HRP20000007B1 - 2,4,4-trisubstituted-1,3-dioxolane antifungals - Google Patents

2,4,4-trisubstituted-1,3-dioxolane antifungals

Info

Publication number: HRP20000007B1
Authority: HR; Croatia
Prior art keywords: alkyl; aryl; alkyloxy; cycloalkyl; hydroxy
Prior art date: 1997-07-11

Application number

HR20000007A

Other languages

English (en)

Croatian (hr)

Inventor

Meerpoel Lieven

Heeres Jan

Christopher Odds Frank

Florent Adolf Vanden Bossche Hugo

Jozef Elisabeth Van Der Veken Louis

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-11

Filing date

1998-07-07

Publication date

2008-12-31

1998-07-07 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

2000-12-31 Publication of HRP20000007A2 publication Critical patent/HRP20000007A2/hr

2008-12-31 Publication of HRP20000007B1 publication Critical patent/HRP20000007B1/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Pyrrole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

HR20000007A 1997-07-11 1998-07-07 2,4,4-trisubstituted-1,3-dioxolane antifungals HRP20000007B1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97202181		1997-07-11
PCT/EP1998/004194 WO1999002523A1 (en)	1997-07-11	1998-07-07	2,4,4-trisubstituted-1,3-dioxolane antifungals

Publications (2)

Publication Number	Publication Date
HRP20000007A2 HRP20000007A2 (en)	2000-12-31
HRP20000007B1 true HRP20000007B1 (en)	2008-12-31

Family

ID=8228553

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20000007A HRP20000007B1 (en)	1997-07-11	1998-07-07	2,4,4-trisubstituted-1,3-dioxolane antifungals

Country Status (33)

Country	Link
US (1)	US6387906B1 (cs)
EP (1)	EP1068200B1 (cs)
KR (1)	KR100540460B1 (cs)
AP (1)	AP1379A (cs)
AR (1)	AR015130A1 (cs)
AT (1)	ATE289303T1 (cs)
AU (1)	AU749760B2 (cs)
BG (1)	BG64314B1 (cs)
BR (1)	BRPI9811679B8 (cs)
CA (1)	CA2295090C (cs)
CZ (1)	CZ297453B6 (cs)
DE (1)	DE69829082T2 (cs)
DK (1)	DK1068200T3 (cs)
EA (1)	EA002828B1 (cs)
EE (1)	EE04155B1 (cs)
ES (1)	ES2238765T3 (cs)
GE (1)	GEP20033054B (cs)
HR (1)	HRP20000007B1 (cs)
HU (1)	HU225159B1 (cs)
ID (1)	ID23783A (cs)
IL (1)	IL133919A (cs)
MY (1)	MY118844A (cs)
NO (1)	NO318328B1 (cs)
NZ (1)	NZ501982A (cs)
PL (1)	PL193703B1 (cs)
PT (1)	PT1068200E (cs)
SI (1)	SI1068200T1 (cs)
SK (1)	SK285321B6 (cs)
TR (1)	TR200000154T2 (cs)
TW (1)	TW593312B (cs)
UA (1)	UA71543C2 (cs)
WO (1)	WO1999002523A1 (cs)
ZA (1)	ZA986160B (cs)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19945982A1 (de)	1999-09-24	2001-03-29	Knoll Ag	Geschwindigkeitsbestimmte Partikel
US20040086567A1 (en) *	2002-10-30	2004-05-06	Pawan Seth	Bioequivalent composition of itraconazole and a hydrophilic polymer
WO2009114080A2 (en) *	2008-03-03	2009-09-17	Stiefel Laboratories, Inc.	Processes for preparing enantiomerically pure diol and dioxolane compounds
US8431699B2 (en) *	2009-02-27	2013-04-30	Vertichem Corporation	Method for manufacture of 2-oxoimidazolidines
CN105777486B (zh) *	2016-03-30	2018-09-11	浙江大学宁波理工学院	一种2-[2-(2，4-二氟苯基)-2-丙烯-1-基]-1，3-丙二醇的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4218458A (en) *	1978-06-23	1980-08-19	Janssen Pharmaceutica, N.V.	Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4619931A (en) *	1983-02-28	1986-10-28	Janssen Pharmaceutica, N.V.	[[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (en) *	1985-12-03	1991-11-26	Alfonsus Guilielmus Knaeps	Derivatives of ¬¬4-¬4-(4-phenyl-1-piperazinyl)- phenoxymethyl\|-1,3-dioxolan-2-yl\|methyl\|-1h-imidazoles and 1h-1,2,4-triazoles
US4788190A (en) *	1986-12-24	1988-11-29	Schering Corporation	2,4,4-tri- and 2,2,4,4-tetra substituted-1,3-dioxolane antifungal, antiallergy compounds
NZ233502A (en) *	1989-06-09	1991-11-26	Janssen Pharmaceutica Nv	4-(1,2,4-triazole- or imidazole-phenyl-substituted) -1-(1,3-dioxolan-4-ylmethoxyphenyl) piperazine derivatives; preparatory processes: fungicidal and antiviral compositions
IL103558A0 (en) *	1991-10-30	1993-03-15	Schering Corp	Tri-substituted tetrahydrofuran antifungals
SG48386A1 (en) *	1994-01-24	1998-04-17	Janssen Pharmaceutica Nv	Watersoluble azole antifungals

