ATE540926T1 - Verbessertes verfahren zur herstellung von montelukastsäure natriumsalz in amorpher form - Google Patents

Verbessertes verfahren zur herstellung von montelukastsäure natriumsalz in amorpher form

Info

Publication number: ATE540926T1
Authority: AT; Austria
Prior art keywords: acid; sodium salt; crude; montelucastic; producing
Prior art date: 2003-06-06

Application number

AT03817134T

Other languages

English (en)

Inventor

Sanjay Suri

Jujhhar Singh

Gurdeep Sarin

Madan TANWAR

Manu Mahendru

Original Assignee

Morepen Lab Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-06

Filing date

2003-06-06

Publication date

2012-01-15

2003-06-06 Application filed by Morepen Lab Ltd filed Critical Morepen Lab Ltd

2012-01-15 Application granted granted Critical

2012-01-15 Publication of ATE540926T1 publication Critical patent/ATE540926T1/de

Links

239000002253 acid Substances 0.000 title abstract 6
238000004519 manufacturing process Methods 0.000 title 1
NOJNFULGOQGBKB-UHFFFAOYSA-M sodium;3-[3-tert-butylsulfanyl-1-[[4-(6-ethoxypyridin-3-yl)phenyl]methyl]-5-[(5-methylpyridin-2-yl)methoxy]indol-2-yl]-2,2-dimethylpropanoate Chemical compound [Na+].C1=NC(OCC)=CC=C1C(C=C1)=CC=C1CN1C2=CC=C(OCC=3N=CC(C)=CC=3)C=C2C(SC(C)(C)C)=C1CC(C)(C)C([O-])=O NOJNFULGOQGBKB-UHFFFAOYSA-M 0.000 title 1
XBPCUCUWBYBCDP-UHFFFAOYSA-N Dicyclohexylamine Chemical class C1CCCCC1NC1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-N 0.000 abstract 4
UCHDWCPVSPXUMX-TZIWLTJVSA-N Montelukast Chemical compound CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1(CC(O)=O)CC1 UCHDWCPVSPXUMX-TZIWLTJVSA-N 0.000 abstract 4
229960005127 montelukast Drugs 0.000 abstract 4
238000000034 method Methods 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
VFAXPOVKNPTBTM-UHFFFAOYSA-N 2-[1-(sulfanylmethyl)cyclopropyl]acetic acid Chemical compound OC(=O)CC1(CS)CC1 VFAXPOVKNPTBTM-UHFFFAOYSA-N 0.000 abstract 1
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 1
FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 abstract 1
-1 alkyl lithium Chemical compound 0.000 abstract 1
230000008878 coupling Effects 0.000 abstract 1
238000010168 coupling process Methods 0.000 abstract 1
238000005859 coupling reaction Methods 0.000 abstract 1
SMBQBQBNOXIFSF-UHFFFAOYSA-N dilithium Chemical compound [Li][Li] SMBQBQBNOXIFSF-UHFFFAOYSA-N 0.000 abstract 1
238000001704 evaporation Methods 0.000 abstract 1
229910052744 lithium Inorganic materials 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
239000003586 protic polar solvent Substances 0.000 abstract 1
229910001415 sodium ion Inorganic materials 0.000 abstract 1
159000000000 sodium salts Chemical class 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Quinoline Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT03817134T 2003-06-06 2003-06-06 Verbessertes verfahren zur herstellung von montelukastsäure natriumsalz in amorpher form ATE540926T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/IN2003/000214 WO2004108679A1 (en)	2003-06-06	2003-06-06	An improved method for the preparation of montelukast acid and sodium salt thereof in amorphous form

Publications (1)

Publication Number	Publication Date
ATE540926T1 true ATE540926T1 (de)	2012-01-15

Family

ID=33495847

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03817134T ATE540926T1 (de)	2003-06-06	2003-06-06	Verbessertes verfahren zur herstellung von montelukastsäure natriumsalz in amorpher form

Country Status (7)

