HRP20171939T1 - Formulacija protutijela i režimi terapije - Google Patents

Formulacija protutijela i režimi terapije Download PDF

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HRP20171939T1
HRP20171939T1 HRP20171939TT HRP20171939T HRP20171939T1 HR P20171939 T1 HRP20171939 T1 HR P20171939T1 HR P20171939T T HRP20171939T T HR P20171939TT HR P20171939 T HRP20171939 T HR P20171939T HR P20171939 T1 HRP20171939 T1 HR P20171939T1
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antibody
seq
heavy chain
light chain
sequence
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HRP20171939TT
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Dingjiang Liu
Holly Zhuohong Huang
David Andrew Martin
Christopher Boyd Russell
David H. Salinger
Scott Walter Baumgartner
Christopher J. Endres
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Kirin-Amgen, Inc.
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Application filed by Kirin-Amgen, Inc. filed Critical Kirin-Amgen, Inc.
Publication of HRP20171939T1 publication Critical patent/HRP20171939T1/hr

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Claims (17)

1. Farmaceutska formulacija, koja sadrži vodenu otopinu pufera glutaminske kiseline i protutijela koje sadrži sekvencu varijabilne domene teškog lanca koja obuhvaća SEQ ID NO:3 i sekvencu varijabilne domene lakog lanca koja obuhvaća SEQ ID NO:4, naznačena time da se navedeno protutijelo specifično veže na ljudski receptor A za IL-17, te što: a) navedena formulacija sadrži glutaminsku kiselinu u koncentraciji od 5-30 mM ± 0,2 mM; b) navedena formulacija ima pH 4,5-5,2 ± 0,2; c) navedena formulacija dalje sadrži 2-4% prolin (mas/v) i 0,005-0,02% (mas/v) polisorbat 20; d) navedeno protutijelo ima koncentraciju od 100 do 150 mg/ml.
2. Farmaceutska formulacija prema zahtjevu 1, naznačena time da protutijelo sadrži sekvencu teškog lanca koja obuhvaća SEQ ID NO:1 i sekvencu lakog lanca koja obuhvaća SEQ ID NO:2, ili alternativno, sekvencu teškog lanca koja obuhvaća SEQ ID NO:12 i sekvencu lakog lanca koja obuhvaća sekvencu SEQ ID NO:2.
3. Farmaceutska formulacija prema zahtjevu 1 ili zahtjevu 2, naznačena time da nadalje ima osmolarnost od 250 do 400 mOsm/L.
4. Farmaceutski kontejner, koji obuhvaća posudu i farmaceutsku formulaciju prema bilo kojem od zahtjeva 1 do 3, naznačena time da je navedena posuda bočica, boca, prethodno napunjena injekcija, ili prethodno napunjena autoinjektorska injekcija.
5. Komplet, naznačen time da sadrži jedan ili više farmaceutskih spremnika prema zahtjevu 4 i upute u vezi s njihovom upotrebom.
6. Farmaceutska formulacija prema bilo kojem od zahtjeva 1-3 naznačena time da je za upotrebu u postupku liječenja psorijaze kod humanog pacijenta, pri čemu je protutijelo u dozi od 70, 140, 210 ili 280 mg.
7. Farmaceutska formulacija za upotrebu prema zahtjevu 6, naznačena time da se navedenom pacijentu daje doza od 70 do 280 mg navedenog protutijela svakog tjedna, svaka dva tjedna i/ili svakog mjeseca.
8. Farmaceutska formulacija za upotrebu prema zahtjevu 7, naznačena time da se doza od 140 mg navedenog protutijela daje pacijentima koji imaju tjelesnu masu koja je manja od ili približno jednaka 100 kg, te da se doza od 210 mg navedenog protutijela daje pacijentima koji imaju tjelesnu masu koja je veća od 100 kg.
