HRP20200076T1 - Kombinacijsko liječenje raka - Google Patents
Kombinacijsko liječenje raka Download PDFInfo
- Publication number
- HRP20200076T1 HRP20200076T1 HRP20200076TT HRP20200076T HRP20200076T1 HR P20200076 T1 HRP20200076 T1 HR P20200076T1 HR P20200076T T HRP20200076T T HR P20200076TT HR P20200076 T HRP20200076 T HR P20200076T HR P20200076 T1 HRP20200076 T1 HR P20200076T1
- Authority
- HR
- Croatia
- Prior art keywords
- cancer
- vrac modulator
- therapy
- anticancer therapy
- use according
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Inorganic Chemistry (AREA)
- Reproductive Health (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (15)
1. VRAC modulator formule I
ili njegova farmaceutski prihvatljiva sol, i terapija protiv raka za uporabu u liječenju raka, pri čemu terapija protiv raka je inhibitor topoizomeraze I odabran od irinotekana, njegovog aktivnog metabolita SN-38 ili topotekana.
2. VRAC modulator i terapija protiv raka za uporabu prema bilo kojem od prethodnih zahtjeva, pri čemu se VRAC modulator primjenjuje prije i/ili istovremeno s i/ili nakon početka terapije protiv raka.
3. VRAC modulator i terapija protiv raka za uporabu prema bilo kojem od prethodnih zahtjeva, pri čemu VRAC modulator je u obliku tableta ili kapsula za oralnu primjenu.
4. VRAC modulator i terapija protiv raka za uporabu prema bilo kojem od prethodnih zahtjeva, pri čemu VRAC modulator je u obliku tekućine za intravenoznu primjenu ili kontinuiranu infuziju.
5. VRAC modulator i terapija protiv raka za uporabu prema bilo kojem od prethodnih zahtjeva, pri čemu rak je otporan na terapiju protiv raka.
6. VRAC modulator i terapija protiv raka za uporabu prema bilo kojem od prethodnih zahtjeva, pri čemu rak je kruti tumor, poput krutog tumora odabranog od sarkoma, karcinoma i limfoma.
7. VRAC modulator i terapija protiv raka za uporabu prema bilo kojem od prethodnih zahtjeva, pri čemu rak je odabran iz skupine koja se sastoji od raka probavnog sustava, raka debelog crijeva, raka dojke, raka pluća (rak pluća ne-malih stanica i rak pluća malih stanica), glioblastoma, raka glave i vrata, zloćudnih melanoma, raka bazalnih stanica kože, raka skvamoznih stanica kože, raka jetre, raka gušterače, raka prostate, analnog raka, raka cerviksa maternice, raka mokraćnog mjehura, raka korpusa maternice, raka jajnika, raka žučnog mjehura, sarkoma, leukemija (mijeloidne i limfne), limfoma, mijelomatoza.
8. VRAC modulator i terapija protiv raka za uporabu prema bilo kojem od prethodnih zahtjeva, pri čemu rak je metastatski rak.
9. VRAC modulator i terapija protiv raka za uporabu prema bilo kojem od prethodnih zahtjeva, pri čemu rak je rak debelog crijeva, poput metastatskog raka debelog crijeva.
10. VRAC modulator i terapija protiv raka za uporabu prema bilo kojem od zahtjeva 1 do 9, pri čemu rak je rak dojke, poput metastatskog raka dojke.
11. VRAC modulator i terapija protiv raka za uporabu prema bilo kojem od zahtjeva 1 do 9, pri čemu rak je glioblastom.
12. VRAC modulator i terapija protiv raka za uporabu prema bilo kojem od zahtjeva 1 do 9, pri čemu rak je rak pluća.
13. Farmaceutski pripravak koji sadrži efikasnu količinu VRAC modulatora formule I
ili njegovu farmaceutski prihvatljivu sol, terapiju protiv raka i jedan ili više farmaceutski prihvatljivih adjuvansa, pomoćnih tvari, nosača, pufera i/ili razrjeđivača, pri čemu terapija protiv raka je inhibitor topoizomeraze I odabran od irinotekana, njegovog aktivnog metabolita SN-38 ili topotekana.
14. Farmaceutski pripravak koji sadrži efikasnu količinu VRAC modulatora formule I
ili njegovu farmaceutski prihvatljivu sol, i efikasnu količinu terapije protiv raka za uporabu kao lijek, pri čemu terapija protiv raka je inhibitor topoizomeraze I odabran od irinotekana, njegovog aktivnog metabolita SN-38 ili topotekana.
