HK4588A - Anti-tumor quinazoline compounds - Google Patents

Anti-tumor quinazoline compounds

Info

Publication number
HK4588A
HK4588A HK45/88A HK4588A HK4588A HK 4588 A HK4588 A HK 4588A HK 45/88 A HK45/88 A HK 45/88A HK 4588 A HK4588 A HK 4588A HK 4588 A HK4588 A HK 4588A
Authority
HK
Hong Kong
Prior art keywords
tumor
quinazoline compounds
quinazoline
compounds
tumor quinazoline
Prior art date
Application number
HK45/88A
Other languages
English (en)
Inventor
William E Kreighbaum
William T Comer
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of HK4588A publication Critical patent/HK4588A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK45/88A 1981-03-06 1988-01-21 Anti-tumor quinazoline compounds HK4588A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/241,317 US4343940A (en) 1979-02-13 1981-03-06 Anti-tumor quinazoline compounds

Publications (1)

Publication Number Publication Date
HK4588A true HK4588A (en) 1988-01-29

Family

ID=22910195

Family Applications (1)

Application Number Title Priority Date Filing Date
HK45/88A HK4588A (en) 1981-03-06 1988-01-21 Anti-tumor quinazoline compounds

Country Status (31)

Country Link
US (1) US4343940A (de)
JP (1) JPS57158780A (de)
KR (1) KR880001852B1 (de)
AR (1) AR231138A1 (de)
AT (1) AT380476B (de)
AU (1) AU556099B2 (de)
BE (1) BE891936A (de)
CA (1) CA1163995A (de)
CH (1) CH647776A5 (de)
CY (1) CY1371A (de)
DE (1) DE3203770C2 (de)
DK (1) DK159442C (de)
ES (1) ES8304095A1 (de)
FI (1) FI71559C (de)
FR (1) FR2501207B1 (de)
GB (1) GB2094295B (de)
GR (1) GR75903B (de)
HK (1) HK4588A (de)
HU (1) HU189997B (de)
IE (1) IE52385B1 (de)
IL (1) IL64875A0 (de)
IT (1) IT1154272B (de)
KE (1) KE3715A (de)
LU (1) LU83903A1 (de)
NL (1) NL8200473A (de)
NZ (1) NZ199576A (de)
PH (1) PH18529A (de)
PT (1) PT74394B (de)
SE (1) SE461732B (de)
SG (1) SG30787G (de)
YU (1) YU42031B (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3131365A1 (de) * 1981-08-07 1983-02-24 Henkel KGaA, 4000 Düsseldorf Neue diglycidyl-substituierte heterocyclische verbindungen, verfahren zu ihrer herstellung und ihre verwendung in arzneimittelzubereitungen mit cytostatischer wirksamkeit
US4963554A (en) * 1990-02-14 1990-10-16 Ortho Pharmaceutical Corporation 6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
US5030635A (en) * 1990-02-14 1991-07-09 Ortho Pharmaceutical Corporation 6-7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides
USRE37650E1 (en) 1991-05-10 2002-04-09 Aventis Pharmacetical Products, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5714493A (en) * 1991-05-10 1998-02-03 Rhone-Poulenc Rorer Pharmaceuticals, Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US6645969B1 (en) 1991-05-10 2003-11-11 Aventis Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase
US5480883A (en) * 1991-05-10 1996-01-02 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
US5710158A (en) * 1991-05-10 1998-01-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
DE69422450T2 (de) * 1993-06-29 2000-06-08 Takeda Chemical Industries, Ltd. Chinoline oder Chinazolin-Derivate und deren Verwendung zur Herstellung eines Medikaments für die Behandlung von Osteoporose
BR9506936A (pt) * 1994-02-23 1997-09-09 Pfizer Derivados de quinazolina substituídos com 4-heterociclila processos para sua preparaçao e seu uso como agentes anticancerosos
US5804396A (en) * 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
TW321649B (de) * 1994-11-12 1997-12-01 Zeneca Ltd
GB9424233D0 (en) * 1994-11-30 1995-01-18 Zeneca Ltd Quinazoline derivatives
US5837524A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polynucleotide products
US5837815A (en) * 1994-12-15 1998-11-17 Sugen, Inc. PYK2 related polypeptide products
GB9508535D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivative
GB9508565D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
GB9508538D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
WO1996033977A1 (en) * 1995-04-27 1996-10-31 Zeneca Limited Quinazoline derivatives
GB9508537D0 (en) * 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
CA2222545A1 (en) * 1995-06-07 1996-12-19 Sugen, Inc. Quinazolines and pharmaceutical compositions
US6143764A (en) * 1995-11-07 2000-11-07 Kirin Beer Kabushiki Kaisha Quinoline and quinazoline derivatives inhibiting platelet-derived growth factor receptor autophosphorylation and pharmaceutical compositions containing the same
