ATE540926T1 - Verbessertes verfahren zur herstellung von montelukastsäure natriumsalz in amorpher form - Google Patents

Verbessertes verfahren zur herstellung von montelukastsäure natriumsalz in amorpher form

Info

Publication number: ATE540926T1
Authority: AT; Austria
Prior art keywords: acid; sodium salt; crude; montelucastic; producing
Prior art date: 2003-06-06

Application number

AT03817134T

Other languages

English (en)

Inventor

Sanjay Suri

Jujhhar Singh

Gurdeep Sarin

Madan TANWAR

Manu Mahendru

Original Assignee

Morepen Lab Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-06

Filing date

2003-06-06

Publication date

2012-01-15

2003-06-06 Application filed by Morepen Lab Ltd filed Critical Morepen Lab Ltd

2012-01-15 Application granted granted Critical

2012-01-15 Publication of ATE540926T1 publication Critical patent/ATE540926T1/de

Links

239000002253 acid Substances 0.000 title abstract 6
238000004519 manufacturing process Methods 0.000 title 1
NOJNFULGOQGBKB-UHFFFAOYSA-M sodium;3-[3-tert-butylsulfanyl-1-[[4-(6-ethoxypyridin-3-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoate Chemical compound [Na+].C1=NC(OCC)=CC=C1C(C=C1)=CC=C1CN1C2=CC=C(OCC=3N=CC(C)=CC=3)C=C2C(SC(C)(C)C)=C1CC(C)(C)C([O-])=O NOJNFULGOQGBKB-UHFFFAOYSA-M 0.000 title 1
XBPCUCUWBYBCDP-UHFFFAOYSA-N Dicyclohexylamine Chemical class C1CCCCC1NC1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-N 0.000 abstract 4
UCHDWCPVSPXUMX-TZIWLTJVSA-N Montelukast Chemical compound CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1(CC(O)=O)CC1 UCHDWCPVSPXUMX-TZIWLTJVSA-N 0.000 abstract 4
229960005127 montelukast Drugs 0.000 abstract 4
238000000034 method Methods 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
VFAXPOVKNPTBTM-UHFFFAOYSA-N 2-[1-(sulfanylmethyl)cyclopropyl]acetic acid Chemical compound OC(=O)CC1(CS)CC1 VFAXPOVKNPTBTM-UHFFFAOYSA-N 0.000 abstract 1
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 1
FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 abstract 1
-1 alkyl lithium Chemical compound 0.000 abstract 1
230000008878 coupling Effects 0.000 abstract 1
238000010168 coupling process Methods 0.000 abstract 1
238000005859 coupling reaction Methods 0.000 abstract 1
SMBQBQBNOXIFSF-UHFFFAOYSA-N dilithium Chemical compound [Li][Li] SMBQBQBNOXIFSF-UHFFFAOYSA-N 0.000 abstract 1
238000001704 evaporation Methods 0.000 abstract 1
229910052744 lithium Inorganic materials 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
239000003586 protic polar solvent Substances 0.000 abstract 1
229910001415 sodium ion Inorganic materials 0.000 abstract 1
159000000000 sodium salts Chemical class 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Quinoline Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT03817134T 2003-06-06 2003-06-06 Verbessertes verfahren zur herstellung von montelukastsäure natriumsalz in amorpher form ATE540926T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/IN2003/000214 WO2004108679A1 (en)	2003-06-06	2003-06-06	An improved method for the preparation of montelukast acid and sodium salt thereof in amorphous form

Publications (1)

Publication Number	Publication Date
ATE540926T1 true ATE540926T1 (de)	2012-01-15

Family

ID=33495847

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03817134T ATE540926T1 (de)	2003-06-06	2003-06-06	Verbessertes verfahren zur herstellung von montelukastsäure natriumsalz in amorpher form

Country Status (7)

Country	Link
US (1)	US8450491B2 (de)
EP (1)	EP1631550B1 (de)
AT (1)	ATE540926T1 (de)
AU (1)	AU2003253247A1 (de)
CA (1)	CA2528228C (de)
PT (1)	PT1631550E (de)
WO (1)	WO2004108679A1 (de)

