HRP20100420T1 - Postupak za pripravu nebivolola - Google Patents

Postupak za pripravu nebivolola Download PDF

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Publication number
HRP20100420T1
HRP20100420T1 HR20100420T HRP20100420T HRP20100420T1 HR P20100420 T1 HRP20100420 T1 HR P20100420T1 HR 20100420 T HR20100420 T HR 20100420T HR P20100420 T HRP20100420 T HR P20100420T HR P20100420 T1 HRP20100420 T1 HR P20100420T1
Authority
HR
Croatia
Prior art keywords
formula
compound
diastereomer
image
mixture
Prior art date
Application number
HR20100420T
Other languages
English (en)
Croatian (hr)
Inventor
Volpicelli Raffaella
Maragni Paolo
Cotarca Livius
Foletto Johnny
Massaccesi Franco
Original Assignee
Zach System S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zach System S.P.A. filed Critical Zach System S.P.A.
Publication of HRP20100420T1 publication Critical patent/HRP20100420T1/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Plural Heterocyclic Compounds (AREA)
HR20100420T 2006-11-27 2007-11-23 Postupak za pripravu nebivolola HRP20100420T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06124837 2006-11-27
PCT/EP2007/010185 WO2008064827A2 (en) 2006-11-27 2007-11-23 Process for preparing nebivolol

Publications (1)

Publication Number Publication Date
HRP20100420T1 true HRP20100420T1 (hr) 2010-09-30

Family

ID=39149443

Family Applications (2)

Application Number Title Priority Date Filing Date
HR20100420T HRP20100420T1 (hr) 2006-11-27 2007-11-23 Postupak za pripravu nebivolola
HRP20130774TT HRP20130774T1 (hr) 2006-11-27 2013-08-16 Nebivolol formijat

Family Applications After (1)

Application Number Title Priority Date Filing Date
HRP20130774TT HRP20130774T1 (hr) 2006-11-27 2013-08-16 Nebivolol formijat

Country Status (16)

Country Link
US (2) US7999124B2 (de)
EP (2) EP2228374B1 (de)
JP (2) JP5259612B2 (de)
CN (2) CN101553485B (de)
AT (1) ATE473224T1 (de)
AU (1) AU2007324896B2 (de)
BR (1) BRPI0719281B8 (de)
CA (2) CA2835833C (de)
DE (1) DE602007007666D1 (de)
ES (2) ES2426399T3 (de)
HR (2) HRP20100420T1 (de)
IL (2) IL198555A (de)
PL (2) PL2099790T3 (de)
PT (1) PT2228374E (de)
SI (2) SI2228374T1 (de)
WO (1) WO2008064827A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2163551B1 (de) 2008-09-08 2011-11-16 Cadila Pharmaceuticals Ltd. Verbesserter Herstellungsprozess für Nebivolol-Hydrocholorid
IT1392067B1 (it) * 2008-10-31 2012-02-09 Zach System Spa Processo di preparazione di nebivololo
IT1395354B1 (it) * 2009-07-23 2012-09-14 Zach System Spa Processo di preparazione di nebivololo
DE102010005953A1 (de) * 2010-01-27 2011-07-28 Corden PharmaChem GmbH, 68305 Verfahren zur Herstellung von Nebivolol
IT1397962B1 (it) 2010-02-11 2013-02-04 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
WO2011132140A2 (en) * 2010-04-20 2011-10-27 Cadila Pharmaceuticals Limited Process for the conversion of (2r)-6-fluoro-2-[(2s)-oxiran-2-yl]-3,4-dihydro-2h-chromene to (2r)-6-fluoro-2-[(2r)-oxiran-2-yl]-3,4-dihydro-2h-chromene
CN102311417B (zh) * 2010-06-29 2013-09-18 成都弘达药业有限公司 一种苯并二氢吡喃类化合物的制备方法
CN102311418B (zh) * 2010-06-29 2013-12-25 成都康弘药业集团股份有限公司 一种苯并二氢吡喃类化合物的制备方法
CN102344431B (zh) * 2010-08-05 2014-03-26 成都康弘药业集团股份有限公司 一种制备奈必洛尔盐酸盐的方法
IT1402974B1 (it) 2010-11-30 2013-09-27 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
CN102180855B (zh) * 2011-03-01 2015-11-25 浙江华海药业股份有限公司 一种奈必洛尔中间体的提纯方法
ITRM20110418A1 (it) * 2011-08-02 2013-02-03 Menarini Int Operations Lu Sa Processo per la preparazione di epossidi quali intermedi per la sintesi del nebivololo.
EP2907809B1 (de) 2014-02-14 2018-08-22 Corden Pharma International GmbH Verfahren zur basenlosen Herstellung von Ketonzwischenprodukten zur Herstellung von Nebivolol
EP2907810A1 (de) 2014-02-14 2015-08-19 Corden Pharma International GmbH Neues Verfahren zur Herstellung von hochreinem Nebivolol-Hydrochlorid
DE102014107132A1 (de) 2014-05-20 2015-11-26 Corden Pharma International Gmbh Verfahren zur Herstellung von Epoxiden die in der Herstellung von Nebivolol und dessen Derivaten einsetzbar sind
GB201506691D0 (en) 2015-04-20 2015-06-03 Greif Int Holding Bv Closure caps
JP6921913B2 (ja) * 2015-05-19 2021-08-18 チョーチアン オウスン ファーマシューティカル カンパニー リミテッド ネビボロールの合成方法及びその中間化合物
ES2901966T3 (es) 2015-05-19 2022-03-24 Zhejiang Ausun Pharmaceutical Co Ltd Método de síntesis de nebivolol y compuesto intermedio del mismo
CN114929680B (zh) * 2019-11-19 2024-06-14 印度鲁宾有限公司 制备苯并二氢吡喃化合物的方法
JP7302870B2 (ja) 2019-12-24 2023-07-04 株式会社サンセイアールアンドディ 遊技機