US6716575B2 (en) 1995-12-18 2004-04-06 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
US7119174B2 (en) * 1995-12-18 2006-10-10 Sugen, Inc. Diagnosis and treatment of AUR1 and/or AUR2 related disorders
GB9624482D0 (en) * 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
BR9707495A (pt) 1996-02-13 1999-07-27 Zeneca Ltd Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente
GB9603097D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline compounds
GB9603095D0 (en) * 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
US6291455B1 (en) 1996-03-05 2001-09-18 Zeneca Limited 4-anilinoquinazoline derivatives
GB9607729D0 (en) * 1996-04-13 1996-06-19 Zeneca Ltd Quinazoline derivatives
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
ATE271603T1 (de) * 1996-12-11 2004-08-15 Sugen Inc Identifizierungsverfahren für substanzen die an das pyk2 polypeptid binden
US6818440B2 (en) * 1997-04-28 2004-11-16 Sugen, Inc. Diagnosis and treatment of alk-7 related disorders
US6228641B1 (en) 1997-05-20 2001-05-08 Sugen, Inc. Diagnosis and treatment of PTP04 related disorders
US7115710B2 (en) * 1997-06-11 2006-10-03 Sugen, Inc. Diagnosis and treatment of PTP related disorders
US6342593B1 (en) 1997-06-11 2002-01-29 Sugen, Inc. Diagnosis and treatment of ALP related disorders
US6388063B1 (en) * 1997-06-18 2002-05-14 Sugen, Inc. Diagnosis and treatment of SAD related disorders
AU2237899A (en) * 1998-01-21 1999-08-09 Sugen, Inc. Human orthologues of wart
DE69926742T2 (de) * 1998-04-14 2006-06-14 Sugen Inc Ste20-verwandte proteinkinasen
WO1999061428A1 (en) 1998-05-28 1999-12-02 Parker Hughes Institute Quinazolines for treating brain tumor
US6800649B1 (en) * 1998-06-30 2004-10-05 Parker Hughes Institute Method for inhibiting c-jun expression using JAK-3 inhibitors
US6313129B1 (en) * 1998-08-21 2001-11-06 Hughes Institute Therapeutic compounds
US6861442B1 (en) 1998-12-30 2005-03-01 Sugen, Inc. PYK2 and inflammation
US6080747A (en) * 1999-03-05 2000-06-27 Hughes Institute JAK-3 inhibitors for treating allergic disorders
US6258820B1 (en) * 1999-03-19 2001-07-10 Parker Hughes Institute Synthesis and anti-tumor activity of 6,7-dialkoxy-4-phenylamino-quinazolines
JP2003512838A (ja) * 1999-10-22 2003-04-08 ファルマシア・アンド・アップジョン・カンパニー ショウジョウバエｇタンパク質結合レセプター、核酸、およびそれに関連する方法。
US7364866B2 (en) * 1999-10-22 2008-04-29 Pharmacia & Upjohn Company Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
US20030162223A1 (en) * 1999-10-22 2003-08-28 Lowery David E. Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
CZ301689B6 (cs) 1999-11-05 2010-05-26 Astrazeneca Ab Derivát chinazolinu a farmaceutický prostredek, který ho obsahuje
US20030082534A1 (en) * 1999-11-16 2003-05-01 Peter Lind Novel G protein-coupled receptors
AU784543B2 (en) * 1999-11-16 2006-04-27 Pharmacia & Upjohn Company Novel G protein-coupled receptors
EP1265925A2 (de) * 2000-02-23 2002-12-18 PHARMACIA & UPJOHN COMPANY G protein-gekoppelte rezeptoren
ES2267748T3 (es) * 2000-04-07 2007-03-16 Astrazeneca Ab Compuestos de quinazolina.
US20050069976A1 (en) * 2001-02-14 2005-03-31 Peter Lind Protein-coupled receptor
CA2494695C (en) * 2002-08-02 2011-04-05 Ab Science 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors
US8450302B2 (en) * 2002-08-02 2013-05-28 Ab Science 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
EP1684750B1 (de) * 2003-10-23 2010-04-28 AB Science 2-aminoaryloxazol-verbindungen als tyrosinkinase-hemmer
AU2006231929B2 (en) 2005-04-04 2012-09-06 Ab Science Substituted oxazole derivatives and their use as tyrosine kinase inhibitors
US8246966B2 (en) * 2006-08-07 2012-08-21 University Of Georgia Research Foundation, Inc. Trypanosome microsome system and uses thereof
WO2008041118A2 (en) 2006-10-04 2008-04-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists
WO2008066755A2 (en) * 2006-11-22 2008-06-05 University Of Georgia Research Foundation, Inc. Tyrosine kinase inhibitors as anti-kinetolastid and anti-apicomplexan agents
US20110008347A1 (en) * 2006-12-01 2011-01-13 Agency For Science ,Technology And Research Cancer-related protein kinases
BR112013022552B1 (pt) 2011-03-04 2021-11-23 Newgen Therapeutics, Inc Compostos de quinazolina substituídos com alcino, seu uso, composição farmacêutica, e kit

