HRP20100568T1 - Rekombinantno modificiran plazmin - Google Patents

Rekombinantno modificiran plazmin Download PDF

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Publication number
HRP20100568T1
HRP20100568T1 HR20100568T HRP20100568T HRP20100568T1 HR P20100568 T1 HRP20100568 T1 HR P20100568T1 HR 20100568 T HR20100568 T HR 20100568T HR P20100568 T HRP20100568 T HR P20100568T HR P20100568 T1 HRP20100568 T1 HR P20100568T1
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Croatia
Prior art keywords
polypeptide
seq
polynucleotide
lysine
domain
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HR20100568T
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English (en)
Croatian (hr)
Inventor
Audrey Hunt Jennifer
Novokhatny Valery
Original Assignee
Talecris Biotherapeutics
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34982338&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20100568(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Talecris Biotherapeutics filed Critical Talecris Biotherapeutics
Publication of HRP20100568T1 publication Critical patent/HRP20100568T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HR20100568T 2004-04-22 2005-04-21 Rekombinantno modificiran plazmin HRP20100568T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56447204P 2004-04-22 2004-04-22
PCT/US2005/013562 WO2005105990A2 (fr) 2004-04-22 2005-04-21 Plasmine a modification par recombinaison

Publications (1)

Publication Number Publication Date
HRP20100568T1 true HRP20100568T1 (hr) 2010-11-30

Family

ID=34982338

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20100568T HRP20100568T1 (hr) 2004-04-22 2005-04-21 Rekombinantno modificiran plazmin

Country Status (27)

Country Link
US (2) US8034913B2 (fr)
EP (2) EP1740698B1 (fr)
JP (1) JP5026254B2 (fr)
KR (1) KR101161819B1 (fr)
CN (2) CN1961070A (fr)
AT (1) ATE476502T1 (fr)
AU (1) AU2005238464B2 (fr)
BR (1) BRPI0510063B8 (fr)
CA (1) CA2563675C (fr)
CY (1) CY1111650T1 (fr)
DE (1) DE602005022692D1 (fr)
DK (1) DK1740698T3 (fr)
EA (1) EA010784B1 (fr)
ES (2) ES2349555T3 (fr)
HR (1) HRP20100568T1 (fr)
IL (1) IL178343A (fr)
MA (1) MA28590B1 (fr)
MX (1) MXPA06012236A (fr)
NO (1) NO338542B1 (fr)
NZ (1) NZ550250A (fr)
PL (2) PL1740698T3 (fr)
PT (2) PT2246417E (fr)
RS (1) RS51623B (fr)
SI (1) SI1740698T1 (fr)
TN (1) TNSN06332A1 (fr)
WO (1) WO2005105990A2 (fr)
ZA (1) ZA200608498B (fr)

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US8231869B2 (en) * 2005-10-20 2012-07-31 Grifols Therapeutics Inc. Recombinant plasmin for opthalmic indications
KR100888022B1 (ko) * 2006-12-21 2009-03-09 재단법인 목암생명공학연구소 면역글로불린 Ｆｃ와 인간 아포리포단백질（ａ）크링글절편의 융합단백질 ＬＫ8­Ｆｃ
JP5539896B2 (ja) * 2007-11-29 2014-07-02 グリフオルス・セラピユーテイクス・インコーポレーテツド 組換え的に改変されたプラスミン
WO2009149199A2 (fr) 2008-06-04 2009-12-10 Talecris Biotherapeutics, Inc. Composition, méthode et nécessaire pour la préparation de plasmine
PT2403865E (pt) 2009-03-03 2015-11-18 Grifols Therapeutics Inc Métodos de preparação de plasminogénio
KR20120050442A (ko) 2009-07-10 2012-05-18 쓰롬보제닉스 엔.브이. 플라스미노겐 및 플라스민의 변이체
US20120189609A1 (en) 2009-08-28 2012-07-26 Thrombogenics Nv Improvement to trabeculectomy
RU2432397C2 (ru) * 2009-11-24 2011-10-27 Федеральное государственное учреждение "Российский кардиологический научно-производственный комплекс" Министерства здравоохранения и социального развития Российской Федерации (ФГУ "РКНПК" Минздравсоцразвития России) РЕКОМБИНАНТНЫЙ ПОЛИПЕПТИД СО СВОЙСТВАМИ ПЛАЗМИНОГЕНА ЧЕЛОВЕКА ПРЕВРАЩАТЬСЯ ПРИ АКТИВАЦИИ В ПЛАЗМИН, КОТОРЫЙ КАТАЛИЗИРУЕТ РАСЩЕПЛЕНИЕ ФИБРИНА, ФРАГМЕНТ ДНК, КОДИРУЮЩИЙ ПОЛИПЕПТИД, РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК ДЛЯ ЭКСПРЕССИИ ПОЛИПЕПТИДА И ТРАНСФОРМИРОВАННАЯ КЛЕТКА Escherichia coli - ПРОДУЦЕНТ ПОЛИПЕПТИДА
RU2432396C2 (ru) * 2009-11-24 2011-10-27 Федеральное государственное учреждение "Российский кардиологический научно-производственный комплекс" Министерства здравоохранения и социального развития Российской Федерации (ФГУ "РКНПК" Минздравсоцразвития России) РЕКОМБИНАНТНЫЙ ПОЛИПЕПТИД СО СВОЙСТВАМИ ПЛАЗМИНОГЕНА ЧЕЛОВЕКА ПРЕВРАЩАТЬСЯ ПРИ АКТИВАЦИИ В ПЛАЗМИН, КОТОРЫЙ КАТАЛИЗИРУЕТ РАСЩЕПЛЕНИЕ ФИБРИНА, ФРАГМЕНТ ДНК, КОДИРУЮЩИЙ ПОЛИПЕПТИД, РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК ДЛЯ ЭКСПРЕССИИ ПОЛИПЕПТИДА И ТРАНСФОРМИРОВАННАЯ КЛЕТКА Escherichia coli - ПРОДУЦЕНТ ПОЛИПЕПТИДА
EP2661493B1 (fr) 2011-01-05 2016-03-30 ThromboGenics N.V. Variantes de plasminogène et de plasmine
JP6000353B2 (ja) 2011-08-12 2016-09-28 スロンボジェニックス・ナムローゼ・フェンノートシャップＴｈｒｏｍｂｏＧｅｎｉｃｓ ＮＶ プラスミノーゲンおよびプラスミンの変異体
CN108463240A (zh) * 2015-12-18 2018-08-28 泰伦基国际有限公司 一种预防或治疗糖尿病性视网膜病变的方法
WO2018107686A1 (fr) 2016-12-15 2018-06-21 深圳瑞健生命科学研究院有限公司 Méthode de traitement de l'athérosclérose et de ses complications
CN108210900A (zh) * 2016-12-15 2018-06-29 深圳瑞健生命科学研究院有限公司 预防和治疗肥胖症的药物及其用途
CN110198732A (zh) 2016-12-15 2019-09-03 泰伦基国际有限公司 一种促进胰岛素受体底物-2表达的方法
JP7168990B2 (ja) 2016-12-15 2022-11-10 タレンゲン インターナショナル リミテッド 肥満症を予防および治療するための方法および薬物
EP4140498A4 (fr) 2020-05-11 2023-11-01 Talengen International Limited Procédé et médicament pour le traitement d'une amyotrophie spinale
CA3196851A1 (fr) 2020-11-25 2022-06-02 Grifols Worldwide Operations Limited Cicatrisation des plaies
US11964004B2 (en) * 2021-03-31 2024-04-23 Shenzhen Bay Laboratory Short in vivo half-life and in vivo unstable recombinant microplasmin, pharmaceutical composition comprising thereof and method of treating thromboembolism related diseases including administration thereof
JP2025524009A (ja) 2022-07-22 2025-07-25 グリフォルス・ワールドワイド・オペレーションズ・リミテッド 臓器の保存およびリコンディショニングのための安定したプラスミン組成物
WO2025235230A1 (fr) * 2024-05-07 2025-11-13 The Scripps Research Institute Molécules de plasmine modifiées et compositions associées pour le traitement de la thrombose
CN119331857B (zh) * 2024-12-19 2025-05-16 南通大学 一种新型重组蛋白Plasminogen-CTM及应用

