HRP20191268T1 - Derivati tieno[2,3-c]pirol-4-ona kao inhibitori erk - Google Patents

Derivati tieno[2,3-c]pirol-4-ona kao inhibitori erk Download PDF

Info

Publication number
HRP20191268T1
HRP20191268T1 HRP20191268T HRP20191268T1 HR P20191268 T1 HRP20191268 T1 HR P20191268T1 HR P20191268 T HRP20191268 T HR P20191268T HR P20191268 T1 HRP20191268 T1 HR P20191268T1
Authority
HR
Croatia
Prior art keywords
compound
salt
cancer
methyl
salt according
Prior art date
Application number
Other languages
English (en)
Croatian (hr)
Inventor
Guillermo S Cortez
Sajan Joseph
Johnathan Alexander Mclean
William T Mcmillen
Michael John Rodriguez
Gaiying Zhao
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HRP20191268T1 publication Critical patent/HRP20191268T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HRP20191268 2014-12-22 2015-12-16 Derivati tieno[2,3-c]pirol-4-ona kao inhibitori erk HRP20191268T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462095185P 2014-12-22 2014-12-22
EP15823869.1A EP3237423B1 (fr) 2014-12-22 2015-12-16 Dérivés de thiéno[2,3-c]pyrrol-4-one comme inhibiteurs erk
PCT/US2015/065940 WO2016106029A1 (fr) 2014-12-22 2015-12-16 Dérivés de thiéno[2,3-c]pyrrol-4-one utilisés en tant qu'inhibiteurs de erk

Publications (1)

Publication Number Publication Date
HRP20191268T1 true HRP20191268T1 (hr) 2019-11-01

Family

ID=55135525

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20191268 HRP20191268T1 (hr) 2014-12-22 2015-12-16 Derivati tieno[2,3-c]pirol-4-ona kao inhibitori erk

Country Status (44)

