HK55183A - Lithium pseudomonate, process for its isolation and its hydrolysis - Google Patents

Lithium pseudomonate, process for its isolation and its hydrolysis

Info

Publication number
HK55183A
HK55183A HK551/83A HK55183A HK55183A HK 55183 A HK55183 A HK 55183A HK 551/83 A HK551/83 A HK 551/83A HK 55183 A HK55183 A HK 55183A HK 55183 A HK55183 A HK 55183A
Authority
HK
Hong Kong
Prior art keywords
lithium
pseudomonate
pseudomonic acid
acid
salt
Prior art date
Application number
HK551/83A
Other languages
English (en)
French (fr)
Inventor
Alan David Curzons
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of HK55183A publication Critical patent/HK55183A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (8)

1. Lithium-pseudomonat.
2. Verfahren zur Isolierung von Lithium-pseudomonat aus einem Pseudomonsäure enthaltenden Rohpräparat, die Maßnahme umfassend, daß das Rohpräparat in ein polares, organisches, mit Wasser nicht mischbares Lösungsmittel, in dem die Pseudomonsäure löslich ist, extrahiert wird, der Extrakt mit einem Lithiumsalz, das in dem mit Wasser nicht mischbaren Lösungsmittel zumindest schwach löslich ist, behandelt wird und das entstandene Lithium-pseudomonat abgetrennt wird.
3. Verfahren gemäß Anspruch 2, wobei das die Pseudomonsäure enthaltende Rohpräparat ein Kulturmedium ist, in oder auf dem Pseudomonsäure-produzierende Bakterienstämme kultivert worden sind.
4. Verfahren gemäß Anspruch 3, wobei das Bakterium Pseudomonas fluorescens ist.
5. Verfahren gemäß der Ansprüche 2 bis 4, wobei das Lithiumsalz, mit dem der Extrakt behandelt wird, eine Alkancarbonsäure.der Formel R-CO2 -Li+ sit, in der R ein Alkylrest mit 1 bis 20 Kohlenstoffatomen ist.
6. Verfahren gemäß Anspruch 5, wobei das Lithiumsalz Lithium-2-äthylhexanoat ist.
7. Verfahren zur Herstellung von Pseudomonsäure, die Maßnahme der Hydrolyse des Lithiumpseudomonats umfassend.
8. Verfahren gemäß Anspruch 7, wobei das Lithium-pseudomonat in einem Verfahren gemäß einem der Ansprüche 2 bis 6 hergestellt wird.
HK551/83A 1978-05-20 1983-11-17 Lithium pseudomonate, process for its isolation and its hydrolysis HK55183A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2095878 1978-05-20

Publications (1)

Publication Number Publication Date
HK55183A true HK55183A (en) 1983-11-25

Family

ID=10154713

Family Applications (1)

Application Number Title Priority Date Filing Date
HK551/83A HK55183A (en) 1978-05-20 1983-11-17 Lithium pseudomonate, process for its isolation and its hydrolysis

Country Status (12)

Country Link
US (2) US4639534A (de)
EP (1) EP0005614B1 (de)
JP (1) JPS54154771A (de)
AT (1) AT364461B (de)
AU (1) AU519228B2 (de)
CA (1) CA1115699A (de)
DE (1) DE2962176D1 (de)
DK (1) DK147914C (de)
ES (1) ES480721A1 (de)
HK (1) HK55183A (de)
KE (1) KE3285A (de)
MY (1) MY8500045A (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8313035D0 (en) * 1983-05-12 1983-06-15 Beecham Group Plc Compound
GB8415579D0 (en) * 1984-06-19 1984-07-25 Beecham Group Plc Compounds
MX7417E (es) * 1984-10-27 1988-10-14 Antibioticos Sa Metodo para la preparacion de acido clavulanico y sus derivados
US5273998A (en) * 1990-05-11 1993-12-28 Yoshitomi Pharmaceutical Industries, Ltd. Process for making an optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compound
GB9026873D0 (en) * 1990-12-11 1991-01-30 Beecham Group Plc Novel compounds
US5594026A (en) * 1990-12-11 1997-01-14 Smithkline Beecham Group P.L.C. Polymorphs of crystalline mupirocin
MXPA01007805A (es) 1999-02-03 2003-06-04 Biogal Gyogyszergyar Proceso para la aislacion del acido pseudomonico a del caldo de cultivo que contiene un complejo de acido pseudomonico. .
YU55601A (sh) 1999-02-03 2003-02-28 Biogal Gyogyszergyar Rt. Proces za pripremu antibiotika pseudomonične kiseline a mikrobiološkim metodom
HUP0500797A2 (en) 2001-06-21 2007-06-28 Biogal Gyogyszergyar Metabolic controlled fermentation process for pseudomonic acid production
CN1625394A (zh) * 2001-12-28 2005-06-08 拜奥盖尔药厂有限公司 结晶和无定形莫匹罗星钙的制备方法
IL150907A (en) * 2002-07-25 2007-07-04 Stephan Cherkez Process for the preparation of stable amorphous calcium pseudomonate
CA2560984A1 (en) 2004-06-01 2005-12-15 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Process for preparation of amorphous form of a drug
GB2441328A (en) * 2006-08-30 2008-03-05 Alpharma Aps A method for obtaining mupirocin calcium
US8267358B1 (en) * 2011-05-10 2012-09-18 Letson Philip D Bag holder

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR510052A (fr) * 1919-02-26 1920-11-26 Salvatore Faso Dispositif de roulement pour tracteurs à chenilles
IL30058A (en) * 1967-08-10 1972-09-28 Lilly Co Eli Process for preparing antibiotic a10388(pyrrolnitrin)
US4071536A (en) * 1971-06-12 1978-01-31 Beecham Group Limited Antibiotics
GB1395907A (en) * 1971-06-12 1975-05-29 Beecham Group Ltd Antibiotics
JPS5270083A (en) * 1975-12-04 1977-06-10 Yoshitomi Pharmaceut Ind Ltd Manufacture of an antibiotics, trans-pseudomonic acid

Also Published As

Publication number Publication date
DK147914C (da) 1985-08-26
JPS6340192B2 (de) 1988-08-10
DK206579A (da) 1979-11-21
MY8500045A (en) 1985-12-31
AT364461B (de) 1981-10-27
KE3285A (en) 1983-06-17
EP0005614B1 (de) 1982-02-24
ATA359779A (de) 1981-03-15
AU4679179A (en) 1979-11-22
EP0005614A1 (de) 1979-11-28
CA1115699A (en) 1982-01-05
JPS54154771A (en) 1979-12-06
ES480721A1 (es) 1980-07-01
AU519228B2 (en) 1981-11-19
US4786742A (en) 1988-11-22
DE2962176D1 (en) 1982-03-25
DK147914B (da) 1985-01-07
US4639534A (en) 1987-01-27

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