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US8231869B2 (en) 2005-10-20 2012-07-31 Grifols Therapeutics Inc. Recombinant plasmin for opthalmic indications
JP5539896B2 (ja) 2007-11-29 2014-07-02 グリフオルス・セラピユーテイクス・インコーポレーテツド 組換え的に改変されたプラスミン

Also Published As

Publication number Publication date
EP1740698A2 (fr) 2007-01-10
MA28590B1 (fr) 2007-05-02
PL1740698T3 (pl) 2011-01-31
EP2246417A1 (fr) 2010-11-03
CN102660564B (zh) 2013-05-08
PL2246417T3 (pl) 2015-06-30
HK1175812A1 (en) 2013-07-12
SI1740698T1 (sl) 2010-11-30
WO2005105990A3 (fr) 2006-01-12
CA2563675C (fr) 2012-08-28
AU2005238464B2 (en) 2011-01-27
NZ550250A (en) 2009-05-31
JP2007533327A (ja) 2007-11-22
US8420079B2 (en) 2013-04-16
IL178343A0 (en) 2007-02-11
ES2349555T3 (es) 2011-01-05
US20100304465A1 (en) 2010-12-02
JP5026254B2 (ja) 2012-09-12
BRPI0510063B8 (pt) 2021-05-25
TNSN06332A1 (en) 2008-02-22
ATE476502T1 (de) 2010-08-15
CN1961070A (zh) 2007-05-09
NO338542B1 (no) 2016-09-05
EP1740698B1 (fr) 2010-08-04
CA2563675A1 (fr) 2005-11-10
HK1150242A1 (en) 2011-11-11
CY1111650T1 (el) 2015-10-07
HK1099341A1 (en) 2007-08-10
PT2246417E (pt) 2015-05-05
MXPA06012236A (es) 2007-01-31
ES2534744T3 (es) 2015-04-28
DK1740698T3 (da) 2010-10-25
EP2246417B1 (fr) 2015-01-21
NO20065050L (no) 2006-11-03
US8034913B2 (en) 2011-10-11
ZA200608498B (en) 2008-07-30
EA200601950A1 (ru) 2007-02-27
BRPI0510063A (pt) 2008-03-11
KR101161819B1 (ko) 2012-07-03
AU2005238464A1 (en) 2005-11-10
PT1740698E (pt) 2010-11-02
DE602005022692D1 (de) 2010-09-16
EA010784B1 (ru) 2008-10-30
WO2005105990A2 (fr) 2005-11-10
RS51623B (sr) 2011-08-31
IL178343A (en) 2010-11-30
BRPI0510063B1 (pt) 2020-03-17
US20110318812A1 (en) 2011-12-29
KR20070006918A (ko) 2007-01-11
CN102660564A (zh) 2012-09-12

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