Country Link
US (3) US9469652B2 (fr)
EP (1) EP3237423B1 (fr)
JP (1) JP6445701B2 (fr)
KR (1) KR101917972B1 (fr)
CN (1) CN107108648B (fr)
AR (1) AR102977A1 (fr)
AU (1) AU2015369983C1 (fr)
BR (1) BR112017011130A2 (fr)
CA (1) CA2966559C (fr)
CL (1) CL2017001514A1 (fr)
CO (1) CO2017005217A2 (fr)
CR (1) CR20170182A (fr)
CY (1) CY1121831T1 (fr)
DK (1) DK3237423T3 (fr)
DO (1) DOP2017000122A (fr)
EA (1) EA031659B1 (fr)
EC (1) ECSP17038500A (fr)
ES (1) ES2738406T3 (fr)
GT (1) GT201700134A (fr)
HR (1) HRP20191268T1 (fr)
HU (1) HUE045933T2 (fr)
IL (1) IL252065B (fr)
JO (1) JO3596B1 (fr)
LT (1) LT3237423T (fr)
MA (1) MA41251B1 (fr)
MD (1) MD3237423T2 (fr)
ME (1) ME03490B (fr)
MX (1) MX371206B (fr)
MY (1) MY178426A (fr)
NZ (1) NZ731531A (fr)
PE (1) PE20171043A1 (fr)
PH (1) PH12017501155B1 (fr)
PL (1) PL3237423T3 (fr)
PT (1) PT3237423T (fr)
RS (1) RS59015B1 (fr)
SG (1) SG11201704521SA (fr)
SI (1) SI3237423T1 (fr)
SV (1) SV2017005443A (fr)
TN (1) TN2017000233A1 (fr)
TR (1) TR201909887T4 (fr)
TW (1) TWI704151B (fr)
UA (1) UA119686C2 (fr)
WO (1) WO2016106029A1 (fr)
ZA (1) ZA201702786B (fr)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3052096T1 (en) 2013-10-03 2018-04-30 Kura Oncology, Inc. EAQ inhibitors and application procedures
TWI704151B (zh) * 2014-12-22 2020-09-11 美商美國禮來大藥廠 Ｅｒｋ抑制劑
JP6322770B2 (ja) 2014-12-22 2018-05-09 イーライ リリー アンド カンパニー Ｅｒｋ阻害剤
WO2017068412A1 (fr) 2015-10-21 2017-04-27 Otsuka Pharmaceutical Co., Ltd. Composés benzolactames utilisés en tant qu'inhibiteurs de protéine kinase
EP3478292A1 (fr) * 2016-06-29 2019-05-08 Eli Lilly and Company Combinaison d'un composé inhibiteur d'erk1/2 avec la gemcitabine ou avec la gemcitabine et nab-paclitaxel pour utilisation dans le traitement du cancer du pancréas
WO2018081204A1 (fr) * 2016-10-26 2018-05-03 Li George Y N-(5-((4-éthylpipérazine-1-yl)méthyl) pyridin-2-yl)-5-fluoro-4-(4-fluoro-1-isopropyl-2-méthyl-1h-benzo[d]imidazol-6-yl)pyrimidin-2-amine deutéré
GB201706327D0 (en) 2017-04-20 2017-06-07 Otsuka Pharma Co Ltd A pharmaceutical compound
BR112020010012A2 (pt) 2017-11-24 2020-10-13 Janssen Pharmaceutica Nv compostos de pirazolopiridinona
WO2019199883A1 (fr) * 2018-04-09 2019-10-17 G1 Therapeutics, Inc. Traitement de cancers ayant des mutations oncogéniques d'entraînement
US12133841B2 (en) * 2018-05-22 2024-11-05 Js Innomed Holdings Ltd. Heterocyclic compounds as kinase inhibitors, compositions comprising the heterocyclic compound, and methods of use thereof
BR112021011894A2 (pt) 2018-12-21 2021-09-08 Daiichi Sankyo Company, Limited Composição farmacêutica
EP3946620B1 (fr) * 2019-03-27 2023-04-26 Eli Lilly and Company Sels de composé 5,6-dihydro-4h-thiéno[2,3-c]pyrrol-4-one utilisés en tant qu'inhibiteurs d'erk
KR20210145773A (ko) * 2019-03-28 2021-12-02 지앙수 헨그루이 메디슨 컴퍼니 리미티드 티에노헤테로고리형 유도체, 이의 제조 방법 및 이의 의약적 용도
WO2020200069A1 (fr) * 2019-03-29 2020-10-08 江苏恒瑞医药股份有限公司 Dérivé pyrrolohétérocyclique, son procédé de préparation et son application en médecine
JP7234418B2 (ja) * 2019-05-16 2023-03-07 イーライ リリー アンド カンパニー Ｂｒａｆｖ６００ｅ大腸癌の治療に使用するためのｅｒｋ１／２阻害剤と、ｂｒａｆ阻害剤およびｅｇｆｒ阻害剤との三重組み合わせ
CN112457326B (zh) * 2019-09-06 2022-02-15 上海凌达生物医药有限公司 一类芳香杂环并内酰胺类化合物、制备方法和用途
AU2020394767B2 (en) * 2019-12-06 2023-05-25 D3 Bio (Wuxi) Co., Ltd. Spiro compound serving as ERK inhibitor, and application thereof
CN110950876B (zh) * 2019-12-10 2021-08-17 上海凌达生物医药有限公司 一类呋喃并内酰胺类化合物、制备方法和用途
WO2021216777A1 (fr) * 2020-04-21 2021-10-28 The Trustees Of The Stevens Institute Of Technology Inhibiteurs d'erk pour thérapie anticancéreuse
US20230331731A1 (en) * 2020-09-29 2023-10-19 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Crystal form of pyrrolo heterocyclic derivative and preparation method therefor
CN114315837B (zh) * 2020-09-29 2023-06-16 江苏恒瑞医药股份有限公司 一种erk抑制剂的结晶形式及其制备方法
WO2023274088A1 (fr) * 2021-06-28 2023-01-05 南京明德新药研发有限公司 Composé de thiazololactame à substitution diméthyle et son utilisation
IL309711A (en) * 2021-06-28 2024-02-01 D3 Bio Wuxi Co Ltd THIAZOLE-LACTAM-SPIROHETEROCYCLIC COMPOUNDS AND THEIR USES
AU2022383957A1 (en) * 2021-11-15 2024-05-30 Erasca, Inc. Thiophene ulk1/2 inhibitors and their use thereof
WO2023137297A2 (fr) * 2022-01-11 2023-07-20 Suvalent Therapeutics, Inc. Inhibiteurs de 5,6-dihydro-4h-thieno[2,3-c]pyrrole sumo et leurs utilisations
US20240352029A1 (en) * 2023-04-14 2024-10-24 Prelude Therapeutics Incorporated CDK Inhibitors And Their Use As Pharmaceuticals
KR20260019479A (ko) 2023-05-04 2026-02-10 레볼루션 메디슨즈, 인크. Ras 관련 질환 또는 장애를 위한 병용 요법
CN121889155A (zh) 2023-08-07 2026-04-17 锐新医药公司 用于治疗ras蛋白相关疾病或病症的rmc-6291
AU2024360465A1 (en) 2023-10-12 2026-04-09 Revolution Medicines, Inc. Macrocyclic ras inhibitors
WO2025171296A1 (fr) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Inhibiteurs de ras
WO2025240847A1 (fr) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Inhibiteurs de ras
US20250375445A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (fr) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Compositions thérapeutiques et procédés de gestion d'effets liés au traitement
WO2026006747A1 (fr) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Inhibiteurs de ras
WO2026015790A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Méthodes de traitement d'une maladie ou d'un trouble lié à ras
WO2026015796A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Méthodes de traitement d'une maladie ou d'un trouble lié à ras
WO2026015801A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Méthodes de traitement d'une maladie ou d'un trouble liés à ras
WO2026015825A1 (fr) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Utilisation d'un inhibiteur de ras pour traiter le cancer du pancréas
WO2026050446A1 (fr) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Inhibiteurs de ras
WO2026072904A2 (fr) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions et méthodes de traitement du cancer du poumon
WO2026090116A2 (fr) 2024-10-21 2026-04-30 Revolution Medicines, Inc. Inhibiteurs de ras
US20260108528A1 (en) 2024-10-22 2026-04-23 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2026090245A1 (fr) 2024-10-22 2026-04-30 Revolution Medicines, Inc. Utilisation d'inhibiteurs ras pour traiter un cancer
WO2026106912A1 (fr) 2024-11-12 2026-05-21 Revolution Medicines, Inc. Inhibiteurs de ras
WO2026112260A1 (fr) 2024-11-21 2026-05-28 Revolution Medicines, Inc. Inhibiteurs de ras
WO2026122764A2 (fr) 2024-12-06 2026-06-11 Revolution Medicines, Inc. Inhibiteurs de ras
WO2026128688A2 (fr) 2024-12-13 2026-06-18 Revolution Medicines, Inc. Inhibiteurs de ras
WO2026161839A1 (fr) 2025-01-27 2026-07-30 Revolution Medicines, Inc. Inhibiteurs de ras

