HRP20100626T1 - Fosfonati, monofosfonamidati, bisfosfonamidati za liječenje virusnih bolesti - Google Patents

Fosfonati, monofosfonamidati, bisfosfonamidati za liječenje virusnih bolesti Download PDF

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Publication number
HRP20100626T1
HRP20100626T1 HR20100626T HRP20100626T HRP20100626T1 HR P20100626 T1 HRP20100626 T1 HR P20100626T1 HR 20100626 T HR20100626 T HR 20100626T HR P20100626 T HRP20100626 T HR P20100626T HR P20100626 T1 HRP20100626 T1 HR P20100626T1
Authority
HR
Croatia
Prior art keywords
image
methyl
butyl
pentyl
carbon atoms
Prior art date
Application number
HR20100626T
Other languages
English (en)
Croatian (hr)
Inventor
Cheng Xiaquin
P. Cook Gary
C. Desai Manoj
Doerffler Edward
He Gong-Xin
U. Kim Choung
A. Lee William
C. Rohloff John
Wang Jianying
Yang Zheng-Yu
Original Assignee
Gilead Sciences
Cheng Xiaquin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences, Cheng Xiaquin filed Critical Gilead Sciences
Publication of HRP20100626T1 publication Critical patent/HRP20100626T1/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/44—Amides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/664—Amides of phosphorus acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HR20100626T 2003-12-30 2004-12-29 Fosfonati, monofosfonamidati, bisfosfonamidati za liječenje virusnih bolesti HRP20100626T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US53374503P 2003-12-30 2003-12-30
US59098704P 2004-07-26 2004-07-26
US60659504P 2004-09-01 2004-09-01
PCT/US2004/043969 WO2005066189A1 (en) 2003-12-30 2004-12-29 Phosphonates, monophosphonamidates, bisphosphonamidates for the treatment of viral diseases

Publications (1)

Publication Number Publication Date
HRP20100626T1 true HRP20100626T1 (hr) 2011-03-31

Family

ID=34753695

Family Applications (3)

Application Number Title Priority Date Filing Date
HR20100626T HRP20100626T1 (hr) 2003-12-30 2004-12-29 Fosfonati, monofosfonamidati, bisfosfonamidati za liječenje virusnih bolesti
HR20060254A HRP20060254A2 (en) 2003-12-30 2004-12-29 Phosphonates, monophosphonamidates, bisphosphonamidates for the treatment of viral diseases
HRP20120699TT HRP20120699T1 (hr) 2003-12-30 2012-09-04 Nukleozid-fosfonati i njihovi analozi za liječenje hpv infekcija

Family Applications After (2)

Application Number Title Priority Date Filing Date
HR20060254A HRP20060254A2 (en) 2003-12-30 2004-12-29 Phosphonates, monophosphonamidates, bisphosphonamidates for the treatment of viral diseases
HRP20120699TT HRP20120699T1 (hr) 2003-12-30 2012-09-04 Nukleozid-fosfonati i njihovi analozi za liječenje hpv infekcija

Country Status (27)

Country Link
US (5) US7553825B2 (de)
EP (2) EP1716162B1 (de)
JP (2) JP4949852B2 (de)
KR (2) KR20120080240A (de)
CN (2) CN1950383B (de)
AP (1) AP2212A (de)
AT (1) ATE478082T1 (de)
AU (2) AU2004312546B2 (de)
BR (1) BRPI0418251C1 (de)
CA (1) CA2550222C (de)
CY (2) CY1111050T1 (de)
DE (1) DE602004028763D1 (de)
DK (2) DK1716162T3 (de)
EA (1) EA011304B1 (de)
ES (2) ES2389602T3 (de)
HR (3) HRP20100626T1 (de)
IL (1) IL176407A (de)
IS (1) IS2994B (de)
NO (2) NO338001B1 (de)
NZ (1) NZ548771A (de)
PL (3) PL2204374T3 (de)
PT (2) PT1716162E (de)
RS (2) RS51476B (de)
SG (1) SG149075A1 (de)
SI (2) SI1716162T1 (de)
WO (1) WO2005066189A1 (de)
ZA (1) ZA200606049B (de)

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Publication number Publication date
AU2011200141B2 (en) 2012-02-16
NO20063479L (no) 2006-10-02
EP2204374A1 (de) 2010-07-07
SI1716162T1 (sl) 2010-12-31
NZ548771A (en) 2010-05-28
US7553825B2 (en) 2009-06-30
JP4949852B2 (ja) 2012-06-13
DK1716162T3 (da) 2011-01-10
ATE478082T1 (de) 2010-09-15
IS8516A (is) 2006-06-21
NO338001B1 (no) 2016-07-18
DK2204374T3 (da) 2012-09-10
SI2204374T1 (sl) 2012-09-28
US8088754B2 (en) 2012-01-03
HRP20060254A2 (en) 2006-10-31
KR101214257B1 (ko) 2012-12-21
KR20060129360A (ko) 2006-12-15
SG149075A1 (en) 2009-01-29
CY1113103T1 (el) 2016-04-13
ES2350983T3 (es) 2011-01-28
BRPI0418251A (pt) 2007-04-17
US20060030545A1 (en) 2006-02-09
BRPI0418251B1 (pt) 2019-09-24
RS52433B (sr) 2013-02-28
PT1716162E (pt) 2010-11-24
ES2389602T3 (es) 2012-10-29
CA2550222C (en) 2013-05-28
CN1950383A (zh) 2007-04-18
NO20150615L (no) 2005-07-01
JP2011137029A (ja) 2011-07-14
US20060046981A1 (en) 2006-03-02
AU2004312546B2 (en) 2010-10-14
AP2006003675A0 (en) 2006-08-31
EA011304B1 (ru) 2009-02-27
CY1111050T1 (el) 2015-06-11
US20050222090A1 (en) 2005-10-06
HK1146061A1 (en) 2011-05-13
JP2007517065A (ja) 2007-06-28
CN101816664B (zh) 2012-04-18
CN101816664A (zh) 2010-09-01
HRP20120699T1 (hr) 2012-09-30
EP1716162A1 (de) 2006-11-02
NO338040B1 (no) 2016-07-25
CA2550222A1 (en) 2005-07-21
IL176407A (en) 2012-12-31
HK1097276A1 (en) 2007-06-22
US8268802B2 (en) 2012-09-18
IS2994B (is) 2018-03-15
US20090149400A1 (en) 2009-06-11
EP1716162B1 (de) 2010-08-18
RS51476B (sr) 2011-04-30
EA200601263A1 (ru) 2006-12-29
IL176407A0 (en) 2006-10-05
PL2204374T3 (pl) 2012-11-30
KR20120080240A (ko) 2012-07-16
PL380828A1 (pl) 2007-03-19
PT2204374E (pt) 2012-09-17
EP2204374B1 (de) 2012-06-13
ZA200606049B (en) 2008-01-08
PL212403B1 (pl) 2012-09-28
AU2011200141A1 (en) 2011-02-03
US20090291922A1 (en) 2009-11-26
BRPI0418251B8 (pt) 2019-10-08
DE602004028763D1 (de) 2010-09-30
WO2005066189A1 (en) 2005-07-21
CN1950383B (zh) 2010-06-09
AU2004312546A1 (en) 2005-07-21
AP2212A (en) 2011-03-01
BRPI0418251C1 (pt) 2021-05-25
PL1716162T3 (pl) 2011-02-28

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