HRP20090151T3 - Indozolone derivatives as 11b-hsd1 inhibitors - Google Patents

Indozolone derivatives as 11b-hsd1 inhibitors

Info

Publication number
HRP20090151T3
HRP20090151T3 HR20090151T HRP20090151T HRP20090151T3 HR P20090151 T3 HRP20090151 T3 HR P20090151T3 HR 20090151 T HR20090151 T HR 20090151T HR P20090151 T HRP20090151 T HR P20090151T HR P20090151 T3 HRP20090151 T3 HR P20090151T3
Authority
HR
Croatia
Prior art keywords
alkyl
fluoro
alkoxy
hydrogen
aryl
Prior art date
Application number
HR20090151T
Other languages
English (en)
Croatian (hr)
Inventor
Amrein Kurt
Cai Jianping
Alan Jr. Goodnow Robert
Hunziker Daniel
Kuhn Bernd
Mayweg Alexander
Neidhart Werner
Original Assignee
F. Hoffmann - La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann - La Roche Ag filed Critical F. Hoffmann - La Roche Ag
Publication of HRP20090151T3 publication Critical patent/HRP20090151T3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HR20090151T 2004-09-29 2005-09-21 Indozolone derivatives as 11b-hsd1 inhibitors HRP20090151T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04104753 2004-09-29
PCT/EP2005/010175 WO2006034804A1 (fr) 2004-09-29 2005-09-21 Derives d'indozolone utilises en tant qu'inhibiteurs de la 11b-hsd1

Publications (1)

Publication Number Publication Date
HRP20090151T3 true HRP20090151T3 (en) 2009-04-30

Family

ID=35447579

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20090151T HRP20090151T3 (en) 2004-09-29 2005-09-21 Indozolone derivatives as 11b-hsd1 inhibitors

Country Status (27)