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4023048A1 (de) * 1990-07-20 1992-01-23 Basf Ag Dicarbonsaeureimide, verfahren zu ihrer herstellung und ihre verwendung als herbizide
US7473691B2 (en) * 2000-09-15 2009-01-06 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
AU2001290912A1 (en) * 2000-09-15 2002-03-26 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
PT1916001E (pt) 2002-03-04 2011-07-18 Imclone Llc Anticorpos humanos específicos para kdr e suas utilizações
US7259161B2 (en) * 2002-11-04 2007-08-21 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of JAK and other protein kinases
UA80571C2 (en) 2002-11-22 2007-10-10 Lilly Co Eli Quinolinyl-pyrrolopyrazoles
US7803806B2 (en) 2005-11-03 2010-09-28 Sgx Pharmaceuticals, Inc. Pyrimidinyl-thiophene kinase modulators
WO2010022121A1 (fr) 2008-08-20 2010-02-25 Schering Corporation Dérivés de pyridine et pyrimidine substituées et leur utilisation dans le traitement d'infections virales
CN102245600A (zh) * 2008-10-08 2011-11-16 百时美施贵宝公司 吡咯烷酮黑色素浓集激素受体-1拮抗剂
PA8852901A1 (es) * 2008-12-22 2010-07-27 Lilly Co Eli Inhibidores de proteina cinasa
ES2537190T3 (es) * 2010-09-01 2015-06-03 Gilead Connecticut, Inc. Piridazinonas, procedimiento de preparación y procedimientos de utilización de las mismas
AR087107A1 (es) 2011-07-27 2014-02-12 Lilly Co Eli Compuesto inhibidor de la señalizacion de la trayectoria notch
PE20150666A1 (es) * 2012-03-01 2015-05-06 Array Biopharma Inc Inhibidores de serina/treonina cinasa
AR090151A1 (es) 2012-03-07 2014-10-22 Lilly Co Eli Compuestos inhibidores de raf
US20140093498A1 (en) * 2012-09-28 2014-04-03 Boehringer Ingelheim International Gmbh Pharmaceutical combinations comprising dual angiopoietin-2 / dll4 binders and anti-vegf-r agents
TWI704151B (zh) * 2014-12-22 2020-09-11 美商美國禮來大藥廠 Ｅｒｋ抑制劑
JP6322770B2 (ja) * 2014-12-22 2018-05-09 イーライ リリー アンド カンパニー Ｅｒｋ阻害剤

