HRP20120135T1 - Derivati stirilpiridina i njihova upotreba kod vezanja na i vizualizacije amiloidnih plakova - Google Patents

Derivati stirilpiridina i njihova upotreba kod vezanja na i vizualizacije amiloidnih plakova Download PDF

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Publication number
HRP20120135T1
HRP20120135T1 HR20120135T HRP20120135T HRP20120135T1 HR P20120135 T1 HRP20120135 T1 HR P20120135T1 HR 20120135 T HR20120135 T HR 20120135T HR P20120135 T HRP20120135 T HR P20120135T HR P20120135 T1 HRP20120135 T1 HR P20120135T1
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HR
Croatia
Prior art keywords
halogen substituted
image
halogen
compound according
formula
Prior art date
Application number
HR20120135T
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English (en)
Croatian (hr)
Inventor
F. Kung Hank
Kung Mei-Ping
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The Trustees Of The University Of Pennsylvania
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Application filed by The Trustees Of The University Of Pennsylvania filed Critical The Trustees Of The University Of Pennsylvania
Publication of HRP20120135T1 publication Critical patent/HRP20120135T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR20120135T 2006-03-30 2007-03-26 Derivati stirilpiridina i njihova upotreba kod vezanja na i vizualizacije amiloidnih plakova HRP20120135T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78715606P 2006-03-30 2006-03-30
PCT/US2007/007400 WO2007126733A2 (fr) 2006-03-30 2007-03-26 Dérivés de styrylpyridine et leurs applications à la liaison et à l'imagerie de plaques amyloïdes

Publications (1)

Publication Number Publication Date
HRP20120135T1 true HRP20120135T1 (hr) 2012-03-31

Family

ID=38326579

Family Applications (2)

Application Number Title Priority Date Filing Date
HR20120135T HRP20120135T1 (hr) 2006-03-30 2007-03-26 Derivati stirilpiridina i njihova upotreba kod vezanja na i vizualizacije amiloidnih plakova
HRP20170857TT HRP20170857T1 (hr) 2006-03-30 2017-06-06 Derivati stirilpiridina i njihova uporaba za vezanje i snimanje amiloidnih naslaga

Family Applications After (1)

Application Number Title Priority Date Filing Date
HRP20170857TT HRP20170857T1 (hr) 2006-03-30 2017-06-06 Derivati stirilpiridina i njihova uporaba za vezanje i snimanje amiloidnih naslaga

Country Status (35)

Country Link
US (3) US7687052B2 (fr)
EP (3) EP2363391A1 (fr)
JP (1) JP5290954B2 (fr)
KR (1) KR101376807B1 (fr)
CN (1) CN101522624B (fr)
AT (1) ATE539060T1 (fr)
AU (1) AU2007243712B2 (fr)
BE (1) BE2013C044I2 (fr)
BR (1) BRPI0710225B1 (fr)
CA (1) CA2644530C (fr)
CR (1) CR10329A (fr)
CY (3) CY1113048T1 (fr)
DK (2) DK2363392T3 (fr)
EA (1) EA017898B1 (fr)
EC (1) ECSP088783A (fr)
ES (2) ES2628882T3 (fr)
FR (1) FR13C0034I2 (fr)
GT (1) GT200800201A (fr)
HR (2) HRP20120135T1 (fr)
HU (2) HUE032660T2 (fr)
IL (1) IL193567A (fr)
LT (1) LT2363392T (fr)
LU (1) LU92232I2 (fr)
MX (1) MX2008012527A (fr)
NO (2) NO342090B1 (fr)
NZ (1) NZ570887A (fr)
PL (2) PL2363392T3 (fr)
PT (2) PT1999109E (fr)
RS (2) RS52222B (fr)
SG (1) SG173338A1 (fr)
SI (2) SI1999109T1 (fr)
TW (1) TWI399366B (fr)
UA (1) UA97802C2 (fr)
WO (1) WO2007126733A2 (fr)
ZA (1) ZA200807955B (fr)