Country	Link
US (1)	US8450491B2 (de)
EP (1)	EP1631550B1 (de)
AT (1)	ATE540926T1 (de)
AU (1)	AU2003253247A1 (de)
CA (1)	CA2528228C (de)
PT (1)	PT1631550E (de)
WO (1)	WO2004108679A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050107612A1 (en) *	2002-12-30	2005-05-19	Dr. Reddy's Laboratories Limited	Process for preparation of montelukast and its salts
US7553853B2 (en)	2003-10-10	2009-06-30	Synthon Bv	Solid-state montelukast
US20070225325A1 (en) *	2004-01-28	2007-09-27	Pliva-Istrazivanje I Razvoj D.O.O.	Solid Forms of Montelukast Acid
KR20060117356A (ko) *	2004-01-30	2006-11-16	테바 파마슈티컬 인더스트리즈 리미티드	몬테루카스트 유리산 다형체
WO2005075427A2 (en) *	2004-01-30	2005-08-18	Teva Pharmaceutical Industries Ltd.	Montelukast sodium polymorphs
EP1760077A1 (de) *	2004-01-30	2007-03-07	Teva Pharmaceutical Industries Ltd.	Polymorphe Formen vonMontelukast freie Säure
WO2005074893A1 (en)	2004-02-03	2005-08-18	Chemagis Ltd.	Stable amorphous forms of montelukast sodium
US7547787B2 (en)	2004-04-21	2009-06-16	Teva Pharmaceutical Industries Ltd.	Processes for preparing montelukast sodium
US20080214822A1 (en) *	2004-11-30	2008-09-04	Medichem, S.A.	Process For the Preparation of a Leukotriene Antagonist
EP1904448B1 (de)	2005-07-05	2011-02-02	Teva Pharmaceutical Industries, Ltd.	Reinigung von montelukast
WO2007004237A2 (en) *	2005-07-05	2007-01-11	Matrix Laboratories Ltd	A process for the preparation of montelukast
US20070161796A1 (en) *	2005-11-16	2007-07-12	Ilan Kor-Sade	Drying methods of montelukast sodium by azeotropic removal of the solvent
ES2403067T3 (es)	2005-12-13	2013-05-13	Msn Laboratories Limited	Un procedimiento mejorado para la preparación de montelukast y sus sales farmaceúticamente aceptables
CA2632954A1 (en) *	2005-12-23	2007-06-28	Glade Organics Private Limited	An improved process for the manufacture of montelukast sodium
PT1976522E (pt)	2005-12-30	2013-09-09	Krka Tovarna Zdravil D D Novo Mesto	Composição farmacêutica contendo montelucaste
EP1996552A1 (de)	2006-03-17	2008-12-03	Synthon B.V.	Montelukast-amantadin-salz
CA2649189A1 (en) *	2006-04-12	2007-10-18	Glade Organics Private Limited	An improved process for the manufacture of montelukast sodium
EP1886998A1 (de) *	2006-08-09	2008-02-13	Esteve Quimica, S.A.	Verfahren zur Reinigung von Montelukast und dessen Aminesalzen
WO2008023044A1 (en) *	2006-08-23	2008-02-28	Sandoz Ag	Process for the preparation of montelukast free acid and its amine salts
US8115004B2 (en)	2006-11-20	2012-02-14	Msn Laboratories Limited	Process for pure montelukast sodium through pure intermediates as well as amine salts
CZ302518B6 (cs) *	2007-07-09	2011-06-29	Zentiva, A. S.	Zpusob izolace a cištení montelukastu
ES2605473T3 (es)	2008-05-26	2017-03-14	Laurus Labs Private Limited	Un procedimiento mejorado para la preparación de Montelukast y sus sales
WO2010148209A2 (en) *	2009-06-19	2010-12-23	Dr. Reddy's Laboratories Ltd.	Preparation of montelukast
EP2287154A1 (de)	2009-07-14	2011-02-23	KRKA, D.D., Novo Mesto	Effiziente Synthese zur Herstellung von Montelukast
EP2552892A1 (de)	2010-03-31	2013-02-06	KRKA, D.D., Novo Mesto	Effiziente synthese zur herstellung von montelukast und neue kristalline form von zwischenprodukten darin
WO2014012954A1 (en)	2012-07-18	2014-01-23	Takeda Gmbh	Treatment of partly controlled or uncontrolled severe asthma
WO2014118796A1 (en)	2013-01-31	2014-08-07	Melody Healthcare Pvt. Ltd.	An in-situ process for the preparation of highly pure montelukast sodium
JP2015007000A (ja) *	2013-06-24	2015-01-15	株式会社トクヤマ	モンテルカスト遊離酸の結晶を製造する方法
JP6173864B2 (ja) *	2013-10-01	2017-08-02	株式会社トクヤマ	モンテルカストナトリウムのアモルファスを製造する方法
CN103570619B (zh) *	2013-11-08	2015-12-09	南京靖龙药物研发有限公司	一种孟鲁司特钠衍生物的制备方法
WO2015110394A1 (en)	2014-01-22	2015-07-30	Takeda Gmbh	Treatment of partly controlled or uncontrolled severe asthma with a pde4 inhibitor (and in combination with a leukotriene modifier)
CN105585524B (zh) *	2016-02-29	2018-03-02	山东新时代药业有限公司	一种由孟鲁司特酸制备孟鲁司特钠的方法
CN105924392B (zh) *	2016-02-29	2018-03-02	山东新时代药业有限公司	一种孟鲁司特钠制备方法
CN107162969A (zh) *	2017-07-05	2017-09-15	成都亿知科技有限公司	孟鲁司特钠晶体及其制备方法和药物组合物
EP3658549B1 (de) *	2017-07-24	2021-05-05	Interquim, S.A.	Verfahren zur herstellung und reinigung des lfa-1-antagonisten lifitegrast
EP3846792A4 (de)	2018-09-06	2022-10-12	Innopharmascreen Inc.	Verfahren und zusammensetzungen zur behandlung von asthma oder morbus parkinson
IT201900008340A1 (it)	2019-06-07	2020-12-07	Genetic S P A	Sali di montelukast e loro composizioni farmaceutiche