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AU2004283832B2 (en) *	2003-10-10	2011-04-07	Synthon B.V.	Solid-state montelukast
EP1709001A2 (de) *	2004-01-28	2006-10-11	Pliva Istrazivanje i Razvoj d.o.o.	Feste formen von montelukastsäure
CA2554572A1 (en) *	2004-01-30	2005-08-18	Teva Pharmaceutical Industries Ltd.	Montelukast free acid polymorphs
EP1760077A1 (de) *	2004-01-30	2007-03-07	Teva Pharmaceutical Industries Ltd.	Polymorphe Formen vonMontelukast freie Säure
WO2005075427A2 (en) *	2004-01-30	2005-08-18	Teva Pharmaceutical Industries Ltd.	Montelukast sodium polymorphs
BRPI0506610A (pt)	2004-02-03	2007-05-02	Chemagis Ltd	montelucaste sódico amorfo, processo de preparação de montelucaste sódico amorfo, composição farmacêutica, método de tratamento utilizando a administração de montelucaste sódico amorfo, co-precipitado amorfo de montelucaste sódico e processo de preparação de co-precipitado amorfo de montelucaste sódico
EP1646612B1 (de) *	2004-04-21	2009-07-01	Teva Pharmaceutical Industries Ltd	Verfahren zur herstellung von montelukast-natrium
WO2006058545A1 (en) *	2004-11-30	2006-06-08	Medichem, S.A.	New process for the preparation of a leukotriene antagonist
CN101213177A (zh) *	2005-07-05	2008-07-02	特瓦制药工业有限公司	孟鲁司特的纯化
WO2007004237A2 (en) *	2005-07-05	2007-01-11	Matrix Laboratories Ltd	A process for the preparation of montelukast
EP1948612A2 (de) *	2005-11-16	2008-07-30	Teva Pharmaceutical Industries Ltd	Verfahren zum trocknen von montelukast-natrium durch azeotrope entfernung des lösungsmittels
US8178680B2 (en)	2005-12-13	2012-05-15	Msn Laboratories Limited	Process for the preparation of Montelukast and its pharmaceutically acceptable salts
EP1968942A4 (de) *	2005-12-23	2010-06-02	Glade Organics Private Ltd	Verbessertes verfahren zur herstellung von montelukast-natrium
PT1976522E (pt)	2005-12-30	2013-09-09	Krka Tovarna Zdravil D D Novo Mesto	Composição farmacêutica contendo montelucaste
CN101432267A (zh)	2006-03-17	2009-05-13	斯索恩有限公司	孟鲁司特金刚烷胺盐
EP2004608B1 (de) *	2006-04-12	2011-09-14	Glade Organics Private Limited	Verbessertes verfahren zur herstellung von montelukast-natrium
EP1886998A1 (de)	2006-08-09	2008-02-13	Esteve Quimica, S.A.	Verfahren zur Reinigung von Montelukast und dessen Aminesalzen
WO2008023044A1 (en) *	2006-08-23	2008-02-28	Sandoz Ag	Process for the preparation of montelukast free acid and its amine salts
US8115004B2 (en)	2006-11-20	2012-02-14	Msn Laboratories Limited	Process for pure montelukast sodium through pure intermediates as well as amine salts
CZ302518B6 (cs) *	2007-07-09	2011-06-29	Zentiva, A. S.	Zpusob izolace a cištení montelukastu
WO2009144742A2 (en) *	2008-05-26	2009-12-03	Aptuit Laurus Pvt Limited	An improved process for preparing montelukast and salts thereof
WO2010148209A2 (en) *	2009-06-19	2010-12-23	Dr. Reddy's Laboratories Ltd.	Preparation of montelukast
EP2287154A1 (de)	2009-07-14	2011-02-23	KRKA, D.D., Novo Mesto	Effiziente Synthese zur Herstellung von Montelukast
WO2011121091A1 (en)	2010-03-31	2011-10-06	Krka, D.D., Novo Mesto	Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein
WO2014012954A1 (en)	2012-07-18	2014-01-23	Takeda Gmbh	Treatment of partly controlled or uncontrolled severe asthma
WO2014118796A1 (en)	2013-01-31	2014-08-07	Melody Healthcare Pvt. Ltd.	An in-situ process for the preparation of highly pure montelukast sodium
JP2015007000A (ja) *	2013-06-24	2015-01-15	株式会社トクヤマ	モンテルカスト遊離酸の結晶を製造する方法
JP6173864B2 (ja) *	2013-10-01	2017-08-02	株式会社トクヤマ	モンテルカストナトリウムのアモルファスを製造する方法
CN103570619B (zh) *	2013-11-08	2015-12-09	南京靖龙药物研发有限公司	一种孟鲁司特钠衍生物的制备方法
EP3096760A1 (de)	2014-01-22	2016-11-30	Takeda GmbH	Behandlung von teilweise kontrolliertem oder unkontrolliertem schweren asthma mit einem pde4-inhibitor (und in kombination mit einem leukotrien-modifikator)
CN105585524B (zh) *	2016-02-29	2018-03-02	山东新时代药业有限公司	一种由孟鲁司特酸制备孟鲁司特钠的方法
CN105924392B (zh) *	2016-02-29	2018-03-02	山东新时代药业有限公司	一种孟鲁司特钠制备方法
CN107162969A (zh) *	2017-07-05	2017-09-15	成都亿知科技有限公司	孟鲁司特钠晶体及其制备方法和药物组合物
ES2876292T3 (es) *	2017-07-24	2021-11-12	Interquim Sa	Procedimiento de preparación y purificación del antagonista de LFA-1 lifitegrast
US10966943B2 (en)	2018-09-06	2021-04-06	Innopharmascreen Inc.	Methods and compositions for treatment of asthma or parkinson's disease
IT201900008340A1 (it)	2019-06-07	2020-12-07	Genetic S P A	Sali di montelukast e loro composizioni farmaceutiche

