HK83293A - Composition of pregnanolole comprising a stable oil-in-water emulsion - Google Patents
Composition of pregnanolole comprising a stable oil-in-water emulsion Download PDFInfo
- Publication number
- HK83293A HK83293A HK832/93A HK83293A HK83293A HK 83293 A HK83293 A HK 83293A HK 832/93 A HK832/93 A HK 832/93A HK 83293 A HK83293 A HK 83293A HK 83293 A HK83293 A HK 83293A
- Authority
- HK
- Hong Kong
- Prior art keywords
- amount
- oil
- pregnanolone
- composition
- emulsion
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Anesthesiology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Claims (8)
- Verfahren zur Herstellung eines Mittels zur intravenösen Verabreichung von 3∝-Hydroxy-5ß- pregnan-20-on (Pregnanolon), dadurch gekennzeichnet, daß eine Öl-in-Wasser-Emulsion hergestellt wird aus den folgenden Komponenten, berechnet auf 100 ml des fertigen Mittels:a) Pregnanolon in einer Menge von 0,1 bis 1,0 g, mit der Maßgabe, daß die Menge von 0,5 g ausgeschlossen ist,b) ein Lipid, ausgewählt aus der Gruppe bestehend aus Kokosnußöl, Borragoöl, Farberdistelöl, Baumwollsamenöl, Sojabohnenöl und einem strukturierten Glyceridlipid vom synthetischen Typ, enthaltend ein Gemisch aus langkettigen und mittelkettigen Fettsäuren im Molekül, in einer Menge von 10 bis 30 g,c) ein Emulgiermittel, ausgewählt aus Eigelbphospholipiden und Sojaphospholipiden in einer Menge von 1 bis 5 g,d) Wasser zur Injektion,e) Glycerin bis zur Isotonie des fertigen Mittels,wobei die Komponente a) im wesentlichen in Komponente b) gelöst wird und die erhaltene Pregnanolon/Lipid-Mischung dann mit den Komponenten c, d) und e) emulgiert wird.
- Verfahren nach Anspruch 1, dadurch gekennzeichnet, daß die Emulsion ferner umfaßt acetylierte Monoglyceride in einer Menge von 0 bis 20 g.
- Verfahren nach Anspruch 2, dadurch gekennzeichnet, daß die Emulsion ferner umfaßt Cholesterylhemisuccinat in einer Menge von 0,01 bis 0,2 g.
- Verfahren nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, daß die Emulsion umfaßt, berechnet auf 100 ml fertiges Mittel:a) Pregnanolon in einer Menge von 0,4 bis 0,5 g,b) Sojabohnenöl in einer Menge von 15 bis 20 g,c) Wasser zur Injektion,d) Glycerin bis zur Isotonie des fertigen Mittels.