Country Link
US (1) US7528158B2 (fr)
EP (1) EP1797042B1 (fr)
JP (1) JP4682207B2 (fr)
KR (1) KR100856164B1 (fr)
CN (1) CN101027286B (fr)
AR (1) AR050952A1 (fr)
AT (1) ATE420076T1 (fr)
AU (1) AU2005289107B2 (fr)
BR (1) BRPI0515931A (fr)
CA (1) CA2581865C (fr)
DE (1) DE602005012292D1 (fr)
DK (1) DK1797042T3 (fr)
ES (1) ES2317305T3 (fr)
HR (1) HRP20090151T3 (fr)
IL (1) IL182212A (fr)
MX (1) MX2007003546A (fr)
MY (1) MY140841A (fr)
NO (1) NO20071617L (fr)
NZ (1) NZ553849A (fr)
PL (1) PL1797042T3 (fr)
PT (1) PT1797042E (fr)
RU (1) RU2392272C2 (fr)
SG (1) SG148178A1 (fr)
SI (1) SI1797042T1 (fr)
TW (1) TWI309646B (fr)
WO (1) WO2006034804A1 (fr)
ZA (1) ZA200702394B (fr)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7579360B2 (en) 2005-06-09 2009-08-25 Bristol-Myers Squibb Company Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
US7572807B2 (en) 2005-06-09 2009-08-11 Bristol-Myers Squibb Company Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
EP2046753A2 (fr) * 2006-07-06 2009-04-15 Brystol-Myers Squibb Company Inhibiteurs de type i de la 11-bêta hydroxystéroïde déshydrogénase pyridone/hydroxypyridine
EP2061767B1 (fr) 2006-08-08 2014-12-17 Sanofi Imidazolidin-2,4-diones arylaminoaryl-alkyl-substituées, procédé de fabrication, médicaments les contenant et leur utilisation
CL2008001839A1 (es) 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.
EP2025674A1 (fr) 2007-08-15 2009-02-18 sanofi-aventis Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament
US20090076783A1 (en) * 2007-09-13 2009-03-19 Tyco Healthcare Retail Services Ag Digitally optimized fastener assembly and method of making the same
US8119658B2 (en) 2007-10-01 2012-02-21 Bristol-Myers Squibb Company Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
WO2009111214A1 (fr) * 2008-03-06 2009-09-11 Merck & Co., Inc. Sulfamides d’hexahydrocyclopentyl[f]indazole et dérivés de ceux-ci servant de modulateurs sélectifs de récepteurs de glucocorticoïde
UY31968A (es) 2008-07-09 2010-01-29 Sanofi Aventis Nuevos derivados heterocíclicos, sus procesos para su preparación, y sus usos terapéuticos
WO2010068601A1 (fr) 2008-12-08 2010-06-17 Sanofi-Aventis Hydrate de fluoroglycoside hétéroaromatique cristallin, ses procédés de fabrication, ses procédés d'utilisation et compositions pharmaceutiques le contenant
KR20120060207A (ko) 2009-08-26 2012-06-11 사노피 신규한 결정성 헤테로방향족 플루오로글리코시드 수화물, 이들 화합물을 포함하는 약제 및 이들의 용도
WO2011107494A1 (fr) 2010-03-03 2011-09-09 Sanofi Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation
EP2582709B1 (fr) 2010-06-18 2018-01-24 Sanofi Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120058A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés d'oxathiazine substitués par des groupes benzyle ou hétérométhylène, leur procédé de production, leur utilisation comme médicament ainsi que produits pharmaceutiques les contenant et leur utilisation
EP2683704B1 (fr) 2011-03-08 2014-12-17 Sanofi Dérivés oxathiazine ramifiés, procédé pour leur préparation, utilisation en tant que médicament, agents pharmaceutiques contenant ces dérivés et leur utilisation
EP2683699B1 (fr) 2011-03-08 2015-06-24 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
EP2683702B1 (fr) 2011-03-08 2014-12-24 Sanofi Nouveaux dérivés de phényle-oxathiazine substitués, leur procédé de fabrication, médicament contenant ces liaisons et son utilisation
EP2766349B1 (fr) 2011-03-08 2016-06-01 Sanofi Dérivés d'oxathiazine substitués par des carbocycles ou des hétérocycles, leur procédé de préparation, médicaments contenant ces composés et leur utilisation
WO2012120051A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés benzyl-oxathiazine substitués avec adamantane ou noradamantane, médicaments contenant ces composés et leur utilisation
US8895547B2 (en) 2011-03-08 2014-11-25 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
WO2012120056A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine tétra-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
WO2013037390A1 (fr) 2011-09-12 2013-03-21 Sanofi Dérivés amides d'acide 6-(4-hydroxyphényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase
WO2013045413A1 (fr) 2011-09-27 2013-04-04 Sanofi Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b] pyridine-4-carboxylique utilisés comme inhibiteurs de kinase
EP3235813A1 (fr) 2016-04-19 2017-10-25 Cidqo 2012, S.L. Dérivés aza-tétra-cycliques
KR101796781B1 (ko) 2016-05-20 2017-11-13 한국화학연구원 신규한 인다졸 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 암 질환의 예방 또는 치료용 약학적 조성물
AU2019318209B2 (en) 2018-08-10 2025-09-25 Diapin Therapeutics, Llc Tri-peptides and treatment of metabolic, cardiovascular and inflammatory disorders
BR112021013557A2 (pt) 2019-01-11 2021-09-21 Grünenthal GmbH Amidas de pirrolidina substituídas iii
US12398097B2 (en) 2019-07-29 2025-08-26 Vanderbilt University WDR5-MYC inhibitors
CN116829524A (zh) * 2021-01-06 2023-09-29 中外制药株式会社 酸性官能团的烷基化方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL84944A (en) 1987-01-19 1992-02-16 Ici Plc Pharmaceutical compositions containing 1,2-dihydro-3h-indazolone derivatives,some new such compounds and their preparation
GB9805520D0 (en) 1998-03-17 1998-05-13 Zeneca Ltd Chemical compounds
SE0001899D0 (sv) * 2000-05-22 2000-05-22 Pharmacia & Upjohn Ab New compounds
FR2836914B1 (fr) * 2002-03-11 2008-03-14 Aventis Pharma Sa Indazoles substitues, compositions les contenant, procede de fabrication et utilisation
NZ566263A (en) 2002-05-24 2009-09-25 Millennium Pharm Inc CCR9 inhibitors and methods of use thereof
EP1696915A1 (fr) * 2003-12-19 2006-09-06 Pfizer, Inc. Derives de benzenesulfonylamino-pyridin-2yl et composes apparentes en tant qu'inhibiteurs de la 11-beta-hydeoxysteroide deshydrogenase type 1 (11-beta-hsd-1) pour le traitement du diabete et de l'obesite

