HRP20172003T1 - Toll-like receptor koji modulira spojeve 4,6-diamino-pirido[3,2-d]pirimidina - Google Patents
Toll-like receptor koji modulira spojeve 4,6-diamino-pirido[3,2-d]pirimidina Download PDFInfo
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- HRP20172003T1 HRP20172003T1 HRP20172003TT HRP20172003T HRP20172003T1 HR P20172003 T1 HRP20172003 T1 HR P20172003T1 HR P20172003T T HRP20172003T T HR P20172003TT HR P20172003 T HRP20172003 T HR P20172003T HR P20172003 T1 HRP20172003 T1 HR P20172003T1
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61P31/20—Antivirals for DNA viruses
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- A61P37/08—Antiallergic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/145—Maleic acid
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
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- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
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- C07C59/255—Tartaric acid
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- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (15)
1. Spoj odabran od
[image]
ili njegova farmaceutski prihvatljiva sol.
2. Spoj patentnog zahtjeva 1, koji je odabran ođ
[image]
[image]
3. Spoj patentnog zahtjeva I, koji je
[image]
ili njegova farmaceutski prihvatljiva sol.
4. Spoj bilo kojeg od patentnih zahtjeva 1 do 3, koji je
[image]
5. Spoj patentnog zahtjeva 1, koji je
[image]
ili njegova farmaceutski prihvatljiva sol.
6. Spoj bilo kojeg od patentnih zahtjeva 1,2 ili 5, koji je
[image]
7. Spoj patentnog zahtjeva 1, koji je
[image]
ili njegova farmaceutski prihvatljiva sol.
8. Spoj bilo kojeg od patentnih zahtjeva 1, 2 ili 7, koji je
[image]
9. Spoj patentnog zahtjeva 1, koji je
[image]
ili njegova farmaceutski prihvatljiva sol.
10. Spoj bilo kojeg od patentnih zahtjeva 1, 2 ili 9, koji je
[image]
11. Farmaceutska kompozicija koja sadrži spoj bilo kojeg od patentnih zahtjeva 1 do 10, ili njegovu farmaceutski prihvatljivu sol, i farmaceutski prihvatljiv ekscipijens.
12. Spoj bilo kojeg od patentnih zahtjeva 1-10, ili njegova farmaceutski prihvatljiva sol, za primjenu u medicinskoj terapiji.
13. Spoj bilo kojeg od patentnih zahtjeva 1-10, ili njegova farmaceutski prihvatljiva sol, za primjenu u liječenju ili prevenciji virusne infekcije hepatitisom B.
14. Spoj ili sol za primjenu iz patentnog zahtjeva 13, gdje je primjena u kombinaciji sa jednim ili više dodatnih terapijskih agenasa.
15. Spoj ili sol za primjenu iz patentnog zahtjeva 14, gdje je primjena u kombinaciji sa jednim, dva, tri ili četiri dodatna terapijska agensa koji su odabrani od grupe koja se sastoji od - inhibitori HBV DNK polimeraze, modulatori toll-like receptora 7, modulatori toll-like receptora 8, modulatori toll-like receptora 7 i 8, modulatori toll-like receptora 3, interferon alfa ligandi, HBsAg inhibitori, spojeva koja ciljaju HbcAg, ciklofilinski inhibitori, HBV terapijske vakcine, HBV profilaktičke vakcine, inhibitori HBV virusnog ulaska, NTCP inhibitori, antisens oligonukleotid koji cilja virusnu iRNK, male interferirajuće RNK (siRNK), inhibitori E antigena hepatitis B virusa, HBx inhibitori, cccDNK inhibitori, HBV antitijela koja uključuju HBV antitijela koja ciljaju površinske antigene virusa hepatitisa B, agonisti timozina, citokini, inhibitori nukleoproteina (inhibitori proteina HBV jezgra ili kapsida), stimulatori gena 1 induciranog retinoinskom kiselinom, stimulatori NOD2, inhibitori rekombinantnog timozin alfa-1 i replikacije hepatitis B virusa, inhibitori sekrecije površinskog antigena hepatitisa B (HbsAg) ili inhibitori sklapanja, IDO inhibitori, i njihove kombinacije.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562128397P | 2015-03-04 | 2015-03-04 | |