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CA2053209C (en)	1990-10-12	1998-12-08	Michel L. Belley	Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
US5565473A (en) *	1990-10-12	1996-10-15	Merck Frosst Canada, Inc.	Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
TW448160B (en) *	1993-12-28	2001-08-01	Merck & Co Inc	Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists
AU2003209043A1 (en) *	2002-02-07	2003-09-02	Dr. Reddy's Laboratories Ltd.	Novel anhydrous amorphous forms of montelukast sodium salt

2003
- 2003-06-06 CA CA2528228A patent/CA2528228C/en not_active Expired - Lifetime
- 2003-06-06 PT PT03817134T patent/PT1631550E/pt unknown
- 2003-06-06 AU AU2003253247A patent/AU2003253247A1/en not_active Abandoned
- 2003-06-06 AT AT03817134T patent/ATE540926T1/de active
- 2003-06-06 WO PCT/IN2003/000214 patent/WO2004108679A1/en not_active Ceased
- 2003-06-06 US US10/576,971 patent/US8450491B2/en not_active Expired - Fee Related
- 2003-06-06 EP EP03817134A patent/EP1631550B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2528228C (en)	2011-09-20
EP1631550B1 (de)	2012-01-11
WO2004108679A1 (en)	2004-12-16
EP1631550A1 (de)	2006-03-08
AU2003253247A1 (en)	2005-01-04
US8450491B2 (en)	2013-05-28
PT1631550E (pt)	2012-04-19
CA2528228A1 (en)	2004-12-16
US20070082925A1 (en)	2007-04-12

Publication	Publication Date	Title
AU2003253247A1 (en)	2005-01-04	An improved method for the preparation of montelukast acid and sodium salt thereof in amorphous form
US20100063291A1 (en)	2010-03-11	Process for preparation of solid montelukast
CN110256403B (zh)	2020-06-19	一种人工合成尼古丁的制备方法
ATE366725T1 (de)	2007-08-15	Verfahren zur herstellung von gereinigten 1,3- substituierten imidazoliumsalzen
IL185885A0 (en)	2008-01-06	Method for preparation of optionally 2-substituted 1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acids
WO2003024906A1 (en)	2003-03-27	Process for preparation of 2,2,2-trifluoroethanol
HRP20110575T1 (hr)	2011-09-30	Postupak pročišćavanja montelukasta i njegovih soli amina
ES2403067T3 (es)	2013-05-13	Un procedimiento mejorado para la preparación de montelukast y sus sales farmaceúticamente aceptables
JP2010500324A (ja)	2010-01-07	モンテルカストの精製方法
EP2004608B1 (de)	2011-09-14	Verbessertes verfahren zur herstellung von montelukast-natrium
ATE297933T1 (de)	2005-07-15	Ein verfahren zur herstellung von hochreinem cefpodoxim-proxetil
JP4318031B2 (ja)	2009-08-19	キノリンカルボアルデヒドの製造法
ATE418541T1 (de)	2009-01-15	Verfahren zur herstellung von carvedilol
TW200611901A (en)	2006-04-16	Method for producing 1, 3-dioxolan-4, 6-dione compound
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ATE349423T1 (de)	2007-01-15	Verfahren zur herstellung von 1- (mercaptomethyl)cyclopropan essigsäure
CN103467276B (zh)	2015-05-06	一种孟鲁司特钠侧链关键中间体的合成方法
ATE375355T1 (de)	2007-10-15	Verfahren zur herstellung von cefpodoxim-proxetil
NO20100848L (no)	2010-06-25	Fremgangsmate for isolering av ARN syrer
WO2012020271A1 (en)	2012-02-16	Process for the preparation of montelukast sodium
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ATE412640T1 (de)	2008-11-15	Verfahren zur gewinnung eines zur gewinnung von valsartan nützlichen valsartan-salzes
Bell	1979	Kinetic Resolution in the Reaction of (2R, 3R)-2, 3-Diacetoxy-and (2R, 3R)-2, 3-Dibenzoyloxy-succinic Anhydrides with Racemic Alcohols