9. Farmaceutska formulacija za upotrebu prema bilo kojem od zahtjeva 6 do 8, naznačena time da se psorijaza bira iz skupine koja sadrži: a) psorijazu koja dovodi do stvaranja plaka; b) umjerenu psorijazu do psorijaze s ozbiljnim simptomima koja dovodi do stvaranja plaka; c) kroničnu umjerenu psorijazu do psorijaze s ozbiljnim simptomima koja dovodi do stvaranja plaka i navedeni pacijenti su kandidati za sistemsku terapiju ili fototerapiju; i d) kroničnu umjerenu psorijazu do psorijaze s ozbiljnim simptomima koja dovodi do stvaranja plaka i što navedeni pacijenti ne reagiraju na, imaju kontraindikaciju prema, ili su netolerantni na druge sistemske terapije uključujući ciklosporin, metotreksat, i psoralen plus fototerapiju ultraljubičastim-A zračenjem.
10. Farmaceutska formulacija za upotrebu prema bilo kojem od zahtjeva 6 do 9, naznačena time da navedena farmaceutska formulacija sadrži oko 140 mg/ml navedenog protutijela, koje je formulirano s 10 ± 0,2 mM glutaminskom kiselinom, 3 ± 0,2% (mas/v) L-prolinom, 0,01 ± 0,002% (mas/v) polisorbatom 20, pH 4,8 ± 0,2.
11. Farmaceutska formulacija za upotrebu prema bilo kojem od zahtjeva 6-10, naznačena time da se navedena farmaceutska formulacija daje subkutano, intradermalno, intramuskularno, i/ili intravenozno.
12. Farmaceutski pripravak koji sadrži protutijelo od oko 100-150 mg/ml, koje je formulirano s: i) glutaminskom kiselinom u koncentraciji od 10 mM; ii) pH od 4,8 ± 0,2; iii) 3% prolinom (mas/v) i 0,01% (mas/v) polisorbatom 20; pri čemu se navedeno protutijelo bira iz skupine koja sadrži: a) protutijelo koje sadrži sekvencu varijabilne domene teškog lanca koja sadrži SEQ ID NO:3 i sekvencu varijabilne domene lakog lanca koja sadrži SEQ ID NO:4, pri čemu se navedeno protutijelo specifično veže za ljudski receptor A za IL-17; i b) protutijelo koje sadrži sekvencu teškog lanca koja sadrži SEQ ID NO:1 i sekvencu lakog lanca koji sadrži SEQ ID NO:2, ili alternativno, sekvencu teškog lanca koja sadrži SEQ ID NO:12 i sekvencu lakog lanca koja sadrži SEQ ID NO:2, za upotrebu u postupku liječenja psorijaznog artritisa kod humanog pacijenta, pri čemu je protutijelo u dozi od 70, 140, 210 ili 280 mg.
13. Farmaceutski pripravak koji sadrži protutijelo od oko 100-150 mg/ml, koje je formulirano s: i) glutaminskom kiselinom u koncentraciji od 10 mM; ii) pH od 4,8 ± 0,2; iii) 3% prolinom (mas/v) i 0,01% (mas/v) polisorbatom 20; pri čemu se navedeno protutijelo bira iz skupine koja sadrži: a) protutijelo koje sadrži sekvencu varijabilne domene teškog lanca koja sadrži SEQ ID NO:3 i sekvencu varijabilne domene lakog lanca koja sadrži SEQ ID NO:4, pri čemu se navedeno protutijelo specifično veže za ljudski receptor A za IL-17; i b) protutijelo koje sadrži sekvencu teškog lanca koja sadrži SEQ ID NO: 1 i sekvencu lakog lanca koji sadrži SEQ ID NO:2, ili alternativno, sekvencu teškog lanca koja sadrži SEQ ID NO:12 i sekvencu lakog lanca koja sadrži SEQ ID NO:2, za upotrebu u postupku liječenja astme kod humanog pacijenta, što je navedeno protutijelo u dozi od 70, 140, 210 ili 280 mg.