| US201562250403P | 2015-11-03 | 2015-11-03 | |
| PCT/US2016/020499 WO2016141092A1 (en) | 2015-03-04 | 2016-03-02 | Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds |
| EP16711723.3A EP3097102B1 (en) | 2015-03-04 | 2016-03-02 | Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20172003T1 true HRP20172003T1 (hr) | 2018-02-23 |
Family
ID=55590135
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20172003TT HRP20172003T1 (hr) | 2015-03-04 | 2016-03-02 | Toll-like receptor koji modulira spojeve 4,6-diamino-pirido[3,2-d]pirimidina |
| HRP20201075TT HRP20201075T1 (hr) | 2015-03-04 | 2020-07-09 | 4,6-diamino-pirido[3,2-d]pirimidinski spojevi i njihova upotreba kao modulatora receptora sličnih tolu |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20201075TT HRP20201075T1 (hr) | 2015-03-04 | 2020-07-09 | 4,6-diamino-pirido[3,2-d]pirimidinski spojevi i njihova upotreba kao modulatora receptora sličnih tolu |
Country Status (43)
Families Citing this family (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008009078A2 (en) | 2006-07-20 | 2008-01-24 | Gilead Sciences, Inc. | 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
| MX380504B (es) | 2010-06-03 | 2025-03-12 | Pharmacyclics Llc | El uso de inhibidores de la tirosina quinasa de bruton (btk). |
| HK1206073A1 (en) | 2012-07-24 | 2015-12-31 | 药品循环有限责任公司 | Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk) |
| WO2016106050A1 (en) | 2014-12-26 | 2016-06-30 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
| SG11201606876RA (en) | 2015-03-04 | 2016-10-28 | Gilead Sciences Inc | Toll like receptor modulator compounds |
| US20180263985A1 (en) * | 2015-09-15 | 2018-09-20 | Gilead Sciences, Inc. | Modulators of toll-like receptors for the treatment of hiv |
| JP6732915B2 (ja) | 2015-12-15 | 2020-07-29 | ギリアード サイエンシーズ， インコーポレイテッド | ヒト免疫不全ウイルス中和抗体 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
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| SI3507276T1 (sl) | 2016-09-02 | 2022-01-31 | Gilead Sciences, Inc. | Spojine modulatorja toličnih receptorjev |
| MA46292A (fr) * | 2016-09-23 | 2019-07-31 | Abbvie Inc | Réglage de dose |
| WO2018054782A1 (en) * | 2016-09-23 | 2018-03-29 | Bayer Pharma Aktiengesellschaft | Combination of pi3k-inhibitors |
| KR20230010826A (ko) | 2016-10-14 | 2023-01-19 | 프리시젼 바이오사이언시스 인코포레이티드 | B형 간염 바이러스 게놈 내의 인식 서열에 대해 특이적인 조작된 메가뉴클레아제 |
| GB201700814D0 (en) | 2017-01-17 | 2017-03-01 | Liverpool School Tropical Medicine | Compounds |
| RU2650610C1 (ru) * | 2017-02-28 | 2018-04-16 | Васильевич Иващенко Александр | Противовирусная композиция и способ ее применения |
| KR101899773B1 (ko) | 2017-03-07 | 2018-09-18 | 일동제약(주) | 베시포비르 디피복실 또는 이의 약제학적 허용되는 염 함유 과립, 상기 과립을 포함하는 약제학적 조성물 및 이의 제조 방법 |
| BR102018007822A2 (pt) | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| WO2018233648A1 (zh) * | 2017-06-21 | 2018-12-27 | 南京明德新药研发股份有限公司 | 作为TLR8激动剂的异噻唑并[4,3-d]嘧啶-5,7-二胺衍生物 |
| AR112412A1 (es) | 2017-08-17 | 2019-10-23 | Gilead Sciences Inc | Formas de sal de colina de un inhibidor de la cápside del vih |
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| CN108069963B (zh) * | 2017-11-17 | 2020-01-14 | 清华大学 | 吡啶并嘧啶衍生物或其盐及其制法、药物组合物和用途 |
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| JP7037667B2 (ja) | 2017-12-20 | 2022-03-16 | インスティチュート オブ オーガニック ケミストリー アンド バイオケミストリー エーエスシーアール，ヴイ．ヴイ．アイ． | Ｓｔｉｎｇアダプタータンパク質を活性化するホスホン酸結合を有する３’３’環状ジヌクレオチド |
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