HRP20080145T3 - Asymmetric hydrogenation process useful for the preparation of cycloalkanoindole derivatives - Google Patents

Asymmetric hydrogenation process useful for the preparation of cycloalkanoindole derivatives

Info

Publication number
HRP20080145T3
HRP20080145T3 HR20080145T HRP20080145T HRP20080145T3 HR P20080145 T3 HRP20080145 T3 HR P20080145T3 HR 20080145 T HR20080145 T HR 20080145T HR P20080145 T HRP20080145 T HR P20080145T HR P20080145 T3 HRP20080145 T3 HR P20080145T3
Authority
HR
Croatia
Prior art keywords
chiral
preparation
asymmetric hydrogenation
hydrogenation process
process useful
Prior art date
Application number
HR20080145T
Other languages
English (en)
Croatian (hr)
Inventor
M. Tellers David
R. Humphrey Guy
Original Assignee
Merck & Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.
Publication of HRP20080145T3 publication Critical patent/HRP20080145T3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Catalysts (AREA)
HR20080145T 2004-04-02 2005-03-29 Asymmetric hydrogenation process useful for the preparation of cycloalkanoindole derivatives HRP20080145T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55897204P 2004-04-02 2004-04-02
PCT/US2005/010501 WO2005097745A1 (en) 2004-04-02 2005-03-29 Asymmetric hydrogenation process useful for the preparation of cycloalkanoindole derivatives

Publications (1)

Publication Number Publication Date
HRP20080145T3 true HRP20080145T3 (en) 2008-04-30

Family

ID=34964828

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20080145T HRP20080145T3 (en) 2004-04-02 2005-03-29 Asymmetric hydrogenation process useful for the preparation of cycloalkanoindole derivatives

Country Status (19)

Country Link
US (1) US7576118B2 (de)
EP (1) EP1737820B1 (de)
JP (1) JP5239071B2 (de)
CN (1) CN1942440B (de)
AR (1) AR048459A1 (de)
AT (1) ATE384046T1 (de)
AU (1) AU2005230897B2 (de)
BR (1) BRPI0509384A (de)
CA (1) CA2561632A1 (de)
CY (1) CY1107223T1 (de)
DE (1) DE602005004393T2 (de)
DK (1) DK1737820T3 (de)
ES (1) ES2297695T3 (de)
HR (1) HRP20080145T3 (de)
PL (1) PL1737820T3 (de)
PT (1) PT1737820E (de)
SI (1) SI1737820T1 (de)
TW (1) TWI344954B (de)
WO (1) WO2005097745A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA019252B1 (ru) 2008-07-23 2014-02-28 Арена Фармасьютикалз, Инк. ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ (1,2,3,4-ТЕТРАГИДРОЦИКЛОПЕНТА[b]ИНДОЛ-3-ИЛ)УКСУСНОЙ КИСЛОТЫ, ПРИМЕНИМЫЕ В ЛЕЧЕНИИ АУТОИММУННЫХ И ВОСПАЛИТЕЛЬНЫХ РАССТРОЙСТВ
SI2342205T1 (sl) 2008-08-27 2016-09-30 Arena Pharmaceuticals, Inc. Substituirani triciklični kislinski derivati kot agonisti S1P1 receptorja, uporabni v zdravljenju avtoimunskih in vnetnih obolenj
SG10201906876PA (en) 2010-01-27 2019-09-27 Arena Pharm Inc Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid and salts thereof
SG183416A1 (en) 2010-03-03 2012-09-27 Arena Pharm Inc Processes for the preparation of s1p1 receptor modulators and crystalline forms thereof
CN102659664B (zh) * 2012-03-28 2015-01-21 中国计量学院 合成分离拉洛皮兰及其类似物的方法
MX386419B (es) 2015-01-06 2025-03-18 Arena Pharm Inc Metodos de condiciones de tratamiento relacionadas con el receptor s1p1.
EP3939965A1 (de) 2015-06-22 2022-01-19 Arena Pharmaceuticals, Inc. Kristallines l-arginin-salz von (r)-2-(7-(4-cyclopentyl-3-(trifluormethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)essigsäure zur verwendung in s1p1-rezeptor-assoziierten erkrankungen
MA47504A (fr) 2017-02-16 2019-12-25 Arena Pharm Inc Composés et méthodes de traitement de l'angiocholite biliaire primitive
WO2018151834A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations
ES2987794T3 (es) 2018-06-06 2024-11-18 Arena Pharm Inc Procedimientos de tratamiento de afecciones relacionadas con el receptor S1P1
CN112955431A (zh) 2018-09-06 2021-06-11 艾尼纳制药公司 可用于治疗自身免疫性病症和炎性病症的化合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0272787B1 (de) 1986-11-14 1992-05-06 Takasago International Corporation Katalytische Produktion von optisch aktiven Carbonsäuren
AR038136A1 (es) * 2002-01-24 2004-12-29 Merck Frosst Canada Inc Cicloalcanindoles con sustitucion con fluor composiciones que contienen estos compuestos y metodos de tratamiento
US20080153817A1 (en) * 2003-08-07 2008-06-26 Dirk Beher Treatment for Alzheimer's Disease and Related Conditions

Also Published As

Publication number Publication date
JP5239071B2 (ja) 2013-07-17
DE602005004393D1 (de) 2008-03-06
TW200606145A (en) 2006-02-16
PT1737820E (pt) 2008-03-17
EP1737820B1 (de) 2008-01-16
AU2005230897B2 (en) 2011-03-03
SI1737820T1 (sl) 2008-04-30
ES2297695T3 (es) 2008-05-01
US20050222428A1 (en) 2005-10-06
AU2005230897A1 (en) 2005-10-20
PL1737820T3 (pl) 2008-05-30
US7576118B2 (en) 2009-08-18
WO2005097745A1 (en) 2005-10-20
CY1107223T1 (el) 2012-11-21
CA2561632A1 (en) 2005-10-20
AR048459A1 (es) 2006-04-26
BRPI0509384A (pt) 2007-09-18
DK1737820T3 (da) 2008-04-28
EP1737820A1 (de) 2007-01-03
DE602005004393T2 (de) 2009-01-08
CN1942440A (zh) 2007-04-04
JP2007532488A (ja) 2007-11-15
TWI344954B (en) 2011-07-11
ATE384046T1 (de) 2008-02-15
CN1942440B (zh) 2011-09-14

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