HRP20040108A2 - Novel imidazolidine derivatives, their preparation and their use as vla-4 antagonists - Google Patents

Novel imidazolidine derivatives, their preparation and their use as vla-4 antagonists Download PDF

Info

Publication number: HRP20040108A2
Authority: HR; Croatia
Prior art keywords: alkyl; optionally substituted; aryl; residue; cycloalkyl
Prior art date: 2001-08-01

Application number

HR20040108A

Other languages

English (en)

Croatian (hr)

Inventor

Volkmar Wehner

Stefanie Flohr

Horst Blum

Hartmut Ruetten

Hans Ulrich Stilz

Original Assignee

Aventis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-01

Filing date

2002-07-20

Publication date

2004-06-30

2002-07-20 Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh

2004-06-30 Publication of HRP20040108A2 publication Critical patent/HRP20040108A2/hr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Hematology (AREA)
Tropical Medicine & Parasitology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Obesity (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

HR20040108A 2001-08-01 2002-07-20 Novel imidazolidine derivatives, their preparation and their use as vla-4 antagonists HRP20040108A2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10137595A DE10137595A1 (de)	2001-08-01	2001-08-01	Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung
PCT/EP2002/008106 WO2003011288A1 (en)	2001-08-01	2002-07-20	Novel imidazolidine derivatives, their preparation and their use as vla-4 antagonists

Publications (1)

Publication Number	Publication Date
HRP20040108A2 true HRP20040108A2 (en)	2004-06-30

Family

ID=7693930

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HR20040108A HRP20040108A2 (en)	2001-08-01	2002-07-20	Novel imidazolidine derivatives, their preparation and their use as vla-4 antagonists

Country Status (29)

Country	Link
US (1)	US6962937B2 (sr)
EP (1)	EP1414444B1 (sr)
JP (1)	JP4676697B2 (sr)
KR (1)	KR100910930B1 (sr)
CN (1)	CN1537000B (sr)
AR (1)	AR036349A1 (sr)
AT (1)	ATE391504T1 (sr)
AU (1)	AU2002328931B2 (sr)
BR (1)	BR0211535A (sr)
CA (1)	CA2455966C (sr)
CO (1)	CO5550452A2 (sr)
DE (2)	DE10137595A1 (sr)
DK (1)	DK1414444T3 (sr)
ES (1)	ES2301673T3 (sr)
HR (1)	HRP20040108A2 (sr)
HU (1)	HUP0401406A3 (sr)
IL (2)	IL160093A0 (sr)
MX (1)	MXPA04000041A (sr)
MY (1)	MY133467A (sr)
NO (1)	NO326696B1 (sr)
NZ (1)	NZ530887A (sr)
PE (1)	PE20030348A1 (sr)
PL (1)	PL365396A1 (sr)
PT (1)	PT1414444E (sr)
RS (1)	RS6104A (sr)
RU (1)	RU2318815C2 (sr)
TW (1)	TWI325863B (sr)
WO (1)	WO2003011288A1 (sr)
ZA (1)	ZA200400194B (sr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2492035A1 (en)	2002-07-11	2004-01-15	Vicuron Pharmaceuticals, Inc.	N-hydroxyamide derivatives possessing antibacterial activity
EP2093218A1 (en) *	2008-02-22	2009-08-26	Ruggero Fariello	Arylalkyl substituted imidazolidinones
CA2723358A1 (en) *	2008-05-05	2009-11-12	Allison B. Reiss	Method for improving cardiovascular risk profile of cox inhibitors
EP3722808B1 (en)	2010-10-25	2024-09-11	Biogen MA Inc.	Methods for determining differences in alpha-4 integrin activity by correlating differences in svcam and/or smadcam levels
EP3995531B1 (en)	2020-06-01	2024-10-09	LG Chem, Ltd.	Method of preparing polymeric microparticles, polymeric microparticles, and medical composition, cosmetic composition, medical article, and cosmetic article each comprising same