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337429C (en) 1983-12-05 1995-10-24 Guy Rosalia Eugene Van Lommen Derivatives of 2,2'-iminobisethanol
CA1337432C (en) * 1988-03-23 1995-10-24 Raymond M. Xhonneux Method of lowering the blood pressure
US8225408B2 (en) * 1997-11-06 2012-07-17 Finjan, Inc. Method and system for adaptive rule-based content scanners
HU227236B1 (en) 2002-11-06 2010-12-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag New process for the production of racemic and the pure [2s[2r*[r[r*]]]]-and [2r[2s*[s[s*]]]]-enantiomers of nebivolol
HRP20080297T3 (en) 2004-07-30 2008-07-31 Torrent Pharmaceuticals Ltd Nebivolol and its pharmaceutically acceptable salts, process for preparation and pharmaceutical compositions of nebivolol
ATE465157T1 (de) * 2004-08-11 2010-05-15 Hetero Drugs Ltd Neues verfahren zur herstellung von nebivololzwischenprodukten
CN1279035C (zh) 2004-08-30 2006-10-11 中国科学院理化技术研究所 光学对映体6－氟－3，4－二氢－2h－1－苯骈吡喃－2－羧酸及6－氟－3，4－二氢－2h－1－苯骈吡喃－2－羧酸酯的合成方法
JP2008528626A (ja) * 2005-01-31 2008-07-31 マイラン ラボラトリーズ インク． ヒドロキシル化されたネビボロールを含む薬学的組成物
US7560575B2 (en) * 2005-12-28 2009-07-14 Acino Pharma Ag Process for preparation of racemic Nebivolol

Also Published As

Publication number Publication date
JP2013100372A (ja) 2013-05-23
PL2099790T3 (pl) 2010-12-31
BRPI0719281B8 (pt) 2021-05-25
JP5735025B2 (ja) 2015-06-17
IL222787A (en) 2015-07-30
CN103087028B (zh) 2014-12-24
PL2228374T3 (pl) 2013-11-29
CA2835833A1 (en) 2008-06-05
AU2007324896A1 (en) 2008-06-05
CN101553485A (zh) 2009-10-07
US20110201831A1 (en) 2011-08-18
SI2099790T1 (sl) 2010-09-30
IL222787A0 (en) 2012-12-31
CA2667919C (en) 2014-10-28
JP2010510969A (ja) 2010-04-08
ES2346371T3 (es) 2010-10-14
ES2426399T3 (es) 2013-10-23
HRP20130774T1 (hr) 2013-11-08
CA2835833C (en) 2014-11-04
US8258323B2 (en) 2012-09-04
JP5259612B2 (ja) 2013-08-07
ATE473224T1 (de) 2010-07-15
WO2008064827A2 (en) 2008-06-05
AU2007324896B2 (en) 2012-08-23
CN103087028A (zh) 2013-05-08
IL198555A0 (en) 2010-02-17
EP2099790B1 (de) 2010-07-07
EP2228374B1 (de) 2013-06-05
PT2228374E (pt) 2013-09-04
EP2228374A1 (de) 2010-09-15
CA2667919A1 (en) 2008-06-05
US7999124B2 (en) 2011-08-16
DE602007007666D1 (de) 2010-08-19
BRPI0719281B1 (pt) 2021-03-30
CN101553485B (zh) 2013-02-06
EP2099790A2 (de) 2009-09-16
BRPI0719281A2 (pt) 2014-03-11
WO2008064827A3 (en) 2008-10-23
US20100056813A1 (en) 2010-03-04
IL198555A (en) 2014-03-31
SI2228374T1 (sl) 2013-12-31

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