1998
- 1998-07-06 TW TW087110868A patent/TW593312B/zh not_active IP Right Cessation
- 1998-07-07 HU HU0004459A patent/HU225159B1/hu unknown
- 1998-07-07 WO PCT/EP1998/004194 patent/WO1999002523A1/en not_active Ceased
- 1998-07-07 UA UA2000010162A patent/UA71543C2/uk unknown
- 1998-07-07 AT AT98940160T patent/ATE289303T1/de active
- 1998-07-07 EE EEP200000020A patent/EE04155B1/xx unknown
- 1998-07-07 HR HR20000007A patent/HRP20000007B1/xx not_active IP Right Cessation
- 1998-07-07 EA EA200000116A patent/EA002828B1/ru not_active IP Right Cessation
- 1998-07-07 EP EP98940160A patent/EP1068200B1/en not_active Expired - Lifetime
- 1998-07-07 MY MYPI98003075A patent/MY118844A/en unknown
- 1998-07-07 TR TR2000/00154T patent/TR200000154T2/xx unknown
- 1998-07-07 BR BRPI9811679A patent/BRPI9811679B8/pt not_active IP Right Cessation
- 1998-07-07 SI SI9830764T patent/SI1068200T1/xx unknown
- 1998-07-07 GE GEAP19985200A patent/GEP20033054B/en unknown
- 1998-07-07 US US09/462,588 patent/US6387906B1/en not_active Expired - Lifetime
- 1998-07-07 ES ES98940160T patent/ES2238765T3/es not_active Expired - Lifetime
- 1998-07-07 PT PT98940160T patent/PT1068200E/pt unknown
- 1998-07-07 AU AU88576/98A patent/AU749760B2/en not_active Expired
- 1998-07-07 DE DE69829082T patent/DE69829082T2/de not_active Expired - Lifetime
- 1998-07-07 CA CA002295090A patent/CA2295090C/en not_active Expired - Lifetime
- 1998-07-07 DK DK98940160T patent/DK1068200T3/da active
- 1998-07-07 AP APAP/P/2000/001730A patent/AP1379A/en active
- 1998-07-07 NZ NZ501982A patent/NZ501982A/xx not_active IP Right Cessation
- 1998-07-07 KR KR1019997012503A patent/KR100540460B1/ko not_active Expired - Lifetime
- 1998-07-07 SK SK1841-99A patent/SK285321B6/sk not_active IP Right Cessation
- 1998-07-07 CZ CZ0463799A patent/CZ297453B6/cs not_active IP Right Cessation
- 1998-07-07 ID IDW20000032A patent/ID23783A/id unknown
- 1998-07-07 PL PL98338009A patent/PL193703B1/pl unknown
- 1998-07-07 IL IL13391998A patent/IL133919A/en not_active IP Right Cessation
- 1998-07-10 ZA ZA9806160A patent/ZA986160B/xx unknown
- 1998-07-10 AR ARP980103376A patent/AR015130A1/es active IP Right Grant
1999
- 1999-12-10 BG BG103982A patent/BG64314B1/bg unknown
2000
- 2000-01-10 NO NO20000114A patent/NO318328B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT1068200E (pt)	2005-07-29
BG103982A (en)	2000-08-31
PL193703B1 (pl)	2007-03-30
AU8857698A (en)	1999-02-08
SK285321B6 (sk)	2006-11-03
BG64314B1 (bg)	2004-09-30
SI1068200T1 (cs)	2005-08-31
AP1379A (en)	2005-03-29
BRPI9811679B8 (pt)	2021-05-25
BR9811679A (pt)	2000-09-19
ES2238765T3 (es)	2005-09-01
DE69829082T2 (de)	2005-12-29
CZ463799A3 (cs)	2000-04-12
EE200000020A (et)	2000-10-16
BRPI9811679B1 (pt)	2016-10-18
TW593312B (en)	2004-06-21
CA2295090A1 (en)	1999-01-21
HRP20000007A2 (en)	2000-12-31
CA2295090C (en)	2009-09-08
HUP0004459A3 (en)	2002-11-28
MY118844A (en)	2005-01-31
EP1068200A1 (en)	2001-01-17
AP2000001730A0 (en)	2000-03-31
US6387906B1 (en)	2002-05-14
ATE289303T1 (de)	2005-03-15
ZA986160B (en)	2000-01-10
EP1068200B1 (en)	2005-02-16
NO318328B1 (no)	2005-03-07
WO1999002523A1 (en)	1999-01-21
KR100540460B1 (ko)	2006-01-12
HK1032404A1 (en)	2001-07-20
HUP0004459A2 (hu)	2002-04-29
IL133919A0 (en)	2001-04-30
NO20000114D0 (no)	2000-01-10
SK184199A3 (en)	2000-07-11
ID23783A (id)	2000-05-11
NO20000114L (no)	2000-03-13
EA002828B1 (ru)	2002-10-31
UA71543C2 (uk)	2004-12-15
DK1068200T3 (da)	2005-06-20
AU749760B2 (en)	2002-07-04
IL133919A (en)	2002-02-10
NZ501982A (en)	2000-10-27
DE69829082D1 (de)	2005-03-24
TR200000154T2 (tr)	2000-06-21
AR015130A1 (es)	2001-04-18
EE04155B1 (et)	2003-10-15
KR20010020576A (ko)	2001-03-15
EA200000116A1 (ru)	2000-08-28
CZ297453B6 (cs)	2006-12-13
PL338009A1 (en)	2000-09-25
HU225159B1 (en)	2006-07-28
GEP20033054B (en)	2003-08-25