- Verwendung eines Mittels, hergestellt nach einem der Ansprüche 1 bis 4, zur Herstellung eines Arzneimittels zum Anästhesieren eines Patienten durch intravenöse Verabreichung.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8600632A SE8600632D0 (sv) | 1986-02-13 | 1986-02-13 | Novel pharmaceutical composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK83293A true HK83293A (en) | 1993-08-20 |
Family
ID=20363448
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK832/93A HK83293A (en) | 1986-02-13 | 1993-08-12 | Composition of pregnanolole comprising a stable oil-in-water emulsion |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5028600A (de) |
| EP (1) | EP0233849B1 (de) |
| JP (1) | JPH0788305B2 (de) |
| AT (1) | ATE64526T1 (de) |
| CA (1) | CA1301651C (de) |
| DE (1) | DE3770830D1 (de) |
| DK (1) | DK175504B1 (de) |
| ES (1) | ES2037742T3 (de) |
| FI (1) | FI88676C (de) |
| GR (1) | GR3002299T3 (de) |
| HK (1) | HK83293A (de) |
| NO (1) | NO175040B (de) |
| SE (1) | SE8600632D0 (de) |
| SG (1) | SG102892G (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9302295D0 (sv) * | 1993-07-02 | 1993-07-02 | Kabi Pharmacia Ab | New pharmaceutical composition |
| US5616330A (en) * | 1994-07-19 | 1997-04-01 | Hemagen/Pfc | Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same |
| US6117429A (en) * | 1997-08-11 | 2000-09-12 | Weider Nutrition International, Inc | Compositions and treatments for reducing potential unwanted side effects associated with long-term administration of androgenic testosterone precursors |
| CN1221249C (zh) | 1998-08-19 | 2005-10-05 | 斯凯伊药品加拿大公司 | 普鲁泊福的可注射水分散体 |
| US20020155161A1 (en) * | 2000-12-29 | 2002-10-24 | Deckelbaum Richard J. | Use of IV emulsions with different triglyceride composition, particle size and apolipoprotein E for targeted tissue delivery of hydrophobic compounds |
| BRPI0312377A8 (pt) * | 2002-07-02 | 2015-12-15 | Altana Pharma Ag | Suspensão aquosa estéril contendo ciclesonida |
| PE20050941A1 (es) | 2003-12-16 | 2005-11-08 | Nycomed Gmbh | Suspensiones acuosas de ciclesonida para nebulizacion |
| CA2580202A1 (en) * | 2004-09-13 | 2006-03-23 | Bharat Serums & Vaccines Ltd. | Stable emulsion compositions for intravenous administration having antimicrobial preservative efficacy |
| CN103491976B (zh) * | 2011-01-14 | 2015-04-01 | 卡思伯特·O·辛普金斯 | 用于处理与缺乏血液供给、休克和神经损伤相关的疾病的方法和组合物 |
| US10478505B2 (en) | 2011-09-23 | 2019-11-19 | The Regents Of The University Of California | Edible oils to enhance delivery of orally administered steroids |
| SG10201606063RA (en) | 2012-01-23 | 2016-09-29 | Sage Therapeutics Inc | Neuroactive steroid formulations and methods of treating cns disorders |
| WO2014028398A2 (en) | 2012-08-13 | 2014-02-20 | The Regents Of The University Of California | Mitigation of epileptic seizures by combination therapy using benzodiazepines and neurosteroids |
| RS62761B1 (sr) | 2012-08-21 | 2022-01-31 | Sage Therapeutics Inc | Alopregnanolon za lečenje refraktornog epileptičkog statusa |
| US20150313915A1 (en) | 2012-11-30 | 2015-11-05 | The Regents Of The University Of California | Anticonvulsant activity of steroids |
| JOP20200195A1 (ar) | 2014-09-08 | 2017-06-16 | Sage Therapeutics Inc | سترويدات وتركيبات نشطة عصبياً، واستخداماتها |
| PH12018501923B1 (en) | 2016-03-08 | 2024-06-28 | Sage Therapeutics Inc | Neuroactive steroids, compositions, and uses thereof |
| KR20210102936A (ko) * | 2018-12-10 | 2021-08-20 | 헤일로 사이언스 엘엘씨 | 안정적인 마취제 제제 및 관련 복용량 형태 |