15. Set dijelova koji sadrži VRAC modulator formule I
ili njegovu farmaceutski prihvatljivu sol, i terapiju protiv raka, pri čemu su VRAC modulator i terapija protiv raka formulirani za istovremenu, sekvencijalnu ili zasebnu primjenu i izborno upute za uporabu, pri čemu terapija protiv raka je inhibitor topoizomeraze I odabran od irinotekana, njegovog aktivnog metabolita SN-38 ili topotekana.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201670325 | 2016-05-17 | ||
| EP17726573.3A EP3458052B1 (en) | 2016-05-17 | 2017-05-17 | Combination treatment of cancer |
| PCT/EP2017/061823 WO2017198700A1 (en) | 2016-05-17 | 2017-05-17 | Combination treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20200076T1 true HRP20200076T1 (hr) | 2020-04-03 |
Family
ID=58800797
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20200076TT HRP20200076T1 (hr) | 2016-05-17 | 2017-05-17 | Kombinacijsko liječenje raka |
| HRP20210572TT HRP20210572T1 (hr) | 2016-05-17 | 2021-04-09 | Kombinacijsko liječenje raka |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20210572TT HRP20210572T1 (hr) | 2016-05-17 | 2021-04-09 | Kombinacijsko liječenje raka |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US11103481B2 (hr) |
| EP (3) | EP3458052B1 (hr) |
| JP (1) | JP7033554B2 (hr) |
| CN (4) | CN109475535A (hr) |
| AU (1) | AU2017266724B2 (hr) |
| BR (1) | BR112018073518A2 (hr) |
| CA (1) | CA3023202A1 (hr) |
| CY (2) | CY1122541T1 (hr) |
| DK (2) | DK3622953T3 (hr) |
| ES (2) | ES2770374T3 (hr) |
| HR (2) | HRP20200076T1 (hr) |
| HU (2) | HUE047542T2 (hr) |
| LT (2) | LT3622953T (hr) |
| PL (2) | PL3622953T3 (hr) |
| PT (2) | PT3622953T (hr) |
| RS (2) | RS59844B1 (hr) |
| SI (2) | SI3458052T1 (hr) |
| SM (2) | SMT202100245T1 (hr) |
| WO (1) | WO2017198700A1 (hr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3458052B1 (en) * | 2016-05-17 | 2019-11-06 | Scandion Oncology A/S | Combination treatment of cancer |
| WO2019165158A1 (en) * | 2018-02-22 | 2019-08-29 | University Of Florida Research Foundation, Incorporated | Il-6 inhibitors and methods of treatment |
| US20210251963A1 (en) * | 2018-09-06 | 2021-08-19 | Scandion Oncology A/S | Urea derivatives for use in the treatment of subjects with elevated expression and/or activity of srpk1 |
| WO2020079051A1 (en) | 2018-10-16 | 2020-04-23 | Scandion Oncology A/S | Compounds for treatment of microbial infection |
| CA3221558A1 (en) | 2021-06-14 | 2022-12-22 | Peter Michael Vestlev | Methods of increasing the plasma drug exposure of anticancer agents |
| EP4104834A1 (en) | 2021-06-14 | 2022-12-21 | Scandion Oncology A/S | Combination treatments for cancer patients and methods for identifying same |
| AU2022292074A1 (en) | 2021-06-14 | 2023-12-14 | Scandion Oncology A/S | Combination treatments for cancer patients and methods for identifying same |
| TW202321205A (zh) | 2021-07-16 | 2023-06-01 | 丹麥商斯坎丁腫瘤公司 | Sco-101的熱力穩定形式 |
| EP4197525A1 (en) | 2021-12-20 | 2023-06-21 | Scandion Oncology A/S | Combination of drugs for the treatment of cancer |
| CN117229258B (zh) * | 2022-06-07 | 2024-07-19 | 杭州壹瑞医药科技有限公司 | N-四唑基芳基脲类衍生物及其制备方法和应用 |
| WO2023242235A1 (en) | 2022-06-14 | 2023-12-21 | Scandion Oncology A/S | Abcg2 inhibitor and nae inhibitor for the treatment of cancer |
| WO2024013058A1 (en) | 2022-07-11 | 2024-01-18 | Scandion Oncology A/S | Salts of sco-101 and methods involving salts |
| WO2025125679A1 (en) | 2023-12-15 | 2025-06-19 | Scandion Oncology A/S | Improved anti-cancer treatment regimen |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
| TR199902593T2 (xx) | 1997-04-22 | 2000-03-21 | Neurosearch A/S | �kame edilmi� fenil t�revleri, bunlar�n haz�rlanmas� ve kullan�m�. |
| OA11665A (en) | 1998-10-22 | 2004-12-08 | Neurosearch As | Substituted phenyl derivatives, their preparation and use. |
