HK65386A - Crystalline benzothiazine dioxide salts - Google Patents

Crystalline benzothiazine dioxide salts

Info

Publication number
HK65386A
HK65386A HK653/86A HK65386A HK65386A HK 65386 A HK65386 A HK 65386A HK 653/86 A HK653/86 A HK 653/86A HK 65386 A HK65386 A HK 65386A HK 65386 A HK65386 A HK 65386A
Authority
HK
Hong Kong
Prior art keywords
benzothiazine
dioxide
carboxamide
pyridyl
hydroxy
Prior art date
Application number
HK653/86A
Other languages
German (de)
English (en)
Inventor
Joseph George Lombardino
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of HK65386A publication Critical patent/HK65386A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Claims (10)

1. Le sel d'éthylènediamine, de monoéthanolamine ou de diéthanolamine du 1,1 -dioxyde du N-(2-pyridyl)-2-méthyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide.
2. Composé suivant la revendication 1, qui est le sel d'éthylénediamine.
3. Composé suivant la revendication 1, qui est le sel de monoéthanolamine.
4. Composé suivant la revendication 1, qui est le sel de diéthanolamine.
5. Composition pharmaceutique comprenant un support pharmaceutiquement acceptable et un sel suivant l'une quelconque des revendications 1 à 4.
6. Composé suivant l'une quelconque des revendications 1 à 4, destiné à être utilisé dans le traitement d'un état arthritique chez un être humain.
HK653/86A 1981-06-01 1986-09-04 Crystalline benzothiazine dioxide salts HK65386A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26898081A 1981-06-01 1981-06-01
US06/367,067 US4434164A (en) 1981-06-01 1982-04-13 Crystalline benzothiazine dioxide salts

Publications (1)

Publication Number Publication Date
HK65386A true HK65386A (en) 1986-09-12

Family

ID=26953436

Family Applications (1)

Application Number Title Priority Date Filing Date
HK653/86A HK65386A (en) 1981-06-01 1986-09-04 Crystalline benzothiazine dioxide salts

Country Status (27)

Country Link
US (1) US4434164A (fr)
EP (1) EP0066459B1 (fr)
KR (1) KR850001883B1 (fr)
AU (1) AU529386B2 (fr)
BG (1) BG37377A3 (fr)
CA (1) CA1209571A (fr)
DD (1) DD211560A5 (fr)
DE (1) DE3260718D1 (fr)
DK (1) DK149024C (fr)
EG (1) EG15811A (fr)
ES (1) ES512723A0 (fr)
FI (1) FI74705C (fr)
GB (1) GB2101589A (fr)
GR (1) GR75476B (fr)
HK (1) HK65386A (fr)
HU (1) HU189586B (fr)
IE (1) IE53160B1 (fr)
IL (1) IL65917A (fr)
MX (1) MX6984E (fr)
MY (1) MY8700126A (fr)
NO (1) NO157979C (fr)
NZ (1) NZ200801A (fr)
OA (1) OA07114A (fr)
PH (1) PH17906A (fr)
PT (1) PT74977B (fr)
RO (1) RO84698B (fr)
YU (1) YU42767B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5913714A (ja) * 1982-07-13 1984-01-24 Taito Pfizer Kk 外用消炎鎮痛剤
RO88420A (fr) * 1983-04-25 1986-01-30 Pfizer Inc,Us Procede pour la preparation des sels basiques de pyroxycam deposes sur supports pharmaceutiques
DE3431588A1 (de) * 1983-09-12 1985-04-04 Pfizer, Inc., New York, N.Y. Kristalline benzothiazindioxid-salze und diese enthaltende pharmazeutische zusammensetzungen
DE3346526C2 (de) * 1983-12-22 1986-12-11 A. Nattermann & Cie GmbH, 5000 Köln Pharmazeutisches Präparat zur therapeutischen Behandlung von rheumatischen Erkrankungen
IT1196307B (it) * 1984-10-22 1988-11-16 Chiesi Farma Spa Formulazioni farmaceutiche acquose di piroxicam monoidrato
US4582831A (en) * 1984-11-16 1986-04-15 Pfizer Inc. Anti-inflammatory polymorphic monoethanolamine salt of N-(2-pyridyl)-2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide compound, composition, and method of use therefor
US4559326A (en) * 1985-01-31 1985-12-17 Pfizer Inc. Antiinflammatory compositions and methods
US4623486A (en) 1985-05-29 1986-11-18 Pfizer Inc. [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity
US4610982A (en) * 1985-06-03 1986-09-09 Pfizer Inc. Anti-inflammatory benzo- and thieno-1,2-thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor
KR890001236B1 (ko) * 1985-10-02 1989-04-28 화이자 인코포레이티드 소염제 조성물의 제조방법
HU200926B (en) * 1988-10-28 1990-09-28 Egyt Gyogyszervegyeszeti Gyar Pharmaceutical composition comprising piroxicam and lactose for use in making tablets or capsules
IT1247492B (it) * 1991-04-18 1994-12-17 Francia Farma Sali ad attivita' antiinfiammatoria, antisettica, detergente e composizioni farmaceutiche
IT1283252B1 (it) * 1996-03-15 1998-04-16 Pulitzer Italiana Soluzioni di piroxicam iniettabili per via parenterale
GB0031107D0 (en) * 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
FR2818641B1 (fr) * 2000-12-21 2004-03-05 Servier Lab Nouveaux derives de 1,1-dioxo-2h-1,2-benzothiazine 3-carboxamides, leur procede de preparation et les compositions pharmaceutiques que les contiennent
KR100446829B1 (ko) * 2002-02-20 2004-09-04 한국유나이티드제약 주식회사 가용화된 피록시캄을 함유한 확산형 정제의 조성물 및그의 제조방법
ES2670872T3 (es) 2003-05-22 2018-06-01 United Therapeutics Corporation Polimorfo de una sal de dietanolamina de treprostinil
US20050176809A1 (en) * 2004-02-05 2005-08-11 Rodlen Laboratories, Inc. Method and compositions for treatment of painful disorders
MX2007013583A (es) * 2005-04-28 2008-03-13 Theraquest Biosciences Llc Metodos y composiciones para tratar el dolor.
US8747897B2 (en) 2006-04-27 2014-06-10 Supernus Pharmaceuticals, Inc. Osmotic drug delivery system
WO2009078965A1 (fr) 2007-12-17 2009-06-25 United Therapeutics Corporation Procédé amélioré de préparation de tréprostinil, l'ingrédient actif dans le remodulin
US9593061B2 (en) 2014-10-20 2017-03-14 United Therapeutics Corporation Synthesis of intermediates for producing prostacyclin derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3591584A (en) 1968-08-27 1971-07-06 Pfizer Benzothiazine dioxides
US4074048A (en) 1976-05-10 1978-02-14 Warner-Lambert Company Process for the preparation of 4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides
US4100347A (en) 1976-06-10 1978-07-11 Pfizer Inc. 3,4-Dihydro-2-methyl-4-oxo-2H-1,2-benzothiazine-3-carboxylic acid-1,1-dioxide
DE2756113A1 (de) 1977-12-16 1979-06-21 Thomae Gmbh Dr K Neue 4-hydroxy-2h-1,2-benzothiazin- 3-carboxamid-1,1-dioxide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4289879A (en) 1980-09-29 1981-09-15 Pfizer Inc. Synthetic method and intermediate for piroxicam