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3298291A (en) * 1965-12-28 1967-01-17 Jack D Layton Paver screed assembly
US3455920A (en) * 1967-01-13 1969-07-15 Squibb & Sons Inc 2,3-dihydro-5 and 6-substituted-2-phenyl-4(1h)-quinazolinones
US3637693A (en) * 1968-07-12 1972-01-25 Du Pont Hydroxyarylquinazolines and their use as uv-absorbers
DE2050092C3 (de) 1970-10-13 1980-04-24 Bayer Ag, 5090 Leverkusen Chinazolondiurethane, Verfahren zu ihrer Herstellung sowie Arzneimittel, die diese Verbindungen enthalten
DE2162327C3 (de) * 1970-12-23 1975-09-18 Sumitomo Chemical Co., Ltd., Osaka (Japan) Verfahren zur Herstellung von 3,4-Oihydro-2(1 H)-chinazolinonen
JPS6011032B2 (ja) 1975-12-16 1985-03-22 大鵬薬品工業株式会社 ２―置換―５―フルオルピリミジン―４―オン誘導体の製造法
US4080455A (en) * 1975-12-16 1978-03-21 Taisho Pharmaceutical Company Limited 5-Fluoropyrimidin-4-one compositions

Also Published As

Publication number Publication date
JPH0337552B2 (de) 1991-06-05
NL8200473A (nl) 1982-10-01
KR830009050A (ko) 1983-12-17
JPS57158780A (en) 1982-09-30
IE820163L (en) 1982-09-06
LU83903A1 (fr) 1982-09-13
IT8247713A0 (it) 1982-02-03
ES509434A0 (es) 1983-02-16
GR75903B (de) 1984-08-02
SE461732B (sv) 1990-03-19
DE3203770C2 (de) 1993-11-04
FI71559B (fi) 1986-10-10
GB2094295B (en) 1984-09-12
AR231138A1 (es) 1984-09-28
CH647776A5 (de) 1985-02-15
CA1163995A (en) 1984-03-20
SG30787G (en) 1988-09-16
US4343940A (en) 1982-08-10
AT380476B (de) 1986-05-26
YU42031B (en) 1988-04-30
IL64875A0 (en) 1982-03-31
DK159442B (da) 1990-10-15
AU7998182A (en) 1982-09-09
DK50482A (da) 1982-09-07
AU556099B2 (en) 1986-10-23
KR880001852B1 (ko) 1988-09-22
FR2501207A1 (fr) 1982-09-10
DK159442C (da) 1991-03-18
NZ199576A (en) 1986-05-09
BE891936A (fr) 1982-07-28
FI820399L (fi) 1982-09-07
IE52385B1 (en) 1987-10-14
IT8247713A1 (it) 1983-08-03
CY1371A (en) 1987-08-07
ES8304095A1 (es) 1983-02-16
SE8200526L (sv) 1982-09-07
YU25682A (en) 1985-03-20
PH18529A (en) 1985-08-02
HU189997B (en) 1986-08-28
ATA39582A (de) 1985-10-15
GB2094295A (en) 1982-09-15
PT74394A (en) 1982-03-01
PT74394B (en) 1984-10-22
FR2501207B1 (fr) 1985-12-06
KE3715A (en) 1987-04-16
FI71559C (fi) 1987-01-19
DE3203770A1 (de) 1982-11-11
IT1154272B (it) 1987-01-21

Similar Documents

Publication Publication Date Title
GB2094295B (en) Anti-tumor quinazoline compounds
GB2111488B (en) 1-oxa- and 1-thia-spirocyclic compounds
HK98787A (en) Substituted quinazolinones
GB2095239B (en) Novel amidine compounds
GB2101580B (en) Allophanoylpiperazine compounds
GB2097003B (en) Phosporus-containing compounds
GB2098604B (en) 3-substituted-2-azetidinone compounds
JPS57163384A (en) Benzopyranoimidazole compounds
PH19011A (en) Quinazoline derivatives
EP0180399A3 (en) Anti-tumor 4-hydroxy-2-cyclopentenones
GB2096598B (en) Novel amidine compounds
GB2106519B (en) Aminooxazolyl compounds
JPS57158763A (en) Novel substituted quinazolines
JPS5738781A (en) Quinazoline compound
GB2104889B (en) Phenethylpiperidine compounds
DE3260771D1 (en) Pyridothienopyridazine compounds
GB2102800B (en) Pyrimidines
GB2105721B (en) Tricyclic quinazolinones
ZA823710B (en) Antihypertensive compounds
GB2096998B (en) Dioxaazabicyclic compounds
GB8311156D0 (en) Anti-tumor compounds
ZA82508B (en) Anti-tumor quinazoline compounds
ZA832792B (en) Quinazoline derivatives
JPS57179163A (en) Antitumor
AU536918B2 (en) Diamino-platinum compound anti-tumor use