HRP20120969T1 - Spoj azola - Google Patents

Spoj azola Download PDF

Info

Publication number
HRP20120969T1
HRP20120969T1 HRP20120969AT HRP20120969T HRP20120969T1 HR P20120969 T1 HRP20120969 T1 HR P20120969T1 HR P20120969A T HRP20120969A T HR P20120969AT HR P20120969 T HRP20120969 T HR P20120969T HR P20120969 T1 HRP20120969 T1 HR P20120969T1
Authority
HR
Croatia
Prior art keywords
carboxylate
piperidine
methylpyridin
acceptable salt
compound according
Prior art date
Application number
HRP20120969AT
Other languages
English (en)
Croatian (hr)
Inventor
Satoshi Aoki
Ryosuke Munakata
Noriyuki Kawano
Kiyohiro Samizu
Hiromasa Oka
Takahiro Ishii
Takashi Sugane
Original Assignee
Astellas Pharma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc. filed Critical Astellas Pharma Inc.
Publication of HRP20120969T1 publication Critical patent/HRP20120969T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HRP20120969AT 2008-07-14 2009-07-13 Spoj azola HRP20120969T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008182251 2008-07-14
PCT/JP2009/062680 WO2010007966A1 (fr) 2008-07-14 2009-07-13 Composé azole

Publications (1)

Publication Number Publication Date
HRP20120969T1 true HRP20120969T1 (hr) 2012-12-31

Family

ID=41550369

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20120969AT HRP20120969T1 (hr) 2008-07-14 2009-07-13 Spoj azola

Country Status (21)

Country Link
US (1) US8207199B2 (fr)
EP (1) EP2308869B1 (fr)
JP (1) JP5423675B2 (fr)
KR (1) KR101566051B1 (fr)
CN (1) CN102099354B (fr)
AU (1) AU2009273105B2 (fr)
BR (1) BRPI0915876B1 (fr)
CA (1) CA2730793C (fr)
CY (1) CY1113439T1 (fr)
DK (1) DK2308869T3 (fr)
ES (1) ES2393245T3 (fr)
HR (1) HRP20120969T1 (fr)
IL (1) IL210226A (fr)
MX (1) MX2011000415A (fr)
PL (1) PL2308869T3 (fr)
PT (1) PT2308869E (fr)
RU (1) RU2493154C2 (fr)
SI (1) SI2308869T1 (fr)
TW (1) TWI434842B (fr)
WO (1) WO2010007966A1 (fr)
ZA (1) ZA201100139B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011085216A2 (fr) 2010-01-08 2011-07-14 Ironwood Pharmaceuticals, Inc. Utilisation d'inhibiteurs de faah pour traiter la maladie de parkinson et le syndrome des jambes sans repos
US20130224151A1 (en) 2010-03-31 2013-08-29 United States Of America Use of FAAH Inhibitors for Treating Abdominal, Visceral and Pelvic Pain
JP2013147430A (ja) * 2010-04-28 2013-08-01 Astellas Pharma Inc 夜間頻尿の予防又は治療剤
TW201206440A (en) * 2010-04-28 2012-02-16 Astellas Pharma Inc Prophylactic or therapeutic agent for diseases associated with pains in urinary organs
FR2974365B1 (fr) * 2011-04-20 2017-08-25 Centre Nat De La Rech Scient (C N R S) 1,2,3-triazoles 1,4-disubstituees, leurs procedes de preparation et leurs utilisations diagnostiques et therapeutiques
DE102012018115A1 (de) 2012-09-13 2014-03-13 Matthias Lehr Aryl-N-(arylalkyl)carbamate als Hemmstoffe der Fatty Acid Amide Hydrolase
MX2015004285A (es) * 2012-10-02 2015-08-06 Sumitomo Dainippon Pharma Co Ltd Derivado de imidazol.
DE102013016573A1 (de) 2013-10-04 2015-04-09 Matthias Lehr 1-Tetrazolylpropan-2-one als Inhibitoren von cytosolischer Phospholipase A2 und Fatty Acid Amide Hydrolase, insbesondere geeignet zur topischen Anwendung
CN106632260B (zh) * 2016-09-29 2019-04-26 上海天慈生物谷生物工程有限公司 一种小分子激酶抑制剂的制备方法
JP2019533022A (ja) * 2016-10-24 2019-11-14 ユマニティ セラピューティクス，インコーポレーテッド 化合物及びその使用
EP3566055B1 (fr) 2017-01-06 2025-03-12 Janssen Pharmaceutica NV Inhibiteurs de la scd pour le traitement de troubles neurologiques
CA3083000A1 (fr) * 2017-10-24 2019-05-02 Yumanity Therapeutics, Inc. Composes et utilisations de ces composes
CN108409727A (zh) * 2017-10-25 2018-08-17 巨德峰 一种脂肪酰胺水解酶抑制剂及其制备方法
WO2019183587A1 (fr) 2018-03-23 2019-09-26 Yumanity Therapeutics, Inc. Composés et leurs utilisations
JP2021522253A (ja) 2018-04-25 2021-08-30 ユマニティ セラピューティクス，インコーポレーテッド 化合物及びその使用
CN108912112A (zh) * 2018-08-14 2018-11-30 李敬敬 一种化合物、制备方法以及其在治疗疼痛中的应用
WO2020154571A1 (fr) 2019-01-24 2020-07-30 Yumanity Therapeutics, Inc. Composés et leurs utilisations
EA202192047A1 (ru) 2019-11-13 2021-12-08 Юманити Терапьютикс, Инк. Соединения и их применение
WO2023086671A1 (fr) * 2021-11-15 2023-05-19 The Broad Institute, Inc. Composés, compositions et méthodes pour induire une activité intracellulaire antimicrobienne et pour prévenir et traiter des infections microbiennes