Also Published As

Publication number Publication date
US4434164A (en) 1984-02-28
FI821918A0 (fi) 1982-05-31
DK149024B (da) 1985-12-23
AU529386B2 (en) 1983-06-02
AU8432282A (en) 1982-12-09
KR830010108A (ko) 1983-12-26
DD211560A5 (de) 1984-07-18
IE821286L (en) 1982-12-01
NO157979B (no) 1988-03-14
FI74705B (fi) 1987-11-30
NZ200801A (en) 1985-01-31
EP0066459B1 (fr) 1984-09-12
RO84698B (ro) 1984-09-30
HU189586B (en) 1986-07-28
EG15811A (en) 1986-12-30
BG37377A3 (en) 1985-05-15
NO821767L (no) 1982-12-02
EP0066459A1 (fr) 1982-12-08
MX6984E (es) 1987-01-19
PT74977A (en) 1982-06-01
YU113782A (en) 1984-12-31
CA1209571A (fr) 1986-08-12
IL65917A (en) 1985-08-30
ES8307775A1 (es) 1983-08-01
IE53160B1 (en) 1988-08-03
DK149024C (da) 1986-06-30
GB2101589A (en) 1983-01-19
FI74705C (fi) 1988-03-10
OA07114A (fr) 1984-03-31
IL65917A0 (en) 1982-08-31
PT74977B (en) 1985-05-17
KR850001883B1 (ko) 1985-12-28
NO157979C (no) 1988-06-22
DK241682A (da) 1982-12-02
YU42767B (en) 1988-12-31
ES512723A0 (es) 1983-08-01
RO84698A (fr) 1984-07-17
MY8700126A (en) 1987-12-31
DE3260718D1 (de) 1984-10-18
GR75476B (fr) 1984-07-23
PH17906A (en) 1985-01-25

Similar Documents

Publication Publication Date Title
EP0066459B1 (fr) Sels cristallins de dioxyde de benzothiazine
US4434163A (en) Water-soluble benzothiazine dioxide salts
EP0057059B1 (fr) Dioxyde de benzothiazine, agents anti-inflammatoires, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0182572B1 (fr) Forme cristalline de sel de dioxyde de benzothiazine
SU1122225A3 (ru) Способ получени кристаллической водорастворимой негигроскопичной этилендиаминовой,моноэтаноламиновой или диэтаноламиновой соли @ -(2-пиридил)-2-метил-4-окси-2 @ -1,2-бензтиазин-3-карбоксамид-1,1-диоксида
CA1197845A (fr) Sels bioxydes cristallins de benzothiazine

Legal Events

Date Code Title Description
PE Patent expired