Also Published As

Publication number Publication date
MD3237423T2 (ro) 2019-11-30
MA41251A (fr) 2017-11-01
DK3237423T3 (da) 2019-07-22
CO2017005217A2 (es) 2017-09-20
AU2015369983B2 (en) 2018-08-23
AU2015369983C1 (en) 2019-02-21
ZA201702786B (en) 2019-02-27
MX2017008242A (es) 2017-10-06
AR102977A1 (es) 2017-04-05
TR201909887T4 (tr) 2019-07-22
HUE045933T2 (hu) 2020-01-28
EA201791133A1 (ru) 2017-10-31
EP3237423A1 (fr) 2017-11-01
PH12017501155B1 (en) 2022-03-25
WO2016106029A1 (fr) 2016-06-30
TWI704151B (zh) 2020-09-11
SG11201704521SA (en) 2017-07-28
CN107108648A (zh) 2017-08-29
USRE48635E1 (en) 2021-07-13
CA2966559A1 (fr) 2016-06-30
PH12017501155A1 (en) 2017-11-27
US9526733B1 (en) 2016-12-27
CR20170182A (es) 2017-06-21
ME03490B (fr) 2020-01-20
JP6445701B2 (ja) 2018-12-26
SI3237423T1 (sl) 2019-08-30
TW201632530A (zh) 2016-09-16
EP3237423B1 (fr) 2019-06-05
SV2017005443A (es) 2018-08-27
KR20170083145A (ko) 2017-07-17
TN2017000233A1 (en) 2018-10-19
CY1121831T1 (el) 2020-07-31
ECSP17038500A (es) 2017-12-01
JP2017538768A (ja) 2017-12-28
LT3237423T (lt) 2019-08-26
BR112017011130A2 (pt) 2017-12-26
RS59015B1 (sr) 2019-08-30
US20160375030A1 (en) 2016-12-29
ES2738406T3 (es) 2020-01-22
CN107108648B (zh) 2019-07-12
UA119686C2 (uk) 2019-07-25
PE20171043A1 (es) 2017-07-19
MX371206B (es) 2020-01-22
US20160176896A1 (en) 2016-06-23
GT201700134A (es) 2018-11-23
PL3237423T3 (pl) 2020-01-31
AU2015369983A1 (en) 2017-05-25
JO3596B1 (ar) 2020-07-05
EA031659B1 (ru) 2019-02-28
NZ731531A (en) 2018-12-21
MA41251B1 (fr) 2019-09-30
CA2966559C (fr) 2019-06-18
KR101917972B1 (ko) 2018-11-12
MY178426A (en) 2020-10-13
IL252065A0 (en) 2017-07-31
DOP2017000122A (es) 2017-06-15
PT3237423T (pt) 2019-08-21
IL252065B (en) 2020-08-31
CL2017001514A1 (es) 2018-02-09
US9469652B2 (en) 2016-10-18

