HRP20120135T1 - Derivati stirilpiridina i njihova upotreba kod vezanja na i vizualizacije amiloidnih plakova - Google Patents

Derivati stirilpiridina i njihova upotreba kod vezanja na i vizualizacije amiloidnih plakova Download PDF

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Publication number
HRP20120135T1
HRP20120135T1 HR20120135T HRP20120135T HRP20120135T1 HR P20120135 T1 HRP20120135 T1 HR P20120135T1 HR 20120135 T HR20120135 T HR 20120135T HR P20120135 T HRP20120135 T HR P20120135T HR P20120135 T1 HRP20120135 T1 HR P20120135T1
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Croatia
Prior art keywords
halogen substituted
image
halogen
compound according
formula
Prior art date
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HR20120135T
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English (en)
Croatian (hr)
Inventor
F. Kung Hank
Kung Mei-Ping
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The Trustees Of The University Of Pennsylvania
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Publication of HRP20120135T1 publication Critical patent/HRP20120135T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR20120135T 2006-03-30 2007-03-26 Derivati stirilpiridina i njihova upotreba kod vezanja na i vizualizacije amiloidnih plakova HRP20120135T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78715606P 2006-03-30 2006-03-30
PCT/US2007/007400 WO2007126733A2 (en) 2006-03-30 2007-03-26 Styrylpyridine derivatives and their use for binding and imaging amyloid plaques

Publications (1)

Publication Number Publication Date
HRP20120135T1 true HRP20120135T1 (hr) 2012-03-31

Family

ID=38326579

Family Applications (2)

Application Number Title Priority Date Filing Date
HR20120135T HRP20120135T1 (hr) 2006-03-30 2007-03-26 Derivati stirilpiridina i njihova upotreba kod vezanja na i vizualizacije amiloidnih plakova
HRP20170857TT HRP20170857T1 (hr) 2006-03-30 2017-06-06 Derivati stirilpiridina i njihova uporaba za vezanje i snimanje amiloidnih naslaga

Family Applications After (1)

Application Number Title Priority Date Filing Date
HRP20170857TT HRP20170857T1 (hr) 2006-03-30 2017-06-06 Derivati stirilpiridina i njihova uporaba za vezanje i snimanje amiloidnih naslaga

Country Status (35)