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK27598A3 (en) * 1996-06-29 1998-11-04 Samjin Pharm Co Ltd Piperazine derivatives and process for the preparation thereof
EP1458374A2 (fr) 2001-12-14 2004-09-22 Novo Nordisk A/S Composes ralentissant l'activite de la lipase hormono-sensible
US6949574B2 (en) 2002-02-08 2005-09-27 Bristol-Myers Squibb Company (Oxime)carbamoyl fatty acid amide hydrolase inhibitors
EA010267B1 (ru) 2002-10-07 2008-06-30 Те Риджентс Оф Те Юниверсити Оф Калифорния Модуляция тревоги через блокаду гидролиза анандамида
FR2854633B1 (fr) * 2003-05-07 2005-06-24 Sanofi Synthelabo Derives de piperidinyl-et piperazinyl-alkylcarbamates, leur preparation et leur application en therapeutique
GB0325956D0 (en) 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
FR2866884B1 (fr) 2004-02-26 2007-08-31 Sanofi Synthelabo Derives d'aryl-et d'heteroaryl-piperidinecarboxylates, leur preparation et leur application en therapeutique
TW200633990A (en) 2004-11-18 2006-10-01 Takeda Pharmaceuticals Co Amide compound
TWI385164B (zh) * 2005-02-17 2013-02-11 Astellas Pharma Inc Pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate derivatives (II)
GB2424955B (en) 2005-04-09 2008-07-16 Siemens Ag Flow meter with conductive coating
GB0510139D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
US7541359B2 (en) 2005-06-30 2009-06-02 Janssen Pharmaceutica N.V. N-heteroarylpiperazinyl ureas as modulators of fatty acid amide hydrolase
JPWO2007020888A1 (ja) 2005-08-12 2009-02-26 武田薬品工業株式会社 脳・神経細胞保護剤および睡眠障害治療薬