14. Farmaceutski pripravak koji sadrži protutijelo od oko 100-150 mg/ml, koje je formulirano s: i) glutaminskom kiselinom u koncentraciji od 10 mM; ii) pH od 4,8 ± 0,2; iii) 3% prolinom (mas/v) i 0,01% (mas/v) polisorbatom 20; pri čemu se navedeno protutijelo bira iz skupine koja sadrži: a) protutijelo koje sadrži sekvencu varijabilne domene teškog lanca koja sadrži SEQ ID NO:3 i sekvencu varijabilne domene lakog lanca koja sadrži SEQ ID NO:4, pri čemu se navedeno protutijelo specifično veže za ljudski receptor A za IL-17; i b) protutijelo koje sadrži sekvencu teškog lanca koja sadrži SEQ ID NO: 1 i sekvencu lakog lanca koji sadrži SEQ ID NO:2, ili alternativno, sekvencu teškog lanca koja sadrži SEQ ID NO:12 i sekvencu lakog lanca koja sadrži SEQ ID NO:2, za upotrebu u postupku liječenja ankilozirajućeg spondilitisa kod humanog pacijenta, što je navedeno protutijelo u dozi od 70, 140, 210 ili 280 mg.
15. Farmaceutski pripravak koji sadrži protutijelo od oko 100-150 mg/ml, koje je formulirano s: i) glutaminskom kiselinom u koncentraciji od 10 mM; ii) pH od 4,8 ± 0,2; iii) 3% prolinom (mas/v) i 0,01% (mas/v) polisorbatom 20; pri čemu se navedeno protutijelo bira iz skupine koja sadrži: a) protutijelo koje sadrži sekvencu varijabilne domene teškog lanca koja sadrži SEQ ID NO:3 i sekvencu varijabilne domene lakog lanca koja sadrži SEQ ID NO:4, pri čemu se navedeno protutijelo specifično veže za ljudski receptor A za IL-17; i b) protutijelo koje sadrži sekvencu teškog lanca koja sadrži SEQ ID NO: 1 i sekvencu lakog lanca koji sadrži SEQ ID NO:2, ili alternativno, sekvencu teškog lanca koja sadrži SEQ ID NO:12 i sekvencu lakog lanca koja sadrži SEQ ID NO:2, za upotrebu u postupku liječenja multiple skleroze kod humanog pacijenta, što je navedeno protutijelo u dozi od 70, 140, 210 ili 280 mg.
16. Formulacija za upotrebu prema bilo kojem od zahtjeva 12 do 15, naznačena time da navedena farmaceutska formulacija nadalje sadrži oko 140 mg/ml navedenog protutijela i što navedeni lijek ima viskoznost od 5 do 7 cP na 25 stupnjeva C.
17. Formulacija za upotrebu prema bilo kojem od zahtjeva 12 do 16, naznačena time da se farmaceutska formulacija daje subkutano, intradermalno, intramuskularno, i/ili intravenozno.
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Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767206B2 (en) 2006-10-02 2010-08-03 Amgen Inc. Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto
JO3244B1 (ar) 2009-10-26 2018-03-08 Amgen Inc بروتينات ربط مستضادات il – 23 البشرية
SI2523688T1 (en) * 2010-01-15 2018-03-30 Kirin-Amgen, Inc. Formulation of antibodies and therapeutic regimes
DK2531218T3 (en) * 2010-02-04 2019-04-01 Csl Behring Ag immunoglobulin
US9932403B2 (en) 2010-05-20 2018-04-03 Ablynx Nv Biological materials related to HER3
CA2885176C (en) 2010-09-22 2018-10-23 Amgen Inc. Carrier immunoglobulins and uses thereof
BR112013025866A2 (pt) * 2011-04-07 2016-12-20 Glaxosmithkline Llc formulações com viscosidade reduzida
UA117218C2 (uk) 2011-05-05 2018-07-10 Мерк Патент Гмбх Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
JOP20200043A1 (ar) 2011-05-10 2017-06-16 Amgen Inc طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول
US20140234330A1 (en) * 2011-07-22 2014-08-21 Amgen Inc. Il-17 receptor a is required for il-17c biology
WO2013078375A2 (en) * 2011-11-23 2013-05-30 Amgen Inc. Administration of alpha4beta7 hetero-dimer-specific antibody
CA2866128C (en) * 2012-03-07 2017-02-28 Eli Lilly And Company Il-17 antibody formulation
EA039663B1 (ru) 2012-05-03 2022-02-24 Амген Инк. Применение антитела против pcsk9 для снижения сывороточного холестерина лпнп и лечения связанных с холестерином расстройств
EP3184542A1 (en) 2012-05-14 2017-06-28 Novo Nordisk A/S Stabilised protein solutions
EP3689369A1 (en) 2013-03-15 2020-08-05 Amgen, Inc Methods for treating psoriasis using an anti-il-23 antibody
US20160031983A1 (en) 2013-03-15 2016-02-04 Amgen Inc. Methods for treating crohn's disease using an anti-il23 antibody
KR102530900B1 (ko) * 2014-03-31 2023-05-12 암젠 케이-에이, 인크. 손발톱 및 두피 건선의 치료 방법
WO2015175861A1 (en) 2014-05-16 2015-11-19 Amgen Inc. Assay for detecting th1 and th2 cell populations
MY186840A (en) * 2014-08-26 2021-08-25 Amgen K A Inc Method for treating psoriasis patient which received anti-tnf-alpha antibody therapy
WO2016039319A1 (ja) * 2014-09-10 2016-03-17 日油株式会社 蛋白質吸着抑制剤及び蛋白質吸着抑制方法
CN121371151A (zh) 2014-12-03 2026-01-23 瑞士杰特贝林生物制品有限公司 具有增加的稳定性的包含免疫球蛋白的药物产品
AR103173A1 (es) 2014-12-22 2017-04-19 Novarits Ag Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17
MX2018003376A (es) 2015-09-17 2018-08-15 Amgen Inc Prediccion de la respuesta clinica a antagonistas de il23 mediante el uso de biomarcadores de la via de il23.
HK1255922A1 (zh) 2015-11-04 2019-09-06 Astrazeneca Ab 二肽基肽酶-4和骨膜素作为嗜酸性粒细胞疾病中嗜酸性粒细胞靶向治疗药物临床反应的预测因子
WO2017112536A1 (en) 2015-12-22 2017-06-29 Amgen Inc. Ccl20 as a predictor of clinical response to il23-antagonists
CN114265251B (zh) 2016-04-19 2024-12-06 Sage电致变色显示有限公司 包括透明导电氧化物层和汇流条的电致变色装置和其形成方法
GB201612043D0 (en) * 2016-07-11 2016-08-24 Crescendo Biologics Ltd Composition for treatment of disorders
CA2974531A1 (en) * 2017-07-26 2019-01-26 Michael Giroux Safety anchor and roof vent
GB201719447D0 (en) 2017-11-23 2018-01-10 Ucb Biopharma Sprl Pharmaceutical composition
JP2021532176A (ja) 2018-07-13 2021-11-25 アストラゼネカ・コラボレイション・ベンチャーズ・リミテッド・ライアビリティ・カンパニーAstrazeneca Collaboration Ventures, Llc ブラジクマブによる潰瘍性大腸炎の処置
PE20212185A1 (es) 2019-02-18 2021-11-11 Lilly Co Eli Formulacion de anticuerpos terapeuticos
WO2021050563A1 (en) * 2019-09-09 2021-03-18 The Rockefeller University Antibody treatment for lesional tissue of hidradenitis suppurativa
WO2021048359A1 (en) 2019-09-11 2021-03-18 Bausch Health Ireland Limited Methods of treating nonalcoholic fatty liver disease (nafld) using il-17ra antibody
MX2022010120A (es) * 2020-02-18 2022-09-05 Amgen Inc Formulaciones de anticuerpos anti-tslp humanos y metodos de uso de los mismos.
CN112891530B (zh) * 2020-06-19 2021-08-24 北京东方百泰生物科技股份有限公司 一种抗il-17ra单克隆抗体的注射制剂
EP4337257A1 (en) * 2021-05-12 2024-03-20 AnaptysBio, Inc. Antibody composition
EP4537345A1 (en) * 2022-06-06 2025-04-16 Fusion Pharmaceuticals Inc. Methods of dosing therapeutic agents
WO2024118430A1 (en) * 2022-12-02 2024-06-06 Regeneron Pharmaceuticals, Inc. Computational fluid dynamics model and methods of use

Family Cites Families (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1000835A (en) 1911-06-19 1911-08-15 Stewart A Minnick Calipers.