| WO2004012733A2 (en) * | 2002-08-01 | 2004-02-12 | Neurosearch A/S | Compounds useful for the treatment of diseases responsive to antiangiogenetic therapy |
| WO2004111017A1 (en) | 2003-06-17 | 2004-12-23 | Neurosearch A/S | Diphenylurea derivatives and their use as chloride channel blockers |
| DE602005015682D1 (de) | 2004-02-04 | 2009-09-10 | Neurosearch As | Dimere azacyclische verbindungen und deren verwendung |
| MX2007007029A (es) | 2004-12-17 | 2007-08-08 | Neurosearch As | Derivados de difenilurea utiles como activadores del canal de potasio. |
| AU2007224457A1 (en) * | 2006-03-14 | 2007-09-20 | Neurosearch A/S | Diphenylurea derivatives and their use as chloride channel blockers or BKca channel modulators |
| JO2885B1 (en) * | 2008-12-22 | 2015-03-15 | ايلي ليلي اند كومباني | Protein kinase inhibitors |
| TWI508954B (zh) * | 2012-04-27 | 2015-11-21 | Nat Defense Medical Ct | 雜環融合蒽醌衍生物、其製備方法與醫藥組合物 |
| EP2919009B1 (en) | 2014-03-10 | 2018-09-19 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft | LRRC8 proteins and protein complexes and methods for identification of channel modulators |
| EP3064207B1 (en) | 2015-03-04 | 2017-12-20 | Scandion Oncology A/S | 4-amino-3-phenylamino-6-phenylpyrazolo[3,4-d]pyrimidine derivatives for use as BCRP inhibitors in therapeutic treatments |
| EP3458052B1 (en) * | 2016-05-17 | 2019-11-06 | Scandion Oncology A/S | Combination treatment of cancer |
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2017
- 2017-05-17 EP EP17726573.3A patent/EP3458052B1/en active Active
- 2017-05-17 PL PL19205104T patent/PL3622953T3/pl unknown
- 2017-05-17 SM SM20210245T patent/SMT202100245T1/it unknown
- 2017-05-17 PL PL17726573T patent/PL3458052T3/pl unknown
- 2017-05-17 SM SM20200053T patent/SMT202000053T1/it unknown
- 2017-05-17 DK DK19205104.3T patent/DK3622953T3/da active
- 2017-05-17 CA CA3023202A patent/CA3023202A1/en active Pending
- 2017-05-17 CN CN201780043536.3A patent/CN109475535A/zh active Pending
- 2017-05-17 ES ES17726573T patent/ES2770374T3/es active Active
- 2017-05-17 PT PT192051043T patent/PT3622953T/pt unknown
- 2017-05-17 CN CN202411725070.3A patent/CN119548493A/zh active Pending
- 2017-05-17 HU HUE17726573A patent/HUE047542T2/hu unknown
- 2017-05-17 BR BR112018073518-3A patent/BR112018073518A2/pt not_active Application Discontinuation
- 2017-05-17 RS RS20200088A patent/RS59844B1/sr unknown
- 2017-05-17 CN CN202411725073.7A patent/CN119548494A/zh active Pending
- 2017-05-17 JP JP2018560218A patent/JP7033554B2/ja active Active
- 2017-05-17 CN CN202411725068.6A patent/CN119564679A/zh active Pending
- 2017-05-17 EP EP21162597.5A patent/EP3854393A1/en active Pending
- 2017-05-17 AU AU2017266724A patent/AU2017266724B2/en active Active
- 2017-05-17 HU HUE19205104A patent/HUE053744T2/hu unknown
- 2017-05-17 EP EP19205104.3A patent/EP3622953B1/en active Active
- 2017-05-17 SI SI201730169T patent/SI3458052T1/sl unknown
- 2017-05-17 PT PT177265733T patent/PT3458052T/pt unknown
- 2017-05-17 LT LTEP19205104.3T patent/LT3622953T/lt unknown
- 2017-05-17 ES ES19205104T patent/ES2870805T3/es active Active
- 2017-05-17 DK DK17726573.3T patent/DK3458052T3/da active
- 2017-05-17 SI SI201730713T patent/SI3622953T1/sl unknown
- 2017-05-17 LT LTEP17726573.3T patent/LT3458052T/lt unknown
- 2017-05-17 WO PCT/EP2017/061823 patent/WO2017198700A1/en not_active Ceased
- 2017-05-17 RS RS20210510A patent/RS61786B1/sr unknown
- 2017-05-17 US US16/302,195 patent/US11103481B2/en active Active
- 2017-05-17 HR HRP20200076TT patent/HRP20200076T1/hr unknown
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2020
- 2020-01-27 CY CY20201100070T patent/CY1122541T1/el unknown
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2021
- 2021-04-09 HR HRP20210572TT patent/HRP20210572T1/hr unknown
- 2021-04-15 CY CY20211100332T patent/CY1124242T1/el unknown
- 2021-07-29 US US17/388,208 patent/US11903927B2/en active Active
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