HRP20040409A2 - 4-(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes - Google Patents

4-(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes Download PDF

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Publication number
HRP20040409A2
HRP20040409A2 HR20040409A HRP20040409A HRP20040409A2 HR P20040409 A2 HRP20040409 A2 HR P20040409A2 HR 20040409 A HR20040409 A HR 20040409A HR P20040409 A HRP20040409 A HR P20040409A HR P20040409 A2 HRP20040409 A2 HR P20040409A2
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Croatia
Prior art keywords
alkyl
substituted
halogen
combinations
carbon atoms
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HR20040409A
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English (en)
Croatian (hr)
Inventor
Liu Ruiping
De Vivo Michael
Ernst Hess Hans-Jurgen
Allen
Keuster Erik
Theim Ashok
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Memory Pharmaceuticals Corporation
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Publication of HRP20040409A2 publication Critical patent/HRP20040409A2/hr

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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D207/24—Oxygen or sulfur atoms
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  • Diabetes (AREA)
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HR20040409A 2001-10-16 2002-10-16 4-(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes HRP20040409A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32931401P 2001-10-16 2001-10-16
PCT/US2002/032834 WO2003032981A1 (fr) 2001-10-16 2002-10-16 Derives 4-(4-alcoky-3-hydroxyphenyle)-2-pyrrolidone utilises en tant qu'inhibiteurs de la pde4 pour le traitement de syndromes neurologiques

Publications (1)

Publication Number Publication Date
HRP20040409A2 true HRP20040409A2 (en) 2005-06-30

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HR20040409A HRP20040409A2 (en) 2001-10-16 2002-10-16 4-(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes

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US (3) US7235579B2 (fr)
EP (1) EP1435944B1 (fr)
JP (2) JP4484515B2 (fr)
KR (2) KR20090080573A (fr)
CN (1) CN1604776A (fr)
AT (1) ATE444065T1 (fr)
AU (1) AU2002335015B8 (fr)
BR (1) BR0213660A (fr)
CA (1) CA2463469A1 (fr)
CO (1) CO5570674A2 (fr)
DE (1) DE60233884D1 (fr)
ES (1) ES2334650T3 (fr)
HR (1) HRP20040409A2 (fr)
IL (1) IL161317A0 (fr)
MX (1) MXPA04003516A (fr)
NO (1) NO20042024L (fr)
NZ (1) NZ532288A (fr)
RU (2) RU2340600C2 (fr)
WO (1) WO2003032981A1 (fr)
ZA (1) ZA200402856B (fr)

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US8153646B2 (en) 2000-08-10 2012-04-10 Dart Neuroscience (Cayman) Ltd. Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation
WO2002054066A2 (fr) * 2000-12-14 2002-07-11 The Burnham Institute Formes non apoptotiques de mort cellulaire et methodes de modulation
IL161317A0 (en) 2001-10-16 2004-09-27 Memory Pharm Corp 4-(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes
US20030157053A1 (en) * 2002-02-19 2003-08-21 Sabina Sperandio Modulators of paraptosis and related methods
AU2003285952A1 (en) 2002-10-21 2004-05-13 Irm Llc Pyrrolidones with anti-hiv activity
ES2211344B1 (es) * 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
SG169900A1 (en) * 2003-04-16 2011-04-29 Memory Pharm Corp 4 - (3,4 - disubstituted phenyl) - pyrrolidin-2-one compounds as phosphodiesterase 4 inhibitors
US20070191267A1 (en) * 2003-04-28 2007-08-16 Ab Science Use of tyrosine kinase inhibitors for treating cerebral ischemia
ES2251866B1 (es) * 2004-06-18 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
ES2251867B1 (es) * 2004-06-21 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
DOP2005000123A (es) 2004-07-02 2011-07-15 Merck Sharp & Dohme Inhibidores de cetp
EP1802615A1 (fr) * 2004-10-20 2007-07-04 Memory Pharmaceuticals Corporation Inhibiteurs de la phosphodiéstérase 4
PL1954684T3 (pl) 2005-11-15 2014-10-31 Otsuka Pharma Co Ltd Związek oksazolowy i kompozycja farmaceutyczna
NZ568904A (en) * 2005-12-30 2011-05-27 Merck Sharp & Dohme 1,3-oxazolidin-2-one derivatives useful as CETP inhibitors
ES2412481T3 (es) * 2006-05-19 2013-07-11 Dart Neuroscience Llc Inhibidores de la fosfodiesterasa 4 para la rehabilitación motora
ES2320954B1 (es) * 2007-03-02 2010-03-16 Laboratorio Almirall S.A. Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo (3,4-d)iridazin-7(6h)-ona.
WO2009067607A2 (fr) * 2007-11-20 2009-05-28 Memory Pharmaceuticals Corporation Combinaisons d'inhibiteurs de pde4 et d'antipsychotiques pour le traitement de troubles psychotiques
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US20090176799A1 (en) 2009-07-09
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AU2002335015B2 (en) 2006-11-02
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