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* Cited by examiner, † Cited by third party
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DE235866C (sr)
DE4009506A1 (de)	1990-03-24	1991-09-26	Hoechst Ag	Hydantoinderivate
DE4126277A1 (de)	1991-08-08	1993-02-11	Cassella Ag	Hydantoinderivate
CA2127462C (en)	1992-01-13	1999-03-23	Roy R. Lobb	Treatment for asthma
JPH07506566A (ja)	1992-02-12	1995-07-20	バイオゲン　インコーポレイテッド	炎症性胃腸病の処置
DE4207254A1 (de)	1992-03-07	1993-09-09	Cassella Ag	4-oxo-2-thioxoimidazolidin-derivate
DE4213634A1 (de)	1992-04-24	1993-10-28	Cassella Ag	2,4-Dioxo-imidazolidin-Derivate
DE4224414A1 (de)	1992-07-24	1994-01-27	Cassella Ag	Phenylimidazolidin-derivate, ihre Herstellung und ihre Verwendung
DE4228717A1 (de)	1992-08-28	1994-03-03	Cassella Ag	Imidazolidin-Derivate
EP0677060A1 (en)	1993-01-08	1995-10-18	Tanabe Seiyaku Co., Ltd.	Peptide inhibitors of cell adhesion
SG44845A1 (en)	1993-01-12	1997-12-19	Biogen Inc	Recombitant anti-vla4 antibody molecules
WO1994017828A2 (en)	1993-02-09	1994-08-18	Biogen, Inc.	Treatment for insulin dependent diabetes
DE4308034A1 (de)	1993-03-13	1994-09-15	Cassella Ag	Neue Heterocyclen, ihre Herstellung und ihre Verwendung
DE4427979A1 (de)	1993-11-15	1996-02-15	Cassella Ag	Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung
AU693143B2 (en)	1993-12-06	1998-06-25	Cytel Corporation	CS-1 peptidomimetics, compositions and methods of using the same
DE69535133T2 (de)	1994-01-25	2008-08-21	Elan Pharmaceuticals, Inc., San Francisco	Humanisierte antikörper gegen das leukozytenadhäsionsmolekül vla-4
AU2958195A (en)	1994-06-29	1996-01-25	Texas Biotechnology Corporation	Process to inhibit binding of the integrin alpha 4 beta 1 to vcam-1 or fibronectin
US5811391A (en)	1994-08-25	1998-09-22	Cytel Corporation	Cyclic CS-1 peptidomimetics, compositions and methods of using same
GB9524630D0 (en)	1994-12-24	1996-01-31	Zeneca Ltd	Chemical compounds
US6306840B1 (en)	1995-01-23	2001-10-23	Biogen, Inc.	Cell adhesion inhibitors
DE19515177A1 (de)	1995-04-28	1996-10-31	Cassella Ag	Hydantoinderivate als Zwischenprodukte für pharmazeutische Wirkstoffe
US6248713B1 (en)	1995-07-11	2001-06-19	Biogen, Inc.	Cell adhesion inhibitors
ATE212990T1 (de)	1996-03-20	2002-02-15	Hoechst Ag	Inhibitoren der knochenresorption und vitronectinrezeptor-antagonisten
JP2000516596A (ja)	1996-07-25	2000-12-12	バイオジェン，インコーポレイテッド	細胞接着インヒビター
DE19647380A1 (de)	1996-11-15	1998-05-20	Hoechst Ag	5-Ring-Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
DE19647382A1 (de) *	1996-11-15	1998-05-20	Hoechst Ag	Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
DE19647381A1 (de) *	1996-11-15	1998-05-20	Hoechst Ag	Neue Heterocyclen als Inhibitoren der Leukozytenadhäsion und VLA-4-Antagonisten
WO1998042656A1 (en)	1997-03-21	1998-10-01	Cytel Corporation	Novel compounds
DE19741235A1 (de) *	1997-09-18	1999-03-25	Hoechst Marion Roussel De Gmbh	Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de)	1997-09-23	1999-03-25	Hoechst Marion Roussel De Gmbh	Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DK1027328T3 (da)	1997-10-31	2006-11-13	Aventis Pharma Ltd	Substituerede anilider
GB9723789D0 (en)	1997-11-12	1998-01-07	Zeneca Ltd	Chemical compounds
DE19751251A1 (de)	1997-11-19	1999-05-20	Hoechst Marion Roussel De Gmbh	Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
AU3716499A (en)	1998-04-21	1999-11-08	Aventis Pharma Limited	Substituted diamines and their use as cell adhesion inhibitors
DE19821483A1 (de)	1998-05-14	1999-11-18	Hoechst Marion Roussel De Gmbh	Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
JP3676677B2 (ja)	1998-06-30	2005-07-27	ファイザー・プロダクツ・インク	炎症性疾患、自己免疫疾患および呼吸疾患の治療において有用なｖｌａ−４依存性細胞結合の非ペプチジル阻害薬
AU1915399A (en)	1998-07-10	2000-02-01	Cytel Corporation	Cs-1 peptidomimetics, compositions and methods of using the same
DE19922462A1 (de) *	1999-05-17	2000-11-23	Aventis Pharma Gmbh	Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate

2001
- 2001-08-01 DE DE10137595A patent/DE10137595A1/de not_active Withdrawn
2002
- 2002-07-20 IL IL16009302A patent/IL160093A0/xx unknown
- 2002-07-20 AT AT02764740T patent/ATE391504T1/de active
- 2002-07-20 ES ES02764740T patent/ES2301673T3/es not_active Expired - Lifetime
- 2002-07-20 WO PCT/EP2002/008106 patent/WO2003011288A1/en not_active Ceased
- 2002-07-20 AU AU2002328931A patent/AU2002328931B2/en not_active Ceased
- 2002-07-20 HU HU0401406A patent/HUP0401406A3/hu unknown
- 2002-07-20 MX MXPA04000041A patent/MXPA04000041A/es active IP Right Grant
- 2002-07-20 RS YU6104A patent/RS6104A/sr unknown
- 2002-07-20 CA CA2455966A patent/CA2455966C/en not_active Expired - Fee Related
- 2002-07-20 JP JP2003516518A patent/JP4676697B2/ja not_active Expired - Fee Related
- 2002-07-20 CN CN028151046A patent/CN1537000B/zh not_active Expired - Fee Related
- 2002-07-20 DK DK02764740T patent/DK1414444T3/da active
- 2002-07-20 PL PL02365396A patent/PL365396A1/xx not_active Application Discontinuation
- 2002-07-20 RU RU2004105966/04A patent/RU2318815C2/ru not_active IP Right Cessation
- 2002-07-20 DE DE60226032T patent/DE60226032T2/de not_active Expired - Lifetime
- 2002-07-20 NZ NZ530887A patent/NZ530887A/en not_active IP Right Cessation
- 2002-07-20 PT PT02764740T patent/PT1414444E/pt unknown
- 2002-07-20 EP EP02764740A patent/EP1414444B1/en not_active Expired - Lifetime
- 2002-07-20 KR KR1020047001524A patent/KR100910930B1/ko not_active Expired - Fee Related
- 2002-07-20 HR HR20040108A patent/HRP20040108A2/hr not_active Application Discontinuation
- 2002-07-20 BR BR0211535-2A patent/BR0211535A/pt active Search and Examination
- 2002-07-26 PE PE2002000672A patent/PE20030348A1/es not_active Application Discontinuation
- 2002-07-30 MY MYPI20022873A patent/MY133467A/en unknown
- 2002-07-30 TW TW091116941A patent/TWI325863B/zh not_active IP Right Cessation
- 2002-07-30 AR ARP020102868A patent/AR036349A1/es active IP Right Grant
- 2002-07-31 US US10/208,182 patent/US6962937B2/en not_active Expired - Lifetime
2004
- 2004-01-12 ZA ZA200400194A patent/ZA200400194B/xx unknown
- 2004-01-26 CO CO04005444A patent/CO5550452A2/es not_active Application Discontinuation
- 2004-01-27 IL IL160093A patent/IL160093A/en not_active IP Right Cessation
- 2004-01-30 NO NO20040426A patent/NO326696B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
TWI325863B (en)	2010-06-11
JP4676697B2 (ja)	2011-04-27
US20030109497A1 (en)	2003-06-12
IL160093A (en)	2009-05-04
HUP0401406A2 (hu)	2004-10-28
CN1537000A (zh)	2004-10-13
RU2004105966A (ru)	2005-06-27
PE20030348A1 (es)	2003-05-14
HK1066166A1 (zh)	2005-03-18
IL160093A0 (en)	2004-06-20
NO20040426L (no)	2004-03-26
ATE391504T1 (de)	2008-04-15
DK1414444T3 (da)	2008-08-04
JP2005504033A (ja)	2005-02-10
RS6104A (sr)	2006-10-27
EP1414444A1 (en)	2004-05-06
MY133467A (en)	2007-11-30
RU2318815C2 (ru)	2008-03-10
DE10137595A1 (de)	2003-02-13
ZA200400194B (en)	2005-03-14
US6962937B2 (en)	2005-11-08
PL365396A1 (en)	2005-01-10
AU2002328931B2 (en)	2008-04-24
MXPA04000041A (es)	2004-05-21
DE60226032T2 (de)	2009-05-20
HUP0401406A3 (en)	2004-11-29
EP1414444B1 (en)	2008-04-09
WO2003011288A1 (en)	2003-02-13
CA2455966C (en)	2011-09-20
ES2301673T3 (es)	2008-07-01
NO326696B1 (no)	2009-02-02
AR036349A1 (es)	2004-09-01
KR100910930B1 (ko)	2009-08-06
BR0211535A (pt)	2004-07-13
KR20040020076A (ko)	2004-03-06
PT1414444E (pt)	2008-05-27
NZ530887A (en)	2005-09-30
CA2455966A1 (en)	2003-02-13
DE60226032D1 (de)	2008-05-21
CO5550452A2 (es)	2005-08-31
CN1537000B (zh)	2010-05-12

Legal Events

Date	Code	Title	Description
2004-06-30	A1OB	Publication of a patent application
2004-12-27	ARAI	Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
2006-02-09	PNAN	Change of the applicant name, address/residence	Owner name: SANOFI-AVENTIS DEUTSCHLAND GMBH, DE
2008-07-18	ODRP	Renewal fee for the maintenance of a patent	Payment date: 20080718 Year of fee payment: 7
2009-05-29	OBST	Application withdrawn

Publication	Publication Date	Title
US5998447A (en)	1999-12-07	Heterocycles as inhibitors of leucocyte adhesion and as VLA-4 antagonists
CA2254420C (en)	2009-05-26	Substituted imidazolidine derivatives, their preparation, their use and pharmaceutical preparations comprising them
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