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ES2628882T3 (es) * 2006-03-30 2017-08-04 The Trustees Of The University Of Pennsylvania Derivados de estirilpiridina, y su uso para unir y formar imágenes de placas amiloides
EP2172444A4 (fr) * 2007-07-04 2010-12-22 Univ Tohoku Sonde de tep ayant un groupe alcoxy substitué par un atome de fluor et un groupe hydroxy
JP5603855B2 (ja) 2008-04-04 2014-10-08 アビッド レディオファーマシューティカルズ、インク． 神経変成疾患の放射性薬剤による画像化
KR20110119670A (ko) * 2008-12-31 2011-11-02 애비드 라디오파마슈티컬스, 인크. 토실레이트 전구체로부터 18ｆ―방사성표지된 스티릴피리딘의 합성 및 그로부터의 안정한 약제학적 조성물
CN102471177A (zh) * 2009-07-10 2012-05-23 拜耳医药股份有限公司 低至中压液相色谱在放射性示踪剂纯化中的应用
EP2501696B1 (fr) 2009-10-15 2016-12-28 Guerbet Agents pour l'imagerie et leur utilisation pour le diagnostic in vivo de maladies neurodégénératrices, notamment la maladie d'alzheimer et des maladies apparentées
CN102762229B9 (zh) * 2009-12-23 2020-12-01 皮拉马影像股份公司 适用于用疏水pet试剂pet成像的配方
WO2011141515A1 (fr) 2010-05-14 2011-11-17 Bayer Pharma Aktiengesellschaft Agents de diagnostic pour l'imagerie d'amyloïdes bêta
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CA2801530C (fr) 2010-06-04 2017-09-12 Piramal Imaging Sa Procede de production de ligands de l'amyloide beta marques au 18f
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TWI504414B (zh) 2010-06-04 2015-10-21 Bayer Schering Pharma Ag 生產Ｆ－１８標記之Ａβ配位體之方法
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EP2627361B1 (fr) * 2010-10-12 2017-09-20 Mayo Foundation For Medical Education And Research Imagerie de méningiomes en utilisant des dérivés de phénylbenzothiazole, stilbène, ou biphénylalcyne
US20140079635A1 (en) * 2011-03-30 2014-03-20 Case Western Reserve University Molecular probes for detecting lipid composition
EP2699157B1 (fr) 2011-04-21 2018-03-14 The Regents of The University of California Nanoparticules magnétiques fonctionnalisées et leur utilisation dans l'imagerie de dépôts amyloïdes et d'enchevêtrements neurofibrillaires
EP2768790A1 (fr) 2011-10-19 2014-08-27 Piramal Imaging SA Procédé amélioré de production de ligands a marqués au f18
WO2013173004A2 (fr) 2012-04-10 2013-11-21 Lantheus Medical Imaging, Inc. Procédés de synthèse d'agent radiopharmaceutique
JP6099045B2 (ja) * 2013-04-30 2017-03-22 国立大学法人京都大学 トリアゾロピリミジン誘導体化合物
JP2014218454A (ja) * 2013-05-07 2014-11-20 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
JP6041751B2 (ja) * 2013-05-07 2016-12-14 日本メジフィジックス株式会社 スチリルピリジン誘導体化合物
CN103645254B (zh) * 2013-11-28 2015-01-07 江苏省原子医学研究所 一种Aβ斑块显像剂前体AV45的含量分析方法
SI3143011T1 (sl) 2014-05-13 2021-08-31 F. Hoffmann-La Roche Ag Devterirane heterociklične spojine in njihova uporaba kot kontrastna sredstva
CN107949383B (zh) 2015-08-18 2022-08-23 加利福尼亚大学董事会 用于成像的含氮氧化合物的淀粉样蛋白结合剂
US10300155B2 (en) 2015-12-31 2019-05-28 Washington University Alpha-synuclein ligands
CN109400615B (zh) * 2017-08-18 2021-07-16 上海交通大学医学院附属新华医院 一种靶向β-淀粉样蛋白的香豆素类化合物及其制备与应用
CN108299287A (zh) * 2018-01-02 2018-07-20 北京师范大学 与Aβ斑块具有高亲和力的N2S2类吡啶基苯乙烯化合物
CN114805190A (zh) * 2022-06-08 2022-07-29 吉林大学第一医院 一种甲基苯胺类Aβ蛋白显像剂的双柱合成方法
CN120187703A (zh) 2022-11-14 2025-06-20 伊莱利利公司 氟贝他吡前体av-105的多晶型物