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5565473A (en) *	1990-10-12	1996-10-15	Merck Frosst Canada, Inc.	Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
DK0480717T3 (da)	1990-10-12	1999-02-08	Merck Frosst Canada Inc	Umættede hydroxyalkylquinolinsyrer som leukotrienantagonister
TW448160B (en) *	1993-12-28	2001-08-01	Merck & Co Inc	Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists
WO2003066598A1 (en) *	2002-02-07	2003-08-14	Dr. Reddy's Laboratories Ltd.	Novel anhydrous amorphous forms of montelukast sodium salt

2003
- 2003-06-06 EP EP03817134A patent/EP1631550B1/de not_active Expired - Lifetime
- 2003-06-06 AU AU2003253247A patent/AU2003253247A1/en not_active Abandoned
- 2003-06-06 CA CA2528228A patent/CA2528228C/en not_active Expired - Lifetime
- 2003-06-06 PT PT03817134T patent/PT1631550E/pt unknown
- 2003-06-06 AT AT03817134T patent/ATE540926T1/de active
- 2003-06-06 US US10/576,971 patent/US8450491B2/en not_active Expired - Fee Related
- 2003-06-06 WO PCT/IN2003/000214 patent/WO2004108679A1/en not_active Ceased

Also Published As

Publication number	Publication date
AU2003253247A1 (en)	2005-01-04
PT1631550E (pt)	2012-04-19
CA2528228A1 (en)	2004-12-16
EP1631550B1 (de)	2012-01-11
WO2004108679A1 (en)	2004-12-16
US20070082925A1 (en)	2007-04-12
US8450491B2 (en)	2013-05-28
EP1631550A1 (de)	2006-03-08
CA2528228C (en)	2011-09-20

Publication	Publication Date	Title
ATE540926T1 (de)	2012-01-15	Verbessertes verfahren zur herstellung von montelukastsäure natriumsalz in amorpher form
CN110256403B (zh)	2020-06-19	一种人工合成尼古丁的制备方法
ATE366725T1 (de)	2007-08-15	Verfahren zur herstellung von gereinigten 1,3- substituierten imidazoliumsalzen
EG25480A (en)	2012-01-15	Method for preparation of optionally 2-substituted1,6-dihydro-6-oxo-4-pyrimidinecarboxylic acids
HRP20110575T1 (hr)	2011-09-30	Postupak pročišćavanja montelukasta i njegovih soli amina
JP2016516744A5 (de)	2017-04-20
CN101490005B (zh)	2011-08-31	孟鲁司特的纯化方法
EP2004608B1 (de)	2011-09-14	Verbessertes verfahren zur herstellung von montelukast-natrium
JP4318031B2 (ja)	2009-08-19	キノリンカルボアルデヒドの製造法
ATE418541T1 (de)	2009-01-15	Verfahren zur herstellung von carvedilol
TW200611901A (en)	2006-04-16	Method for producing 1, 3-dioxolan-4, 6-dione compound
WO2006069113A3 (en)	2006-08-17	Method to produce a carboxylic acid ester from a carboxylic acid ammonium salt by alcoholysis
DE602005021461D1 (de)	2010-07-08	Verfahren zur herstellung von cabergolin
CN102643162B (zh)	2014-08-06	一种制备1-(2-氯苯基)-2-(4-氟苯基)丙烯的方法
Shen et al.	2015	Synthesis of (6 R, 12 R)-6, 12-Dimethylpentadecan-2-one, the Female-Produced Sex Pheromone from Banded Cucumber Beetle Diabrotica balteata, Based on a Chiron Approach
CN103467276B (zh)	2015-05-06	一种孟鲁司特钠侧链关键中间体的合成方法
NO20100848L (no)	2010-06-25	Fremgangsmate for isolering av ARN syrer
WO2000052012A8 (en)	2001-04-05	A method for synthesizing porphyrin compounds
ATE412640T1 (de)	2008-11-15	Verfahren zur gewinnung eines zur gewinnung von valsartan nützlichen valsartan-salzes
Bell	1979	Kinetic Resolution in the Reaction of (2R, 3R)-2, 3-Diacetoxy-and (2R, 3R)-2, 3-Dibenzoyloxy-succinic Anhydrides with Racemic Alcohols
JPH02164A (ja)	1990-01-05	レチナールの製造方法
Zheng et al.	2011	A partial synthesis of 5, 8-O-dimethylshikonin and 6-isomer of 5, 8-O-dimethylshikonin
WO2008062471A3 (en)	2008-07-10	A mild method for the production of di-n-propylacetic acid (valproic acid)
WO2008102671A1 (ja)	2008-08-28	４－ヒドロキシイソロイシンの精製方法
DD202000A5 (de)	1983-08-24	Verfahren zur herstellung neuer terpen-derivate