Country Link
US (3) US7687052B2 (da)
EP (3) EP2363391A1 (da)
JP (1) JP5290954B2 (da)
KR (1) KR101376807B1 (da)
CN (1) CN101522624B (da)
AT (1) ATE539060T1 (da)
AU (1) AU2007243712B2 (da)
BE (1) BE2013C044I2 (da)
BR (1) BRPI0710225B1 (da)
CA (1) CA2644530C (da)
CR (1) CR10329A (da)
CY (3) CY1113048T1 (da)
DK (2) DK1999109T3 (da)
EA (1) EA017898B1 (da)
EC (1) ECSP088783A (da)
ES (2) ES2378785T3 (da)
FR (1) FR13C0034I2 (da)
GT (1) GT200800201A (da)
HR (2) HRP20120135T1 (da)
HU (2) HUE032660T2 (da)
IL (1) IL193567A (da)
LT (1) LT2363392T (da)
LU (1) LU92232I2 (da)
MX (1) MX2008012527A (da)
NO (2) NO342090B1 (da)
NZ (1) NZ570887A (da)
PL (2) PL1999109T3 (da)
PT (2) PT1999109E (da)
RS (2) RS56171B1 (da)
SG (1) SG173338A1 (da)
SI (2) SI2363392T1 (da)
TW (1) TWI399366B (da)
UA (1) UA97802C2 (da)
WO (1) WO2007126733A2 (da)
ZA (1) ZA200807955B (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1999109T3 (pl) * 2006-03-30 2012-05-31 Univ Pennsylvania Pochodne styrylopirydyny i ich zastosowanie do wiązania i obrazowania blaszek amyloidowych
EP2172444A4 (en) * 2007-07-04 2010-12-22 Univ Tohoku PET PROBE WITH FLUORO-SUBSTITUTED ALKOXY GROUP AND HYDROXYGRUPPE
JP5603855B2 (ja) * 2008-04-04 2014-10-08 アビッド レディオファーマシューティカルズ、インク． 神経変成疾患の放射性薬剤による画像化
PT2381967T (pt) * 2008-12-31 2017-02-24 Avid Radiopharmaceuticals Inc Síntese de estirilpiridinas radiomarcadas com 18f a partir de precursores tosilato e as suas composições farmacêuticas estáveis
CA2767475A1 (en) * 2009-07-10 2011-01-13 Bayer Pharma Aktiengesellschaft Usage of low to medium-pressure liquid chromatography for the purification of radiotracers
US20120263646A1 (en) 2009-10-15 2012-10-18 Guerbet Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
MX336896B (es) * 2009-12-23 2016-02-05 Piramal Imaging Sa Formulaciones adecuadas para la generacion de imagenes pet con agentes pet hidrofobicos.
WO2011141515A1 (en) 2010-05-14 2011-11-17 Bayer Pharma Aktiengesellschaft Diagnostic agents for amyloid beta imaging
CA2801525A1 (en) * 2010-06-04 2011-12-08 Piramal Imaging Sa Method for production of f-18 labeled amyloid beta ligands
TWI504414B (zh) 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
SG185782A1 (en) 2010-06-04 2013-01-30 Piramal Imaging Sa Method for production of f-18 labeled amyloid beta ligands
WO2011151282A1 (en) * 2010-06-04 2011-12-08 Bayer Pharma Aktiengesellschaft Method for production of f-18 labeled amyloid beta ligand
CN101891674B (zh) * 2010-06-24 2012-11-14 山东大学 4-苯乙烯基吡啶类化合物及其制备方法与应用
EP2627361B1 (en) * 2010-10-12 2017-09-20 Mayo Foundation For Medical Education And Research Imaging of meningiomas using phenylbenzothiazole, stilbene, or biphenylalkyne derivatives
US20140079635A1 (en) * 2011-03-30 2014-03-20 Case Western Reserve University Molecular probes for detecting lipid composition
EP2699157B1 (en) 2011-04-21 2018-03-14 The Regents of The University of California Functionalized magnetic nanoparticles and use in imaging amyloid deposits and neurofibrillary tangles
EP2768790A1 (en) 2011-10-19 2014-08-27 Piramal Imaging SA IMPROVED METHOD FOR PRODUCTION OF F-18 LABELED Aß LIGANDS
PT2836241T (pt) 2012-04-10 2019-05-30 Lantheus Medical Imaging Inc Métodos de síntese de radiofármacos
JP6099045B2 (ja) * 2013-04-30 2017-03-22 国立大学法人京都大学 トリアゾロピリミジン誘導体化合物
JP6041751B2 (ja) * 2013-05-07 2016-12-14 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
JP2014218454A (ja) * 2013-05-07 2014-11-20 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
CN103645254B (zh) * 2013-11-28 2015-01-07 江苏省原子医学研究所 一种Aβ斑块显像剂前体AV45的含量分析方法
HUE053939T2 (hu) 2014-05-13 2021-08-30 Hoffmann La Roche Deuterált heterociklikus vegyületek és képalkotó kontrasztanyagként való használatuk
CA2994178C (en) 2015-08-18 2024-03-19 The Regents Of The University Of California Nitroxide containing amyloid binding agents for imaging and therapeutic uses
US10300155B2 (en) 2015-12-31 2019-05-28 Washington University Alpha-synuclein ligands
CN109400615B (zh) * 2017-08-18 2021-07-16 上海交通大学医学院附属新华医院 一种靶向β-淀粉样蛋白的香豆素类化合物及其制备与应用
CN108299287A (zh) * 2018-01-02 2018-07-20 北京师范大学 与Aβ斑块具有高亲和力的N2S2类吡啶基苯乙烯化合物
CN114805190A (zh) * 2022-06-08 2022-07-29 吉林大学第一医院 一种甲基苯胺类Aβ蛋白显像剂的双柱合成方法
WO2024107620A1 (en) 2022-11-14 2024-05-23 Eli Lilly And Company Polymorphic forms of florbetapir precursor av-105