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
IL83878A (en) 1987-09-13 1995-07-31 Yeda Res & Dev Soluble protein corresponding to tnf inhibitory protein its preparation and pharmaceutical compositions containing it
IL98078A0 (en) 1991-05-07 1992-06-21 Yeda Res & Dev Pharmaceutical compositions comprising an anticytokyne
US5204244A (en) 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
GB8807803D0 (en) 1988-03-31 1988-05-05 Glaxo Group Ltd Biochemical product
KR900700134A (ko) 1988-04-15 1990-08-11 원본미기재 Il-2 수용체-특이적 키메릭 항체
IL94039A (en) 1989-08-06 2006-09-05 Yeda Res & Dev Antibodies to tbp - 1 and their use
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5116964A (en) 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
DE59010941D1 (de) 1989-04-21 2005-03-24 Amgen Inc TNF-Rezeptor, TNF bindende Proteine und dafür kodierende DNAs
DE3922089A1 (de) 1989-05-09 1990-12-13 Basf Ag Neue proteine und ihre herstellung
AU636608B2 (en) 1989-05-18 1993-05-06 Yeda Research And Development Co. Ltd. Tumor necrosis factor binding protein II, it's purification and antibodies thereto
IL95031A (en) 1989-07-18 2007-03-08 Amgen Inc Method for the production of a human recombinant tumor necrosis factor inhibitor
US5703088A (en) 1989-08-21 1997-12-30 Beth Israel Deaconess Medical Center, Inc. Topical application of spiperone or derivatives thereof for treatment of pathological conditions associated with immune responses
US5395760A (en) 1989-09-05 1995-03-07 Immunex Corporation DNA encoding tumor necrosis factor-α and -β receptors
CA2065346C (en) 1989-09-05 2005-03-29 Craig A. Smith Tumor necrosis factor-.alpha. and-.beta. receptors
DE59010908D1 (de) 1989-09-12 2000-08-10 Hoffmann La Roche TNF-bindende Proteine
JPH03127800A (ja) 1989-10-13 1991-05-30 Teijin Ltd 腫瘍壊死因子活性抑制物質
ES2080098T3 (es) 1989-12-13 1996-02-01 Yeda Res & Dev Expresion de la proteina de union i al factor de necrosis tumoral tbp-i recombinante.
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
EP1690935A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
US5136021A (en) 1990-02-27 1992-08-04 Health Research, Inc. TNF-inhibitory protein and a method of production
US6552170B1 (en) 1990-04-06 2003-04-22 Amgen Inc. PEGylation reagents and compounds formed therewith
US6458360B1 (en) 1990-04-25 2002-10-01 The Johns Hopkins University Soluble complement regulatory molecules
GB2243569A (en) 1990-05-02 1991-11-06 Andrew Langdon Brush with timer
EP0464533B1 (de) 1990-06-28 1998-07-29 Hoechst Aktiengesellschaft Fusionsproteine mit immunglobulinanteilen, ihre Herstellung und Verwendung
WO1992001002A1 (en) 1990-07-11 1992-01-23 Teijin Limited Tumor necrosis factor activity inhibitor and production thereof
GEP20002142B (en) 1991-01-18 2000-06-25 Amgen Inc Method for Treatment and Prevention of TNF Mediated Diseases
AU1674292A (en) 1991-03-15 1992-10-21 Synergen, Inc. Pegylation of polypeptides
IL99120A0 (en) 1991-08-07 1992-07-15 Yeda Res & Dev Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them
EP0611302B1 (en) 1991-10-15 2000-03-29 MULLARKEY, Michael F. Receptors for treating late phase inflammatory responses
US5716805A (en) 1991-10-25 1998-02-10 Immunex Corporation Methods of preparing soluble, oligomeric proteins
DE69233528T2 (de) 1991-11-25 2006-03-16 Enzon, Inc. Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen
DE69333027T2 (de) 1992-03-30 2004-05-06 Immunex Corp., Seattle Fusionsprotein , das zwei rezeptoren des tumornekrose-faktors enthält
CA2118119C (en) 1992-04-30 2001-07-31 Robert C. Thompson Methods for treating interleukin-1 and tumor necrosis factor mediated diseases
JPH05312248A (ja) 1992-05-08 1993-11-22 Nissan Motor Co Ltd シフトレバー装置
NZ256293A (en) 1992-09-15 1997-06-24 Immunex Corp Method of treating tumour necrosis factor - mediated inflammation by use of tnf antagonist
ATE199392T1 (de) 1992-12-04 2001-03-15 Medical Res Council Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung
US6562333B1 (en) 1993-06-14 2003-05-13 Schering Corporation Purified mammalian CTLA-8 antigens and related reagents
ES2229264T5 (es) 1995-03-23 2009-12-17 Immunex Corporation Receptor il-17.