Similar Documents

Publication Publication Date Title
HK1202541A1 (en) 2-amino, 6-phenyl substituted pyrido [2, 3 - d] pyrimidine derivatives useful as raf kinase inhibitors
SI2989100T1 (en) NAFTIRIDINE DERIVATIVES USED AS ANTAGONISTS INTEGRITY OF ALFA-V-BETA-6
NZ629432A (en) Heterocyclyl compounds as mek inhibitors
MD4779B1 (ro) Compuşi aril sau heteroaril biciclici condensaţi şi utilizarea acestora ca inhibitori IRAK4
SG11201907095UA (en) DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO [1,2-a]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS
HRP20201949T1 (hr) 7-benzil-4-(4-(trifluorometil)benzil)-1,2,6,7,8,9-heksahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(4h)-on i njegove soli i njihova primjena u terapiji
EA201300620A1 (ru) ПРОИЗВОДНЫЕ ИМИДАЗО[1,2-b]ПИРИДАЗИНА И ИМИДАЗО[4,5-b]ПИРИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ JAK
PE20161246A1 (es) Acrilamidas de pirrolo[2,3-d]pirimidinilo, pirrolo[2,3-b]pirazinilo y pirrolo[2,3-d]piridinilo
SI3873884T1 (sl) 3-(kinolin-8-il)-1,4-dihidropirido[3,4-d]pirimidin-2,4-dionski derivati kot zaviralci integrina alfa4beta7 za zdravljenje vnetnih bolezni
PE20120534A1 (es) PIRIMIDINAS FUSIONADAS COMO INHIBIDORES DE Akt
EA201591255A1 (ru) ПРОИЗВОДНЫЕ ПИРРОЛО[2,3-d]ПИРИМИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС-РОДСТВЕННЫХ КИНАЗ (JAK)
IL241573B (en) Transformed histories of [2h]imidazo-[1,2-a]pyrazolo[4,3-e]pyrimidine-4[5h]-one, a pharmaceutical preparation containing them and their use as drugs
GEP20156417B (en) Pyrrolo [2,3-d] pyrimidine derivatives as inhibitors of tropomyosin-related kinases
HRP20120762T1 (hr) Tetrasupstituirani piridazini kao inhibitori hedgehog puta
HRP20201094T1 (hr) IMIDAZO[1,2-a]PIRIDINI, NAMIJENJENI LIJEČENJU ILI SPRJEČAVANJU HIPERURIKEMIJE ILI GIHTA
WO2013004995A8 (fr) Composés pyrimidinones et leur utilisation
PE20090944A1 (es) PIRIMIDINAS BICICLICAS FUSIONADAS COMO INHIBIDORES DE LA VIA Pi3K/AKT
MX2021002255A (es) Formas cristalinas de 3-(imidazo[1,2-b] piridazin-3- iletinil)-4-metil-n-(4-[(4-metilpiperazin-1-il) metil]-3-(trifluorometil)fenil) benzamida y su sal de monoclorhidrato.
JP2016540803A5 (fr)
ME02840B (fr) Composés phénoxyéthyl pipéridine
NZ628910A (en) Heterocyclic amide derivatives as p2x7 receptor antagonists
MX2015014025A (es) Derivados de n-(2,3-dihidro-1h-pirrolo[2,3,b]piridin-5-il)-4-quina zolinamina y n-(2,3-dihidro-1h-indol-5-il)-4-quinazolinamina novedosos como inhibidores de perk.
EA201691934A1 (ru) Замещенные 4,5,6,7-тетрагидро-пиразоло[1,5-альфа]пиримидиновые производные и 2,3-дигидро-1h-имидазо[1,2-бета]пиразольные производные в качестве ингибиторов ros1
MX2015012896A (es) Inhibidores de pirrolo [2,3-b] piridina cdk9 cinasa.
EA201790179A1 (ru) [1,2,4]триазоло[4,3-b]пиридазины для применения в лечении пролиферативных заболеваний