HRP20040180A2 - Purification and crystalline forms of zaleplon - Google Patents

Purification and crystalline forms of zaleplon

Info

Publication number
HRP20040180A2
HRP20040180A2 HR20040180A HRP20040180A HRP20040180A2 HR P20040180 A2 HRP20040180 A2 HR P20040180A2 HR 20040180 A HR20040180 A HR 20040180A HR P20040180 A HRP20040180 A HR P20040180A HR P20040180 A2 HRP20040180 A2 HR P20040180A2
Authority
HR
Croatia
Prior art keywords
zaleplon
solution
water
organic solvent
solid
Prior art date
Application number
HR20040180A
Other languages
English (en)
Croatian (hr)
Inventor
Erika Feher
Ferenc Korodi
Erika Magyar
Claude Singer
Original Assignee
Biogal Gyogyszergyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/170,673 external-priority patent/US6884888B2/en
Application filed by Biogal Gyogyszergyar filed Critical Biogal Gyogyszergyar
Publication of HRP20040180A2 publication Critical patent/HRP20040180A2/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/145555—Hetero-N
    • Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HR20040180A 2001-08-01 2002-08-01 Purification and crystalline forms of zaleplon HRP20040180A2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US30939101P 2001-08-01 2001-08-01
US31790701P 2001-09-06 2001-09-06
US38819902P 2002-06-12 2002-06-12
US10/170,673 US6884888B2 (en) 2001-06-12 2002-06-12 Process for the production of N-[3-(3-cyanopyrazolo[1,5-a] pyrimidin-7-yl) phenyl]-N-ethylacetamide (zaleplon)
PCT/US2002/024553 WO2003011228A2 (en) 2001-08-01 2002-08-01 Purification and crystalline forms of zaleplon

Publications (1)

Publication Number Publication Date
HRP20040180A2 true HRP20040180A2 (en) 2004-12-31

Family

ID=27496922

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20040180A HRP20040180A2 (en) 2001-08-01 2002-08-01 Purification and crystalline forms of zaleplon

Country Status (14)