Also Published As

Publication number Publication date
US20110118311A1 (en) 2011-05-19
JP5423675B2 (ja) 2014-02-19
PL2308869T3 (pl) 2013-02-28
TW201014840A (en) 2010-04-16
SI2308869T1 (sl) 2012-12-31
BRPI0915876B1 (pt) 2019-07-09
RU2011105151A (ru) 2012-08-20
MX2011000415A (es) 2011-03-15
US8207199B2 (en) 2012-06-26
CY1113439T1 (el) 2016-06-22
ES2393245T3 (es) 2012-12-19
IL210226A (en) 2014-07-31
JPWO2010007966A1 (ja) 2012-01-05
CA2730793C (fr) 2014-12-30
TWI434842B (zh) 2014-04-21
KR20110038671A (ko) 2011-04-14
AU2009273105A1 (en) 2010-01-21
IL210226A0 (en) 2011-03-31
BRPI0915876A2 (pt) 2015-11-03
ZA201100139B (en) 2012-03-28
EP2308869A4 (fr) 2011-07-27
CN102099354B (zh) 2013-07-10
EP2308869A1 (fr) 2011-04-13
PT2308869E (pt) 2012-12-06
WO2010007966A1 (fr) 2010-01-21
DK2308869T3 (da) 2012-10-08
KR101566051B1 (ko) 2015-11-04
RU2493154C2 (ru) 2013-09-20
CA2730793A1 (fr) 2010-01-21
AU2009273105B2 (en) 2013-09-05
CN102099354A (zh) 2011-06-15
EP2308869B1 (fr) 2012-09-19

Similar Documents

Publication Publication Date Title
HRP20120969T1 (hr) Spoj azola
NZ592792A (en) Heterocyclically substituted aryl compounds as hif inhibitors
NO20081434L (no) 5-(fenylisoksazolyletoksy)-triazol-3-yl substituert pyridinsammensetninger for behandling av neurologisk, psykiatrisk eller smerteforstyrrelser
JP2004531473A5 (fr)
JP2006500348A5 (fr)
RU2017127135A (ru) Терапевтическое средство против рака желчных протоков
HRP20160421T1 (hr) Derivat azola
UA90545C2 (ru) Твердая фармацевтическая лекарственная форма для перорального введения с быстрым высвобождением ингибитора фактора ха свертывания крови
WO2010100476A3 (fr) Procédé amélioré
JP2011502958A5 (fr)
BR112013032122A2 (pt) liberação modificada de 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluorometil)fenil] benzamida solubilizada usando ácidos orgânicos
NO20084853L (no) Forbindelser som er agonister av muscarinreseptorer og som kan vaere effektive i behandling av smerte, Alzheimers sykdom og/eller schizofreni
PE20090948A1 (es) Inhibidor de la proteina activadora de la 5-lipoxigenasa (flap)
IL198775A0 (en) Novel intermediate and process useful in the preparation of {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1h-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone
NZ596154A (en) Cyclic compound having substituted phenyl group
JP2008513405A5 (fr)
JP2020500192A5 (fr)
EA201590687A1 (ru) Лечение легкой и умеренной болезни альцгеймера
EA201490960A1 (ru) Состав 4-метил-3-[[4-(3-пиридинил)-2-пиримидинил]амино]-n-[5-(4-метил-1h-имидазол-1-ил)-3-(трифторметил)фенил]бензамид с немедленным высвобождением
WO2007034279A3 (fr) Antagonistes de c3a et leurs compositions pharmaceutiques
JP2016520636A5 (fr)
JP2016525113A5 (fr)
NO20052803L (no) Komplekser av e-2-metoksy-n-(3-{4-(3-metyl-pyridin-3-yloksy)-fenylam ino)-kinazolin-6-yl}-allyl)acetamid, deres fremstillingsmate og bruk
EA201270527A1 (ru) Комбинация
HRP20171295T1 (hr) Derivat 6-okso-1,6-dihidro-piridazina za upotrebu za liječenje hepatocelularnog karcinoma (hcc)