Legal Events

Date	Code	Title	Description
2000-12-31	A1OB	Publication of a patent application
2001-06-06	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2008-12-31	B1PR	Patent granted
2017-06-26	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20170626 Year of fee payment: 20
2018-07-09	PB20	Patent expired after termination of 20 years	Effective date: 20180707

Publication	Publication Date	Title
ATE282614T1 (de)	2004-12-15	Phenylharnstoff und phenylthioharnstoffderivate
TW330202B (en)	1998-04-21	Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals
DK0879820T3 (da)	2002-04-02	Benzamidanaloger anvendelige som PARP (ADP-Ribosyltransferase, ADPRT) DNA-reparations enzyminhibitorer
MX9700883A (es)	1997-08-30	Derivados sustituidos de la quinazolina.
DK20290A (da)	1990-01-25	Formuleringer med forsinket afgivelse
DK0765314T3 (da)	2003-08-25	Benzoheterocykliske derivater, der kan anvendes som vasopressin- eller oxytocinmodulatorer
YU25201A (sh)	2003-04-30	Derivati izosorbid mononitrata i njihova upotreba kao vazodilatacionih agensa sa redukovanom tolerancijom
EP1333029A4 (en)	2006-07-19	Pyrimidine derivatives and herbicides containing them
TR200001010T2 (tr)	2000-09-21	Ürokinaz önleyicileri olan izokinolinler.
AR041256A1 (es)	2005-05-11	Indoles sustituidos en posicion 2,4 y su uso como moduladores de 5-ht6
DK0734380T3 (da)	2002-11-04	4-Benzoylisoxazoler samt deres anvendelse som herbicider
FI881392A0 (fi)	1988-03-23	Framstaellning av antiarytmiska laekemedel.
TR199902115T2 (xx)	2000-01-21	2,3- Dihidrofuro (3,2-b) piridiun t�revleri, haz�rlan��lar� ve terapide uygulanmalar�.
DE3668171D1 (de)	1990-02-15	1-aryl-5-alkoximinoalkylamino-pyrazole.
HRP20010885B1 (en)	2010-07-31	Ethanesulfonyl-piperidine derivatives
MX9202994A (es)	1992-07-01	Derivados de 2-aminoacetamida.
DK0705263T3 (da)	1997-05-05	Carbocycliske nukleoside midler anvendelige som selektive inhibitorer af proinflammatoriske cytokiner
DK0676399T3 (da)	2000-03-20	Methotrexaderivater
NZ501982A (en)	2000-10-27	N-oxide forms of 2,4,4-trisubstituted-1,3-dioxolane as anti-fungal agents
ATE41935T1 (de)	1989-04-15	Substituierte 5-amino-1-aryl-pyrazole.
ES2065992T3 (es)	1995-03-01	Uso de derivados de imidazopirazol como analgesicos y agentes anti-inflamatorios.
CO5050357A1 (es)	2001-06-27	Compuestos de 1-alquilo-4-benzoilo-5-hidroxipirazola y su uso como herbicidas
CO4970732A1 (es)	2000-11-07	Antifungales 1,3-dioxolano 2,4,4-trisubstituidos
MX9204939A (es)	1993-03-01	Inhibidores 5-bis-aminometilen-1,3-dioxan-4,6-diona n,n',n'-trisubstituidas, de la acil coenzima a: colesterol-aciltransferasa.
IE860281L (en)	1986-08-02	5-sulfonamido-1-aryl-pyrazoles