Country Link
US (2) US6852858B2 (pl)
EP (1) EP1430054A4 (pl)
JP (1) JP2005523874A (pl)
CA (1) CA2453751A1 (pl)
CZ (1) CZ200471A3 (pl)
HR (1) HRP20040180A2 (pl)
HU (1) HUP0402253A3 (pl)
IL (1) IL160076A0 (pl)
IS (1) IS7128A (pl)
MX (1) MXPA04001035A (pl)
NO (1) NO20040887L (pl)
PL (1) PL374176A1 (pl)
SK (1) SK472004A3 (pl)
WO (1) WO2003011228A2 (pl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1305315A2 (en) * 2000-08-03 2003-05-02 Wyeth Polymorphs of zaleplon and methods for the preparation thereof
US20050032818A1 (en) * 2001-06-12 2005-02-10 Entire Interest N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylacetamide and crystalline forms of zaleplon
ES2223311T1 (es) * 2001-06-12 2005-03-01 Biogal Gyogyszergyar Rt. Procedimiento para la preparacion de n-(3-(3-cianopirazol(1,5-a)pirimidin-7-il)fenil)-n-etilacetamida (zaleplon).
PL374176A1 (pl) * 2001-08-01 2005-10-03 Biogal Gyogyszergyar Rt Sposób oczyszczania N-[3-(3-cyjanopirazolo [1,5-a] pirymidyn-7-ylo)fenylo]-N-etyloacetamidu (zaleplonu) i krystaliczne formy zaleplonu wytworzone tymsposobem
US20050119281A1 (en) * 2002-02-15 2005-06-02 Biogal Gyogyszergyar Rt Powder composition comprising zaleplon of defined particle size distribution and pharmaceutical products made therefrom
CZ293015B6 (cs) * 2002-10-25 2004-01-14 Léčiva, A.S. Způsob výroby N-ethyl-N-[3-(3-methyl-pyrazolo[1,5-a]pyrimidin-7-yl)-fenyl]-acetamidu (zaleplonu)
DE112004001615T5 (de) 2003-09-04 2006-06-14 Cipla Ltd. Zaleplon-Synthese
DE602004025747D1 (de) * 2004-01-14 2010-04-08 Mallinckrodt Inc Zweiphasiges verfahren zur synthese ausgewählter pyrazolopyrimidine
HUP0400325A3 (en) 2004-02-02 2005-11-28 Richter Gedeon Vegyeszet Pure n-[3-(-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethyl-acetamide, process for its preparation and intermediates
US20090259038A1 (en) * 2004-12-08 2009-10-15 Kuraray Co., Ltd. Process for producing (5alpha7alpha)-3-spiro-2'-(1',3'-dioxolan)-24-oxocholest-22-en-7-yl benzoate
WO2007043939A1 (en) * 2005-10-07 2007-04-19 Astrazeneca Ab Novel crystalline form of 3,5-dibromo-n- [(2s)-2-(-4-fluorophenyl)-4-(3-morpholin-4-ylazetidin-1-yl)butyl] -n-methylbenzamide, modification a
US7761955B1 (en) * 2007-08-30 2010-07-27 Hiltz Erik D Dual port cleaning and extraction apparatus
US8171598B1 (en) 2010-07-26 2012-05-08 Erik Daniel Hiltz Dual port cleaning and extraction apparatus
TWI665190B (zh) 2013-11-15 2019-07-11 阿克比治療有限公司 ｛［５－（３－氯苯基）－３－羥基吡啶－２－羰基］胺基｝乙酸之固體型式，其組合物及用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4626538A (en) 1983-06-23 1986-12-02 American Cyanamid Company [7-(3-disubstituted amino)phenyl]pyrazolo[1,5-a]pyrimidines
US5714607A (en) 1995-12-01 1998-02-03 American Cyanamid Company Process improvement in the synthesis of N- 3-(3-cyano-pyrazolo 1,5-a!pyrimidin-7-yl)phenyl!-N-ethylacetamide
US6485746B1 (en) 2000-08-25 2002-11-26 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
DE10004790B4 (de) 2000-02-01 2004-09-09 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System zur Verabreichung von Zaleplon, Verfahren zu seiner Herstellung und seine Verwendung
WO2001078725A2 (en) 2000-04-13 2001-10-25 Synthon B.V. Modified release formulations containing a hypnotic agent
EP1305315A2 (en) * 2000-08-03 2003-05-02 Wyeth Polymorphs of zaleplon and methods for the preparation thereof
AR029780A1 (es) 2000-12-13 2003-07-16 Gador Sa Procedimiento mejorado para la obtencion de n-[3(3-ciano-pirazolo[1,5-a]pirimidin-7-il)fenil]-n-etil-acetamida
ES2223311T1 (es) 2001-06-12 2005-03-01 Biogal Gyogyszergyar Rt. Procedimiento para la preparacion de n-(3-(3-cianopirazol(1,5-a)pirimidin-7-il)fenil)-n-etilacetamida (zaleplon).
PL374176A1 (pl) 2001-08-01 2005-10-03 Biogal Gyogyszergyar Rt Sposób oczyszczania N-[3-(3-cyjanopirazolo [1,5-a] pirymidyn-7-ylo)fenylo]-N-etyloacetamidu (zaleplonu) i krystaliczne formy zaleplonu wytworzone tymsposobem
ATE368667T1 (de) * 2002-02-14 2007-08-15 Cilag Ag Verfahren zur herstellung von n-ethyl-n-(3-(3- cyanopyrazolo-(1,5-a)-pyrimidin-7-yl)phenyl)- acetamid
PL207322B1 (pl) 2002-05-14 2010-11-30 Adamed Społka Z Ograniczoną Odpowiedzialnością Sposób wytwarzania zaleplonu
CZ293015B6 (cs) * 2002-10-25 2004-01-14 Léčiva, A.S. Způsob výroby N-ethyl-N-[3-(3-methyl-pyrazolo[1,5-a]pyrimidin-7-yl)-fenyl]-acetamidu (zaleplonu)

Also Published As

Publication number Publication date
WO2003011228A3 (en) 2003-10-30
CA2453751A1 (en) 2003-02-13
EP1430054A2 (en) 2004-06-23
PL374176A1 (pl) 2005-10-03
MXPA04001035A (es) 2004-06-22
US7348429B2 (en) 2008-03-25
US20050065168A1 (en) 2005-03-24
CZ200471A3 (cs) 2004-11-10
EP1430054A4 (en) 2005-06-22
HUP0402253A2 (hu) 2005-02-28
JP2005523874A (ja) 2005-08-11
NO20040887L (no) 2004-02-27
IS7128A (is) 2004-01-28
IL160076A0 (en) 2004-06-20
SK472004A3 (en) 2004-12-01
WO2003011228A2 (en) 2003-02-13
US20030130291A1 (en) 2003-07-10
US6852858B2 (en) 2005-02-08
HUP0402253A3 (en) 2005-12-28

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