US6680057B1 (en) 1995-03-23 2004-01-20 Immunex Corporation Methods of treating autoimmune disease by administering interleukin-17 receptor
EP0839196B1 (en) 1995-07-19 2005-05-11 Genetics Institute, LLC Human ctla-8 and uses of ctla-8-related proteins
US6074849A (en) 1995-07-19 2000-06-13 Genetics Institute, Inc. Polynucleotides encoding human CTLA-8 related proteins
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
TW555765B (en) 1996-07-09 2003-10-01 Amgen Inc Low molecular weight soluble tumor necrosis factor type-I and type-II proteins
US6406867B1 (en) 1996-08-16 2002-06-18 Human Genome Sciences, Inc. Antibody to human endokine alpha and methods of use
AU7408998A (en) 1996-11-27 1998-06-22 Immunex Corporation Method of regulating nitric oxide production
EP1972194A1 (en) 1996-12-03 2008-09-24 Amgen Fremont Inc. Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
US6482923B1 (en) 1997-09-17 2002-11-19 Human Genome Sciences, Inc. Interleukin 17-like receptor protein
EP1015488B1 (en) 1997-09-17 2009-09-09 Human Genome Sciences, Inc. Interleukin-17 receptor-like protein
ES2292242T5 (es) 1998-05-15 2011-05-04 Genentech, Inc. Utilizaciones terapéuticas de polipéptidos homólogos de il-17.
JP2000247903A (ja) * 1999-03-01 2000-09-12 Chugai Pharmaceut Co Ltd 長期安定化製剤
US6833268B1 (en) 1999-06-10 2004-12-21 Abgenix, Inc. Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
CZ305123B6 (cs) 1999-10-04 2015-05-13 Novartis Vaccines And Diagnostics, Inc. Způsob výroby kapalného farmaceutického prostředku
EP1266002A2 (en) 2000-03-16 2002-12-18 Amgen Inc., Il-17 receptor like molecules and uses thereof
TWI322154B (en) 2000-03-16 2010-03-21 Amgen Inc Il-17 receptor like molecules and uses thereof
US20030180255A1 (en) 2000-08-24 2003-09-25 Genentech, Inc. IL-17 homologous polypeptides and therapeutic uses thereof
CA2425506A1 (en) 2000-10-18 2002-08-01 Immunex Corporation Methods for treating rheumatoid arthritis using il-17 antagonists
CA2476934C (en) 2002-02-27 2009-06-16 Immunex Corporation Stabilized tnfr-fc composition comprising arginine
US20050153880A1 (en) 2002-06-27 2005-07-14 Yukio Goto Methods of treating or preventing ibd with il-18
CN1678634A (zh) 2002-06-28 2005-10-05 多曼蒂斯有限公司 免疫球蛋白单个变体抗原结合区及其特异性构建体
DE10333317A1 (de) 2003-07-22 2005-02-17 Biotecon Therapeutics Gmbh Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA)
JP2007501252A (ja) 2003-08-05 2007-01-25 スリーエム イノベイティブ プロパティズ カンパニー 免疫応答調整剤を含有する製剤
GB0321703D0 (en) * 2003-09-16 2003-10-15 Imerys Minerals Ltd Surface modified fillers for polymer resin compositions
WO2005063291A1 (ja) 2003-12-25 2005-07-14 Kirin Beer Kabushiki Kaisha 抗体を含有する安定な水性医薬製剤
IL159670A0 (en) 2003-12-31 2004-06-01 Yeda Res & Dev Use of il-18 binding protein in inflammations
JP2008501826A (ja) 2004-06-04 2008-01-24 デジグナー モレキュールズ インコーポレイテッド フリーラジカル硬化可能なポリエステル類およびその使用方法
GB0425569D0 (en) 2004-11-19 2004-12-22 Celltech R&D Ltd Biological products
WO2006088925A2 (en) 2005-02-14 2006-08-24 Wyeth Use of il17-f in diagnosis and therapy of airway inflammation