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000963A1 (fr) * 1990-07-12 1992-01-23 Yoshitomi Pharmaceutical Industries, Ltd. Composes de styryle et leur utilisation comme medicaments
JPH0545875A (ja) * 1991-08-08 1993-02-26 Konica Corp 感光性組成物
US6020436A (en) * 1993-03-09 2000-02-01 The Chromaline Corporation Photosensitive resin composition
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
AU2001239544A1 (en) * 2000-03-22 2001-10-03 Bf Research Institute, Inc. Image diagnosis probe based on substituted azobenzene or analogue thereof for disease attributable to amyloid accumulation and composition for image diagnosis containing the same
US8007954B2 (en) 2000-11-09 2011-08-30 The Trustees Of The University Of Pennsylvania Use of sulfur-containing fuels for direct oxidation fuel cells
JP2002182254A (ja) 2000-12-18 2002-06-26 Fuji Photo Film Co Ltd 非線形光学材料とその製造方法
CN1299777C (zh) * 2001-08-27 2007-02-14 宾夕法尼亚州大学理事会 茋衍生物及其用于结合和成像淀粉样蛋白斑的用途
JP2005529464A (ja) 2002-06-06 2005-09-29 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア セラミックアノード及びそれを生産する方法
WO2004016271A1 (en) * 2002-08-14 2004-02-26 Axxima Pharmaceuticals Ag Pyrimidones as antiviral agents
JP4482352B2 (ja) 2004-03-11 2010-06-16 本田技研工業株式会社 固体高分子型燃料電池
EP2213652B1 (en) * 2004-12-17 2014-10-22 The Trustees of The University of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
US7858072B2 (en) * 2004-12-17 2010-12-28 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
JP2008546804A (ja) * 2005-06-24 2008-12-25 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア 造影剤として用いるためのリガンドの放射性標識ペグ化
PL1999109T3 (pl) * 2006-03-30 2012-05-31 Univ Pennsylvania Pochodne styrylopirydyny i ich zastosowanie do wiązania i obrazowania blaszek amyloidowych
US20080253967A1 (en) * 2007-04-13 2008-10-16 Kung Hank F Halo-Stilbene Derivatives And Their Use For Binding And Imaging Of Amyloid Plaques

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Publication number Publication date
MX2008012527A (es) 2008-10-14
CN101522624A (zh) 2009-09-02
NO2018030I1 (no) 2018-09-11
EP2363392A1 (en) 2011-09-07
WO2007126733A2 (en) 2007-11-08
US20080038195A1 (en) 2008-02-14
KR20080106564A (ko) 2008-12-08
NO342090B1 (no) 2018-03-19
BRPI0710225B1 (pt) 2021-07-13
EA017898B1 (ru) 2013-04-30
JP5290954B2 (ja) 2013-09-18
PT1999109E (pt) 2012-03-16
UA97802C2 (uk) 2012-03-26
NZ570887A (en) 2011-05-27
ATE539060T1 (de) 2012-01-15
EP1999109A2 (en) 2008-12-10
FR13C0034I1 (da) 2013-08-09
HUE032660T2 (en) 2017-10-30
CY1113048T1 (el) 2015-11-04
US8506929B2 (en) 2013-08-13
ES2628882T3 (es) 2017-08-04
IL193567A0 (en) 2009-05-04
NO20084590L (no) 2008-12-29
IL193567A (en) 2014-03-31
WO2007126733A3 (en) 2008-03-06
CY2013024I1 (el) 2015-11-04
CA2644530C (en) 2015-05-19
DK1999109T3 (da) 2012-04-02
BRPI0710225A2 (pt) 2011-08-02
EP2363391A1 (en) 2011-09-07
CR10329A (es) 2008-10-29
LU92232I2 (fr) 2013-08-26
US20130129624A1 (en) 2013-05-23
AU2007243712A1 (en) 2007-11-08
EP2363392B1 (en) 2017-05-03
US7687052B2 (en) 2010-03-30
BE2013C044I2 (da) 2026-04-24
RS56171B1 (sr) 2017-11-30
CN101522624B (zh) 2013-11-06
JP2009532349A (ja) 2009-09-10
KR101376807B1 (ko) 2014-03-20
RS52222B (sr) 2012-10-31
LU92232I9 (da) 2019-01-15
SI2363392T1 (sl) 2017-09-29
ZA200807955B (en) 2012-11-28
PL2363392T3 (pl) 2017-10-31
HRP20170857T1 (hr) 2017-12-01
ECSP088783A (es) 2008-10-31
EP1999109B1 (en) 2011-12-28
HUS1300028I1 (hu) 2017-08-28
US20090123369A1 (en) 2009-05-14
TWI399366B (zh) 2013-06-21
TW200838852A (en) 2008-10-01
CY1119048T1 (el) 2018-01-10
CY2013024I2 (el) 2015-11-04
CA2644530A1 (en) 2007-11-08
PL1999109T3 (pl) 2012-05-31
PT2363392T (pt) 2017-06-15
GT200800201A (es) 2009-08-20
US8840866B2 (en) 2014-09-23
EA200870389A1 (ru) 2009-04-28
AU2007243712B2 (en) 2013-01-10
ES2378785T3 (es) 2012-04-17
FR13C0034I2 (fr) 2014-03-07
SG173338A1 (en) 2011-08-29
SI1999109T1 (sl) 2012-04-30
DK2363392T3 (da) 2017-07-03
LT2363392T (lt) 2017-07-25

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