HRP20080018T3 - 5-amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2h-pyrido[2,3-d]pyrimidine derivatives and related compounds for the treatment of cancer - Google Patents

5-amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2h-pyrido[2,3-d]pyrimidine derivatives and related compounds for the treatment of cancer

Info

Publication number
HRP20080018T3
HRP20080018T3 HR20080018T HRP20080018T HRP20080018T3 HR P20080018 T3 HRP20080018 T3 HR P20080018T3 HR 20080018 T HR20080018 T HR 20080018T HR P20080018 T HRP20080018 T HR P20080018T HR P20080018 T3 HRP20080018 T3 HR P20080018T3
Authority
HR
Croatia
Prior art keywords
group
atom
alkyl group
different
alkyl
Prior art date
Application number
HR20080018T
Other languages
English (en)
Croatian (hr)
Inventor
Sakai Toshiyuki
Kawasaki H.
Abe H.
Hayakawa K.
Iida T.
Kikuchi S.
Yamaguchi T.
Nanayama T.
Kurachi H.
Tamaru M.
Hori Y.
Takahashi M.
Yoshida T.
Original Assignee
Japan Tobacco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco filed Critical Japan Tobacco
Publication of HRP20080018T3 publication Critical patent/HRP20080018T3/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Addiction (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
HR20080018T 2004-06-11 2005-06-10 5-amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2h-pyrido[2,3-d]pyrimidine derivatives and related compounds for the treatment of cancer HRP20080018T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2004174770 2004-06-11
JP2004327111 2004-11-10
PCT/JP2005/011082 WO2005121142A1 (fr) 2004-06-11 2005-06-10 Dérivés de 5-amino-2,4,7-trioxo-3,4,7,8-tétrahydro-2h-pyrido’2,3-d! pyrimidine et composés apparentés pour le traitement du cancer

Publications (1)

Publication Number Publication Date
HRP20080018T3 true HRP20080018T3 (en) 2008-01-31

Family

ID=34970318

Family Applications (2)

Application Number Title Priority Date Filing Date
HR20080018T HRP20080018T3 (en) 2004-06-11 2005-06-10 5-amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2h-pyrido[2,3-d]pyrimidine derivatives and related compounds for the treatment of cancer
HRP20121020TT HRP20121020T1 (hr) 2004-06-11 2012-12-12 DERIVATI 5-AMINO-2,4,7-TRIOKSO-3,4,7,8-TETRAHIDRO-2H-PIRIDO[2,3-d]PIRIMIDINA I SRODNI SPOJEVI, NAMIJENJENI LIJEÄŚENJU RAKA

Family Applications After (1)

Application Number Title Priority Date Filing Date
HRP20121020TT HRP20121020T1 (hr) 2004-06-11 2012-12-12 DERIVATI 5-AMINO-2,4,7-TRIOKSO-3,4,7,8-TETRAHIDRO-2H-PIRIDO[2,3-d]PIRIMIDINA I SRODNI SPOJEVI, NAMIJENJENI LIJEÄŚENJU RAKA

Country Status (27)

Country Link
EP (3) EP1761528B1 (fr)
JP (3) JP4163738B2 (fr)
KR (1) KR100883289B1 (fr)
CN (2) CN101912400B (fr)
AT (1) ATE383360T1 (fr)
AU (1) AU2005252110B2 (fr)
BR (1) BRPI0511967B8 (fr)
CA (2) CA2569850C (fr)
CY (3) CY1107253T1 (fr)
DE (1) DE602005004286T2 (fr)
DK (2) DK2298768T3 (fr)
ES (2) ES2397825T3 (fr)
FR (1) FR14C0083I2 (fr)
HR (2) HRP20080018T3 (fr)
IL (1) IL179671A0 (fr)
LU (1) LU92602I2 (fr)
ME (1) ME01480B (fr)
MX (1) MXPA06014478A (fr)
NL (1) NL300701I1 (fr)
NO (2) NO338355B1 (fr)
NZ (1) NZ552090A (fr)
PL (2) PL2298768T3 (fr)
PT (2) PT1761528E (fr)
RS (2) RS50569B (fr)
RU (1) RU2364596C2 (fr)
SI (2) SI1761528T1 (fr)
WO (1) WO2005121142A1 (fr)

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MXPA06014478A (es) 2007-03-21
RU2364596C2 (ru) 2009-08-20
CN101006086A (zh) 2007-07-25
WO2005121142A1 (fr) 2005-12-22
PT1761528E (pt) 2008-04-15
AU2005252110B2 (en) 2008-09-04
CY1113538T1 (el) 2016-06-22
AU2005252110A1 (en) 2005-12-22
NO2016021I2 (no) 2016-11-24
PT2298768E (pt) 2012-12-05
NL300701I2 (fr) 2015-12-29
CN101912400A (zh) 2010-12-15
JP2008201788A (ja) 2008-09-04
KR100883289B1 (ko) 2009-02-11
NL300701I1 (fr) 2015-12-29
CY2014045I2 (el) 2019-07-10
SI1761528T1 (sl) 2008-06-30
RS50569B (sr) 2010-05-07
NO20070155L (no) 2007-02-13
CN101006086B (zh) 2010-09-29
DK2298768T3 (da) 2013-01-02
CA2569850C (fr) 2011-04-05
JP4163738B2 (ja) 2008-10-08
NZ552090A (en) 2009-06-26
DK1761528T3 (da) 2008-05-05
CA2727841A1 (fr) 2005-12-22
FR14C0083I2 (fr) 2015-02-20
BRPI0511967B1 (pt) 2019-05-07
SI2298768T1 (en) 2013-01-31
EP1761528B1 (fr) 2008-01-09
BRPI0511967B8 (pt) 2021-05-25
DE602005004286D1 (de) 2008-02-21
CN101912400B (zh) 2013-06-26
KR20070034581A (ko) 2007-03-28
DE602005004286T2 (de) 2009-01-02
JP2008501631A (ja) 2008-01-24
CY1107253T1 (el) 2012-11-21
JP5421974B2 (ja) 2014-02-19
CY2014045I1 (el) 2019-07-10
HRP20121020T1 (hr) 2013-01-31
FR14C0083I1 (fr) 2015-02-01
PL2298768T3 (pl) 2013-03-29
BRPI0511967A (pt) 2008-01-22
IL179671A0 (en) 2007-05-15
ATE383360T1 (de) 2008-01-15
EP1894932A1 (fr) 2008-03-05
ME01480B (fr) 2014-04-20
EP2298768B1 (fr) 2012-11-14
NO2016021I1 (no) 2016-11-24
LU92602I2 (fr) 2015-10-27
ES2297723T3 (es) 2008-05-01
HK1107084A1 (en) 2008-03-28
RS52670B (sr) 2013-06-28
JP2012072155A (ja) 2012-04-12
EP1761528A1 (fr) 2007-03-14
EP2298768A1 (fr) 2011-03-23
RU2007101158A (ru) 2008-07-20
ES2397825T3 (es) 2013-03-11
EP2298768B9 (fr) 2013-04-24
NO338355B1 (no) 2016-08-08

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