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JP4482352B2 (ja) 2004-03-11 2010-06-16 本田技研工業株式会社 固体高分子型燃料電池
US7858072B2 (en) * 2004-12-17 2010-12-28 The Trustees Of The University Of Pennsylvania Stilbene derivatives and their use for binding and imaging amyloid plaques
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ES2628882T3 (es) 2006-03-30 2017-08-04 The Trustees Of The University Of Pennsylvania Derivados de estirilpiridina, y su uso para unir y formar imágenes de placas amiloides
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Publication number Publication date
PL1999109T3 (pl) 2012-05-31
PT2363392T (pt) 2017-06-15
FR13C0034I1 (fr) 2013-08-09
US20130129624A1 (en) 2013-05-23
CY1119048T1 (el) 2018-01-10
CA2644530C (fr) 2015-05-19
GT200800201A (es) 2009-08-20
EP2363392A1 (fr) 2011-09-07
ECSP088783A (es) 2008-10-31
DK2363392T3 (en) 2017-07-03
TWI399366B (zh) 2013-06-21
US8840866B2 (en) 2014-09-23
SG173338A1 (en) 2011-08-29
ES2378785T3 (es) 2012-04-17
HRP20170857T1 (hr) 2017-12-01
IL193567A0 (en) 2009-05-04
US7687052B2 (en) 2010-03-30
NO20084590L (no) 2008-12-29
AU2007243712B2 (en) 2013-01-10
US8506929B2 (en) 2013-08-13
JP2009532349A (ja) 2009-09-10
MX2008012527A (es) 2008-10-14
EP1999109A2 (fr) 2008-12-10
SI1999109T1 (sl) 2012-04-30
WO2007126733A3 (fr) 2008-03-06
US20080038195A1 (en) 2008-02-14
JP5290954B2 (ja) 2013-09-18
BRPI0710225B1 (pt) 2021-07-13
AU2007243712A1 (en) 2007-11-08
KR20080106564A (ko) 2008-12-08
RS52222B (sr) 2012-10-31
PT1999109E (pt) 2012-03-16
BE2013C044I2 (fr) 2026-04-24
NO2018030I1 (no) 2018-09-11
EA017898B1 (ru) 2013-04-30
CN101522624A (zh) 2009-09-02
NZ570887A (en) 2011-05-27
RS56171B1 (sr) 2017-11-30
BRPI0710225A2 (pt) 2011-08-02
DK1999109T3 (da) 2012-04-02
CY1113048T1 (el) 2015-11-04
NO342090B1 (no) 2018-03-19
LU92232I9 (fr) 2019-01-15
CN101522624B (zh) 2013-11-06
HUS1300028I1 (hu) 2017-08-28
EP2363392B1 (fr) 2017-05-03
ATE539060T1 (de) 2012-01-15
LT2363392T (lt) 2017-07-25
HUE032660T2 (en) 2017-10-30
EP2363391A1 (fr) 2011-09-07
TW200838852A (en) 2008-10-01
CY2013024I2 (el) 2015-11-04
US20090123369A1 (en) 2009-05-14
UA97802C2 (uk) 2012-03-26
CR10329A (es) 2008-10-29
LU92232I2 (fr) 2013-08-26
WO2007126733A2 (fr) 2007-11-08
EA200870389A1 (ru) 2009-04-28
PL2363392T3 (pl) 2017-10-31
ZA200807955B (en) 2012-11-28
CY2013024I1 (el) 2015-11-04
FR13C0034I2 (fr) 2014-03-07
ES2628882T3 (es) 2017-08-04
EP1999109B1 (fr) 2011-12-28
KR101376807B1 (ko) 2014-03-20
SI2363392T1 (sl) 2017-09-29
CA2644530A1 (fr) 2007-11-08
IL193567A (en) 2014-03-31

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