04-02
DE3609052C2 (de) 1994-10-27
GB2172594B (en) 1988-06-08
GB8507577D0 (en) 1985-05-01
DE3609052A1 (de) 1986-09-25
CZ419591A3 (en) 1993-03-17

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Legal Events

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PF Patent in force
PE Patent expired

Effective date: 20050321