Also Published As

Publication number Publication date
SI1797042T1 (sl) 2009-04-30
IL182212A (en) 2011-03-31
EP1797042A1 (fr) 2007-06-20
MY140841A (en) 2010-01-29
JP2008514659A (ja) 2008-05-08
AU2005289107A1 (en) 2006-04-06
SG148178A1 (en) 2008-12-31
CA2581865A1 (fr) 2006-04-06
ATE420076T1 (de) 2009-01-15
MX2007003546A (es) 2007-05-18
KR100856164B1 (ko) 2008-09-03
RU2392272C2 (ru) 2010-06-20
US20060069269A1 (en) 2006-03-30
DE602005012292D1 (de) 2009-02-26
IL182212A0 (en) 2007-07-24
CN101027286A (zh) 2007-08-29
DK1797042T3 (da) 2009-03-02
TWI309646B (en) 2009-05-11
US7528158B2 (en) 2009-05-05
NO20071617L (no) 2007-04-20
AR050952A1 (es) 2006-12-06
ZA200702394B (en) 2008-11-26
PT1797042E (pt) 2009-02-12
PL1797042T3 (pl) 2009-06-30
TW200626558A (en) 2006-08-01
ES2317305T3 (es) 2009-04-16
CN101027286B (zh) 2011-05-25
KR20070047839A (ko) 2007-05-07
NZ553849A (en) 2010-04-30
CA2581865C (fr) 2010-04-20
WO2006034804A1 (fr) 2006-04-06
AU2005289107B2 (en) 2010-12-16
BRPI0515931A (pt) 2008-08-12
EP1797042B1 (fr) 2009-01-07
HK1107348A1 (en) 2008-04-03
RU2007116033A (ru) 2008-11-10
JP4682207B2 (ja) 2011-05-11

Similar Documents

Publication Publication Date Title
HRP20090151T3 (en) Indozolone derivatives as 11b-hsd1 inhibitors
EP1724262A4 (fr) Derive de 1-(2h)-isoquinolone
WO2006109075A3 (fr) Composes pharmaceutiques
NO20051826L (no) Heterosyklisk substituerte piperaziner for behandling av schizofreni
MX2009006024A (es) Derivados de heteroaril piridopirimidona sustituidos.
NO20092770L (no) Nye aminopyrimidinderivater som PLK1-inhibitorer
DE602006007012D1 (de) Pyridinderivate als dipeptedyl-peptidase-hemmer
AR049739A1 (es) Derivados de aril-piridina
NO20082388L (no) Heteroaryl substituerte piperidinderivater som L-CPT1 inhibitorer
HRP20020175B1 (hr) N-heterociklički derivati kao inhibitori nos
PE20081775A1 (es) Compuestos macrociclicos como inhibidores del factor viia
ATE463483T1 (de) 6-substituierte isochinolinderivate als rock-1- inhibitoren
MXPA05008619A (es) Derivados novedosos de 2-piridincarboxamida.
PT1261602E (pt) Derivados imidazol-2-carboxamida como inibidores de cinase raf
NO20090952L (no) N-(aminoheteroaryl) - lh - indol-2-karboksamidderivater og fremstilling og terapeutisk anvendelse derav
EA200201259A1 (ru) Производные бензимидазола, их получение и терапевтическое применение
MX2009007954A (es) Derivado de heterocicliden-n-(aril) acetamida.
EA200971061A1 (ru) Пиримидоновые соединения гетероариламидов
HRP20080493T3 (hr) Supstituirani kinolinski derivati kao mitotski inhibitori kinezina
DK1585493T3 (da) Triazinderivater som UV-absorbenter
TW200745034A (en) New compounds
TW200745032A (en) Novel heterobicyclic derivatives
MX2007007428A (es) Compuestos heterociclicos, antagonistas de ccr2b.
EA200971060A1 (ru) Гетероариламидные пиримидоновые производные
WO2008155670A3 (fr) Composés d'arylamide de pyrimidone