JP2008543839A (ja) 2005-06-14 2008-12-04 アムジェン インコーポレーテッド 自己緩衝タンパク質製剤
WO2007019232A2 (en) 2005-08-03 2007-02-15 Immunogen, Inc. Immunoconjugate formulations
CA2618068C (en) 2005-08-05 2016-02-16 Amgen Inc. Stable aqueous protein or antibody pharmaceutical formulations and their preparation
DE602006009834D1 (de) 2005-09-01 2009-11-26 Schering Corp Verwendung von il-23 und il-17-antagonisten zur behandlung von autoimmuner entzündlicher augenerkrankung
WO2007047738A1 (en) 2005-10-18 2007-04-26 Zymogenetics, Inc. Il-17c antagonists and methods of using the same
US20070135343A1 (en) 2005-11-01 2007-06-14 Wyeth Sodium chloride solution for drug reconstitution or dilution
JP5231810B2 (ja) 2005-12-28 2013-07-10 中外製薬株式会社 抗体含有安定化製剤
JP2009525986A (ja) 2006-02-03 2009-07-16 メディミューン，エルエルシー タンパク質製剤
US7767206B2 (en) 2006-10-02 2010-08-03 Amgen Inc. Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto
UA99716C2 (ru) * 2006-10-02 2012-09-25 Кирин-Амген Инк. Антитело, которое специфично связывает человеческий il-17 рецептор а (il-17ra)
CA2666842A1 (en) 2006-10-18 2008-04-24 Zymogenetics, Inc. Il-17c antagonists and methods of using the same
FR2910324B1 (fr) 2006-12-21 2009-03-06 Biomerieux Sa Nouveau medicament pour le traitement d'un cancer gastrique
EP2129401B8 (en) * 2006-12-21 2020-01-15 Amgen Inc. Stable buffered formulations containing polypeptides
GB0700523D0 (en) 2007-01-11 2007-02-21 Insense Ltd The Stabilisation Of Proteins
CA2679588A1 (en) 2007-03-26 2008-10-02 Zymogenetics, Inc. Soluble il-17ra/rc fusion proteins and related methods
EP2170958A1 (en) 2007-06-13 2010-04-07 Amgen Inc. Il-17 heteromeric receptor complex
WO2009006301A2 (en) 2007-06-29 2009-01-08 Battelle Memorial Institute Protein stabilization
WO2009026122A1 (en) 2007-08-17 2009-02-26 Amgen Inc. Formulations of antibodies and fc-fusion molecules using polycations
JP2011514335A (ja) 2008-02-21 2011-05-06 アムジェン インコーポレイテッド Ｉｌ−１７ｒａ−ｉｌ−１７ｒｂアンタゴニストおよび該アンタゴニストの使用
TW201117824A (en) 2009-10-12 2011-06-01 Amgen Inc Use of IL-17 receptor a antigen binding proteins
SI2523688T1 (en) 2010-01-15 2018-03-30 Kirin-Amgen, Inc. Formulation of antibodies and therapeutic regimes
MX356279B (es) 2010-10-08 2018-05-22 Novartis Ag Star Métodos para el tratamiento de soriasis usando antagonistas de il-17.
EP3214442A1 (en) 2010-10-25 2017-09-06 F. Hoffmann-La Roche AG Treatment of gastrointestinal inflammation and psoriasis and asthmainflammation and psoriasis a
BR112013025845A2 (pt) * 2011-04-07 2018-09-04 Glaxosmithkline Llc formulações com viscosidade reduzida
BR112013025866A2 (pt) * 2011-04-07 2016-12-20 Glaxosmithkline Llc formulações com viscosidade reduzida
US20140234330A1 (en) 2011-07-22 2014-08-21 Amgen Inc. Il-17 receptor a is required for il-17c biology
KR102530900B1 (ko) 2014-03-31 2023-05-12 암젠 케이-에이, 인크. 손발톱 및 두피 건선의 치료 방법
MY186840A (en) 2014-08-26 2021-08-25 Amgen K A Inc Method for treating psoriasis patient which received anti-tnf-alpha antibody therapy

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