| WO2021034883A1 (en) * | 2019-08-19 | 2021-02-25 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Topical neurosteroid formulations |
| US11969434B1 (en) | 2022-08-29 | 2024-04-30 | Lipocine Inc. | Oral allopregnanolone compositions and methods of use |
| CN114344309B (zh) * | 2021-12-30 | 2024-02-06 | 南京迈诺威医药科技有限公司 | 一种别孕烷醇酮衍生物自乳化制剂及其制备方法 |
| US12186327B2 (en) | 2022-08-29 | 2025-01-07 | Lipocine Inc. | Oral allopregnanolone compositions and methods of use |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1215702B (de) * | 1962-07-03 | 1966-05-05 | Merck Ag E | Verfahren zur Herstellung von 1alpha-Alkylthio-3-keto-androstanen |
| CA895860A (en) * | 1969-11-05 | 1972-03-21 | Kruger Gunther | PROCESS FOR THE PREPARATION OF 3.alpha.-HYDROXY-5.beta.-PREGNAN-20-ONE |
| US3917830A (en) * | 1970-12-17 | 1975-11-04 | Glaxo Lab Ltd | Steroidal anaesthetic composition for intraveneous injection |
| US3900561A (en) * | 1970-12-17 | 1975-08-19 | Glaxo Lab Ltd | Pharmaceutical compositions |
| US4168308A (en) * | 1976-03-12 | 1979-09-18 | Apoteksvarucentralen Vitrum Ab | Composition for enhancing the administration of pharmacologically active agents |
| JPS609726B2 (ja) * | 1980-05-15 | 1985-03-12 | 株式会社 ミドリ十字 | ステロイド製剤 |
| JPS5716818A (en) * | 1981-04-25 | 1982-01-28 | Green Cross Corp:The | Steroid fatty emulsion |
| JPS60258110A (ja) * | 1984-06-05 | 1985-12-20 | Daigo Eiyou Kagaku Kk | 静脈注射可能なプロゲステロン乳化注射液 |
-
1986
- 1986-02-13 SE SE8600632A patent/SE8600632D0/xx unknown
-
1987
- 1987-01-29 ES ES198787850029T patent/ES2037742T3/es not_active Expired - Lifetime
- 1987-01-29 AT AT87850029T patent/ATE64526T1/de not_active IP Right Cessation
- 1987-01-29 DE DE8787850029T patent/DE3770830D1/de not_active Expired - Fee Related
- 1987-01-29 EP EP87850029A patent/EP0233849B1/de not_active Expired - Lifetime
- 1987-02-06 DK DK198700621A patent/DK175504B1/da not_active IP Right Cessation
- 1987-02-12 FI FI870589A patent/FI88676C/fi not_active IP Right Cessation
- 1987-02-12 JP JP62028395A patent/JPH0788305B2/ja not_active Expired - Fee Related
- 1987-02-12 CA CA000529609A patent/CA1301651C/en not_active Expired - Fee Related
- 1987-02-12 NO NO870560A patent/NO175040B/no not_active IP Right Cessation
-
1989
- 1989-02-28 US US07/316,576 patent/US5028600A/en not_active Expired - Lifetime
-
1991
- 1991-07-11 GR GR91400996T patent/GR3002299T3/el unknown
-
1992
- 1992-10-07 SG SG1028/92A patent/SG102892G/en unknown
-
1993
- 1993-08-12 HK HK832/93A patent/HK83293A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK175504B1 (da) | 2004-11-15 |
| DE3770830D1 (de) | 1991-07-25 |
| NO175040C (de) | 1994-08-24 |
| NO870560L (no) | 1987-08-14 |
| EP0233849B1 (de) | 1991-06-19 |
| NO870560D0 (no) | 1987-02-12 |
| JPH0788305B2 (ja) | 1995-09-27 |
| GR3002299T3 (en) | 1992-12-30 |
| EP0233849A1 (de) | 1987-08-26 |
| CA1301651C (en) | 1992-05-26 |
| FI870589A0 (fi) | 1987-02-12 |
| FI88676B (fi) | 1993-03-15 |
| JPS62192322A (ja) | 1987-08-22 |
| DK62187D0 (da) | 1987-02-06 |
| ATE64526T1 (de) | 1991-07-15 |
| SG102892G (en) | 1992-12-04 |
| FI870589L (fi) | 1987-08-14 |
| US5028600A (en) | 1991-07-02 |
| ES2037742T3 (es) | 1993-07-01 |
| NO175040B (no) | 1994-05-16 |
| DK62187A (da) | 1987-08-14 |
| FI88676C (fi) | 1993-06-28 |
| SE8600632D0 (sv) | 1986-02-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PF | Patent in force | ||
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20060129 |